WO2001068052A3 - Phosphate based biodegradable polymers - Google Patents

Phosphate based biodegradable polymers Download PDF

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Publication number
WO2001068052A3
WO2001068052A3 PCT/US2001/007603 US0107603W WO0168052A3 WO 2001068052 A3 WO2001068052 A3 WO 2001068052A3 US 0107603 W US0107603 W US 0107603W WO 0168052 A3 WO0168052 A3 WO 0168052A3
Authority
WO
WIPO (PCT)
Prior art keywords
biodegradable polymers
featured
biodegradable
phosphate based
based biodegradable
Prior art date
Application number
PCT/US2001/007603
Other languages
French (fr)
Other versions
WO2001068052A2 (en
Inventor
Kam Leong
Wen Jie
Ren-Xi Zhuo
Hai-Quan Mao
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Priority to AU2001247346A priority Critical patent/AU2001247346A1/en
Publication of WO2001068052A2 publication Critical patent/WO2001068052A2/en
Publication of WO2001068052A3 publication Critical patent/WO2001068052A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
    • C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
    • C08G79/04—Phosphorus linked to oxygen or to oxygen and carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation

Abstract

Featured are biodegradable polymers comprising repeat units derived from cyclic phosphate monomers and optionally further comprising repeat units derived from lactide or caprolactone monomers. Also featured are methods for preparing the biodegradable polymers of the invention and biodegradable polymer compositions comprising a biologically active substance and a biodegradable polymer. Additionally featured are articles and microspheres prepared from biodegradable polymers and polymer compositions of the invention. Further, methods for the controlled release of a biologically active substance using the biodegradable polymers of the invention are also described.
PCT/US2001/007603 2000-03-10 2001-03-10 Phosphate based biodegradable polymers WO2001068052A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001247346A AU2001247346A1 (en) 2000-03-10 2001-03-10 Phosphate based biodegradable polymers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18847700P 2000-03-10 2000-03-10
US60/188,477 2000-03-10

Publications (2)

Publication Number Publication Date
WO2001068052A2 WO2001068052A2 (en) 2001-09-20
WO2001068052A3 true WO2001068052A3 (en) 2002-03-07

Family

ID=22693323

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/007603 WO2001068052A2 (en) 2000-03-10 2001-03-10 Phosphate based biodegradable polymers

Country Status (3)

Country Link
US (1) US6805876B2 (en)
AU (1) AU2001247346A1 (en)
WO (1) WO2001068052A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8460367B2 (en) 2000-03-15 2013-06-11 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US6797704B2 (en) 2000-10-06 2004-09-28 The Johns Hopkins University Systemic delivery of compounds through non-invasive bladder administration
SG125885A1 (en) * 2000-12-05 2006-10-30 Univ Singapore A polymer and nerve guide conduits formed thereof
WO2002092667A1 (en) * 2001-05-14 2002-11-21 Johns Hopkins Singapore Pte Ltd. Biodegradable polyphosphates for controlled release of bioactive substances
SE0202619D0 (en) * 2002-09-05 2002-09-05 Fredrik Nederberg New Polymers and Applications
EP1549253A4 (en) * 2002-09-26 2010-11-03 Endovascular Devices Inc Apparatus and method for delivery of mitomycin through an eluting biocompatible implantable medical device
CA2526541C (en) * 2004-12-01 2013-09-03 Tyco Healthcare Group Lp Novel biomaterial drug delivery and surface modification compositions
US8263105B2 (en) * 2004-12-01 2012-09-11 Tyco Healthcare Group Lp Biomaterial drug delivery and surface modification compositions
WO2006069282A2 (en) * 2004-12-22 2006-06-29 California Institute Of Technology Degradable p0lymers and methods of preparation thereof
US20070142287A1 (en) * 2005-12-20 2007-06-21 Biomed Solutions, Llc Compositions And Methods For Treatment Of Cancer
US7846361B2 (en) 2006-07-20 2010-12-07 Orbusneich Medical, Inc. Bioabsorbable polymeric composition for a medical device
EP2073754A4 (en) 2006-10-20 2012-09-26 Orbusneich Medical Inc Bioabsorbable polymeric composition and medical device background
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
CN101125916B (en) * 2007-06-26 2010-06-23 天大药业（珠海）有限公司 Biodegradation polymer and its preparing process and application
WO2009029242A1 (en) * 2007-08-24 2009-03-05 Michigan State University Functionalization of polyglycolides by 'click' chemistry
US8394914B2 (en) 2007-08-24 2013-03-12 Board Of Trustees Of Michigan State University Functional polyglycolide nanoparticles derived from unimolecular micelles
US8535477B2 (en) 2009-02-21 2013-09-17 Sofradim Production Medical devices incorporating functional adhesives
EP2588525A4 (en) 2010-06-29 2015-06-10 Covidien Lp Microwave-powered reactor and method for in situ forming implants
US8865857B2 (en) 2010-07-01 2014-10-21 Sofradim Production Medical device with predefined activated cellular integration
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament
US10336861B2 (en) 2017-04-06 2019-07-02 International Business Machines Corporation Phosphorus-containing caprolactone monomers for synthesis of flame retardant polycaprolactones
US10308875B2 (en) 2017-05-08 2019-06-04 International Business Machines Corporation Flame retardant polycaprolactone
US11530298B2 (en) 2017-06-12 2022-12-20 Translate Bio, Inc. Poly(phosphoesters) for delivery of nucleic acids

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386757A2 (en) * 1989-03-09 1990-09-12 The Johns Hopkins University School Of Medicine Biodegradable poly(phosphoesters)
WO1998044020A1 (en) * 1997-04-03 1998-10-08 Guilford Pharmaceuticals Inc. Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
WO1998046286A1 (en) * 1997-04-14 1998-10-22 Johns Hopkins University School Of Medicine Biodegradable compounds, compositions, articles and methods for making and using the same
WO1998048859A1 (en) * 1997-04-30 1998-11-05 Guilford Pharmaceuticals Inc. Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386757A2 (en) * 1989-03-09 1990-09-12 The Johns Hopkins University School Of Medicine Biodegradable poly(phosphoesters)
WO1998044020A1 (en) * 1997-04-03 1998-10-08 Guilford Pharmaceuticals Inc. Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
WO1998046286A1 (en) * 1997-04-14 1998-10-22 Johns Hopkins University School Of Medicine Biodegradable compounds, compositions, articles and methods for making and using the same
WO1998048859A1 (en) * 1997-04-30 1998-11-05 Guilford Pharmaceuticals Inc. Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same

Also Published As

Publication number Publication date
WO2001068052A2 (en) 2001-09-20
US6805876B2 (en) 2004-10-19
AU2001247346A1 (en) 2001-09-24
US20020155092A1 (en) 2002-10-24

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