WO2001068116A3 - Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections - Google Patents

Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections Download PDF

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Publication number
WO2001068116A3
WO2001068116A3 PCT/US2001/007839 US0107839W WO0168116A3 WO 2001068116 A3 WO2001068116 A3 WO 2001068116A3 US 0107839 W US0107839 W US 0107839W WO 0168116 A3 WO0168116 A3 WO 0168116A3
Authority
WO
WIPO (PCT)
Prior art keywords
preventing
respiratory virus
polynucleotide sequences
viral infections
respiratory
Prior art date
Application number
PCT/US2001/007839
Other languages
French (fr)
Other versions
WO2001068116A2 (en
Inventor
Nest Gary Van
Original Assignee
Dynavax Tech Corp
Nest Gary Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dynavax Tech Corp, Nest Gary Van filed Critical Dynavax Tech Corp
Priority to AT01916581T priority Critical patent/ATE476983T1/en
Priority to AU4358701A priority patent/AU4358701A/en
Priority to DE60142775T priority patent/DE60142775D1/en
Priority to CA2402268A priority patent/CA2402268C/en
Priority to JP2001566680A priority patent/JP2003526672A/en
Priority to EP01916581A priority patent/EP1261352B1/en
Priority to AU2001243587A priority patent/AU2001243587C1/en
Publication of WO2001068116A2 publication Critical patent/WO2001068116A2/en
Publication of WO2001068116A3 publication Critical patent/WO2001068116A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Abstract

The invention provides methods of preventing and/or treating infection by a respiratory virus such as respiratory syncytial virus (RSV), particularly reducing infection and/or one or more symptoms of respiratory virus infection. A polynucleotide comprising an immunostimulatory sequence (an 'ISS') is administered to an individual which is at risk of bieing exposed to a respiratory virus, has been exposed to a respiratory virus or is infected with a respiratory virus. The ISS is administered without any antigens of the respiratory virus. Administration of the ISS results in reduced incidence and/or severity of one or more symptoms of respiratory virus infection.
PCT/US2001/007839 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections WO2001068116A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AT01916581T ATE476983T1 (en) 2000-03-10 2001-03-12 IMMUNO-STIMULATING POLYNUCLEOTIDE SEQUENCES FOR USE IN PREVENTING AND TREATING VIRAL RESPIRATORY DISEASES
AU4358701A AU4358701A (en) 2000-03-10 2001-03-12 Methods of preventing and treating respiratory viral infeciton using immunomodulatory polynucleotide sequences
DE60142775T DE60142775D1 (en) 2000-03-10 2001-03-12 IMMUNOSTIMULATING POLYNUCLEOTIDE SEQUENCES FOR USE IN THE PREVENTION AND TREATMENT OF VIRAL DISORDERS OF THE RESPIRATORY WAYS
CA2402268A CA2402268C (en) 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections
JP2001566680A JP2003526672A (en) 2000-03-10 2001-03-12 Methods of preventing and treating respiratory viral infections using immunomodulatory polynucleotide sequences
EP01916581A EP1261352B1 (en) 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections
AU2001243587A AU2001243587C1 (en) 2000-03-10 2001-03-12 Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide sequences.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18858300P 2000-03-10 2000-03-10
US60/188,583 2000-03-10
US09/802,686 2001-03-09
US09/802,686 US20010046967A1 (en) 2000-03-10 2001-03-09 Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide

Publications (2)

Publication Number Publication Date
WO2001068116A2 WO2001068116A2 (en) 2001-09-20
WO2001068116A3 true WO2001068116A3 (en) 2002-08-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/007839 WO2001068116A2 (en) 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections

Country Status (8)

Country Link
US (3) US20010046967A1 (en)
EP (1) EP1261352B1 (en)
JP (1) JP2003526672A (en)
AT (1) ATE476983T1 (en)
AU (2) AU4358701A (en)
CA (1) CA2402268C (en)
DE (1) DE60142775D1 (en)
WO (1) WO2001068116A2 (en)

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Publication number Publication date
CA2402268A1 (en) 2001-09-20
AU4358701A (en) 2001-09-24
JP2003526672A (en) 2003-09-09
EP1261352B1 (en) 2010-08-11
AU2001243587C1 (en) 2006-11-16
AU2001243587B2 (en) 2005-11-24
US20040009942A1 (en) 2004-01-15
WO2001068116A2 (en) 2001-09-20
CA2402268C (en) 2012-10-02
EP1261352A2 (en) 2002-12-04
ATE476983T1 (en) 2010-08-15
US20010046967A1 (en) 2001-11-29
DE60142775D1 (en) 2010-09-23
US20100035975A1 (en) 2010-02-11
US8226957B2 (en) 2012-07-24

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