WO2001081890A3 - Hydrogel biosensor and biosensor-based health alarm system - Google Patents

Hydrogel biosensor and biosensor-based health alarm system Download PDF

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Publication number
WO2001081890A3
WO2001081890A3 PCT/US2001/012934 US0112934W WO0181890A3 WO 2001081890 A3 WO2001081890 A3 WO 2001081890A3 US 0112934 W US0112934 W US 0112934W WO 0181890 A3 WO0181890 A3 WO 0181890A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogel
analyte
biosensor
alarm system
concentration
Prior art date
Application number
PCT/US2001/012934
Other languages
French (fr)
Other versions
WO2001081890A2 (en
Inventor
In Suk Han
Jules John Magda
Seok Lew
Young San Jean
Original Assignee
Biotech Inc M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotech Inc M filed Critical Biotech Inc M
Priority to JP2001578926A priority Critical patent/JP2004507283A/en
Priority to EP01957060A priority patent/EP1309845A4/en
Priority to AU2001278840A priority patent/AU2001278840A1/en
Publication of WO2001081890A2 publication Critical patent/WO2001081890A2/en
Publication of WO2001081890A3 publication Critical patent/WO2001081890A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N13/04—Investigating osmotic effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
    • G01N33/48792—Data management, e.g. communication with processing unit
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N2001/021—Correlating sampling sites with geographical information, e.g. GPS

Abstract

A biosensor (10) has a hydrogel (30) in a rigid and preferably biocompatible enclosure (20). The hydrogel (30) includes an immobilized analyte binding molecule (ABM) and an immobilized analyte. The immobilized analyte competitively binds with free analyte to the ABM, thus changing the number of crosslinks in the hydrogel (30), which changes hydrogel swelling tendency (and thus the osmotic pressure) in its confined space in proportion to the concentration of free analyte concentration. By measuring the change in hydrogel pressure with a pressure transducer (40), the biosensor (10) is able to accurately measure the concentration of the free analyte molecule without the problem of oxygen limitations and interference encountered by prior art biosensors. A battery (64) powered telemeter (60) operably engaged to the pressure transducer (40) sends a radio data signal to a receiver (66) containing an alarm system operably attached to a computer (62). Furthermore, an alarm system utilizes such a sensor to automatically notify a person that the analyte level is outside desired predetermined parameters, and/or to automatically inject an agent to counteract the adverse analyte levels.
PCT/US2001/012934 2000-04-22 2001-04-20 Hydrogel biosensor and biosensor-based health alarm system WO2001081890A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2001578926A JP2004507283A (en) 2000-04-22 2001-04-20 Hydrogel biosensor and health alarm system based on biosensor (HYDROGELBIOSENSORANDBIOENSENSOR-BASEDHEALTHALARMSYSTEM)
EP01957060A EP1309845A4 (en) 2000-04-22 2001-04-20 Hydrogel biosensor and biosensor-based health alarm system
AU2001278840A AU2001278840A1 (en) 2000-04-22 2001-04-20 Hydrogel biosensor and biosensor-based health alarm system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19905700P 2000-04-22 2000-04-22
US60/199,057 2000-04-22

Publications (2)

Publication Number Publication Date
WO2001081890A2 WO2001081890A2 (en) 2001-11-01
WO2001081890A3 true WO2001081890A3 (en) 2002-02-21

Family

ID=22736031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/012934 WO2001081890A2 (en) 2000-04-22 2001-04-20 Hydrogel biosensor and biosensor-based health alarm system

Country Status (5)

Country Link
EP (1) EP1309845A4 (en)
JP (1) JP2004507283A (en)
KR (1) KR20030031895A (en)
AU (1) AU2001278840A1 (en)
WO (1) WO2001081890A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8870742B2 (en) 2006-04-06 2014-10-28 Ethicon Endo-Surgery, Inc. GUI for an implantable restriction device and a data logger

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AUPR808001A0 (en) * 2001-10-05 2001-10-25 Ragless, Clive Lindsay Method and apparatus for determining concentration of a chemical substance in a solution
US6809507B2 (en) * 2001-10-23 2004-10-26 Medtronic Minimed, Inc. Implantable sensor electrodes and electronic circuitry
DE10311622B4 (en) * 2003-03-17 2005-06-09 Disetronic Licensing Ag Sensory membrane osmometer and osmotic measuring method for the quantitative determination of low-molecular affinity ligands
DE10311623B4 (en) * 2003-03-17 2005-09-01 Disetronic Licensing Ag Membrane osmometer and method for the selective determination of specific analytes
US7615375B2 (en) * 2003-12-18 2009-11-10 Xerox Corporation Osmotic reaction cell for monitoring biological and non-biological reactions
US7553669B2 (en) * 2003-12-18 2009-06-30 Palo Alto Resaerch Center Incorporated Osmotic reaction detector for monitoring biological and non-biological reactions
EP1937139A2 (en) * 2005-10-11 2008-07-02 Koninklijke Philips Electronics N.V. Individually activated sensors for implantable devices
EP2160973A1 (en) * 2008-09-05 2010-03-10 Visgeneer, Inc. Rechargeable biosensor
KR101135624B1 (en) * 2009-01-15 2012-04-17 한양대학교 산학협력단 A biosensor coated with electroactive polymer layer for extension of biosensor life span
WO2010082790A2 (en) * 2009-01-15 2010-07-22 한양대학교 산학협력단 Electroresponsive device for extending the life of biosensors, and a biosensor employing the same
KR101065748B1 (en) * 2009-03-17 2011-09-19 한양대학교 산학협력단 A biosensor coated with electroactive polymer layer showing bending behavior
CN102175863B (en) * 2011-02-23 2013-11-27 谭森 Early warning method for Legionella
US9506888B2 (en) 2011-04-13 2016-11-29 3M Innovative Properties Company Vapor sensor including sensor element with integral heating
JP5955379B2 (en) 2011-04-13 2016-07-20 スリーエム イノベイティブ プロパティズ カンパニー Method for detecting volatile organic compounds
KR101968999B1 (en) 2011-04-13 2019-04-15 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Method of using an absorptive sensor element
WO2013090188A1 (en) 2011-12-13 2013-06-20 3M Innovative Properties Company Method for identification and quantitative determination of an unknown organic compound in a gaseous medium
US20150110719A1 (en) * 2012-05-08 2015-04-23 Health Line International Corp. Hydrogel based delivery and sensor
US8920628B2 (en) 2012-11-02 2014-12-30 Roche Diagnostics Operations, Inc. Systems and methods for multiple analyte analysis
CN103977776B (en) * 2014-04-21 2016-04-13 苏州康磁医疗科技有限公司 The quick intelligent aqueous gel capable of a kind of sugar based on gold surface and synthetic method thereof
KR101754774B1 (en) 2015-12-29 2017-07-06 주식회사 스칼라팍스트롯 Biochip and Method of manufacturing the Biochip
WO2018186657A1 (en) * 2017-04-04 2018-10-11 주식회사 스칼라팍스트롯 Biochip
KR102037800B1 (en) * 2017-04-04 2019-10-30 주식회사 스칼라팍스트롯 Biochip
RU2670653C9 (en) * 2017-05-03 2018-12-11 Федеральное государственное бюджетное учреждение науки Институт высокомолекулярных соединений Российской академии наук Device for delivery of physical active or medicinal drug on basis of electro-controlled composite polymer material
CN108232225B (en) * 2018-01-02 2020-11-27 泰顺永庆电力技术有限公司 Vanadium battery diaphragm containing adamantane structure and preparation method thereof
CN114343651A (en) * 2021-12-09 2022-04-15 中国科学院深圳先进技术研究院 Flexible contact with gradient porosity, gel semi-dry electrode containing flexible contact and electroencephalogram cap containing flexible contact
CN115219262B (en) * 2022-09-19 2022-11-29 吉林大学 Hydrogel solar evaporator water purification efficiency testing device and testing method

Citations (1)

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US6268161B1 (en) * 1997-09-30 2001-07-31 M-Biotech, Inc. Biosensor

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GB9200638D0 (en) * 1992-01-10 1992-03-11 Leicester Polytechnic Drug system
US5544651A (en) * 1992-09-08 1996-08-13 Wilk; Peter J. Medical system and associated method for automatic treatment
US6198394B1 (en) * 1996-12-05 2001-03-06 Stephen C. Jacobsen System for remote monitoring of personnel
AU6931500A (en) * 1999-08-27 2001-03-26 M-Biotech, Inc. Glucose biosensor

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Publication number Priority date Publication date Assignee Title
US6268161B1 (en) * 1997-09-30 2001-07-31 M-Biotech, Inc. Biosensor

Non-Patent Citations (1)

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See also references of EP1309845A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8870742B2 (en) 2006-04-06 2014-10-28 Ethicon Endo-Surgery, Inc. GUI for an implantable restriction device and a data logger

Also Published As

Publication number Publication date
KR20030031895A (en) 2003-04-23
EP1309845A4 (en) 2005-10-12
EP1309845A2 (en) 2003-05-14
AU2001278840A1 (en) 2001-11-07
WO2001081890A2 (en) 2001-11-01
JP2004507283A (en) 2004-03-11

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