WO2001085740A3 - Inositolglycans and their uses - Google Patents

Inositolglycans and their uses Download PDF

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Publication number
WO2001085740A3
WO2001085740A3 PCT/GB2001/002088 GB0102088W WO0185740A3 WO 2001085740 A3 WO2001085740 A3 WO 2001085740A3 GB 0102088 W GB0102088 W GB 0102088W WO 0185740 A3 WO0185740 A3 WO 0185740A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
ipg
inositolglycans
cyclitol
mimetic
Prior art date
Application number
PCT/GB2001/002088
Other languages
French (fr)
Other versions
WO2001085740A2 (en
Inventor
Manuel Martin-Lomas
Thomas William Rademacher
Hugo Norbert Caro
Irene Francois
Original Assignee
Rodaris Pharmaceuticals Ltd
Martin Lomas Manuel
Thomas William Rademacher
Hugo Norbert Caro
Irene Francois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0011594A external-priority patent/GB0011594D0/en
Priority claimed from US09/798,005 external-priority patent/US6953781B2/en
Application filed by Rodaris Pharmaceuticals Ltd, Martin Lomas Manuel, Thomas William Rademacher, Hugo Norbert Caro, Irene Francois filed Critical Rodaris Pharmaceuticals Ltd
Priority to EP01934120A priority Critical patent/EP1406913A2/en
Priority to AU60426/01A priority patent/AU6042601A/en
Priority to CA002433183A priority patent/CA2433183A1/en
Publication of WO2001085740A2 publication Critical patent/WO2001085740A2/en
Publication of WO2001085740A3 publication Critical patent/WO2001085740A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Abstract

Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by administration of an IPG second messenger or an IPG antagonist thereof. In particular, the compounds are based on the 1,6 linkage of a sugar residue and a cyclitol.
PCT/GB2001/002088 2000-05-12 2001-05-11 Inositolglycans and their uses WO2001085740A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01934120A EP1406913A2 (en) 2000-05-12 2001-05-11 Inositolglycans and their uses
AU60426/01A AU6042601A (en) 2000-05-12 2001-05-11 Compounds and their uses
CA002433183A CA2433183A1 (en) 2000-05-12 2001-05-11 Inositolglycans and their uses

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US20359600P 2000-05-12 2000-05-12
GB0011594.9 2000-05-12
US60/203,596 2000-05-12
GB0011594A GB0011594D0 (en) 2000-05-12 2000-05-12 Compounds and their uses
US09/798,005 US6953781B2 (en) 2000-05-12 2001-03-02 Compounds and their uses
US09/798,005 2001-03-02

Publications (2)

Publication Number Publication Date
WO2001085740A2 WO2001085740A2 (en) 2001-11-15
WO2001085740A3 true WO2001085740A3 (en) 2002-03-28

Family

ID=27255717

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/002088 WO2001085740A2 (en) 2000-05-12 2001-05-11 Inositolglycans and their uses

Country Status (4)

Country Link
EP (1) EP1406913A2 (en)
AU (1) AU6042601A (en)
CA (1) CA2433183A1 (en)
WO (1) WO2001085740A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2878850B1 (en) * 2004-12-02 2008-10-31 Cis Bio Internat Sa DERIVATIVES OF INOSITOL-1-PHOSPHATE
US20100197625A1 (en) * 2006-12-21 2010-08-05 D Alarcao Marc Synthetic lipophilic inositol glycans for treatment of cancer and glucose-metabolism disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004938A (en) * 1996-11-28 1999-12-21 Hoescht Aktiengesellschaft Inositolglycans having insulin-like action

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004938A (en) * 1996-11-28 1999-12-21 Hoescht Aktiengesellschaft Inositolglycans having insulin-like action

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
C. DERAPPE ET AL.: "Characterization of a new oligosaccharide containing myo-inositol found in pregnancy urine", CARBOHYDRATE RESEARCH, vol. 115, 1983, pages 221 - 229, XP002171185 *
KISHTA REDDY ET AL: "Insulin Second Messengers: Synthesis of 6-O-(2-Amino-2-deoxy-a-D-gluc opyranosyl)-D-chiro-inositol-1-phosphate", TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 34, no. 49, 1993, pages 7869 - 7872, XP002098904, ISSN: 0040-4020 *
MARTIN-LOMAS M ET AL: "The solution conformation of glycosyl inositols related to inositolphosphoglycan (IPG) mediators", TETRAHEDRON: ASYMMETRY,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM,NL, vol. 11, no. 1, January 2000 (2000-01-01), pages 37 - 51, XP004202370, ISSN: 0957-4166 *
PLOURDE ET AL: "SYNTHESIS OF A POTENTIALLY INSULIN-MIMETIC PHOSPHODISACCHARIDE", TETRAHEDRON LETTERS,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM,NL, vol. 31, no. 19, 1990, pages 2693 - 2696, XP000915412, ISSN: 0040-4039 *
VARELA-NIETO I ET AL: "Cell signalling by inositol phosphoglycans from different species", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. B. COMPARATIVE BIOCHEMISTRY,GB,PERGAMON PRESS, LONDON, vol. 115B, no. 2, 1996, pages 223 - 241, XP002115446, ISSN: 0305-0491 *
ZAPATA A ET AL: "BUILDING BLOCKS FOR THE SYNTHESIS OF GLYCOSYL-MYO-INOSITOLS INVOLVED IN THE INSULIN INTRACELLULAR SIGNALLING PROCESS", CARBOHYDRATE RESEARCH,NL,ELSEVIER SCIENTIFIC PUBLISHING COMPANY. AMSTERDAM, vol. 234, 9 October 1992 (1992-10-09), pages 93 - 106, XP002058259, ISSN: 0008-6215 *

Also Published As

Publication number Publication date
WO2001085740A2 (en) 2001-11-15
AU6042601A (en) 2001-11-20
EP1406913A2 (en) 2004-04-14
CA2433183A1 (en) 2001-11-15

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