WO2001087151A3 - Method and device for the noninvasive determination of hemoglobin and hematocrit - Google Patents

Method and device for the noninvasive determination of hemoglobin and hematocrit Download PDF

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Publication number
WO2001087151A3
WO2001087151A3 PCT/US2001/014542 US0114542W WO0187151A3 WO 2001087151 A3 WO2001087151 A3 WO 2001087151A3 US 0114542 W US0114542 W US 0114542W WO 0187151 A3 WO0187151 A3 WO 0187151A3
Authority
WO
WIPO (PCT)
Prior art keywords
determination
hematocrit
hemoglobin
temperature
hemoglobin concentration
Prior art date
Application number
PCT/US2001/014542
Other languages
French (fr)
Other versions
WO2001087151A2 (en
Inventor
Omar S Khalil
Xiaomao Wu
Shu-Jen Yeh
Charles F Hanna
Stanislaw Kantor
Tzyy-Wen Jeng
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to CA002404925A priority Critical patent/CA2404925A1/en
Priority to JP2001583624A priority patent/JP2003533261A/en
Priority to EP01933059A priority patent/EP1282380A2/en
Publication of WO2001087151A2 publication Critical patent/WO2001087151A2/en
Publication of WO2001087151A3 publication Critical patent/WO2001087151A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring haematocrit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1491—Heated applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/043—Arrangements of multiple sensors of the same type in a linear array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6824—Arm or wrist

Abstract

A method for the determination of hemoglobin and hematocrit by means of an apparatus that is capable of controlling the temperature of a defined subcutaneous volume of human skin. The method involves a calculation of hemoglobin concentration and hematocrit value that takes into consideration the values of optical parameters of the sample at various pre-set temperatures. It employs steady state optical measurements of samples, such as, for example, human tissue, by means of a reflectance tissue photometer and localized control of the temperature of the sample. An optical signal from a defined subcutaneous volume of human skin is measured as the temperature of this volume is controlled. This allows determination of hemoglobin concentration and hematocrit value non-invasively in a population of subjects having different skin colors by means of steady state reflectance measurements. The determination of hemoglobin concentration and hematocrit value is useful for monitoring patients, testing at the point of care, and screening for anemia. This method has the advantage for the determination of analytes in weak cardiac pulse situations, such as, for example, in elderly patients.
PCT/US2001/014542 2000-05-08 2001-05-07 Method and device for the noninvasive determination of hemoglobin and hematocrit WO2001087151A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002404925A CA2404925A1 (en) 2000-05-08 2001-05-07 Method and device for the noninvasive determination of hemoglobin and hematocrit
JP2001583624A JP2003533261A (en) 2000-05-08 2001-05-07 Method and apparatus for non-invasive quantification of hemoglobin and hematocrit
EP01933059A EP1282380A2 (en) 2000-05-08 2001-05-07 Noninvasive optical determination of hemoglobin and hematocrit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/566,415 US6662031B1 (en) 1998-05-18 2000-05-08 Method and device for the noninvasive determination of hemoglobin and hematocrit
US09/566,415 2000-05-08

Publications (2)

Publication Number Publication Date
WO2001087151A2 WO2001087151A2 (en) 2001-11-22
WO2001087151A3 true WO2001087151A3 (en) 2002-05-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/014542 WO2001087151A2 (en) 2000-05-08 2001-05-07 Method and device for the noninvasive determination of hemoglobin and hematocrit

Country Status (6)

Country Link
US (1) US6662031B1 (en)
EP (1) EP1282380A2 (en)
JP (1) JP2003533261A (en)
AU (1) AU2001238033A1 (en)
CA (1) CA2404925A1 (en)
WO (1) WO2001087151A2 (en)

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WO2001087151A2 (en) 2001-11-22
AU2001238033A1 (en) 2001-11-20

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