WO2001088159A3 - Cd28 synthebody for the modulation of immune responses - Google Patents

Cd28 synthebody for the modulation of immune responses Download PDF

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Publication number
WO2001088159A3
WO2001088159A3 PCT/US2001/015707 US0115707W WO0188159A3 WO 2001088159 A3 WO2001088159 A3 WO 2001088159A3 US 0115707 W US0115707 W US 0115707W WO 0188159 A3 WO0188159 A3 WO 0188159A3
Authority
WO
WIPO (PCT)
Prior art keywords
variants
binding
cdr
binding sequence
synthebody
Prior art date
Application number
PCT/US2001/015707
Other languages
French (fr)
Other versions
WO2001088159A2 (en
Inventor
Ronald Martin Burch
Daniel Andrew Soltis
Paul Kaladas
Original Assignee
Euro Celtique Sa
Ronald Martin Burch
Daniel Andrew Soltis
Paul Kaladas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa, Ronald Martin Burch, Daniel Andrew Soltis, Paul Kaladas filed Critical Euro Celtique Sa
Priority to AU2001261628A priority Critical patent/AU2001261628A1/en
Publication of WO2001088159A2 publication Critical patent/WO2001088159A2/en
Publication of WO2001088159A3 publication Critical patent/WO2001088159A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

The present invention provides variants of an immunoglobulin variable domain having at least one CDR region and framework regions flanking the CDR. The variant includes (a) the CDR region having added or substituted therein at least one binding sequence and (b) the flanking framework regions, wherein the binding sequence is heterologous to the CDR and is a binding sequence from a binding site of a binding pair, and wherein the binding sequence is a CD80 and/or CD86 receptor-binding portion of CD28. Also disclosed and claimed are molecules, immunoglobulins, and compositions including these variants, as well as nucleic acids and expression vectors encoding these variants, and methods of using the variants for immunotherapy.
PCT/US2001/015707 2000-05-16 2001-05-16 Cd28 synthebody for the modulation of immune responses WO2001088159A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001261628A AU2001261628A1 (en) 2000-05-16 2001-05-16 Cd28 synthebody for the modulation of immune responses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20448300P 2000-05-16 2000-05-16
US60/204,483 2000-05-16

Publications (2)

Publication Number Publication Date
WO2001088159A2 WO2001088159A2 (en) 2001-11-22
WO2001088159A3 true WO2001088159A3 (en) 2002-04-11

Family

ID=22758081

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015707 WO2001088159A2 (en) 2000-05-16 2001-05-16 Cd28 synthebody for the modulation of immune responses

Country Status (2)

Country Link
AU (1) AU2001261628A1 (en)
WO (1) WO2001088159A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9528088B2 (en) 2002-06-28 2016-12-27 Life Technologies Corporation Methods for eliminating at least a substantial portion of a clonal antigen-specific memory T cell subpopulation

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10240418A1 (en) * 2002-09-02 2004-03-11 Avontec Gmbh Formulation for introducing nucleic acids into eukaryotic cells
WO2005021595A1 (en) * 2003-08-28 2005-03-10 Euro-Celtique S.A. Methods of antibody engineering using antibody display rules
CA2594356C (en) 2005-01-05 2018-07-17 F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H. Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
AT503889B1 (en) 2006-07-05 2011-12-15 Star Biotechnologische Forschungs Und Entwicklungsges M B H F MULTIVALENT IMMUNE LOBULINE
AT503902B1 (en) 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw METHOD FOR MANIPULATING IMMUNE LOBULINS
US8921279B2 (en) 2007-06-26 2014-12-30 F-Star Biotechnologische Forschungs—und Entwicklungsges. m.b.H Display of binding agents
EP2113255A1 (en) 2008-05-02 2009-11-04 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Cytotoxic immunoglobulin
SI2344540T1 (en) 2008-10-02 2018-04-30 Aptevo Research And Development Llc Cd86 antagonist multi-target binding proteins
AU2010324686B2 (en) * 2009-11-30 2016-05-19 Genentech, Inc. Antibodies for treating and diagnosing tumors expressing SLC34A2 (TAT211 = SEQID2 )
SG11201403223PA (en) * 2011-12-22 2014-07-30 Hoffmann La Roche Expression vector organization, novel production cell generation methods and their use for the recombinant production of polypeptides

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO1996022377A1 (en) * 1995-01-19 1996-07-25 Armitage, Ian, M. Activation of t-cells by modified, antigenic immunoglobulins
WO1999025378A1 (en) * 1997-11-14 1999-05-27 Euro-Celtique, S.A. Immunoglobulin molecules having a synthetic variable region and modified specificity
WO1999029344A1 (en) * 1994-09-19 1999-06-17 National Jewish Center For Immunology And Respiratory Medicine Product and process for targeting an immune response

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029344A1 (en) * 1994-09-19 1999-06-17 National Jewish Center For Immunology And Respiratory Medicine Product and process for targeting an immune response
WO1996022377A1 (en) * 1995-01-19 1996-07-25 Armitage, Ian, M. Activation of t-cells by modified, antigenic immunoglobulins
WO1999025378A1 (en) * 1997-11-14 1999-05-27 Euro-Celtique, S.A. Immunoglobulin molecules having a synthetic variable region and modified specificity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Peptides for the new millennium", 2000, KLUWER ACADEMIC PUBL., DORDRECHT, THE NETHERLANDS, XP001031358 *
A. TRUNEH ET AL.: "Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): Analysis by site-directed mutagenesis.", MOLECULAR IMMUNOLOGY, vol. 33, no. 3, February 1996 (1996-02-01), Oxford, GB, pages 321 - 334, XP001031316 *
H. ZAGHOUANI ET AL.: "Engineered immunoglobulin molecules as vehicles for T cell epitopes.", INTERNATIONAL REVIEWS OF IMMUNOLOGY, vol. 10, no. 2-3, 1993, Switzerland, pages 265 - 278, XP002177699 *
J. COOK ET AL.: "Recombinant antibodies containing an engineered B-cell epitope capable of eliciting conformation-specific antibody responses.", VACCINE, vol. 13, no. 18, December 1995 (1995-12-01), Guildford, GB, pages 1770 - 1778, XP004057383 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9528088B2 (en) 2002-06-28 2016-12-27 Life Technologies Corporation Methods for eliminating at least a substantial portion of a clonal antigen-specific memory T cell subpopulation

Also Published As

Publication number Publication date
WO2001088159A2 (en) 2001-11-22
AU2001261628A1 (en) 2001-11-26

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