WO2001097826A3 - Hemostatic compositions, devices and methods - Google Patents

Hemostatic compositions, devices and methods Download PDF

Info

Publication number
WO2001097826A3
WO2001097826A3 PCT/US2001/019145 US0119145W WO0197826A3 WO 2001097826 A3 WO2001097826 A3 WO 2001097826A3 US 0119145 W US0119145 W US 0119145W WO 0197826 A3 WO0197826 A3 WO 0197826A3
Authority
WO
WIPO (PCT)
Prior art keywords
factor
composition
procoagulant
hemostatic
methods
Prior art date
Application number
PCT/US2001/019145
Other languages
French (fr)
Other versions
WO2001097826A2 (en
Inventor
Charles R Spillert
Original Assignee
Univ New Jersey Med
Charles R Spillert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New Jersey Med, Charles R Spillert filed Critical Univ New Jersey Med
Priority to AU2001266926A priority Critical patent/AU2001266926A1/en
Publication of WO2001097826A2 publication Critical patent/WO2001097826A2/en
Priority to US10/315,918 priority patent/US7094428B2/en
Publication of WO2001097826A3 publication Critical patent/WO2001097826A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/28—Mercury; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Abstract

A hemostatic composition which comprises at least one procoagulant metal ion, such as silver (I) or mercury (II), and at least one procoagulant biopolymer, such as collagen, thrombin, prothrombin, fibrin, fibrinogen, heparinase, Factor VIIa, Factor VIII, Factor IXa, Factor Xa, Factor XII, von Willebrand Factor, a selectin, a procoagulant venom, a plasminogen activator inhibitor, glycoprotein IIb-IIIa, a protease, or plasma. The composition in the form of a paste, dough, glue, liquid, lyophilized powder or foam, may be provided, for application to a wound. A hemostatic device is also described which comprises a hemostatic composition as described above. The device may be in the form of, for example, a plug, bandage, gauze, cloth, tampon, membrane or sponge. Methods are also provided for prophylaxis or treatment of bleeding at a site by application to the site of the composition or device as described.
PCT/US2001/019145 2000-06-16 2001-06-15 Hemostatic compositions, devices and methods WO2001097826A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001266926A AU2001266926A1 (en) 2000-06-16 2001-06-15 Hemostatic compositions, devices and methods
US10/315,918 US7094428B2 (en) 2000-06-16 2002-12-10 Hemostatic compositions, devices and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21222900P 2000-06-16 2000-06-16
US60/212,229 2000-06-16

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/315,918 Continuation US7094428B2 (en) 2000-06-16 2002-12-10 Hemostatic compositions, devices and methods

Publications (2)

Publication Number Publication Date
WO2001097826A2 WO2001097826A2 (en) 2001-12-27
WO2001097826A3 true WO2001097826A3 (en) 2003-01-09

Family

ID=22790122

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019145 WO2001097826A2 (en) 2000-06-16 2001-06-15 Hemostatic compositions, devices and methods

Country Status (2)

Country Link
AU (1) AU2001266926A1 (en)
WO (1) WO2001097826A2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846076B2 (en) 2006-05-26 2014-09-30 Z-Medica, Llc Hemostatic sponge
US8858969B2 (en) 2010-09-22 2014-10-14 Z-Medica, Llc Hemostatic compositions, devices, and methods
US8938898B2 (en) 2006-04-27 2015-01-27 Z-Medica, Llc Devices for the identification of medical products
US9005609B2 (en) 2003-08-07 2015-04-14 Ethicon, Inc. Hemostatic compositions containing sterile thrombin
US9072806B2 (en) 2012-06-22 2015-07-07 Z-Medica, Llc Hemostatic devices
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8709038B2 (en) 2002-12-20 2014-04-29 Boston Scientific Scimed, Inc. Puncture hole sealing device
US20040122349A1 (en) 2002-12-20 2004-06-24 Lafontaine Daniel M. Closure device with textured surface
US7942897B2 (en) 2003-07-10 2011-05-17 Boston Scientific Scimed, Inc. System for closing an opening in a body cavity
US8440225B2 (en) 2003-08-07 2013-05-14 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US20060019868A1 (en) 2004-01-30 2006-01-26 Pendharkar Sanyog M Hemostatic compositions and devices
US7109163B2 (en) 2004-01-30 2006-09-19 Ethicon, Inc. Hemostatic compositions and devices
US8119160B2 (en) 2004-06-29 2012-02-21 Ethicon, Inc. Hemostatic compositions and devices
CA2597940A1 (en) 2005-02-15 2006-08-24 Virginia Commonwealth University Mineral technologies (mt) for acute hemostasis and for the treatment of acute wounds and chronic ulcers
WO2013131520A2 (en) 2012-03-06 2013-09-12 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
ES2645082T3 (en) * 2012-03-12 2017-12-04 The Regents Of The University Of California Methods and compositions for treating wounds and reducing the risk of incisional hernias
JP6390873B2 (en) 2013-06-21 2018-09-19 フェッローサン メディカル ディバイス エー／エス Dry composition expanded under reduced pressure and syringe for holding the same
RU2678592C1 (en) 2013-12-11 2019-01-30 Ферросан Медикал Дивайсиз А/С Dry composition comprising extrusion enhancer
BR112017007466B1 (en) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S method for preparing a dry composition, method for reconstituting the dry composition, paste, dry composition, container, homeostatic kit, and, using a dry composition
JP6747650B2 (en) 2014-12-24 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス Syringe for holding and mixing the first substance and the second substance
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
DK3496770T3 (en) * 2016-08-12 2021-06-21 Biomup France Sas Hemostatic flowable material
US10953130B2 (en) 2017-08-31 2021-03-23 Victor Matthew Phillips Solid hemostatic composition and methods of making the same
KR101989054B1 (en) * 2017-11-28 2019-06-13 (주)다림티센 Hemostatic agent and container containing the same
KR20210008479A (en) 2018-05-09 2021-01-22 훼로산 메디칼 디바이스 에이/에스 How to prepare a hemostatic composition

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3523023A1 (en) * 1985-06-27 1987-01-08 Ruhland Nachf Gmbh Dr Silver-containing collagen sponges or collagen fasciae, and use thereof in the preparation of a covering material for skin lesions
EP0437095A2 (en) * 1990-01-12 1991-07-17 JOHNSON & JOHNSON MEDICAL, INC. Process for preparing a neutralized oxidized cellulose product and its method of use
JPH0517369A (en) * 1991-07-09 1993-01-26 Terumo Corp Thromboembolic agent
US5413786A (en) * 1986-04-11 1995-05-09 Sekisui Kagaku Kogyo Kabushiki Kaisha Method of accelerating blood coagulation using a metal complex of oxidized ellagic acid
WO1999004828A2 (en) * 1997-07-28 1999-02-04 Fidia Advanced Biopolymers, S.R.L. Use of hyaluronic acid derivatives in the preparation of biomaterials
EP0956869A2 (en) * 1998-05-15 1999-11-17 Hogy Medical Co., Ltd. Tissue sealant

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3523023A1 (en) * 1985-06-27 1987-01-08 Ruhland Nachf Gmbh Dr Silver-containing collagen sponges or collagen fasciae, and use thereof in the preparation of a covering material for skin lesions
US5413786A (en) * 1986-04-11 1995-05-09 Sekisui Kagaku Kogyo Kabushiki Kaisha Method of accelerating blood coagulation using a metal complex of oxidized ellagic acid
EP0437095A2 (en) * 1990-01-12 1991-07-17 JOHNSON & JOHNSON MEDICAL, INC. Process for preparing a neutralized oxidized cellulose product and its method of use
JPH0517369A (en) * 1991-07-09 1993-01-26 Terumo Corp Thromboembolic agent
WO1999004828A2 (en) * 1997-07-28 1999-02-04 Fidia Advanced Biopolymers, S.R.L. Use of hyaluronic acid derivatives in the preparation of biomaterials
EP0956869A2 (en) * 1998-05-15 1999-11-17 Hogy Medical Co., Ltd. Tissue sealant

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GOODWIN C A ET AL: "Increased expression of procoagulant activity on the surface of human platelets exposed to heavy-metal compounds.", THE BIOCHEMICAL JOURNAL. ENGLAND 15 MAY 1995, vol. 308 ( Pt 1), 15 May 1995 (1995-05-15), pages 15 - 21, XP008007678, ISSN: 0264-6021 *
KANEKO H ET AL: "Mercury compounds induce a rapid increase in procoagulant activity of monocyte-like U937", BRITISH JOURNAL OF HAEMATOLOGY, OXFORD, GB, vol. 87, no. 1, May 1994 (1994-05-01), pages 87 - 93, XP002106328, ISSN: 0007-1048 *
PATENT ABSTRACTS OF JAPAN vol. 017, no. 291 (C - 1067) 4 June 1993 (1993-06-04) *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9005609B2 (en) 2003-08-07 2015-04-14 Ethicon, Inc. Hemostatic compositions containing sterile thrombin
US8938898B2 (en) 2006-04-27 2015-01-27 Z-Medica, Llc Devices for the identification of medical products
US8846076B2 (en) 2006-05-26 2014-09-30 Z-Medica, Llc Hemostatic sponge
US9078782B2 (en) 2006-05-26 2015-07-14 Z-Medica, Llc Hemostatic fibers and strands
US9333117B2 (en) 2006-05-26 2016-05-10 Z-Medica, Llc Clay-based hemostatic agents and devices for the delivery thereof
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US8858969B2 (en) 2010-09-22 2014-10-14 Z-Medica, Llc Hemostatic compositions, devices, and methods
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US9072806B2 (en) 2012-06-22 2015-07-07 Z-Medica, Llc Hemostatic devices
US9352066B2 (en) 2012-06-22 2016-05-31 Z-Medica, Llc Hemostatic devices

Also Published As

Publication number Publication date
WO2001097826A2 (en) 2001-12-27
AU2001266926A1 (en) 2002-01-02

Similar Documents

Publication Publication Date Title
WO2001097826A3 (en) Hemostatic compositions, devices and methods
IL222773B (en) Biaryl compounds, pharmaceutical compositions comprising the same, use of such compounds in the manufacture of medicaments and in vitro methods and devices using such compounds
WO1998057678A3 (en) Compositions containing thrombin and microfibrillar collagen
ES2183606T3 (en) GRANULATE FIBRINE ADHESIVE AND PROCEDURE FOR PREPARATION.
MX9603285A (en) Plasma concentrate and tissue sealant compositions.
ATE20824T1 (en) ENRICHED PLASMA DERIVES TO SUPPORT WOUND CLOSURE AND HEALING.
DK1232254T3 (en) Process for preparing a reversibly inactive acidified plasma component
ATE236666T1 (en) HEMOSTATIC SEALANTS FOR TISSUES
YU67003A (en) Carrier with solid fibrinogen and solid thrombin
WO2003057072A3 (en) Hemostatic compositions and methods for controlling bleeding
WO2003047530A3 (en) Storage-stable fibrin sealant
NZ574653A (en) Solid dressing for treating wounded tissue
EP0341007A3 (en) Surgical adhesive material
ATE307111T1 (en) SERINE PROTEASE INHIBITORS
WO2010002435A3 (en) Hemostatic pouch and method to stabilize hemostatic components
ATE53299T1 (en) HEMOSTATIC IRRIGATION SOLUTION.
DE69906047D1 (en) FULLY RECOMBINANT TISSUE ADHESIVE
DE60328909D1 (en) COMPOSITION FOR THE TREATMENT OF ICHTHYOSIS USING ANTITRYPSIN
DK0691858T3 (en) Two-component fibrin glue
ES2254092T3 (en) USE OF ANTIFIBRINOLITIC AGENTS FOR PREPARATION OF STAMPS, COMPRESSES AND APOSITOS.
Sachetto et al. Modulation of the mammalian coagulation system by venoms and other proteins from snakes, arthropods, nematodes and insects
MD2328G2 (en) Fibrinous adhesive and use thereof for endoscopic hemostasis of variceal hemorrhages in hepatic cirrhosis
DE50311422D1 (en) THROMBIN RENEWABLE AND THROMBOOK-CONTAINING PHARMACEUTICAL ACTIVE INGREDIENTS AND MEDICAMENTS
CA3005026A1 (en) Sealant formulation and uses thereof
WO2008023163A3 (en) Composite material comprising fibrinogen and bioactive glass as a wound dressing

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10315918

Country of ref document: US

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP