WO2002000272A3 - Composition and method for the repair and regeneration of cartilage and other tissues - Google Patents

Composition and method for the repair and regeneration of cartilage and other tissues Download PDF

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Publication number
WO2002000272A3
WO2002000272A3 PCT/CA2001/000959 CA0100959W WO0200272A3 WO 2002000272 A3 WO2002000272 A3 WO 2002000272A3 CA 0100959 W CA0100959 W CA 0100959W WO 0200272 A3 WO0200272 A3 WO 0200272A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood
composition
bone
tissue
present
Prior art date
Application number
PCT/CA2001/000959
Other languages
French (fr)
Other versions
WO2002000272A2 (en
Inventor
Caroline D Hoemann
Michael D Buschmann
Marc D Mckee
Original Assignee
Biosyntech Canada Inc
Caroline D Hoemann
Michael D Buschmann
Marc D Mckee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BRPI0112109-0A priority Critical patent/BR0112109A/en
Priority to AU2001268882A priority patent/AU2001268882B2/en
Priority to DE60117984T priority patent/DE60117984T8/en
Priority to CA002412505A priority patent/CA2412505C/en
Priority to MXPA03000203A priority patent/MXPA03000203A/en
Priority to CN01814068.8A priority patent/CN1471412B8/en
Priority to AU6888201A priority patent/AU6888201A/en
Priority to KR1020027017970A priority patent/KR100880622B1/en
Application filed by Biosyntech Canada Inc, Caroline D Hoemann, Michael D Buschmann, Marc D Mckee filed Critical Biosyntech Canada Inc
Priority to JP2002505053A priority patent/JP5089006B2/en
Priority to NZ523763A priority patent/NZ523763A/en
Priority to IL15349001A priority patent/IL153490A0/en
Priority to EP01947086A priority patent/EP1294414B1/en
Publication of WO2002000272A2 publication Critical patent/WO2002000272A2/en
Publication of WO2002000272A3 publication Critical patent/WO2002000272A3/en
Priority to IL153490A priority patent/IL153490A/en
Priority to HK03106897A priority patent/HK1055563A1/en
Priority to CY20061100743T priority patent/CY1106313T1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
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    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
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    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
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Abstract

The present invention relates to a new method for repairing human or animal tissues such as cartilage, meniscus, ligament, tendon, bone, skin, cornea, periodontal tissues, abscesses, resected tumors, and ulcers. The method comprises the step of introducing into the tissue a temperature-dependent polymer gel composition such that the composition adhere to the tissue and promote support for cell proliferation for repairing the tissue. Other than a polymer, the composition preferably comprises a blood component such as whole blood, processed blood, venous blood, arterial blood, blood from bone, blood from bone-marrow, bone marrow, umbilical cord blood, placenta blood, erythrocytes, leukocytes, monocytes, platelets, fibrinogen, thrombin and platelet rich plasma. The present invention also relates to a new composition to be used with the method of the present invention.
PCT/CA2001/000959 2000-06-29 2001-06-29 Composition and method for the repair and regeneration of cartilage and other tissues WO2002000272A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP2002505053A JP5089006B2 (en) 2000-06-29 2001-06-29 Compositions and methods for repair and regeneration of cartilage and other tissues
AU2001268882A AU2001268882B2 (en) 2000-06-29 2001-06-29 Composition and method for the repair and regeneration of cartilage and other tissues
NZ523763A NZ523763A (en) 2000-06-29 2001-06-29 Compostion and method for the repair and regeneration of cartilage and other tissues
MXPA03000203A MXPA03000203A (en) 2000-06-29 2001-06-29 Composition and method for the repair and regeneration of cartilage and other tissues.
CN01814068.8A CN1471412B8 (en) 2000-06-29 2001-06-29 For repairing and regeneration of cartilage and the composition of other tissue and the purposes of said composition
AU6888201A AU6888201A (en) 2000-06-29 2001-06-29 Composition and method for the repair and regeneration of cartilage and other tissues
KR1020027017970A KR100880622B1 (en) 2000-06-29 2001-06-29 Composition and method for the repair and regeneration of cartilage and other tissues
BRPI0112109-0A BR0112109A (en) 2000-06-29 2001-06-29 composition and method for the correction and regeneration of cartilage and other tissues
DE60117984T DE60117984T8 (en) 2000-06-29 2001-06-29 COMPOSITION AND METHOD FOR REPAIRING AND REGENERATING CARTIL AND OTHER WOVEN FABRICS
CA002412505A CA2412505C (en) 2000-06-29 2001-06-29 Composition and method for the repair and regeneration of cartilage and other tissues
IL15349001A IL153490A0 (en) 2000-06-29 2001-06-29 Composition and method for the repair and regeneration of cartilage and other tissues
EP01947086A EP1294414B1 (en) 2000-06-29 2001-06-29 Composition and method for the repair and regeneration of cartilage and other tissues
IL153490A IL153490A (en) 2000-06-29 2002-12-16 Composition and method for the repair and regeneration of cartilage and other tissues
HK03106897A HK1055563A1 (en) 2000-06-29 2003-09-25 Composition and method for the repair and regeneration of cartilage and other tissues
CY20061100743T CY1106313T1 (en) 2000-06-29 2006-06-07 COMPOSITION AND METHOD FOR THE RESTORATION AND REGENERATION OF CARTILAGE AND OTHER TISSUES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21471700P 2000-06-29 2000-06-29
US60/214,717 2000-06-29

Publications (2)

Publication Number Publication Date
WO2002000272A2 WO2002000272A2 (en) 2002-01-03
WO2002000272A3 true WO2002000272A3 (en) 2002-08-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/000959 WO2002000272A2 (en) 2000-06-29 2001-06-29 Composition and method for the repair and regeneration of cartilage and other tissues

Country Status (21)

Country Link
US (4) US20020082220A1 (en)
EP (1) EP1294414B1 (en)
JP (1) JP5089006B2 (en)
KR (1) KR100880622B1 (en)
CN (1) CN1471412B8 (en)
AT (1) ATE320277T1 (en)
AU (2) AU6888201A (en)
BR (1) BR0112109A (en)
CA (1) CA2412505C (en)
CY (1) CY1106313T1 (en)
DE (1) DE60117984T8 (en)
DK (1) DK1294414T3 (en)
ES (1) ES2260241T3 (en)
HK (1) HK1055563A1 (en)
IL (2) IL153490A0 (en)
MX (1) MXPA03000203A (en)
NZ (1) NZ523763A (en)
PT (1) PT1294414E (en)
SG (1) SG149679A1 (en)
WO (1) WO2002000272A2 (en)
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