WO2002002172A1 - Dna palindrome - oligoguanylic acid compositions and uses thereof - Google Patents

Dna palindrome - oligoguanylic acid compositions and uses thereof Download PDF

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Publication number
WO2002002172A1
WO2002002172A1 PCT/US2001/020443 US0120443W WO0202172A1 WO 2002002172 A1 WO2002002172 A1 WO 2002002172A1 US 0120443 W US0120443 W US 0120443W WO 0202172 A1 WO0202172 A1 WO 0202172A1
Authority
WO
WIPO (PCT)
Prior art keywords
acid compositions
oligoguanylic
dna palindrome
palindrome
dna
Prior art date
Application number
PCT/US2001/020443
Other languages
French (fr)
Other versions
WO2002002172A9 (en
WO2002002172A3 (en
Inventor
Hideko Kaji
Akira Kaji
Saburo Yamamoto
Original Assignee
Univ Jefferson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jefferson filed Critical Univ Jefferson
Publication of WO2002002172A1 publication Critical patent/WO2002002172A1/en
Publication of WO2002002172A9 publication Critical patent/WO2002002172A9/en
Publication of WO2002002172A3 publication Critical patent/WO2002002172A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/43—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for artificial insemination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides an oligonucleotide for stimulating an immune response in a mammal. The oligonucleotides of the invention are palindromic and flanked by up to 11 guanylic acid residues. The immune response is stimulated by administering the oligonucleotides of the invention and inducing the secretion of cytokines.
PCT/US2001/020443 2000-06-30 2001-06-27 Dna palindrome - oligoguanylic acid compositions and uses thereof WO2002002172A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21547500P 2000-06-30 2000-06-30

Publications (3)

Publication Number Publication Date
WO2002002172A1 true WO2002002172A1 (en) 2002-01-10
WO2002002172A9 WO2002002172A9 (en) 2002-07-18
WO2002002172A3 WO2002002172A3 (en) 2002-10-10

Family

ID=22803128

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/020443 WO2002002172A1 (en) 2000-06-30 2001-06-27 Dna palindrome - oligoguanylic acid compositions and uses thereof

Country Status (1)

Country Link
WO (1) WO2002002172A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7718623B2 (en) * 2004-02-27 2010-05-18 Emori & Co., Ltd. Immunostimulatory oligonucleotide that induces interferon alpha

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468520A2 (en) * 1990-07-27 1992-01-29 MITSUI TOATSU CHEMICALS, Inc. Immunostimulatory remedies containing palindromic DNA sequences
WO1994008053A1 (en) * 1992-09-29 1994-04-14 Isis Pharmaceuticals, Inc. Oligonucleotides having a conserved g4 core sequence
WO1998016247A1 (en) * 1996-10-11 1998-04-23 The Regents Of The University Of California Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
WO1998018810A1 (en) * 1996-10-30 1998-05-07 The University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
WO1998037919A1 (en) * 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
WO1998052581A1 (en) * 1997-05-20 1998-11-26 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
WO1999058118A2 (en) * 1998-05-14 1999-11-18 Cpg Immunopharmaceuticals Gmbh METHODS FOR REGULATING HEMATOPOIESIS USING CpG-OLIGONUCLEOTIDES

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468520A2 (en) * 1990-07-27 1992-01-29 MITSUI TOATSU CHEMICALS, Inc. Immunostimulatory remedies containing palindromic DNA sequences
WO1994008053A1 (en) * 1992-09-29 1994-04-14 Isis Pharmaceuticals, Inc. Oligonucleotides having a conserved g4 core sequence
WO1998016247A1 (en) * 1996-10-11 1998-04-23 The Regents Of The University Of California Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
WO1998018810A1 (en) * 1996-10-30 1998-05-07 The University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
WO1998037919A1 (en) * 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
WO1998052581A1 (en) * 1997-05-20 1998-11-26 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
WO1999058118A2 (en) * 1998-05-14 1999-11-18 Cpg Immunopharmaceuticals Gmbh METHODS FOR REGULATING HEMATOPOIESIS USING CpG-OLIGONUCLEOTIDES

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 148, no. 12, 15 June 1992 (1992-06-15), pages 4072 - 4076, XP002098020, ISSN: 0022-1767 *
SONEHARA K ET AL: "HEXAMER PALINDROMIC OLIGONUCLEOTIDES WITH 5'-CG-3' MOTIF(S) INDUCE PRODUCTION OF INTERFERON", JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, MARY ANN LIEBERT, NEW YORK, NY, US, vol. 16, no. 10, October 1996 (1996-10-01), pages 799 - 803, XP000863569, ISSN: 1079-9907 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7718623B2 (en) * 2004-02-27 2010-05-18 Emori & Co., Ltd. Immunostimulatory oligonucleotide that induces interferon alpha

Also Published As

Publication number Publication date
WO2002002172A9 (en) 2002-07-18
WO2002002172A3 (en) 2002-10-10

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