WO2002002172A3 - Dna palindrome - oligoguanylic acid compositions and uses thereof - Google Patents

Dna palindrome - oligoguanylic acid compositions and uses thereof Download PDF

Info

Publication number
WO2002002172A3
WO2002002172A3 PCT/US2001/020443 US0120443W WO0202172A3 WO 2002002172 A3 WO2002002172 A3 WO 2002002172A3 US 0120443 W US0120443 W US 0120443W WO 0202172 A3 WO0202172 A3 WO 0202172A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid compositions
oligoguanylic
dna palindrome
palindrome
dna
Prior art date
Application number
PCT/US2001/020443
Other languages
French (fr)
Other versions
WO2002002172A9 (en
WO2002002172A1 (en
Inventor
Hideko Kaji
Akira Kaji
Saburo Yamamoto
Original Assignee
Univ Jefferson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jefferson filed Critical Univ Jefferson
Publication of WO2002002172A1 publication Critical patent/WO2002002172A1/en
Publication of WO2002002172A9 publication Critical patent/WO2002002172A9/en
Publication of WO2002002172A3 publication Critical patent/WO2002002172A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/43—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for artificial insemination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Abstract

The present invention provides an oligonucleotide for stimulating an immune response in a mammal. The oligonucleotides of the invention are palindromic and flanked by up to 11 guanylic acid residues. The immune response is stimulated by administering the oligonucleotides of the invention and inducing the secretion of cytokines.
PCT/US2001/020443 2000-06-30 2001-06-27 Dna palindrome - oligoguanylic acid compositions and uses thereof WO2002002172A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21547500P 2000-06-30 2000-06-30

Publications (3)

Publication Number Publication Date
WO2002002172A1 WO2002002172A1 (en) 2002-01-10
WO2002002172A9 WO2002002172A9 (en) 2002-07-18
WO2002002172A3 true WO2002002172A3 (en) 2002-10-10

Family

ID=22803128

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/020443 WO2002002172A1 (en) 2000-06-30 2001-06-27 Dna palindrome - oligoguanylic acid compositions and uses thereof

Country Status (1)

Country Link
WO (1) WO2002002172A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3976742B2 (en) * 2004-02-27 2007-09-19 江守商事株式会社 Immunostimulatory oligonucleotides that induce interferon alpha

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468520A2 (en) * 1990-07-27 1992-01-29 MITSUI TOATSU CHEMICALS, Inc. Immunostimulatory remedies containing palindromic DNA sequences
WO1994008053A1 (en) * 1992-09-29 1994-04-14 Isis Pharmaceuticals, Inc. Oligonucleotides having a conserved g4 core sequence
WO1998016247A1 (en) * 1996-10-11 1998-04-23 The Regents Of The University Of California Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
WO1998018810A1 (en) * 1996-10-30 1998-05-07 The University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
WO1998037919A1 (en) * 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
WO1998052581A1 (en) * 1997-05-20 1998-11-26 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
WO1999058118A2 (en) * 1998-05-14 1999-11-18 Cpg Immunopharmaceuticals Gmbh METHODS FOR REGULATING HEMATOPOIESIS USING CpG-OLIGONUCLEOTIDES

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0468520A2 (en) * 1990-07-27 1992-01-29 MITSUI TOATSU CHEMICALS, Inc. Immunostimulatory remedies containing palindromic DNA sequences
WO1994008053A1 (en) * 1992-09-29 1994-04-14 Isis Pharmaceuticals, Inc. Oligonucleotides having a conserved g4 core sequence
WO1998016247A1 (en) * 1996-10-11 1998-04-23 The Regents Of The University Of California Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
WO1998018810A1 (en) * 1996-10-30 1998-05-07 The University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
WO1998037919A1 (en) * 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
WO1998052581A1 (en) * 1997-05-20 1998-11-26 Ottawa Civic Hospital Loeb Research Institute Vectors and methods for immunization or therapeutic protocols
WO1999058118A2 (en) * 1998-05-14 1999-11-18 Cpg Immunopharmaceuticals Gmbh METHODS FOR REGULATING HEMATOPOIESIS USING CpG-OLIGONUCLEOTIDES

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 148, no. 12, 15 June 1992 (1992-06-15), pages 4072 - 4076, XP002098020, ISSN: 0022-1767 *
SONEHARA K ET AL: "HEXAMER PALINDROMIC OLIGONUCLEOTIDES WITH 5'-CG-3' MOTIF(S) INDUCE PRODUCTION OF INTERFERON", JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, MARY ANN LIEBERT, NEW YORK, NY, US, vol. 16, no. 10, October 1996 (1996-10-01), pages 799 - 803, XP000863569, ISSN: 1079-9907 *

Also Published As

Publication number Publication date
WO2002002172A9 (en) 2002-07-18
WO2002002172A1 (en) 2002-01-10

Similar Documents

Publication Publication Date Title
WO2004053104A3 (en) 5’ cpg nucleic acids and methods of use
DE60036950D1 (en) COMPOSITIONS FOR STIMULATING CYTOKIN SECRETION AND INDUCING AN IMMUNE RESPONSE
WO2001051083A3 (en) Innate immunity-stimulating compositions of cpg and saponin and methods thereof
MXPA04011937A (en) Immunostimulatory oligonucleotides and uses thereof.
AU7621600A (en) Human rnase h and oligonucleotide compositions thereof
WO2001079464A3 (en) Nucleic acids encoding polypeptides having haloperoxidase activity
WO2000061151A3 (en) Oligodeoxynucleotide and its use to induce an immune response
EP1732598A4 (en) Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions
HUP0100197A3 (en) Compositions and vaccines to enhance an immune response of nucleic acid vaccination
WO2005097175A3 (en) Human glp-1 mimetibodies, compositions, methods and uses
PT1446162E (en) Combination motif immune stimulatory oligonucleotides with improved activity
WO2004002417A3 (en) Mammalian ch1 deleted mimetibodies, compositions, methods and uses
WO2001079465A3 (en) Nucleic acids encoding polypeptides having haloperoxidase activity
WO2000054803A3 (en) Immunostimulatory nucleic acids and antigens
AU2003210687A1 (en) Methods and composition for delivering nucleic acids and/or proteins to the intestinal mucosa
WO2004005476A3 (en) Nucleic acid compositions for stimulating immune responses
WO2001032832A3 (en) Antisense inhibition of nucleolin expression
WO2002016549A3 (en) METHODS OF TREATMENT OR PREVENTION OF AUTOIMMUNE DISEASES WITH CpG-CONTAINING POLYNUCLEOTIDE
IL153388A0 (en) Manipulation of negative stranded rna viruses by rearrangement of their genes and uses thereof
WO2000053776A3 (en) Human kallikrein-like genes
WO1999024077A3 (en) Compositions and methods for targeted delivery of biologically-active factors
WO2001092330A3 (en) Use of acrp30 globular head to promote increases in muscle mass and muscle differentiation
WO2000030667A3 (en) Compositions and methods using lactadherin or variants thereof
NZ331063A (en) Isolated nucleotide sequences encoding for mature LS- DNase which is resistant to actin inhibition
WO1999056784A3 (en) Inprovements in gene therapy using compositions comprising a polynucleotide and a nuclease inhibitor or interleukin-10

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: C2

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

COP Corrected version of pamphlet

Free format text: PUBLISHED INTERNATIONAL SEARCH REPORT DELETED (2 PAGES) (WITH AN UPDATED VERSION OF THE FRONT PAGE)

AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase in:

Ref country code: JP