WO2002005877A1

WO2002005877A1 - Liquid filling device

Info

Publication number: WO2002005877A1
Application number: PCT/JP2001/006160
Authority: WO
Inventors: Hiroyuki Yunoki; Kouichi Tachikawa; Masaaki Kasai
Original assignee: Terumo Kabushiki Kaisha
Priority date: 2000-07-17
Filing date: 2001-07-17
Publication date: 2002-01-24
Also published as: AU2001269535A1; JP4598359B2

Abstract

A liquid filling device (1) capable of preventing foreign matter from entering therein and a contamination thereof by bacteria with a simple structure and also completing the preparations for filling liquid such as chemicals by an easy operation, comprising an outer tube (3) having a liquid storage space (33) formed therein, a liquid leading part (4) formed projectedly at the end part of the outer tube (3) and having, therein, a flow path (41) communicating with the liquid storage space (33), an inner plug (valve mechanism) (7) installed on the outer periphery of the liquid leading part (4) and opening and closing the flow path (41), and a hub (operating member) (11) operating the inner plug (7) by rotating about the axis of the liquid leading part (4), wherein the hub (11) holds a needle tube (12) at the tip part thereof, and the inner plug (7) is rotated according to the rotation of the hub (11) so as to be displaced to a first position for interrupting the flow path (41) and a liquid leading path (71) provided in the inner plug (7) and a second position for communicating the flow path (41) with the liquid leading path (71).

Description

Liquid injection device

TECHNICAL FIELD The present invention is the brightness related to the liquid injection device _£

Background art

book

A chemical solution or the like is stored in advance. This prefilled syringe includes an outer cylinder having a discharge port at the tip, a gasket inserted into the outer cylinder, and a plunger (pusher) connected to the gasket. The medicine is stored in the enclosed space. Further, in order to prevent leakage of the chemical solution from the outlet and to maintain the sterility of the chemical solution, a film for sealing the outlet in a liquid-tight manner is attached to the outlet. When administering a drug solution in an outer cylinder to a patient, first, the film that seals the outlet is peeled off, and then an injection needle having a needle body is attached to the tip of the outer cylinder. 'And in this state, the needle is punctured into the blood vessel of the patient, and the plunger is pressed toward the distal end of the outer cylinder to inject the drug solution into the blood vessel. However, since the above operation is performed in the air, after the film is peeled off, there is a possibility that the chemical solution is contaminated with bacteria or the like, or a foreign substance is mixed in the chemical solution, and this operation is complicated. is there. Disclosure of the invention

An object of the present invention is to provide a liquid injecting device that can prevent contamination of foreign matter and bacteria by a simple configuration, and a liquid injecting device that can complete preparation for injecting a liquid such as a drug solution by a simple operation. It is to provide.

Such an object is achieved by the present invention described in the following (1) to (12).

(1) an outer cylinder having a liquid storage space inside,

A liquid guide portion protrudingly formed at an end of the outer cylinder and having a flow path therein communicating with the liquid storage space;

A valve mechanism that is installed on the outer periphery of the liquid guide unit and that opens and closes the flow path;

A liquid injecting device, comprising: an operating member that operates the valve mechanism by rotation about an axis of the liquid guide portion.

(2) the valve mechanism is constituted by a cylindrical inner plug installed between the outer periphery of the liquid guide portion and the operation member,

The liquid injection device according to (1), wherein the inner plug has a liquid guide path communicating with the flow path and opening the flow path.

(3) The inner plug rotates with the rotation of the operation member, and the first position where the flow path and the liquid guide path are shut off communicates the flow path and the liquid guide path. The liquid injection device of (2), which is displaced to the second position and.

(4) The liquid injection device according to (3), wherein when the inner plug is at the second position, the waveguide and the liquid storage space communicate with each other via the flow path.

(5) The inner plug engages with the liquid guide, and engages to prevent detachment from the liquid guide. The liquid injecting device according to any one of (2) to (4), which has a portion.

(6) The liquid injecting device according to any one of (1) to (5), wherein an end of the flow path opposite to the liquid storage space has a side hole opened in a side surface of the liquid guide.

(7) The liquid injecting device according to (6), further including a marker indicating a position of the liquid guide portion and / or the side hole.

(8) The liquid injecting device according to any one of (1) to (7), further comprising a hook means for defining a rotation position of the operation member with respect to the liquid guide portion.

(9) The liquid injection device according to (8), wherein the locking means has a function of positioning the operation member at least at the first position and the second position.

(10) The liquid injection device according to any one of (1) to (9), wherein the operation member holds a pipe at a distal end thereof.

(11) The liquid injector according to (11), wherein the operation member also serves as a hub of the needle tube.

(12) The liquid injection device according to any one of (1) to (11), wherein the liquid injection device is a prefilled syringe. BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is a partial cross-sectional view of the liquid injection device of the present invention.

FIG. 2 is a vertical cross-sectional view showing the configuration of the distal end portion of the liquid injection device of the present invention (the state where the inner plug is at the flow path blocking position).

FIG. 3 is a sectional view taken along line AA in FIG.

FIG. 4 is a sectional view taken along line BB in FIG. FIG. 5 is a vertical cross-sectional view showing the configuration of the distal end portion of the liquid injection device of the present invention (the state in which the inner plug is at the flow path communication position).

FIG. 6 is a cross-sectional view taken along line C-C in FIG.

FIG. 7 is a sectional view taken along line DD in FIG. BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, a liquid injection device of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings. In the following description, a liquid injector in which a liquid is stored in advance will be described as a representative. Also, the tip side of the figure is the tip and the plunger side is the base end.

FIG. 1 is a partial cross-sectional view of the liquid injection device of the present invention. FIG. 2 is a vertical cross-sectional view showing the configuration of the distal end portion of the liquid injection device of the present invention (with the inner plug at the flow path blocking position). Is a cross-sectional view taken along line A-A in FIG. 2, FIG. 4 is a cross-sectional view taken along line B-B in FIG. 2, and FIG. 5 is a configuration of the distal end portion of the liquid injection device of the present invention. FIG. 6 is a cross-sectional view taken along the line C-C in FIG. 5, and FIG. 7 is a cross-sectional view taken along the line D-D in FIG. In the following description, the upper side in FIGS. 1, 2 and 5 is referred to as a “proximal end”, and the lower side is referred to as a “distal end”.

The liquid injection device 1 shown in FIG. 1 includes a liquid injection device main body (prefilled syringe) 2, an inner plug 7 installed at a distal end of the liquid injection device main body 2, and a liquid injection device main body through the inner plug 7. 2 and an injection needle 10 attached thereto. Hereinafter, the configuration of each unit will be described.

The liquid injection device main body 2 has an outer cylinder (syringe outer cylinder) 3 and a projecting shape at the tip of the outer cylinder 3. And a plunger (pusher) 6 that is connected to the gasket 5 and moves the gasket 5 within the outer cylinder 3. ing.

The outer cylinder 3 is formed of a bottomed cylindrical member having a bottom portion 31, and a liquid storage space 33 is formed in a portion surrounded by a gasket 5 described below.

The liquid Q is stored in the liquid storage space 33. The liquid Q to be stored is, for example, a saccharide injection such as glucose, an electrolyte correction injection such as sodium chloride and potassium lactate, a vitamin, a vaccine, an antibiotic injection, a contrast agent, and a steroid. Drug solutions, protease inhibitors, fat emulsions, anticancer agents, anesthetics, stimulants, various drug solutions such as narcotics, or distilled water, disinfectants, liquid foods, alcohols and the like.

A plate-shaped flange 32 is provided on the outer periphery of the proximal end of the outer cylinder 3. When the plunger 6 is moved relative to the outer cylinder 3, the operation can be performed by putting a finger on the flange 32. The flange 32 may be formed integrally with the outer periphery of the base end of the outer cylinder 3, or the flange 32 and the outer cylinder 3 may be manufactured separately and joined.

As each of the constituent material of the outer tube 3 and will be described later plunger 6, for example, cyclic polyolefins (e.g., ethylene and tetracyclo ^{[4. 4. 0. I 2 ·} 5. 1 7 1 °] _ 3- dodecene copolymer Polyester, such as polyvinyl chloride, polyethylene chloride, polypropylene, polystyrene, poly (4-methylpentene-11), polycarbonate, acrylic resin, acrylic nitrile-butadiene-styrene copolymer, and polyethylene terephthalate. Butadiene-styrene copolymer, poly Examples include various resins such as amides (eg, nylon 6, nylon 6,6, nylon 6,10, nylon 12), polyethersulfone, and polysulfone. Among them, in that molding is easy, cyclic polyolefins (e.g., E styrene and tetracyclo ^{^{[4. 4. 0. I 2 · 5}} . 1 7 1 °] -3- dodecene copolymer), polypropylene, poly Preferred are resins such as 1- (4-methylpentene-1), polyethersulfone, and polysulfone.

It is preferable that the constituent material of the outer cylinder 3 be substantially transparent in order to secure the visibility of the inside.

In addition, a liquid guide portion 4 that is smaller in diameter than the body portion of the outer tube 3 and protrudes toward the front end is formed at the front end of the outer tube 3 at the center of the bottom portion 31.

The liquid guide section 4 has a substantially cylindrical shape, and a flow path 41 communicating with the liquid storage space 33 is formed inside the liquid guide section 4. An end of the flow channel 41 opposite to the liquid storage space 33 forms a pair of side holes 42 that are open to the side surface of the liquid guide 4. These side holes 42 are provided substantially at opposite sides (at 180 ° intervals) through the axis of the liquid guide 4.

Further, a ring-shaped concave portion 43 which is recessed inward is formed on the outer periphery of the distal end portion of the liquid guide portion 4. An engagement portion 72 of the inner plug 7, which will be described later, is engaged with the concave portion 43.

An inner stopper 7 to be described later is attached (installed) to the outer periphery (periphery) of the liquid introducing section 4.

A gasket 5 made of an elastic material is housed in the outer cylinder 3. The gasket 5 has a hollow portion 51, and the hollow portion 51 has a plunger 6 described later. The heads 63 of the two fit together.

By operating the plunger 6, the gasket 5 can slide in the outer cylinder 3 in the axial direction (longitudinal direction) of the outer cylinder 3 either on the base end side or on the distal end side. A ring-shaped protrusion 52 may be formed on the outer peripheral portion of the gasket 5 along its axial direction. The protrusion 52 slides while being in close contact with the inner peripheral surface 34 of the outer cylinder 3, so that liquid tightness is more reliably maintained and slidability is improved. The position and the number of the protrusions 52 are not particularly limited.

The constituent material of the gasket 5 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, and poly Elastic materials such as various thermoplastic elastomers such as amides, olefins, and styrenes, and mixtures thereof are exemplified.

The gasket 5 only needs to have at least the outer peripheral portion made of the above-described elastic material. For example, the gasket 5 has a core portion (not shown) made of a resin material. May be configured such that an elastic material is disposed so as to cover.

The outer periphery of the gasket 5 is, for example, polytetrafluoroethylene or a copolymer thereof, ethylene-tetrafluoroethylene copolymer, tetrafluoroethylene, PVDF (polyvinylidene flow). Ride), PCTFE (polychlorotrifluoroethylene), TFE (tetrafluoroethylene), FEP (fluorinated polyethylene propylene), and other films composed of a fluororesin. Thereby, the slidability of the gasket 5 with respect to the inner peripheral surface 34 of the outer cylinder 3 is improved.

In such a gasket 5, the gasket 5 is moved in the axial direction within the outer cylinder 3. Plunger 6 is connected.

In FIG. 1, the plunger 6 is formed of a plate piece having a cross-shaped cross section, and a plate member 61 is integrally formed at the front end side. At the base end of the plunger 6, a plate-like flange 62 is provided. The plunger 6 is operated by hanging the flange 62 with a finger or the like. The flange 62 may be formed integrally with the base end of the plunger 6, or the flange 62 and the plunger 6 may be separately manufactured and joined.

At the tip of the plunger 6, a mushroom-shaped head (connecting portion) 63 is formed to be inserted and fitted into the hollow portion 51 of the gasket 5.

On the outer periphery of the liquid guide 4, a substantially cylindrical inner plug 7 is installed so as to be rotatable relative to the liquid guide 4 around the axis of the liquid guide 4.

The inner stopper 7 constitutes a valve mechanism having a function of opening and closing the flow path 41 of the liquid guide section 4.

The inner stopper 7 is formed with a liquid guide channel 71 that communicates with the flow channel 41 of the liquid guide section 4 and opens the flow channel 41. The liquid guide channel 71 is formed from the middle of the side of the inner plug 7 and extends to the tip of the inner plug 7 along the axial direction.

The inner plug 7 is located at a first position where the flow path 41 and the liquid guide path 71 are cut off, that is, the position shown in FIG. 2 (hereinafter, the position of the inner plug 7 is referred to as a “flow path cutoff position”). ), The side holes 42 are sealed in a liquid-tight manner. Thus, the liquid Q stored in the liquid storage space 33 only stops filling the flow path 41 and is prevented from leaking out of the liquid injection device main body 2.

On the other hand, the inner stopper 7 is located at a second position where the flow path 41 and the liquid guide path 71 communicate with each other, that is, At the position shown in FIG. 5 (hereinafter, the position of the inner plug 7 is referred to as a “flow path communication position”), the liquid guide path 71 communicates with the liquid storage space 33 via the flow path 41, The liquid Q stored in the storage space 33 can be discharged to the outside of the liquid injector main body 2.

A ring-shaped engaging portion 72 protruding inward is formed on the inner periphery of the distal end portion of the inner plug 7. The engagement of the engaging portion 72 with the concave portion 43 of the liquid guide portion 4 prevents the inner plug 7 from being detached (disengaged) from the liquid guide portion 4 more reliably.

Further, a ring-shaped projection 73 protruding outward is formed on the outer periphery of the distal end of the inner plug 7. The projection 73 engages with a concave portion 112 of the hub 11 described later.

As a constituent material of such an inner plug 7, when the inner peripheral surface of the inner stopper 7 is in close contact with the outer peripheral surface of the liquid guide portion 4 and the inner stopper 7 is in the flow path blocking position, each side hole 42 is formed. Any material can be used as long as it can be sealed in a liquid-tight manner. For example, HDPE (high-density polyethylene), LDPE (low-density polyethylene), PP (polypropylene), PE (polyethylene), etc. A material similar to the material can be used.

A hub 11 of the later-described injection needle 10 is attached to the outer periphery of the inner plug 7. That is, the inner stopper 7 is provided between the liquid introduction part 4 and the hub 11.

The injection needle 10 has a hub 11 and a tube 12 fixed (held) to the tip of the hub 11.

The hub 11 is formed of a substantially cylindrical member, and the inner plug 7 is inserted into its inner cavity 11 1. The inner peripheral surface of the hub 11 and the outer peripheral surface of the inner plug 7 are in close contact with each other. Hub 1 1 and inner plug 7 Fits liquid tight.

For this reason, for example, with the liquid injection device main body 2 held and fixed by hand or the like, the hub is gripped by the other hand or the like, and the hub 11 is rotated clockwise around the axis of the liquid guide section 4 ( Or counterclockwise), the inner stopper 7 rotates in the same direction about the axis of the liquid guide 4 as the hub 11 rotates. As a result, the inner plug 7 is displaced between the flow path blocking position (first position) and the flow path communication position (second position).

That is, the hub 11 also functions as an operating member that operates the inner plug (valve mechanism) 7 by rotation about the axis of the liquid guide 4.

In the hub 11, a recessed portion 112 engaged with the projection 73 of the inner plug 7 is formed on the inner periphery of the tip end of the hub 11 so as to be recessed and recessed outward in a ring shape. I have. The engagement of the recesses 112 with the projections 73 allows the hub 11 to be securely (liquid-tightly) mounted by the inner stopper 7. Therefore, the hub 11 (injection needle 10) is more reliably prevented from being detached (detached) from the inner plug 7.

The hub 11 may be coupled (attached) to the inner plug 7 only by a fitting force. For example, the hub 11 may be fused (heat fusion, high frequency fusion, ultrasonic fusion, or the like), an adhesive, or the like. It may be fixed (fixed) by a method such as adhesion by using.

The hub 11 is preferably made of a transparent (colorless and transparent), colored transparent or translucent resin, and the internal visibility is secured. Thereby, the liquid guide part 71 of the inner plug 7 can be visually recognized from the outside.

The constituent material of such a hub 11 is not particularly limited. Polyolefin such as polyethylene, polypropylene, polybutadiene, ethylene-vinyl acetate copolymer, polyvinyl chloride, polyurethane, polystyrene, polymethyl methacrylate Resin materials such as polyester, acrylic resin, ABS resin, AS resin, ionomer, polyacetal, polyphenylene sulfide, and polyether ether ketone, such as polyester, polycarbonate, polyamide, polyethylene terephthalate, and polybutylene terephthalate. Is mentioned.

A hollow needle tube 12 is fixed (fixed) to the distal end portion of the hub, and the lumen 121 of the needle tube 12 communicates with the lumen portion 111 of the hub 11.

The needle tube 12 is made of, for example, a metal material such as stainless steel, aluminum or an aluminum alloy, titanium or a titanium alloy. A sharp tip 122 is formed at the distal end of the needle tube 12. The shape of the tip 122 is not particularly limited, and may have a blade surface inclined at a predetermined angle with respect to the axis of the needle tube 12 as shown in the figure.

Examples of the method of fixing (fixing) the needle tube 12 to the hub include a method such as fitting, force crimping, fusion, bonding with an adhesive, or a method using these together.

In addition, a cap P for enclosing the tip 12 may be attached to the tip side of the hub 11 of the liquid injector 1 when not in use. The cap P has a function of preventing danger and preventing contamination of the pipe 12.

As the constituent material of the cap P, for example, the same constituent materials as those listed for the outer cylinder 3 and the plunger 6 can be used.

In such a liquid injection device 1, a lock means 8 for defining a rotation position of the hub (operation member) 11 with respect to the liquid guide portion 4 may be provided.

In the present embodiment, the rotation of the hub 11 around the axis of the liquid introduction section 4 is required. The inner plug 7 is configured to rotate about the axis of the liquid introducing section 4 integrally (or in conjunction with). Therefore, if the rotational position of the inner stopper 7 with respect to the liquid guide 4 is defined, the rotational position of the hub 11 with respect to the liquid guide 4 is also defined. Therefore, the locking means 8 in the present embodiment is configured to regulate the rotational position of the inner plug 7 with respect to the liquid guide 4.

Hereinafter, the locking means 8 will be described with reference to FIGS.

The inner plug 7 has a mountain-shaped convex portion 81 formed on the inner periphery of the base end portion so as to protrude inward. In the cross-sectional shape of the mountain-shaped convex portion 81, the apex portion 811 forms an angle of less than 180 ° (substantially a right angle in the present embodiment).

On the other hand, on the outer periphery of the base end portion of the liquid guide portion 4, a total of three valley-shaped recesses of a pair of valley-shaped recesses 82 and a valley-shaped recessed portion 83 provided therebetween are provided with a mountain-shaped convex portion 8. It is formed corresponding to the shape of 1. The pair of valley-shaped recesses 8 2 are respectively installed on the substantially opposite sides via the axis of the liquid guide portion 4 corresponding to the side holes 42, and the valley-shaped recesses 8 3 are substantially the same as the pair of valley-shaped recesses 8 2. It is located in the middle, that is, at a position that is approximately 90 ° from each of the valley-shaped concave portions 82. The locking means 8 is constituted by these mountain-shaped convex portions 81 and valley-shaped concave portions 82, 83.

In addition, at the base end of the liquid guide portion 4, a small-diameter portion 8 whose outer diameter is set to a predetermined length by a predetermined length is formed in a portion between the valley-shaped concave portion 83 and the adjacent valley-shaped concave portion 82. 4 is formed. Thereby, a gap is formed between the outer surface 841 of the small diameter portion 84 and the inner peripheral surface of the base end portion of the inner plug 7. The width of this gap (the length in the radial direction in FIGS. 4 and 7) is set shorter than the height of the mountain-shaped protrusion 81.

When the inner plug 7 is at the flow path blocking position (see Fig. 4), the mountain-shaped convex portion 81 has a valley-shaped concave. It is engaged with part 83, and its position is defined (positioned). From this state, when the liquid injection device main body 2 is grasped by hand and, for example, the hub 11 is rotated approximately 90 ° counterclockwise in FIG. 4 around the axis of the liquid guide 4, Inner plug 7 rotates approximately 90 ° in the same direction about the axis of liquid guide 4, reaches the flow path communication position (see Fig. 7), and peak-shaped protrusion 81 engages with valley-shaped recess 82 I do. When the inner plug 7 comes to the flow path communication position as described above, the side surface 8 12 of the mountain-shaped convex portion 8 1 comes into contact with the upper side surface 8 2 1 of the valley-shaped concave portion 8 2. Further rotation in the same direction about the axis of part 4 is prevented (restricted). That is, the inner plug 7 is defined (positioned) at the channel communication position.

In addition, from the state where the inner stopper 7 is in the flow path blocking position, the liquid injection device main body 2 is grasped by hand, and the hub 11 is rotated about 90 ° clockwise in FIG. By rotating the inner plug 7, the inner plug 7 can be set to the flow path communication position.

Further, such a liquid injection device 1 may have a marker 9 that indicates the position of the liquid guide channel 71 of the inner stopper 7 and the position of each side hole 42 of the liquid guide portion 4.

In the figure, the first contact 9 has a groove 91 formed on the outer periphery of the base end of the inner stopper 6 at a position corresponding to the liquid guide channel 71, and an outer periphery of the distal end of the outer cylinder 3 (in the vicinity of the bottom 31). (Outer periphery) and a pair of grooves 92 formed at positions corresponding to the side holes 42.

Thereby, for example, even when it is difficult to visually recognize the inside of the liquid injection device 1 (the flow path 41, the liquid guide path 71, etc.), the groove 91 coincides with one of the grooves 92. When it is turned on (see Fig. 5), it can be seen that the inner plug 7 is located at the flow path communicating position, and that the grooves 91 do not coincide with any of the grooves 92, and that the grooves 9 When it is 0 ° apart (see Fig. 2), it can be seen that the inner plug 7 is at the flow path blocking position. this Therefore, it is convenient (advantageous) in operating the liquid injection device 1.

Further, it is preferable that the groove 91 is provided so as to substantially coincide with the position of the blade surface formed on the needle tip 122 of the needle tube 122. In this case, the groove 91 can also indicate the position of the blade surface. Therefore, in the operation of puncturing the needle tube 12 into, for example, a blood vessel of a patient, the liquid injection device 1 should be used with the groove 91 positioned upward and the blade surface of the needle tube 12 directed upward. Thereby, this operation can be performed more reliably.

The marker 9 is not limited to the one shown in the figure, and may be one showing only one of the liquid guide channel 71 and the side hole 42.

In addition, the outer periphery of the distal end portion of the outer cylinder 3 (the outer periphery near the bottom 31) is at a position perpendicular to each side hole 42, that is, a position that can indicate that the inner plug 7 is at the flow path blocking position. And three grooves may be provided.

In addition, instead of the grooves (the grooves 91 and the grooves 92), the grooves 9 may be formed by, for example, projections, printing, siposlits, or the like.

Further, it is preferable that at least the inside of such a liquid injecting instrument 1 is previously subjected to a sterilization treatment such as high-pressure steam sterilization, gas sterilization or radiation sterilization.

Further, in such a liquid injection device 1, a center 7 that fits into both the liquid guide section 4 and the hub 11 is provided, and the liquid guide path 7 1 and the flow path 41 of the inner plug 7 are connected. Since the flow path 41 is opened by the communication, when the liquid Q is discharged from the liquid storage space 33, the amount of the liquid Q remaining in the liquid storage space 33 is extremely small (for example, 7 to 10). 10 L). Therefore, especially when an expensive chemical solution is stored as the liquid Q in the liquid storage space 33, there is an advantage that the chemical solution can be effectively used. Further, since an existing product can be used as the injection needle 10, it is advantageous in reducing the manufacturing cost of the liquid injection device 1.

Next, an example of a method for using the liquid injection device 1 of the present invention will be described. In the following description, a case where the liquid Q is injected into a blood vessel of a patient will be described.

[1] First, open the packaging material and remove the liquid injection device 1 stored in the packaging material (not shown). In this state, the inner plug 7 is located at a flow path blocking position (first position) where the flow path 41 and the liquid guide path 71 are blocked (see FIGS. 2 to 4). As a result, the inner stopper 7 seals each side hole 42 in a liquid-tight manner, and prevents the liquid Q in the liquid storage space 33 and the flow path 41 from leaking out of the liquid injection device body 2. Preventing.

At this time, since the grooves 91 and the grooves 92 do not coincide with each other, it can be easily recognized that the inner plug 7 is located at the flow path blocking position.

[2] Next, the outer cylinder 3 of the liquid injection device main body 2 is gripped and fixed by hand, and the hub 11 of the injection needle 10 is gripped by the other hand, and the hub 11 is connected to the axis of the liquid guide 4. 3 and 4, the inner stopper 7 rotates in the same direction as the hub 11 around the axis of the liquid guide 4 as the hub 11 rotates. To rotate. At this time, the top portion 811 of the mountain-shaped convex portion 81 passes over the shoulder portion 842 of the small-diameter portion 84 (see FIGS. 3 and 4). As a result, the peak-shaped convex portion 81 is separated from the valley-shaped concave portion 83, and the engagement between the peak-shaped convex portion 81 and the valley-shaped concave portion 83 is released.

[3] Further, when the hub 11 is rotated around the counterclockwise direction in FIGS. 3 and 4 about the axis of the liquid guide 4, the inner stopper 7 also moves with the axis of the liquid guide 4 as a center. Rotate in the same direction. At this time, the top 811 of the mountain-shaped projection 81 moves in the same direction along the outer surface 841, while sliding on the outer surface 841 of the small diameter portion 84. Therefore, turn the hub 1 1 A rotating load acts on the hand of the operator who is turning.

Then, when the top portion 811 passes through the shoulder portion 843 of the small-diameter portion 84, the mountain-shaped convex portion 81 enters the concave-shaped concave portion 82 and engages with the concave-shaped concave portion 82. As a result, the inner plug 7 becomes the flow path communication position (second position), and the flow path 41 communicates with the liquid guide path 71.

At this time, the rotation load is reduced at once, and the load change is transmitted to the operator's hand rotating the hub 11 (a so-called click feeling is obtained), and the inner plug 7 is connected to the flow path. The position can be easily confirmed.

Further, at this time, since the groove 91 of the inner plug 7 and the groove 92 of the outer cylinder 3 coincide with each other, it is also possible to recognize that the inner plug 7 has reached the flow path communication position. In this state, even if the hub 11 is to be rotated counterclockwise in FIG. 7 about the axis of the liquid guide 4, the side surface 8 12 of the mountain-shaped convex portion 8 1 and the valley-shaped concave portion 8 2 Since the upper surface 8 21 abuts, the inner stopper 7 is prevented from rotating counterclockwise in FIG. 7 around the axis of the liquid guide 4 (restricted). Therefore, the hub 11 is prevented from rotating counterclockwise in FIG. 7 about the axis of the liquid guide section 4. That is, it is desirable that the hub 11 be locked at the flow path blocking position.

[4] Next, remove the cap P from the liquid injector 1. Thus, the preparation for injecting the liquid Q in the liquid injection device 1 into the blood vessel of the patient is completed.

[5] Then, the needle tube 12 of the liquid injection device 1 is punctured into the blood vessel of the patient. As a result, the inside of the blood vessel of the patient and the inside of the liquid storage space 33 communicate with each other via the flow path 41, the liquid guide part 71, the lumen 122 of the needle tube 12, and the like.

[6] From the state of the above step [5], tip the flange 62 of the plunger 6 with a finger etc. When pressed toward the end, the gasket 5 moves toward the tip, and the volume of the liquid injection space 33 decreases. As a result, the liquid Q sequentially passes through the flow path 41, the liquid guide path 71, the space at the distal end of the lumen 11 1 of the nozzle 11, and the lumen 12 1 of the needle tube 12, Administered (injected) into the patient's blood vessels.

In such a liquid injection device 1, (1) the knob 11 is operated to rotate the inner stopper 7 with respect to the axis of the liquid introduction part 4, and the flow path 41 communicates with the liquid introduction path 71. (2) Complete preparations for injecting the liquid Q stored in the liquid injector 1 into the patient's blood vessel by simply performing the two-step operation of removing the cap P immediately before puncturing the patient's blood vessel. Therefore, the operability is excellent. Further, in such a liquid injecting device 1, since it is not necessary to connect the injection needle 10 to the liquid injecting device body in the atmosphere, foreign matter may be mixed into the liquid Q, or the liquid Q may be contaminated by bacteria or the like. Can be prevented more reliably.

Note that, in the liquid injection device 1 of the present embodiment, the same operation as described above occurs even when the arm 11 is rotated clockwise in FIGS. 3 and 4 around the axis of the liquid guide 4. As described above, the liquid injection device of the present invention has been described with respect to the illustrated embodiment. However, the present invention is not limited to this, and each part constituting the liquid injection device may have any function that can exhibit the same function. It can be replaced with that of the configuration.

The liquid injection device of the present invention can be used not only for injecting a liquid into a blood vessel of a patient, but also, for example, mixing a liquid that needs to be adjusted in an infusion bag, for example. Can also be used for

In the liquid injection device of the present invention, what is stored in the liquid storage space is not limited to a liquid, and may be, for example, a solid substance (including a semi-solid substance). No. In this case, the plunger is moved toward the base end while the inner plug is at the flow path communicating position to increase the volume of the liquid storage space. As a result, once a liquid capable of dissolving (or dispersing) a solid substance (for example, an infusion solution) is sucked into the liquid storage space, the solid substance is dissolved (or dispersed), and then the liquid is injected (discharged). ).

In addition, in the liquid injection device of the present invention, the side hole of the flow path may be provided at least at one position on the side surface of the liquid guide portion. In the case where only one side hole is provided, correspondingly, only one valley-shaped recess constituting the locking means and only one groove serving as a marker may be formed. Industrial applicability

As described above, according to the present invention, since the opening and closing of the valve mechanism can be performed from the outside, it is possible to prevent contamination by foreign substances and bacteria when preparing for injection of a liquid such as a chemical solution. Further, the above preparation can be completed with a simple operation.

Further, when the locking means is provided, it becomes easy to set the open / close state of the valve mechanism. In addition, when the marker is provided, it is easy to confirm the open / closed state of the valve mechanism.

Claims

The scope of the claims

1. an outer cylinder having a liquid storage space inside,

A liquid injecting device, comprising: an operating member that operates the valve mechanism by rotation about an axis of the liquid guiding portion.

2. The valve mechanism is constituted by a cylindrical inner plug installed between the outer periphery of the liquid guide section and the operation member,

The liquid injection device according to claim 1, wherein the inner plug has a waveguide that communicates with the flow path and opens the flow path.

3. The inner plug rotates with the rotation of the operation member, and the first position where the flow path and the liquid guide section are shut off, and the first position where the flow path and the liquid guide section communicate with each other. 3. The liquid injection device according to claim 2, wherein the liquid injection device is displaced between two positions.

4. The liquid injection device according to claim 3, wherein, when the inner plug is at the second position, the waveguide communicates with the liquid storage space via the flow path.

5. The liquid injection device according to any one of claims 2 to 4, wherein the inner stopper has an engaging portion that engages with the liquid guide portion and prevents the liquid guide portion from being detached from the liquid guide portion.

6. The liquid injection device according to any one of claims 1 to 5, wherein an end of the flow channel opposite to the liquid storage space has a side hole that opens to a side surface of the liquid guide portion.

7. A marker for indicating the position of the liquid guide path and Z or the side hole. The liquid injection device according to item 1.

8. The liquid injection means according to any one of claims 1 to 7, further comprising an opening means for defining a rotational position of the operation member with respect to the liquid guide section.

9. The liquid injection device according to claim 8, wherein the locking means has a function of positioning the operation member at least at the first position and the second position.

10. The liquid injection device according to any one of claims 1 to 9, wherein the operation member holds a needle tube at a distal end thereof.

11. The liquid injector according to claim 10, wherein the operation member doubles as the eight pieces of the needle tube.

12. The liquid injection device according to any one of claims 1 to 11, wherein the liquid injection device is a prefilled syringe.