WO2002006287A3 - Macrocyclic mri contrast agents - Google Patents

Macrocyclic mri contrast agents Download PDF

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Publication number
WO2002006287A3
WO2002006287A3 PCT/US2001/022491 US0122491W WO0206287A3 WO 2002006287 A3 WO2002006287 A3 WO 2002006287A3 US 0122491 W US0122491 W US 0122491W WO 0206287 A3 WO0206287 A3 WO 0206287A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
contrast agents
macrocyclic
moiety
mri contrast
Prior art date
Application number
PCT/US2001/022491
Other languages
French (fr)
Other versions
WO2002006287A9 (en
WO2002006287A2 (en
Inventor
Timothy J Hubin
Thomas J Meade
Original Assignee
California Inst Of Techn
Timothy J Hubin
Thomas J Meade
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn, Timothy J Hubin, Thomas J Meade filed Critical California Inst Of Techn
Priority to AU2001276956A priority Critical patent/AU2001276956A1/en
Publication of WO2002006287A2 publication Critical patent/WO2002006287A2/en
Publication of WO2002006287A9 publication Critical patent/WO2002006287A9/en
Publication of WO2002006287A3 publication Critical patent/WO2002006287A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Abstract

The invention relates to novel magnetic resonance imaging contrast agents of Formula: (I) wherein A-B is a structure selected from the group consisting of -CR2-CR2-, -CR=CR-, -CR2-CR2-CR2-, CR=CR-CR2- and -CR2-CR=CR; X?1 and X2¿ are independently selected from the group consisting of CR¿2? COO, CR2COOH, CR(CR2COO)2, CR(CR2COOH)2; each R is independently selected from the group consisting of hydrogen, alkyl, aryl, alcohol, amine, amido, nitro, ether, ester, ketone, imino, aldehyde, alkoxy, carbonyl, halogen, sulfur containing moiety, phosphorus containing moiety, targeting moiety, moiety, or, together with an adjacent R group forms an alkyl or aryl group.
PCT/US2001/022491 2000-07-17 2001-07-17 Macrocyclic mri contrast agents WO2002006287A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001276956A AU2001276956A1 (en) 2000-07-17 2001-07-17 Macrocyclic mri contrast agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21858100P 2000-07-17 2000-07-17
US60/218,581 2000-07-17

Publications (3)

Publication Number Publication Date
WO2002006287A2 WO2002006287A2 (en) 2002-01-24
WO2002006287A9 WO2002006287A9 (en) 2002-07-18
WO2002006287A3 true WO2002006287A3 (en) 2002-10-17

Family

ID=22815661

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022491 WO2002006287A2 (en) 2000-07-17 2001-07-17 Macrocyclic mri contrast agents

Country Status (3)

Country Link
US (1) US6656450B2 (en)
AU (1) AU2001276956A1 (en)
WO (1) WO2002006287A2 (en)

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US20030198597A1 (en) * 2002-04-22 2003-10-23 Meade Thomas J. Novel macrocyclic activatible magnetic resonance imaging contrast agents
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US9050378B2 (en) 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
US20060088475A1 (en) * 2004-05-10 2006-04-27 Northwestern University Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase
US7306785B2 (en) * 2004-09-23 2007-12-11 General Electric Company Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US8834840B1 (en) 2006-10-04 2014-09-16 Northwestern University Magnetic resonance imaging of self-assembled biomaterial scaffolds
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US20100029909A1 (en) * 2008-05-23 2010-02-04 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US8580231B2 (en) 2008-05-23 2013-11-12 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US20120095185A1 (en) * 2010-09-20 2012-04-19 Nordion (Canada) Inc. Process for chelating copper ions using cb-te2a bifunctional chelate

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Also Published As

Publication number Publication date
WO2002006287A9 (en) 2002-07-18
WO2002006287A2 (en) 2002-01-24
US6656450B2 (en) 2003-12-02
AU2001276956A1 (en) 2002-01-30
US20020049308A1 (en) 2002-04-25

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