WO2002007809B1 - Drug delivery and catheter systems, apparatus and processes - Google Patents
Drug delivery and catheter systems, apparatus and processesInfo
- Publication number
- WO2002007809B1 WO2002007809B1 PCT/US2001/023187 US0123187W WO0207809B1 WO 2002007809 B1 WO2002007809 B1 WO 2002007809B1 US 0123187 W US0123187 W US 0123187W WO 0207809 B1 WO0207809 B1 WO 0207809B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tube
- holes
- cylindrical
- control
- hole
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 15
- 238000012377 drug delivery Methods 0.000 title 1
- 239000000463 material Substances 0.000 claims abstract 15
- 239000012530 fluid Substances 0.000 claims abstract 2
- 238000003780 insertion Methods 0.000 claims abstract 2
- 230000037431 insertion Effects 0.000 claims abstract 2
- 239000000725 suspension Substances 0.000 claims abstract 2
- 239000012528 membrane Substances 0.000 claims 7
- 102000002067 Protein Subunits Human genes 0.000 claims 4
- 108010001267 Protein Subunits Proteins 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 238000009826 distribution Methods 0.000 claims 3
- 238000005086 pumping Methods 0.000 claims 2
- 206010030113 Oedema Diseases 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 238000005553 drilling Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 238000012800 visualization Methods 0.000 claims 1
- 238000010276 construction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
Abstract
A class of customizable injection devices or delivery instrumentswhose basic form is a stiff tube with holes of user-selectable size at several user-selectable places is described. The use of this device includes a method of selection and construction of a particular device from such a class of devices for a particular treatment procedure using computer-assisted means. Thus, the user may make selections among available or creatable choices (such as selection of hole size, hole location, number of holes, etc.), and a method can be practiced for making such user-selection serve the goals of delivery of materials such as drugs, cells, or of devices sufficiently small and numerous to be delivered in fluid suspension. The tube should be relatively stiff in the sense that it deflects by no more than an amount between 0° and 15° under the stresses of insertion and placement at the end of a catheter.
Claims
1. A tube for delivering materials to internal tissue of a patient, said tube conmprising a lumen for carrying the material, holes from said lumen to an exterior surface of the tube, and control elements for modifying flow rates of the material from said lumen through said holes, the control elements comprising a) rotatable surfaces that expose different numbers of holes or different sizes of holes, b) at least one moveable membrane associated with holes, or c ^ a oiiasimechanical system that alters flow rates through the holes,
2. The tube of claim 1 wherein at least one control element comprises a membrane that can be moved relative to a hole to π»dify a flow rate through that hole.
3. The tube of claim 1 wherein said control element comprises a movable element that rotates to [can] block ot expose a hole.
-4. The tube of claim 1 wherein said control element comprises a movable element within the lumen, underneath the holes.
5. The tube of claim 1 wherem said control element comprises a movable element on an exterior surface of said tube over the holes.
6. The tube of claim 3 wherein said control element comprises a movable element on an exterior surface of said tube over the holes.
7. The tube of claim 1 wherein said control element positions membranes with predetermined material conductivity adjacent to at least one hole to control material flow through that hole.
8. The tube of Claim 1 where said tube is assembled from a set of cylindrical sub- units, at least two of said cylindrical subunits having different arrangements of side holes.
9. The tube of Claim 1 where said tube is assembled from a set of cylindrical sub- units, at least two of said cylindrical subunits having different holes and different control elements.
29
10. A method for delivering material to tissue within a patient con-prising inserting the device of claim 1 into a patient, and controlling a rate of flow of the material through a hole in the tube by controlling the control element.
11. A method for delivering material to tissue by modifying [specifying] a modifiable [class] set of tubes for the delivery of materials capable of passing through bodily tissue in solution or suspension in a biocompatible fluid, [with] at least two overlying tubes in the set of tubes having outlet holes that are variable in number, size and placement, optional membranes being inserted between said outlet holes to modify the flow.
12. The tube of Claim 1, where the body of the tube is a flexible catheter, capable of following a blood vessel, ventricle or other curved lumen in the body.
13. The tube of Claim 1, where the body of the tube is a rigid probe, capable of bein forced through soft tissue in a straight or curved line.
14. The tube of Claim 1 where delivery parameters having been predetermined, a xtermination is then made to design specific distributions and locations of opening on the tube to effect those delivery parameters, and the holes are created according to design effecting those delivery parameters.
15. The tube of Claim 1 where tie holes are created according to predetermined design parameters, and deliveiy control is provided by fully or partially openable sliding covers for holes, with a capability that less than aJJ holes in the tube may be selected for deϋvery.
16. The method of claim 10 where a medical practitioner selects the number, size and placement of the holes, and the penetrability and placement of internal membranes, selection based on computer predictions as to the distribution of delivered material when material in a chosen concentration is passed down the tube with a selected time course of pressure or of pumping rate.
30
17. The method of claim 10 wherein a planned position of the tube within the body is shown on a computer display of a computer system, and a medical practitioner uses a graphical interface to specify regions where high concentration of the delivered material is respectively desired or to be avoided, or where it is essential to limit pressure above background, edema or the time for which either occurs, and the computer system uses a model of the diffusion and transport process to define a set of holes and membranes that will result in satisfying these criteria, and then the designed set of holes and/or membranes are provided in a tube.
18. The process of claim 17 where the graphical interface uses a mouse, tablet or [similar) 2D input device to control an image on a screen iu which slices of a body scan are displayed.
19. The process of claim 1 where the graphical interface uses a 3d input device to control an image in a stereographic display in which volume-rendered images of a body scan are displayed.
20. The process of claim 10 wherein a medical practitioner specifies only the region in which a rigid tube is to be placed, together with regions where piercing by the tube would be unacceptable, and a computer defines an entry path which achieves ancillary criteria including at least one parameter selected from the group consisting of a) minimal damage en route to the target region, and b) ininimal time spent drilling through bone to open a pathway.
21. The method of claim 17 wherein imaging is used at the time of insertion of a catheter to confirm that the catheter has been placed in the planned position.
22. The method of claim 1 wherein a real-time visualization of distributed material is used to confirm that distribution of material is occurring in accordance with a predetermined plan, and where deviation from said predetermined plan is found, a controller modifies the pumping rate or pressure if appropriate.
23. The method of claim 21 wherem said controller is a computer.
31
24. The tube of Claim 2 where said tube is assembled from a set of cylindrical sub- units, at least two of said cylindrical subunits having different arrangements of side holes.
25. The tube of Claim 2 where said tube is assembled from a set of cylindrical sub- units, at least two of said cylindrical subunits having different size holes and control elements.
25. The tube of claim 3 said tube is assembled from at least two cylindrical subunits, each of said at least two cylindrical subunits having different flow properties through surfaces of the cylinders.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001277120A AU2001277120A1 (en) | 2000-07-26 | 2001-07-24 | Drug delivery and catheter systems, apparatus and processes |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/626,059 | 2000-07-26 | ||
US09/626,059 US6464662B1 (en) | 2000-07-26 | 2000-07-26 | Drug delivery and catheter systems, apparatus and processes |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002007809A1 WO2002007809A1 (en) | 2002-01-31 |
WO2002007809B1 true WO2002007809B1 (en) | 2002-04-11 |
Family
ID=24508780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/023187 WO2002007809A1 (en) | 2000-07-26 | 2001-07-24 | Drug delivery and catheter systems, apparatus and processes |
Country Status (3)
Country | Link |
---|---|
US (1) | US6464662B1 (en) |
AU (1) | AU2001277120A1 (en) |
WO (1) | WO2002007809A1 (en) |
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-
2000
- 2000-07-26 US US09/626,059 patent/US6464662B1/en not_active Expired - Lifetime
-
2001
- 2001-07-24 AU AU2001277120A patent/AU2001277120A1/en not_active Abandoned
- 2001-07-24 WO PCT/US2001/023187 patent/WO2002007809A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US6464662B1 (en) | 2002-10-15 |
WO2002007809A1 (en) | 2002-01-31 |
AU2001277120A1 (en) | 2002-02-05 |
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