WO2002010335A3 - ANTIBODIES SPECIFIC FOR UNGULATE PrP - Google Patents

ANTIBODIES SPECIFIC FOR UNGULATE PrP Download PDF

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Publication number
WO2002010335A3
WO2002010335A3 PCT/US2001/022648 US0122648W WO0210335A3 WO 2002010335 A3 WO2002010335 A3 WO 2002010335A3 US 0122648 W US0122648 W US 0122648W WO 0210335 A3 WO0210335 A3 WO 0210335A3
Authority
WO
WIPO (PCT)
Prior art keywords
prpsc
ungulate
native
situ
antibodies specific
Prior art date
Application number
PCT/US2001/022648
Other languages
French (fr)
Other versions
WO2002010335A2 (en
Inventor
Stanley B Prusiner
Jiri Safar
Anthony R Williamson
Dennis R Burton
Original Assignee
Univ California
Scripps Research Inst
Stanley B Prusiner
Jiri Safar
Anthony R Williamson
Dennis R Burton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Scripps Research Inst, Stanley B Prusiner, Jiri Safar, Anthony R Williamson, Dennis R Burton filed Critical Univ California
Priority to AU7597701A priority Critical patent/AU7597701A/en
Priority to JP2002516054A priority patent/JP2004509858A/en
Priority to AU2001275977A priority patent/AU2001275977B2/en
Priority to CA002416029A priority patent/CA2416029A1/en
Priority to EP01953539A priority patent/EP1368644A2/en
Publication of WO2002010335A2 publication Critical patent/WO2002010335A2/en
Publication of WO2002010335A3 publication Critical patent/WO2002010335A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2872—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against prion molecules, e.g. CD230
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Abstract

The present invention provides antibodies that specifically bind with a high degree of binding affinity to a native ungulate PrPC in situ and/or a denatured ungulate PrPSc, but not to a native ungulate PrPSc in situ. Preferred antibodies bind native bovine PrPC and treated PrPSc but not native bovine PrPSc in situ and can be used in an assay to determine if a sample is infected with infectious prions, i.e. pathogenic PrPSc.
PCT/US2001/022648 2000-07-27 2001-07-17 ANTIBODIES SPECIFIC FOR UNGULATE PrP WO2002010335A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU7597701A AU7597701A (en) 2000-07-27 2001-07-17 Antibodies specific for ungulate prp
JP2002516054A JP2004509858A (en) 2000-07-27 2001-07-17 Antibodies specific for ungulate PrP
AU2001275977A AU2001275977B2 (en) 2000-07-27 2001-07-17 Antibodies specific for ungulate PrP
CA002416029A CA2416029A1 (en) 2000-07-27 2001-07-17 Antibodies specific for ungulate prp
EP01953539A EP1368644A2 (en) 2000-07-27 2001-07-17 ANTIBODIES SPECIFIC FOR UNGULATE PrP

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/627,218 US6537548B1 (en) 2000-07-27 2000-07-27 Antibodies specific for ungulate PrP
US09/627,218 2000-07-27

Publications (2)

Publication Number Publication Date
WO2002010335A2 WO2002010335A2 (en) 2002-02-07
WO2002010335A3 true WO2002010335A3 (en) 2003-07-10

Family

ID=24513726

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022648 WO2002010335A2 (en) 2000-07-27 2001-07-17 ANTIBODIES SPECIFIC FOR UNGULATE PrP

Country Status (6)

Country Link
US (3) US6537548B1 (en)
EP (1) EP1368644A2 (en)
JP (1) JP2004509858A (en)
AU (2) AU7597701A (en)
CA (1) CA2416029A1 (en)
WO (1) WO2002010335A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ536054A (en) * 2002-04-09 2009-10-30 Scripps Research Inst Motif-grafted hybrid polypeptides and uses thereof
US20060035242A1 (en) 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
GB0402123D0 (en) * 2004-01-30 2004-03-03 Protherics Plc Method
US20050256425A1 (en) 2004-05-11 2005-11-17 Inpro Biotechnology, Inc. Device, system and method for extracting and preparing brain tissue
MX2007008497A (en) * 2005-01-13 2007-09-14 Novartis Vaccines & Diagnostic Elisa assays using prion-specific peptide reagents.
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
WO2006102099A2 (en) * 2005-03-18 2006-09-28 The Regents Of The University Of California ANTIBODIES SPECIFIC FOR HUMAN AND BOVINE PrP
EP1931695B1 (en) 2005-09-09 2013-04-10 Novartis AG Prion-specific peptoid reagents
BRPI0910550A2 (en) * 2008-04-30 2015-09-29 Novartis Ag assay for pathogenic conformers
US10391068B2 (en) 2012-08-06 2019-08-27 Trustees Of Boston University Prion protein ligands as therapeutic agents for neurodegenerative disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042829A1 (en) * 1998-02-20 1999-08-26 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
NL246462A (en) * 1959-08-06
US4806627A (en) 1987-05-29 1989-02-21 Research Foundation Of Mental Hygiene Inc. Hybrid cell lines producing monoclonal antibodies dircted against scrapie-associated fibril proteins
US5792901A (en) 1994-05-13 1998-08-11 The Regents Of The University Of California Detecting prions in a sample and prion preparation and transgenic animal used for same
US5908969A (en) 1994-05-13 1999-06-01 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
JP3495738B2 (en) 1995-09-14 2004-02-09 ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア Natural PrPsc-specific antibody
US5891641A (en) 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US6528269B1 (en) 1998-06-22 2003-03-04 Case Western Reserve University Immunological agents specific for prion protein (PRP)
US6261790B1 (en) 1999-07-15 2001-07-17 The United States Of America As Represented By The Secretary Of Agriculture Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies
AU780414B2 (en) 1999-07-27 2005-03-17 D-Gen Limited Fragments of cellular prion protein and methods useful in the diagnosis and treatment of prion diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042829A1 (en) * 1998-02-20 1999-08-26 The Regents Of The University Of California Assay for specific strains of multiple disease related conformations of a protein

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
PERETZ DAVID ET AL: "A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform.", JOURNAL OF MOLECULAR BIOLOGY, vol. 273, no. 3, 31 October 1997 (1997-10-31), pages 614 - 622, XP002234132, ISSN: 0022-2836 *
PRUSINER S B ET AL: "GENETICS OF PRIONS", ANNUAL REVIEW OF GENETICS, ANNUAL REVIEWS INC., PALO ALTO, CA, US, vol. 31, 1997, pages 139 - 175, XP002901001, ISSN: 0066-4197 *
PRUSINER S B ET AL: "IMMUNOLOGIC AND MOLECULAR BIOLOGIC STUDIES OF PRION PROTEINS IN BOVINE SPONGIFORM ENCEPHALOPATHY", JOURNAL OF INFECTIOUS DISEASES, CHICAGO, IL, US, vol. 167, 1 March 1993 (1993-03-01), pages 602 - 613, XP002036867, ISSN: 0022-1899 *
SAFAR J ET AL: "Eight prion strains have PrPsc molecules with different conformations", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 4, no. 10, October 1998 (1998-10-01), pages 1157 - 1165, XP002230960, ISSN: 1078-8956 *
See also references of EP1368644A2 *

Also Published As

Publication number Publication date
JP2004509858A (en) 2004-04-02
WO2002010335A2 (en) 2002-02-07
AU2001275977B2 (en) 2006-10-19
US20030143224A1 (en) 2003-07-31
US6537548B1 (en) 2003-03-25
US7094553B2 (en) 2006-08-22
AU7597701A (en) 2002-02-13
CA2416029A1 (en) 2002-02-07
US20060239996A1 (en) 2006-10-26
EP1368644A2 (en) 2003-12-10

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