WO2002012447B1 - Isolation and use of solid tumor stem cells - Google Patents
Isolation and use of solid tumor stem cellsInfo
- Publication number
- WO2002012447B1 WO2002012447B1 PCT/US2001/024243 US0124243W WO0212447B1 WO 2002012447 B1 WO2002012447 B1 WO 2002012447B1 US 0124243 W US0124243 W US 0124243W WO 0212447 B1 WO0212447 B1 WO 0212447B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- solid tumor
- tumor stem
- stem cells
- cells
- population
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0695—Stem cells; Progenitor cells; Precursor cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70585—CD44
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/42—Notch; Delta; Jagged; Serrate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
Abstract
Claims
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2417909A CA2417909C (en) | 2000-08-03 | 2001-08-02 | Isolation and use of solid tumor stem cells |
AU7813401A AU7813401A (en) | 2000-08-03 | 2001-08-02 | Isolation and use of solid tumor stem cells |
EP10179961.7A EP2359863B1 (en) | 2000-08-03 | 2001-08-02 | Isolation and use of solid tumor stem cells |
AU2001278134A AU2001278134B2 (en) | 2000-08-03 | 2001-08-02 | Isolation and use of solid tumor stem cells |
EP01956101.8A EP1343871B1 (en) | 2000-08-03 | 2001-08-02 | Isolation and use of solid tumor stem cells |
ES01956101.8T ES2553796T3 (en) | 2000-08-03 | 2001-08-02 | Isolation and use of solid tumor stem cells |
JP2002517738A JP5352037B2 (en) | 2000-08-03 | 2001-08-02 | Isolation and use of solid tumor stem cells |
US10/343,692 US7115360B2 (en) | 2000-08-03 | 2001-08-02 | Isolation and use of solid tumor stem cells |
US11/529,869 US7850961B2 (en) | 2000-08-03 | 2006-09-29 | Methods for targeting solid tumor stem cells in a solid tumor using a notch4 receptor antagonist |
US11/607,780 US7754206B2 (en) | 2000-08-03 | 2006-12-01 | Method for treating cancer using a Notch4 ligand antagonist |
US11/651,214 US20090004205A1 (en) | 2000-08-03 | 2007-01-09 | Prospective identification and characterization of breast cancer stem cells |
US11/788,489 US20080194022A1 (en) | 2000-08-03 | 2007-04-20 | Isolation and use of solid tumor stem cells |
US11/776,935 US8044259B2 (en) | 2000-08-03 | 2007-07-12 | Determining the capability of a test compound to affect solid tumor stem cells |
US12/758,540 US20110033481A1 (en) | 2000-08-03 | 2010-04-12 | Prospective identification and characterization of breast cancer stem cells |
US12/979,991 US8357491B2 (en) | 2000-08-03 | 2010-12-28 | Isolation and use of solid tumor stem cells |
US13/241,701 US8420885B2 (en) | 2000-08-03 | 2011-09-23 | Determining the capability of a test compound to affect solid tumor stem cells |
US13/563,884 US20120295350A1 (en) | 2000-08-03 | 2012-08-01 | Prospective Identification and Characterization of Breast Cancer Stem Cells |
US13/714,921 US20140011274A1 (en) | 2000-08-03 | 2012-12-14 | Isolation and use of solid tumor stem cells |
US13/795,381 US9089556B2 (en) | 2000-08-03 | 2013-03-12 | Method for treating cancer using an antibody that inhibits notch4 signaling |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22279400P | 2000-08-03 | 2000-08-03 | |
US60/222,794 | 2000-08-03 | ||
US24031700P | 2000-10-13 | 2000-10-13 | |
US60/240,317 | 2000-10-13 | ||
US09/920,517 US6984522B2 (en) | 2000-08-03 | 2001-08-01 | Isolation and use of solid tumor stem cells |
US09/920,517 | 2001-08-01 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/920,517 Continuation US6984522B2 (en) | 2000-08-03 | 2001-08-01 | Isolation and use of solid tumor stem cells |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10343692 A-371-Of-International | 2001-08-02 | ||
US10/343,692 A-371-Of-International US7115360B2 (en) | 2000-08-03 | 2001-08-02 | Isolation and use of solid tumor stem cells |
US11/529,869 Continuation US7850961B2 (en) | 2000-08-03 | 2006-09-29 | Methods for targeting solid tumor stem cells in a solid tumor using a notch4 receptor antagonist |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002012447A2 WO2002012447A2 (en) | 2002-02-14 |
WO2002012447A3 WO2002012447A3 (en) | 2003-04-24 |
WO2002012447B1 true WO2002012447B1 (en) | 2003-07-03 |
Family
ID=27397140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/024243 WO2002012447A2 (en) | 2000-08-03 | 2001-08-02 | Isolation and use of solid tumor stem cells |
Country Status (7)
Country | Link |
---|---|
US (13) | US6984522B2 (en) |
EP (2) | EP2359863B1 (en) |
JP (1) | JP5352037B2 (en) |
AU (2) | AU7813401A (en) |
CA (1) | CA2417909C (en) |
ES (1) | ES2553796T3 (en) |
WO (1) | WO2002012447A2 (en) |
Cited By (3)
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---|---|---|---|---|
US9228020B2 (en) | 2006-09-29 | 2016-01-05 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
US9492538B2 (en) | 2000-08-03 | 2016-11-15 | The Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
US9599620B2 (en) | 2012-10-31 | 2017-03-21 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a DLL4 antagonist |
Families Citing this family (186)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7361336B1 (en) * | 1997-09-18 | 2008-04-22 | Ivan Bergstein | Methods of cancer therapy targeted against a cancer stem line |
US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
CA2469204A1 (en) * | 2001-12-07 | 2003-06-19 | Regents Of The University Of Michigan | Prospective identification and characterization of breast cancer stem cells |
US20030226159A1 (en) * | 2002-04-16 | 2003-12-04 | Bachoo Robert M. | Cancer models |
AU2003277153A1 (en) | 2002-09-27 | 2004-04-19 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
US20060084599A1 (en) * | 2003-03-05 | 2006-04-20 | Maine Medical Center | Compositions, methods and kits relating to notch signaling |
WO2004090110A2 (en) * | 2003-03-31 | 2004-10-21 | Bresagen Inc. | Compositions and methods for the control, differentiation and/or manipulation of pluripotent cells through a gamma-secretase signaling pathway |
US20040265281A1 (en) * | 2003-04-07 | 2004-12-30 | Denis Rodgerson | System capable of treating and defining various diseases using stem cells |
GB0310191D0 (en) * | 2003-05-02 | 2003-06-04 | Cytovation As | Method of generating and isolating tumour cells |
US20060019256A1 (en) * | 2003-06-09 | 2006-01-26 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
US7413734B2 (en) | 2003-06-27 | 2008-08-19 | Ethicon, Incorporated | Treatment of retinitis pigmentosa with human umbilical cord cells |
US8491883B2 (en) | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
US7875273B2 (en) | 2004-12-23 | 2011-01-25 | Ethicon, Incorporated | Treatment of Parkinson's disease and related disorders using postpartum derived cells |
US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
US20050193432A1 (en) * | 2003-11-18 | 2005-09-01 | Whitehead Institute For Biomedical Research | Xenograft model of functional normal and malignant human breast tissues in rodents and methods thereof |
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US20050232927A1 (en) * | 2004-02-03 | 2005-10-20 | The Regents Of The University Of Michigan | Compositions and methods for characterizing, regulating, diagnosing, and treating cancer |
US20060121624A1 (en) * | 2004-03-03 | 2006-06-08 | Huang Lotien R | Methods and systems for fluid delivery |
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US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
WO2008121102A2 (en) * | 2006-02-21 | 2008-10-09 | The Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
US20070243192A1 (en) * | 2006-02-21 | 2007-10-18 | Regents Of The University Of Michigan | Growth hormone receptor antagonist cancer treatment |
KR20090013752A (en) * | 2006-03-16 | 2009-02-05 | 헬스 리서치 인코포레이티드 | Inhibition of breast carcinoma stem cell growth and metastasis |
WO2008063213A2 (en) | 2006-04-10 | 2008-05-29 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of psoriatic arthritis |
WO2007134274A2 (en) * | 2006-05-12 | 2007-11-22 | Attenuon, Llc | Antibodies to urokinase- type plasminogen activator receptor(upar)bind cancer stem cells: use in diagnosis and therapy |
US7919092B2 (en) | 2006-06-13 | 2011-04-05 | Oncomed Pharmaceuticals, Inc. | Antibodies to notch receptors |
WO2007147074A2 (en) * | 2006-06-14 | 2007-12-21 | Living Microsystems, Inc. | Use of highly parallel snp genotyping for fetal diagnosis |
US8137912B2 (en) * | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
EP2589668A1 (en) * | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US20080124721A1 (en) * | 2006-06-14 | 2008-05-29 | Martin Fuchs | Analysis of rare cell-enriched samples |
WO2007147165A2 (en) * | 2006-06-16 | 2007-12-21 | Bresagen, Inc. | Human cancer stem cell culture compositions comprising erbb2 variants and methods of use thereof |
AU2007277508A1 (en) * | 2006-07-28 | 2008-01-31 | Chundsell Medicals Ab | Embryonic stem cell markers for cancer diagnosis and prognosis |
US20110244501A1 (en) * | 2006-08-02 | 2011-10-06 | Biogen Idec Ma Inc. | Cancer stem cells |
WO2008030538A2 (en) * | 2006-09-07 | 2008-03-13 | Stemline Therapeutics, Inc. | Cancer stem cell-targeted cancer therapy |
WO2008030616A2 (en) * | 2006-09-07 | 2008-03-13 | Stemline Therapeutics, Inc. | Monitoring cancer stem cells |
WO2008036419A2 (en) * | 2006-09-22 | 2008-03-27 | The Regents Of The University Of Michigan | Aldehyde dehydrogenase 1(aldh1) as a cancer stem cell marker |
CA2700573C (en) * | 2006-09-26 | 2016-11-22 | Cedars-Sinai Medical Center | Cancer stem cell antigen vaccines and methods |
US8871211B2 (en) * | 2006-09-28 | 2014-10-28 | Cedars-Sinai Medical Center | Cancer vaccines and vaccination methods |
ITMI20062100A1 (en) * | 2006-10-31 | 2008-05-01 | Fondazione I R C C S Istituto Neurologico | METHOD FOR THE STIMULATION OF DENDRITIC CELLS AND CELL PRODUCT SO OBTAINED FOR AUTOLOGOUS IMMUNOTHERAPY OF HUMAN SOLID TUMORS |
US8765390B2 (en) * | 2006-12-08 | 2014-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and isolation of squamous carcinoma stem cells |
EP2610267A1 (en) | 2006-12-18 | 2013-07-03 | Genentech, Inc. | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases |
NZ578181A (en) * | 2006-12-20 | 2012-02-24 | Novarx | Universal tumor cell vaccine for anti cancer therapeutic and prophylactic utilization |
US8309354B2 (en) * | 2007-01-22 | 2012-11-13 | Macrogenics West, Inc. | Human cancer stem cells |
WO2008091641A2 (en) | 2007-01-24 | 2008-07-31 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
CA2676292C (en) * | 2007-02-01 | 2017-09-19 | Dana-Farber Cancer Institute, Inc. | Cell co-culture systems and uses thereof |
WO2008100563A2 (en) * | 2007-02-14 | 2008-08-21 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
WO2008143795A1 (en) * | 2007-05-11 | 2008-11-27 | Champions Biotechnology, Inc. | Human mesenchymal chrondrosarcoma xenograft model and its use in chemosensitivity testing |
WO2008140751A1 (en) * | 2007-05-11 | 2008-11-20 | Champions Biotechnology, Inc. | Human leiosarcoma and non small cell lung cancer lung xenograft models |
JP5190861B2 (en) * | 2007-05-11 | 2013-04-24 | オリンパス株式会社 | Biological tissue decomposition method |
EP2155249A4 (en) * | 2007-05-15 | 2011-11-16 | Oncomed Pharm Inc | Compositions and methods for diagnosing and treating cancer |
JP5171945B2 (en) * | 2007-06-13 | 2013-03-27 | マサチューセッツ インスティテュート オブ テクノロジー | Methods and agents for inhibiting tumor growth |
KR101113167B1 (en) * | 2007-06-14 | 2012-03-07 | 미쯔이 죠센 가부시키가이샤 | Flow cytometer having cell-fractionation function and method of fractionating living cells |
PT2173379E (en) | 2007-07-02 | 2015-11-24 | Oncomed Pharm Inc | Compositions and methods for treating and diagnosing cancer |
EP2676678A1 (en) * | 2007-07-17 | 2013-12-25 | The General Hospital Corporation | Methods to identify and enrich populations of ovarian cancer stem cells and somatic stem cells and uses thereof |
US20110244502A1 (en) | 2007-08-10 | 2011-10-06 | Whitehead Institute For Biomedical Research | Hormone responsive tissue culture system and uses thereof |
EP2037265A1 (en) * | 2007-09-17 | 2009-03-18 | Adnagen AG | Solid phase cell isolation and/or enrichment method |
EP2188630A4 (en) * | 2007-10-02 | 2010-11-03 | Univ Rochester | Methods and compositions related to synergistic responses to oncogenic mutations |
BRPI0818183A2 (en) | 2007-10-05 | 2019-07-16 | Ethicon Inc | Renal tissue repair and regeneration using cells derived from human umbilical cord tissue |
US8236538B2 (en) | 2007-12-20 | 2012-08-07 | Advanced Technologies And Regenerative Medicine, Llc | Methods for sterilizing materials containing biologically active agents |
US20110124032A1 (en) * | 2008-02-01 | 2011-05-26 | Maximilian Diehn | Methods and Compositions for Treating Carcinoma Stem Cells |
US8008032B2 (en) * | 2008-02-25 | 2011-08-30 | Cellective Dx Corporation | Tagged ligands for enrichment of rare analytes from a mixed sample |
WO2009111644A2 (en) * | 2008-03-05 | 2009-09-11 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating pancreatic cancer |
US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
JP5560270B2 (en) | 2008-07-08 | 2014-07-23 | オンコメッド ファーマシューティカルズ インコーポレイテッド | NOTCH binding agents and antagonists and methods of use thereof |
EP2318040A4 (en) * | 2008-07-24 | 2013-05-01 | Univ Central Florida Res Found | Therapy targeting cancer stem cells |
DK2328923T3 (en) | 2008-09-02 | 2016-03-21 | Cedars Sinai Medical Center | CD133 epitopes |
AU2009294415B2 (en) * | 2008-09-19 | 2015-09-24 | Medimmune Llc | Antibodies directed to DLL4 and uses thereof |
SI2334812T1 (en) | 2008-09-20 | 2017-05-31 | The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
BRPI0919473A2 (en) | 2008-09-26 | 2017-08-29 | Oncomed Pharm Inc | FRIZZLED BINDING AGENTS AND THEIR USES |
US20100093552A1 (en) | 2008-10-09 | 2010-04-15 | Asit Panja | Use and identification of biomarkers for gastrointestinal diseases |
EP2340303B1 (en) * | 2008-10-24 | 2016-10-12 | Childrens Hospital Los Angeles | Amniotic fluid cells and uses thereof |
SI2356462T1 (en) | 2008-11-11 | 2017-05-31 | The Regents Of The University Of Michigan | Anti-cxcr1 compositions and methods |
EP2379088B1 (en) | 2008-12-19 | 2018-02-28 | DePuy Synthes Products, Inc. | Treatment of lung and pulmonary diseases and disorders |
US10179900B2 (en) * | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
WO2010097793A2 (en) * | 2009-02-26 | 2010-09-02 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Isolated populations of renal stem cells and methods of isolating and using same |
US8170320B2 (en) | 2009-03-03 | 2012-05-01 | Hologic, Inc. | Mammography/tomosynthesis systems and methods automatically deriving breast characteristics from breast x-ray images and automatically adjusting image processing parameters accordingly |
US8762069B2 (en) * | 2009-03-11 | 2014-06-24 | Institute for Medical Biomathematics | Therapeutic implications of dickkopf affecting cancer stem cell fate |
JP5908394B2 (en) | 2009-03-26 | 2016-04-26 | デピュイ・シンセス・プロダクツ・インコーポレイテッド | Human umbilical cord tissue cells as a therapy for Alzheimer's disease |
PT2427485T (en) * | 2009-05-07 | 2017-03-13 | Immunocellular Therapeutics Ltd | Cd133 epitopes |
DK2488204T3 (en) | 2009-10-16 | 2016-06-06 | Oncomed Pharm Inc | Therapeutic combination and use of DLL4 antagonist antibodies and blood pressure lowering agents |
EP2496690A4 (en) * | 2009-11-05 | 2013-07-24 | Sloan Kettering Inst Cancer | Catenae: serosal cancer stem cells |
WO2011063237A2 (en) | 2009-11-19 | 2011-05-26 | Oncomed Pharmaceuticals, Inc. | Jagged-binding agents and uses thereof |
CA2782299A1 (en) * | 2009-12-01 | 2011-06-09 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancers comprising k-ras mutations |
JP5808054B2 (en) * | 2009-12-25 | 2015-11-10 | 中外製薬株式会社 | Anticancer drug target search and screening method using non-human animal model transplanted with NOG established cancer cell line |
TWI535445B (en) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt antagonists and methods of treatment and screening |
CN102958534B (en) | 2010-01-13 | 2014-11-05 | 昂考梅德药品有限公司 | Notch1 binding agents and methods of use thereof |
US20110312503A1 (en) | 2010-01-23 | 2011-12-22 | Artemis Health, Inc. | Methods of fetal abnormality detection |
CA2788575C (en) | 2010-01-28 | 2015-04-21 | Shuichi Takayama | Hanging drop devices, systems and/or methods |
CA2794674A1 (en) | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
CA2806127C (en) | 2010-07-23 | 2021-12-21 | Advanced Cell Technology, Inc. | Methods for detection of rare subpopulations of cells and highly purified compositions of cells |
US9778264B2 (en) | 2010-09-03 | 2017-10-03 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
CN103313726B (en) * | 2010-09-03 | 2016-08-17 | 施特姆森特克斯股份有限公司 | The qualification of cell subsets and enrichment |
US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
AU2011308567B2 (en) | 2010-10-01 | 2015-09-03 | Fundacion Centro Nacional De Investigaciones Oncologicas, Carlos Iii | Manipulation of stem cell function by p53 isoforms |
SG196836A1 (en) | 2010-10-06 | 2014-02-13 | Pharmalogicals Res Pte Ltd | Cancer stem cell population and method for production thereof |
US9677042B2 (en) | 2010-10-08 | 2017-06-13 | Terumo Bct, Inc. | Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
JP2013540276A (en) | 2010-10-25 | 2013-10-31 | マサチューセッツ インスティテュート オブ テクノロジー | Metakaryotic stem cells that heal wounds and methods of use thereof |
US8912156B1 (en) | 2011-02-04 | 2014-12-16 | Whitehead Institute For Biomedical Research | Markers for and methods of targeting tumor stem cells |
US9791449B2 (en) | 2011-06-03 | 2017-10-17 | The General Hospital Corporation | Ovarian cancer stem cells and methods of isolation and uses thereof |
CN106167526A (en) | 2011-07-15 | 2016-11-30 | 昂考梅德药品有限公司 | RSPO bonding agent and its application |
US10018630B2 (en) | 2011-09-07 | 2018-07-10 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell isolation |
PL3485903T3 (en) | 2011-09-23 | 2023-06-12 | Mereo Biopharma 5, Inc. | Vegf/dll4 binding agents and uses thereof |
CA2849011A1 (en) | 2011-10-05 | 2013-04-11 | Genentech, Inc. | Methods of treating liver conditions using notch2 antagonists |
US9327023B2 (en) | 2011-10-25 | 2016-05-03 | The Regents Of The University Of Michigan | HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells |
US20140302511A1 (en) | 2011-10-28 | 2014-10-09 | Pharmalogicals Research Pte. Ltd. | Cancer stem cell-specific molecule |
WO2013096686A1 (en) | 2011-12-23 | 2013-06-27 | Advanced Technologies And Regenerative Medicine, Llc | Detection of human umbilical cord tissue-derived cells |
US10247731B2 (en) * | 2012-02-22 | 2019-04-02 | Verik Bio, Inc. | System for immunotherapy targeting tumor propagation and progression |
US20140147861A1 (en) * | 2012-05-04 | 2014-05-29 | The Regents of the University of Califomia | Markers to identify primary cells from tumor biopsies |
CA2874343C (en) | 2012-05-21 | 2021-11-09 | Fluidigm Corporation | Single-particle analysis of particle populations |
AU2013289990B2 (en) | 2012-07-13 | 2018-06-14 | Oncomed Pharmaceuticals, Inc. | RSPO3 binding agents and uses thereof |
EP2882441B1 (en) * | 2012-08-09 | 2020-04-29 | Celgene Corporation | Treatment of immune-related and inflammatory diseases |
US20150038511A1 (en) | 2012-08-09 | 2015-02-05 | Celgene Corporation | Treatment of immune-related and inflammatory diseases |
MX357675B (en) | 2012-08-13 | 2018-07-18 | Genentech Inc | Anti-jagged anitbodies and methods of use. |
JP2015526087A (en) * | 2012-08-15 | 2015-09-10 | ネオステム オンコロジー リミテッド ライビリティ カンパニー | Rapid preparation of high purity cancer stem cells and high purity cancer stem cell populations |
US20160017293A1 (en) * | 2012-08-15 | 2016-01-21 | Neostem Oncology, Llc | Individualized high purity hepatocellular carcinoma stem cells, methods and use of the same |
US11183269B2 (en) | 2012-10-09 | 2021-11-23 | Five3 Genomics, Llc | Systems and methods for tumor clonality analysis |
CN104854839B (en) * | 2012-10-19 | 2018-10-12 | 交互数字专利控股公司 | More hypothesis rate adaptations of HTTP steaming transfer |
JP2015536933A (en) | 2012-10-23 | 2015-12-24 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Methods of treating neuroendocrine tumors using Wnt pathway binding agents |
CN105073195A (en) | 2013-02-04 | 2015-11-18 | 昂科梅德制药有限公司 | Methods and monitoring of treatment with a Wnt pathway inhibitor |
US20140234351A1 (en) | 2013-02-14 | 2014-08-21 | Immunocellular Therapeutics, Ltd. | Cancer vaccines and vaccination methods |
AU2014249344A1 (en) * | 2013-03-11 | 2015-09-10 | Neostem Oncology, Llc | Method of induction and purification of a cell population responsible for vasculary mimicry and use of the same |
AU2014248713A1 (en) * | 2013-03-12 | 2015-09-10 | Neostem Oncology, Llc | Individualized high-purity glioblastoma multiforme stem cells and methods for stimulating immune response |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
WO2014151866A1 (en) | 2013-03-15 | 2014-09-25 | Genentech, Inc. | Compositions and methods for diagnosis and treatment of hepatic cancers |
EP3049155A1 (en) * | 2013-09-27 | 2016-08-03 | Vaccinogen International Partners, LP | Autologous tumor vaccines and methods |
WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
EP3097418B1 (en) * | 2014-01-20 | 2021-04-28 | National Centre For Cell Science | A tumor deconstruction platform for the analysis of intra-tumor heterogeneity |
KR102030891B1 (en) | 2014-02-12 | 2019-10-11 | 제넨테크, 인크. | Anti-jagged1 antibodies and methods of use |
EP3613841B1 (en) | 2014-03-25 | 2022-04-20 | Terumo BCT, Inc. | Passive replacement of media |
EP3145513B1 (en) | 2014-05-19 | 2023-11-15 | Celgene Corporation | 3-(4-((4-(morpholinomethyl-benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione for the treatment of systemic lupus erythematosus |
US10883994B2 (en) | 2014-06-25 | 2021-01-05 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Identification of cancer stem cells markers and use of same for diagnosis and treatment |
WO2016044295A1 (en) | 2014-09-16 | 2016-03-24 | Oncomed Pharmaceuticals, Inc. | Treatment of fibrotic diseases |
JP6830059B2 (en) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | Scheduled cell feeding |
EP3212233B1 (en) | 2014-10-31 | 2020-06-24 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
RU2720280C2 (en) | 2015-04-16 | 2020-04-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Human notch4 antibody |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
AU2016326609B2 (en) | 2015-09-23 | 2023-03-09 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
EP3566053A4 (en) * | 2017-01-04 | 2020-11-25 | National Taiwan University | Biomarkers for lung cancer stem cells |
US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
JP2021534785A (en) | 2018-08-28 | 2021-12-16 | フレッド ハッチンソン キャンサー リサーチ センター | Methods and Compositions for Adoptive T Cell Therapy Using Induced Notch Signaling |
CN110487998B (en) * | 2019-08-13 | 2023-01-31 | 迈克医疗电子有限公司 | Parameter optimization method and device for magnetic separation system, analysis instrument and storage medium |
KR20220116475A (en) * | 2019-12-12 | 2022-08-23 | 아킬레스 테라퓨틱스 유케이 리미티드 | Methods for obtaining nucleic acids for sequencing |
RU2735982C2 (en) * | 2020-06-02 | 2020-11-11 | Федеральное государственное бюджетное учреждение | Method for prediction of radiosensitivity of malignant growths of upper respiratory tract |
WO2023225352A2 (en) * | 2022-05-20 | 2023-11-23 | Helex Inc. | Methods for assessment of effects of gene editing |
Family Cites Families (306)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3687808A (en) * | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
US4089003A (en) * | 1977-02-07 | 1978-05-09 | Motorola, Inc. | Multifrequency microstrip antenna |
US4109496A (en) * | 1977-12-20 | 1978-08-29 | Norris Industries | Trapped key mechanism |
US4323546A (en) * | 1978-05-22 | 1982-04-06 | Nuc Med Inc. | Method and composition for cancer detection in humans |
US4411990A (en) | 1979-06-13 | 1983-10-25 | University Patents, Inc. | Primary bioassay of human tumor stem cells |
US4873191A (en) * | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
US4584268A (en) | 1981-10-13 | 1986-04-22 | Ceriani Roberto Luis | Method and compositions for carcinoma diagnosis |
US4612282A (en) * | 1981-12-15 | 1986-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Monoclonal antibodies reactive with human breast cancer |
US4670393A (en) * | 1982-03-22 | 1987-06-02 | Genentech, Inc. | DNA vectors encoding a novel human growth hormone-variant protein |
NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4753894A (en) | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
US4960716A (en) | 1984-05-01 | 1990-10-02 | Ciba Corning Diagnostics Corp. | Monoclonal antibodies specific for 330 KD breast tumor antigen and assay using said monoclonal antibodies |
US5019497A (en) * | 1984-11-09 | 1991-05-28 | Lennart Olsson | Human squamous lung carcinoma cell specific antigens and antibodies |
US5034506A (en) * | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
US4751177A (en) | 1985-06-13 | 1988-06-14 | Amgen | Methods and kits for performing nucleic acid hybridization assays |
EP0228075B1 (en) | 1986-01-03 | 1991-04-03 | Molecular Diagnostics, Inc. | Eucaryotic genomic dna dot-blot hybridization method |
US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4877745A (en) | 1986-11-17 | 1989-10-31 | Abbott Laboratories | Apparatus and process for reagent fluid dispensing and printing |
GB2198290B (en) * | 1986-11-29 | 1990-05-09 | Stc Plc | Dual band circularly polarised antenna with hemispherical coverage |
US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
US6270961B1 (en) | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
US5080891A (en) * | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
US5087570A (en) | 1988-05-10 | 1992-02-11 | Weissman Irving L | Homogeneous mammalian hematopoietic stem cell composition |
US4981785A (en) * | 1988-06-06 | 1991-01-01 | Ventrex Laboratories, Inc. | Apparatus and method for performing immunoassays |
US4968103A (en) * | 1988-07-22 | 1990-11-06 | Photofinish Cosmetics Inc. | Method of making a brush |
WO1990001564A1 (en) | 1988-08-09 | 1990-02-22 | Microprobe Corporation | Methods for multiple target analyses through nucleic acid hybridization |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5994617A (en) | 1988-09-19 | 1999-11-30 | Hsc Research Development Corporation | Engraftment of immune-deficient mice with human cells |
CA1335181C (en) | 1988-10-11 | 1995-04-11 | R. Alan Hardwick | System for selective cell separation from cell concentrate |
GB8823869D0 (en) * | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5534617A (en) * | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
US5688666A (en) * | 1988-10-28 | 1997-11-18 | Genentech, Inc. | Growth hormone variants with altered binding properties |
DE68919715T2 (en) | 1988-12-28 | 1995-04-06 | Stefan Miltenyi | METHOD AND MATERIALS FOR HIGHLY GRADUATED MAGNETIC SPLITTING OF BIOLOGICAL MATERIALS. |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
GB8901778D0 (en) | 1989-01-27 | 1989-03-15 | Univ Court Of The University O | Manipulatory technique |
US5219726A (en) | 1989-06-02 | 1993-06-15 | The Salk Institute For Biological Studies | Physical mapping of complex genomes |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
US5545522A (en) | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
US6583115B1 (en) | 1989-10-12 | 2003-06-24 | Ohio University/Edison Biotechnology Institute | Methods for treating acromegaly and giantism with growth hormone antagonists |
JP2802518B2 (en) * | 1989-10-13 | 1998-09-24 | 戸田工業株式会社 | Magnetic recording media |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
US5614396A (en) * | 1990-06-14 | 1997-03-25 | Baylor College Of Medicine | Methods for the genetic modification of endogenous genes in animal cells by homologous recombination |
US5489677A (en) * | 1990-07-27 | 1996-02-06 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms |
US5602240A (en) * | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5661016A (en) * | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
ES2246502T3 (en) * | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | TRANSGENIC NON-HUMAN ANIMALS ABLE TO PRODUCE HETEROLOGICAL ANTIBODIES. |
ATE164395T1 (en) * | 1990-12-03 | 1998-04-15 | Genentech Inc | METHOD FOR ENRICHMENT OF PROTEIN VARIANTS WITH MODIFIED BINDING PROPERTIES |
CA2097708A1 (en) | 1990-12-06 | 1992-06-07 | Stephen P. A. Fodor | Very large scale immobilized polymer synthesis |
DE69132905T2 (en) | 1990-12-06 | 2002-08-01 | Affymetrix Inc N D Ges D Staat | Detection of nucleic acid sequences |
DE4039677A1 (en) | 1990-12-12 | 1992-06-17 | Boehringer Mannheim Gmbh | UNIVERSAL BINDING FILM |
US5856441A (en) * | 1991-05-03 | 1999-01-05 | Yale University | Serrate fragments and derivatives |
IE20030749A1 (en) * | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
IL101728A (en) | 1991-05-03 | 2007-08-19 | Univ Yale | Human notch and delta, binding domains in toporythmic proteins, and methods based thereon |
ATE196548T1 (en) | 1991-05-10 | 2000-10-15 | Genentech Inc | SELECTING AGONISTS AND ANTAGONISTS OF LIGANDS |
US6429186B1 (en) | 1991-05-10 | 2002-08-06 | Genentech, Inc. | Ligand antagonists for treatment of breast cancer |
US5539082A (en) * | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
US5719262A (en) * | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
US5714331A (en) * | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US5851832A (en) | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
US5750376A (en) | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
ES2136092T3 (en) * | 1991-09-23 | 1999-11-16 | Medical Res Council | PROCEDURES FOR THE PRODUCTION OF HUMANIZED ANTIBODIES. |
DE69230873T3 (en) | 1991-09-24 | 2006-04-06 | Keygene N.V. | Selective restriction fragment amplification: general procedure for DNA fingerprinting |
US5753229A (en) * | 1991-09-25 | 1998-05-19 | Mordoh; Jose | Monoclonal antibodies reactive with tumor proliferating cells |
US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
JP3509859B2 (en) * | 1991-11-07 | 2004-03-22 | ナノトロニクス,インコーポレイテッド | Hybridization of chromophore and fluorophore conjugated polynucleotides to create donor-donor energy transfer systems |
US6353150B1 (en) | 1991-11-22 | 2002-03-05 | Hsc Research And Development Limited Partnership | Chimeric mammals with human hematopoietic cells |
US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
US5869282A (en) * | 1991-12-11 | 1999-02-09 | Imperial Cancer Research Technology, Ltd. | Nucleotide and protein sequences of the serrate gene and methods based thereon |
US6004924A (en) * | 1991-12-11 | 1999-12-21 | Imperial Cancer Research Technology, Ltd. | Protein sequences of serrate gene products |
EP0552108B1 (en) * | 1992-01-17 | 1999-11-10 | Lakowicz, Joseph R. | Energy transfer phase-modulation fluoro-immunoassay |
US5376313A (en) * | 1992-03-27 | 1994-12-27 | Abbott Laboratories | Injection molding a plastic assay cuvette having low birefringence |
US5786158A (en) | 1992-04-30 | 1998-07-28 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
US20050112121A1 (en) | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
US5840484A (en) | 1992-07-17 | 1998-11-24 | Incyte Pharmaceuticals, Inc. | Comparative gene transcript analysis |
US5654183A (en) | 1992-07-27 | 1997-08-05 | California Institute Of Technology | Genetically engineered mammalian neural crest stem cells |
US5849553A (en) | 1992-07-27 | 1998-12-15 | California Institute Of Technology | Mammalian multipotent neural stem cells |
NZ256154A (en) | 1992-07-27 | 1997-02-24 | California Inst Of Techn | Production of mammalian multipotent neural stem cells, antibodies |
US5693482A (en) | 1992-07-27 | 1997-12-02 | California Institute Of Technology | Neural chest stem cell assay |
US5589376A (en) | 1992-07-27 | 1996-12-31 | California Institute Of Technology | Mammalian neural crest stem cells |
DE69333366T2 (en) | 1992-10-30 | 2004-09-16 | The General Hospital Corp., Boston | A NEW CELL CYCLE CONTROL PROTEIN |
GB9223084D0 (en) * | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
JP3106021B2 (en) * | 1992-11-30 | 2000-11-06 | キヤノン株式会社 | Pattern data compression method and apparatus and output method and apparatus |
JP3189279B2 (en) * | 1993-02-19 | 2001-07-16 | 日本新薬株式会社 | Pharmaceutical composition containing nucleic acid copolymer |
US5639606A (en) * | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
US5876978A (en) * | 1993-04-06 | 1999-03-02 | Medical College Of Ohio | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
US5643765A (en) * | 1993-04-06 | 1997-07-01 | University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
US5744306A (en) | 1993-04-19 | 1998-04-28 | Emory University | Methods for nucleic acid detection, sequencing, and cloning using exonuclease |
US5674694A (en) | 1993-09-21 | 1997-10-07 | Biologic & Immunologic Science Laboratories, Inc. | Clonogenic assay for detecting micro levels of tumor cells in hematopoietic samples |
US5681860A (en) | 1993-09-21 | 1997-10-28 | The Trustees Of Columbia University In The City Of New York | Method of increasing expression of HLA, cell surface and TAA antigens of cells using 3-(N-acetylamino)-5-(N-decyl-N-methylamino)-benzyl alcohol |
AU8126694A (en) | 1993-10-26 | 1995-05-22 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
US5599677A (en) * | 1993-12-29 | 1997-02-04 | Abbott Laboratories | Immunoassays for prostate specific antigen |
US5654419A (en) | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
US6015880A (en) | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
ATE336587T1 (en) * | 1994-06-10 | 2006-09-15 | Genvec Inc | ADENOVIRUS VECTOR SYSTEMS AND CELL LINES |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US6156305A (en) | 1994-07-08 | 2000-12-05 | Baxter International Inc. | Implanted tumor cells for the prevention and treatment of cancer |
US5710000A (en) | 1994-09-16 | 1998-01-20 | Affymetrix, Inc. | Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping |
US5650317A (en) | 1994-09-16 | 1997-07-22 | Michigan State University | Human breast epithelial cell type with stem cell and luminal epithelial cell characteristics |
US5567326A (en) | 1994-09-19 | 1996-10-22 | Promega Corporation | Multisample magnetic separation device |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
WO1996013597A2 (en) * | 1994-10-28 | 1996-05-09 | The Trustees Of The University Of Pennsylvania | Improved adenovirus and methods of use thereof |
US6218166B1 (en) | 1994-12-09 | 2001-04-17 | John Wayne Cancer Institute | Adjuvant incorporation into antigen carrying cells: compositions and methods |
US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
US5872154A (en) * | 1995-02-24 | 1999-02-16 | The Trustees Of The University Of Pennsylvania | Method of reducing an immune response to a recombinant adenovirus |
US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US6090822A (en) * | 1995-03-03 | 2000-07-18 | Margolin; Solomon B. | Treatment of cytokine growth factor caused disorders |
US5707618A (en) * | 1995-03-24 | 1998-01-13 | Genzyme Corporation | Adenovirus vectors for gene therapy |
US6091001A (en) | 1995-03-29 | 2000-07-18 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
US5633161A (en) * | 1995-03-29 | 1997-05-27 | Millennium Pharmaceuticals, Inc. | Murine gene fomy030 coding for tumor progression inhibitor |
US5641870A (en) * | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
US5821108A (en) | 1995-04-07 | 1998-10-13 | The Board Of Trustees Of The Leland Stanford Junior University | Enrichment for a thymocyte subset having progenitor cell activity using c-kit as a selection marker |
AU705616B2 (en) | 1995-04-21 | 1999-05-27 | Cell Genesys, Inc. | Generation of large genomic DNA deletions |
US5753439A (en) | 1995-05-19 | 1998-05-19 | Trustees Of Boston University | Nucleic acid detection methods |
US5610620A (en) * | 1995-05-19 | 1997-03-11 | Comant Industries, Inc. | Combination antenna |
US6019978A (en) * | 1995-06-05 | 2000-02-01 | The Wistar Institute Of Anatomy And Biology | Replication-defective adenovirus human type 5 recombinant as a vaccine carrier |
US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
ATE445705T1 (en) * | 1995-06-15 | 2009-10-15 | Crucell Holland Bv | PACKAGING SYSTEMS FOR HUMAN RECOMBINANT ADENOVIRUSES FOR GENE THERAPY |
US6117985A (en) * | 1995-06-16 | 2000-09-12 | Stemcell Technologies Inc. | Antibody compositions for preparing enriched cell preparations |
ES2334953T3 (en) | 1995-06-28 | 2010-03-17 | Imperial Cancer Research Technology Limited | SEQUENCES OF NUCLEOTIDES AND PROTEINS OF DELTA GENES OF VERTEBRATES AND METHODS BASED ON THE SAME. |
US5733729A (en) | 1995-09-14 | 1998-03-31 | Affymetrix, Inc. | Computer-aided probability base calling for arrays of nucleic acid probes on chips |
ES2190388T3 (en) * | 1995-09-21 | 2006-04-01 | Genentech, Inc. | VARIANTS OF HUMAN GROWTH HORMONE. |
US5780300A (en) | 1995-09-29 | 1998-07-14 | Yale University | Manipulation of non-terminally differentiated cells using the notch pathway |
US5986170A (en) * | 1995-11-13 | 1999-11-16 | Corixa Corporation | Murine model for human carcinoma |
CA2237589A1 (en) | 1995-11-16 | 1997-05-22 | Michael W. Dahm | Method of quantifying tumour cells in a body fluid and a suitable test kit |
JP4283891B2 (en) | 1995-11-17 | 2009-06-24 | 旭化成株式会社 | Differentiation-inhibiting polypeptide |
US5598677A (en) * | 1995-12-19 | 1997-02-04 | Rehm, Iii; Frederick G. | Insulated covering for building sheathing |
WO1997023782A1 (en) | 1995-12-22 | 1997-07-03 | Abbott Laboratories | Fluorescence polarization immunoassay diagnostic method |
US5720722A (en) * | 1996-01-11 | 1998-02-24 | Medela, Incorporated | Connector for use in single and double breast pumping and breast pump using same |
US5994316A (en) | 1996-02-21 | 1999-11-30 | The Immune Response Corporation | Method of preparing polynucleotide-carrier complexes for delivery to cells |
US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
DE69713336T2 (en) | 1996-03-30 | 2002-12-05 | Science Park Raf S P A | Process for the production of activated labeled tumor-specific T cells and their use in the treatment of tumors |
US5753506A (en) | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
US6716974B1 (en) | 1996-05-31 | 2004-04-06 | Maine Medical Center Research Institute | Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids |
JP2000512134A (en) | 1996-05-31 | 2000-09-19 | ザ ナショナル アメリカン レッド クロス | Methods and compositions for therapeutic and diagnostics based on Jagged / Notch proteins and nucleic acids |
US5928638A (en) | 1996-06-17 | 1999-07-27 | Systemix, Inc. | Methods for gene transfer |
US5885529A (en) * | 1996-06-28 | 1999-03-23 | Dpc Cirrus, Inc. | Automated immunoassay analyzer |
FR2751986B1 (en) | 1996-08-01 | 1998-12-31 | Inst Nat Sante Rech Med | GENE INVOLVED IN CADASIL, DIAGNOSTIC METHOD AND THERAPEUTIC APPLICATION |
EP0963432A4 (en) * | 1996-08-29 | 2002-11-20 | Univ California | Kuz, a novel family of metalloproteases |
US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
KR20000049096A (en) | 1996-10-11 | 2000-07-25 | 린다 에스. 스티븐슨 | Cancer immunotherapy using tumor cells combined with mixed lymphocytes |
US5994132A (en) * | 1996-10-23 | 1999-11-30 | University Of Michigan | Adenovirus vectors |
US5859535A (en) * | 1997-02-12 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | System for determining size and location of defects in material by use of microwave radiation |
SE508356C2 (en) * | 1997-02-24 | 1998-09-28 | Ericsson Telefon Ab L M | Antenna Installations |
US6165709A (en) | 1997-02-28 | 2000-12-26 | Fred Hutchinson Cancer Research Center | Methods for drug target screening |
DE69837839T2 (en) * | 1997-03-07 | 2007-12-13 | Clare Chemical Research LLC, Denver | Fluorometric detection with visible light |
US6080912A (en) * | 1997-03-20 | 2000-06-27 | Wisconsin Alumni Research Foundation | Methods for creating transgenic animals |
US20020137890A1 (en) | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
US20030180784A1 (en) | 1997-04-04 | 2003-09-25 | Millennium Pharmaceuticals, Inc. | Novel human Delta3 compositions and therapeutic and diagnostic uses therefor |
US20060122373A1 (en) | 1997-04-04 | 2006-06-08 | Millennium Pharmaceuticals, Inc. | Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof |
US6121045A (en) * | 1997-04-04 | 2000-09-19 | Millennium Biotherapeutics, Inc. | Human Delta3 nucleic acid molecules |
DE69836131T3 (en) | 1997-04-04 | 2017-06-14 | Millennium Pharmaceuticals, Inc. | NEW HUMAN DELTA3 COMPOSITION AND ITS THERAPEUTIC AND DIAGNOSTIC USES |
DE19715484A1 (en) | 1997-04-14 | 1998-10-15 | Boehringer Mannheim Gmbh | Procedure for applying reagent spots |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
US5830730A (en) * | 1997-05-08 | 1998-11-03 | The Regents Of The University Of California | Enhanced adenovirus-assisted transfection composition and method |
US5894869A (en) * | 1997-05-12 | 1999-04-20 | Crosman Corporation | CO2 cartridge pressurization device |
CA2288218C (en) | 1997-05-14 | 2013-03-12 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel differentiation-inhibitor |
US6379925B1 (en) | 1997-06-18 | 2002-04-30 | The Trustees Of Columbia University In The City Of New York | Angiogenic modulation by notch signal transduction |
AU8162898A (en) | 1997-06-18 | 1999-01-04 | Trustees Of Columbia University In The City Of New York, The | Angiogenic modulation by notch signal transduction |
US6136952A (en) * | 1997-06-25 | 2000-10-24 | University Of Washington | Human jagged polypeptide, encoding nucleic acids and methods of use |
CA2290736A1 (en) | 1997-07-11 | 1999-01-21 | Introgene B.V. | Interleukin-3 gene therapy for cancer |
US6004528A (en) | 1997-09-18 | 1999-12-21 | Bergstein; Ivan | Methods of cancer diagnosis and therapy targeted against the cancer stemline |
US7361336B1 (en) * | 1997-09-18 | 2008-04-22 | Ivan Bergstein | Methods of cancer therapy targeted against a cancer stem line |
DE69804653T2 (en) | 1997-10-31 | 2002-11-28 | Pe Corp Ny Foster City | METHOD AND DEVICE FOR PRODUCING MATRIXES OF SAMPLES |
US6197523B1 (en) * | 1997-11-24 | 2001-03-06 | Robert A. Levine | Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
US6183968B1 (en) | 1998-03-27 | 2001-02-06 | Incyte Pharmaceuticals, Inc. | Composition for the detection of genes encoding receptors and proteins associated with cell proliferation |
US5981225A (en) * | 1998-04-16 | 1999-11-09 | Baylor College Of Medicine | Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same |
US5965352A (en) | 1998-05-08 | 1999-10-12 | Rosetta Inpharmatics, Inc. | Methods for identifying pathways of drug action |
US6218122B1 (en) | 1998-06-19 | 2001-04-17 | Rosetta Inpharmatics, Inc. | Methods of monitoring disease states and therapies using gene expression profiles |
US6818213B1 (en) * | 1998-07-13 | 2004-11-16 | Board Of Regents, The University Of Texas System | Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids |
AU4870599A (en) | 1998-07-27 | 2000-02-21 | Amgen, Inc. | Delta-related polypeptides |
WO2000009675A1 (en) | 1998-08-14 | 2000-02-24 | Aventis Pharmaceuticals Products Inc. | Adenovirus formulations for gene therapy |
CA2341061A1 (en) | 1998-08-27 | 2000-03-09 | Aventis Pharma S.A. | Targeted adenovirus vectors for delivery of heterologous genes |
GB9819681D0 (en) | 1998-09-09 | 1998-11-04 | Smithkline Beecham Plc | Novel compounds |
US6146830A (en) | 1998-09-23 | 2000-11-14 | Rosetta Inpharmatics, Inc. | Method for determining the presence of a number of primary targets of a drug |
CA2343963A1 (en) * | 1998-10-02 | 2000-04-13 | The Government Of The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services, The National Institutes Of Health | Apotosis inducing agents and methods |
DE69939327D1 (en) | 1998-11-02 | 2008-09-25 | Curis Inc | FUNCTIONAL ANTAGONISTS OF HEDGEHOG ACTIVITY |
WO2000028090A2 (en) | 1998-11-12 | 2000-05-18 | Nyxis, Inc. | Diagnostic assay for cancer |
US6291516B1 (en) | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
US6610484B1 (en) | 1999-01-26 | 2003-08-26 | Cytyc Health Corporation | Identifying material from a breast duct |
US6215894B1 (en) | 1999-02-26 | 2001-04-10 | General Scanning, Incorporated | Automatic imaging and analysis of microarray biochips |
EP1119368A2 (en) | 1999-03-03 | 2001-08-01 | Biogen, Inc. | Methods of modulating lipid metabolism and storage |
US20030003572A1 (en) | 1999-03-05 | 2003-01-02 | David J. Anderson | Isolation and enrichment of neural stem cells from uncultured tissue based on cell-surface marker expression |
US20030119029A1 (en) | 1999-04-30 | 2003-06-26 | Regents Of The University Of Michigan | Compositions and methods relating to novel benzodiazepine compounds and targets thereof |
WO2000073337A1 (en) | 1999-06-01 | 2000-12-07 | Biogen, Inc. | Polymer conjugates of hedgehog proteins and uses |
US6703221B1 (en) | 1999-08-19 | 2004-03-09 | Chiron Corporation | Notch receptor ligands and uses thereof |
EP1690872A3 (en) | 1999-12-01 | 2006-08-23 | Genentech, Inc. | Composition and methods for the diagnosis of tumours |
US6380362B1 (en) | 1999-12-23 | 2002-04-30 | Genesis Research & Development Corporation Ltd. | Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use |
AU2000226035A1 (en) | 2000-01-10 | 2001-07-24 | Cd Warehouse, Inc. | Method and apparatus for arranging for sales using centralized ordering and decentralized shipping |
US20040048249A1 (en) | 2000-01-21 | 2004-03-11 | Tang Y. Tom | Novel nucleic acids and secreted polypeptides |
JP2003520266A (en) | 2000-01-24 | 2003-07-02 | メルク シャープ エンド ドーム リミテッド | γ-secretase inhibitor |
GB0005251D0 (en) | 2000-03-03 | 2000-04-26 | Merck Sharp & Dohme | Therapeutic compounds |
US7115653B2 (en) | 2000-03-30 | 2006-10-03 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
US20050070578A1 (en) | 2000-03-30 | 2005-03-31 | Baxter Anthony David | Small organic molecule regulators of cell proliferation |
GB0008710D0 (en) | 2000-04-07 | 2000-05-31 | Merck Sharp & Dohme | Therapeutic compounds |
US7498304B2 (en) | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
AU2001268513A1 (en) | 2000-06-17 | 2002-01-02 | Third Wave Technologies, Inc. | Nucleic acid accessible hybridization sites |
CA2414015A1 (en) | 2000-06-21 | 2001-12-27 | Incyte Genomics, Inc. | Human receptors |
US6632620B1 (en) * | 2000-06-22 | 2003-10-14 | Andrew N. Makarovskiy | Compositions for identification and isolation of stem cells |
DE10031380A1 (en) | 2000-06-28 | 2002-01-10 | Merck Patent Gmbh | Process for the transfer of alkylidene groups to organic compounds |
GB0016681D0 (en) | 2000-07-06 | 2000-08-23 | Merck Sharp & Dohme | Therapeutic compounds |
WO2002008765A2 (en) | 2000-07-26 | 2002-01-31 | Stanford University | Basal cell markers in breast cancer and uses thereof |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
WO2002018544A2 (en) | 2000-08-31 | 2002-03-07 | Loyola University Chicago | Method and reagents for treatment of skin disorders by modulating the notch pathway |
US6689744B2 (en) | 2000-09-22 | 2004-02-10 | Genentech, Inc. | Notch receptor agonists and uses |
US20020061289A1 (en) * | 2000-10-04 | 2002-05-23 | Boman Bruce M. | Stem cell-based methods for preventing and treating tumor |
US7708998B2 (en) | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
US7413873B2 (en) | 2001-01-30 | 2008-08-19 | The Regents Of The University Of California | Method of detection and treatment of colon cancer |
US20020169300A1 (en) | 2001-01-30 | 2002-11-14 | Waterman Marian L. | Method of detection and treatment of colon cancer by analysis of beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 |
US20030064384A1 (en) | 2001-04-02 | 2003-04-03 | Mien-Chie Hung | Beta-catenin is a strong and independent prognostic factor for cancer |
US7713526B2 (en) | 2001-05-01 | 2010-05-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
US20030044409A1 (en) | 2001-05-01 | 2003-03-06 | Carson Dennis A. | Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens |
WO2002088081A2 (en) | 2001-05-01 | 2002-11-07 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
WO2002102978A2 (en) | 2001-06-15 | 2002-12-27 | Genentech, Inc. | Human growth hormone antagonists |
US7171311B2 (en) | 2001-06-18 | 2007-01-30 | Rosetta Inpharmatics Llc | Methods of assigning treatment to breast cancer patients |
US20040023244A1 (en) | 2001-06-21 | 2004-02-05 | Griffin Jennifer A | Receptors |
EP1406998B1 (en) * | 2001-06-22 | 2007-08-22 | StemCells, Inc. | Liver engrafting cells, assays, and uses thereof |
WO2003000893A2 (en) | 2001-06-26 | 2003-01-03 | Decode Genetics Ehf. | Nucleic acids encoding g protein-coupled receptors |
EP1411938B1 (en) | 2001-07-02 | 2005-07-06 | Tas, Sinan | Use of cyclopamine for the manufacture of a medicament for the treatemnt of psoriasis |
CA2452151C (en) | 2001-07-02 | 2012-01-03 | Sinan Tas | Use of cyclopamine, an inducer of the differentiation and apoptosis of the basal cell carcinoma (bcc) cells, in the treatment of bcc's and other tumors that use the hedgehog/smoothened pathway for proliferation of apoptosis |
AU2002317105A1 (en) | 2001-07-05 | 2003-01-21 | University Of British Columbia | Methods for identifying therapeutic agents for treating diseases involving wnt polypeptides and wnt receptors |
JP2004537314A (en) | 2001-07-25 | 2004-12-16 | ロランティス リミテッド | Methods for detecting Notch signaling modulators |
CA2455100C (en) | 2001-07-27 | 2013-05-28 | Curis, Inc. | Mediators of hedgehog signaling pathways,compositions and uses related thereto |
US7122675B2 (en) | 2001-08-03 | 2006-10-17 | Schering Corporation | Gamma secretase inhibitors |
EP1492765B1 (en) | 2001-08-03 | 2011-07-06 | Schering Corporation | Novel gamma secretase inhibitors |
WO2003042246A2 (en) | 2001-11-14 | 2003-05-22 | Lorantis Limited | Inhibitors of the notch signalling pathway for use in the treatment of cancer |
US20050137130A1 (en) | 2001-11-14 | 2005-06-23 | Bodmer Mark W. | Medical treatment |
AU2002352967A1 (en) | 2001-11-29 | 2003-06-10 | The Trustees Of Princeton University | Increased emission efficiency in organic light-emitting devices on high-index substrates |
CA2469204A1 (en) | 2001-12-07 | 2003-06-19 | Regents Of The University Of Michigan | Prospective identification and characterization of breast cancer stem cells |
EP1465984A1 (en) | 2002-01-17 | 2004-10-13 | Kobenhavns Universitet | A suprabasal breast cell line with stem cell properties |
GB0201674D0 (en) | 2002-01-25 | 2002-03-13 | Lorantis Ltd | Medical treatment |
US20050089896A1 (en) | 2003-02-18 | 2005-04-28 | Roy Frans V. | Method to control tumor progression and invasiveness |
US20030185829A1 (en) | 2002-03-12 | 2003-10-02 | Erich Koller | Jagged 2 inhibitors for inducing apoptosis |
EP3115470B1 (en) | 2002-03-13 | 2018-07-18 | Genomic Health, Inc. | Gene expression profiling in biopsied tumor tissues |
JP2005529876A (en) | 2002-04-22 | 2005-10-06 | ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン | Modulators of the Hedgehog signaling pathway, compositions related thereto and uses |
EP2365004B1 (en) | 2002-06-21 | 2016-01-06 | Johns Hopkins University School of Medicine | Membrane associated tumor endothelium markers |
GB0218879D0 (en) | 2002-08-14 | 2002-09-25 | Lorantis Ltd | Medical treatment |
US7803370B2 (en) | 2002-08-30 | 2010-09-28 | Oncotherapy Science, Inc. | Method for treating synovial sarcoma |
AU2003267563A1 (en) | 2002-09-10 | 2004-04-30 | Lorantis Limited | Pharmaceutical composition and medical treatments comprising notch ligand proteins |
GB0221952D0 (en) | 2002-09-20 | 2002-10-30 | Novartis Forschungsstiftung | Wnt mediated ErbB1 signalling,compositions and uses related thereto |
CA2501235A1 (en) | 2002-10-04 | 2004-04-22 | The Regents Of The University Of California | Methods for treating cancer by inhibiting wnt signaling |
CA2503390A1 (en) | 2002-11-01 | 2004-05-21 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
WO2004073657A2 (en) | 2003-02-19 | 2004-09-02 | Protein Design Labs, Inc. | Methods of diagnosis of cancer and other diseases, composition and methods of screening for modulators of cancer and other diseases |
JP2007525167A (en) | 2003-04-01 | 2007-09-06 | ジェンザイム・コーポレーション | Breast endothelial cell expression pattern |
WO2004097030A2 (en) | 2003-04-28 | 2004-11-11 | Bristol-Myers Squibb Company | Prognostic breast cancer biomarkers |
WO2004099379A2 (en) | 2003-05-02 | 2004-11-18 | Health Research, Inc. | Use of jag2 expression in diagnosis of plasma cell disorders |
US20060019256A1 (en) | 2003-06-09 | 2006-01-26 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
GB0321805D0 (en) | 2003-09-18 | 2003-10-15 | Univ Wales Medicine | Human tumour growth patterns |
US6894522B2 (en) * | 2003-10-06 | 2005-05-17 | International Business Machines Corporation | Specific site backside underlaying and micromasking method for electrical characterization of semiconductor devices |
US20050232927A1 (en) | 2004-02-03 | 2005-10-20 | The Regents Of The University Of Michigan | Compositions and methods for characterizing, regulating, diagnosing, and treating cancer |
US20050221476A1 (en) | 2004-03-18 | 2005-10-06 | Arindom Sen | Chemical dissociation of cell aggregates |
CA2566549C (en) | 2004-05-12 | 2014-01-14 | The Walter And Eliza Hall Institute Of Medical Research | A method for isolating mammary stem cells |
US20060040883A1 (en) | 2004-05-14 | 2006-02-23 | The Regents Of The University Of California | Methods for treating cancer using anti-Wnt2 monoclonal antibodies and siRNA |
KR101487481B1 (en) | 2004-08-27 | 2015-01-28 | 인피니티 디스커버리, 인코포레이티드 | Cyclopamine analogues and methods of use thereof |
WO2006027693A2 (en) | 2004-09-09 | 2006-03-16 | Exonhit Therapeutics Sa | Tumor specific genes and variant rnas and uses thereof as targets for cancer therapy and diagnosis |
GB0421838D0 (en) | 2004-09-30 | 2004-11-03 | Congenia S R L | Cancer markers |
US8048418B2 (en) | 2004-10-29 | 2011-11-01 | Regeneron Pharmaceuticals, Inc. | Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists |
US20060134121A1 (en) | 2004-10-29 | 2006-06-22 | Gavin Thurston | DII4 antagonists, assays, and therapeutic methods thereof |
US20080107648A1 (en) * | 2005-12-16 | 2008-05-08 | Regeneron Pharmaceuticals, Inc. | Therapeutic methods for inhibiting tumor growth with DII4 antagonists |
WO2006052128A1 (en) | 2004-11-10 | 2006-05-18 | Hubrecht Laboratorium | Treatment of an intestinal adenoma and/or adenocarcinoma by inhibition of notch pathway activation |
AU2006259583A1 (en) | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
WO2006135886A2 (en) | 2005-06-13 | 2006-12-21 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
AU2006308847C1 (en) | 2005-10-31 | 2012-05-10 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for treating and diagnosing cancer |
US20070220621A1 (en) | 2005-10-31 | 2007-09-20 | Clarke Michael F | Genetic characterization and prognostic significance of cancer stem cells in cancer |
US7714014B2 (en) | 2005-12-09 | 2010-05-11 | The Regents Of The University Of California | Targeting GLI proteins in human cancer by small molecules |
US20070243192A1 (en) | 2006-02-21 | 2007-10-18 | Regents Of The University Of Michigan | Growth hormone receptor antagonist cancer treatment |
WO2008121102A2 (en) | 2006-02-21 | 2008-10-09 | The Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
WO2008057144A2 (en) | 2006-05-15 | 2008-05-15 | The Brigham And Women's Hospital, Inc. | Functional negative regulatory domain sequences from human notch1 and 2 and isolated lnr domains from human notch1 |
BRPI0710411A2 (en) * | 2006-06-06 | 2012-04-10 | Genentch Inc Empresa Americana | METHODS FOR TREATING A TUMOR, FOR TREATING A PATHOLOGICAL CONDITION ASSOCIATED WITH ANGIOGENESIS, TO STIMULATING ENDOTHELIAL CELL PROLIFERATION, TO REDUCE OR INHIBIT ENDOTHELIAL CELL DIFFERENTIATION, TO REDUCE OR INHIBIT TO DEVELOP, DETERMINING, DETECTING EFFECTIVENESS OF AN ANTI-ANGIOGENIC AGENT, USES OF A DLL4 ANTAGONIST AND USE OF A DLL4 AGONISTER |
WO2008036419A2 (en) | 2006-09-22 | 2008-03-27 | The Regents Of The University Of Michigan | Aldehyde dehydrogenase 1(aldh1) as a cancer stem cell marker |
US7700113B2 (en) | 2006-10-19 | 2010-04-20 | Maine Medical Research Institute, A Division Of Maine Medical Center | Inhibiting breast cancer cell growth by administering an intracellular domain of NOTCH2 |
KR20150023953A (en) | 2006-10-19 | 2015-03-05 | 제넨테크, 인크. | Anti-Notch3 agonist antibodies and their use in the treatment of Notch3-related diseases |
ITRM20060583A1 (en) | 2006-10-27 | 2008-04-28 | Francesco Bistoni | USE OF THE TIMAMA ALFA 1 FOR THE PREPARATION OF A MEDICATION FOR THE PREVENTION AND CARE OF ALLERGIES |
WO2008070042A2 (en) | 2006-12-04 | 2008-06-12 | Medimmune, Inc. | High potency recombinant antibodies, methods for producing them and use in cancer therapy |
RU2448979C2 (en) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Human antibodies to delta-like human ligand-4 |
EP2610267A1 (en) | 2006-12-18 | 2013-07-03 | Genentech, Inc. | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases |
WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
JP2010517944A (en) | 2007-01-26 | 2010-05-27 | バイオインヴェント インターナショナル アーベー | DLL4 signaling inhibitor and use thereof |
US20100062012A1 (en) | 2007-03-05 | 2010-03-11 | Ioannides Constantin G | Negative Genetic Regulation of Cancer Cell Renewal in Synergy with Notch- or Numb-Specific Immunotherapy |
GB0709333D0 (en) | 2007-05-15 | 2007-06-20 | Smart Targeting Ltd | Binding protein |
PE20090321A1 (en) * | 2007-06-04 | 2009-04-20 | Genentech Inc | ANTI-NOTCH1 NRR ANTIBODIES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION |
CN101808648B (en) | 2007-07-25 | 2013-04-03 | 博洛尼亚大学阿尔玛母校研究室 | Pharmaceutical composition and pharmaceutical kit for the treatment of hepatocellular carcinoma |
RU2532830C2 (en) | 2007-08-23 | 2014-11-10 | Дзе Трастиз Оф Коламбия Юниверсити Ин Дзе Сити Оф Нью Йорк | Compositions of humanised notch fused proteins and methods of treating |
US8377886B2 (en) | 2007-09-14 | 2013-02-19 | Albert Einstein College Of Medicine Of Yeshiva University | Use of gamma secretase inhibitors and notch pathway inhibitors for treatment and prevention of renal disease |
WO2009075565A1 (en) | 2007-12-12 | 2009-06-18 | Erasmus University Medical Center Rotterdam | Methods for controlling vasculogenesis |
JP5560270B2 (en) * | 2008-07-08 | 2014-07-23 | オンコメッド ファーマシューティカルズ インコーポレイテッド | NOTCH binding agents and antagonists and methods of use thereof |
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Cited By (4)
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US9492538B2 (en) | 2000-08-03 | 2016-11-15 | The Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
US9228020B2 (en) | 2006-09-29 | 2016-01-05 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
US9376497B2 (en) | 2006-09-29 | 2016-06-28 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
US9599620B2 (en) | 2012-10-31 | 2017-03-21 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a DLL4 antagonist |
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