WO2002015896A3 - Methods and compositions for potentiating antibiotic action against persistent/tolerant pathogenic microorganisms - Google Patents

Methods and compositions for potentiating antibiotic action against persistent/tolerant pathogenic microorganisms Download PDF

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Publication number
WO2002015896A3
WO2002015896A3 PCT/US2001/026516 US0126516W WO0215896A3 WO 2002015896 A3 WO2002015896 A3 WO 2002015896A3 US 0126516 W US0126516 W US 0126516W WO 0215896 A3 WO0215896 A3 WO 0215896A3
Authority
WO
WIPO (PCT)
Prior art keywords
microbial
methods
tolerant
compositions
gene targets
Prior art date
Application number
PCT/US2001/026516
Other languages
French (fr)
Other versions
WO2002015896A2 (en
Inventor
Kim Lewis
Original Assignee
Tufts College
Kim Lewis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts College, Kim Lewis filed Critical Tufts College
Priority to AU2001286741A priority Critical patent/AU2001286741A1/en
Publication of WO2002015896A2 publication Critical patent/WO2002015896A2/en
Publication of WO2002015896A3 publication Critical patent/WO2002015896A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

The invention provides methods and reagents for the treatment of a microbial infection or decontamination of a microbial surface contamination, particularly those characterized by a population of persistent or tolerant cells such as occur in biofilm and certain planktonic bacterial populations. The invention is further directed to methods of identifying microbial tolerance gene targets and antagonsits of these microbial tolerance gene targets as well as for identifying microbial intolerance gene targets and agonists of these microbial intolerance gene targets.
PCT/US2001/026516 2000-08-25 2001-08-27 Methods and compositions for potentiating antibiotic action against persistent/tolerant pathogenic microorganisms WO2002015896A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001286741A AU2001286741A1 (en) 2000-08-25 2001-08-27 Methods and compositions for potentiating antibiotic action against persistent/tolerant pathogenic microorganisms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22804200P 2000-08-25 2000-08-25
US60/228,042 2000-08-25

Publications (2)

Publication Number Publication Date
WO2002015896A2 WO2002015896A2 (en) 2002-02-28
WO2002015896A3 true WO2002015896A3 (en) 2004-01-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026516 WO2002015896A2 (en) 2000-08-25 2001-08-27 Methods and compositions for potentiating antibiotic action against persistent/tolerant pathogenic microorganisms

Country Status (2)

Country Link
AU (1) AU2001286741A1 (en)
WO (1) WO2002015896A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8834514B2 (en) 2006-08-30 2014-09-16 Xennovate Medical Llc Resilient band medical device

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL151214A0 (en) * 2002-08-12 2003-04-10 Doron Neri Method and apparatus for animal behavior modification
US20080097517A1 (en) 2006-10-23 2008-04-24 Webtec Converting, Llc. External Nasal Dilator and Methods of Manufacture
WO2008121867A1 (en) * 2007-03-28 2008-10-09 University Of Medicine And Dentistry Of New Jersey Mrna interferase from myxococcus xanthus
WO2008137128A2 (en) * 2007-05-03 2008-11-13 Northeastern University Methods of treating fungal infections
AU2014326756B2 (en) * 2013-09-24 2019-08-29 The Regents Of The University Of Michigan Compositions and method for destabilizing, altering, and dispersing biofilms
US9801909B2 (en) * 2015-04-06 2017-10-31 The Penn State Research Foundation Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C
AU2018379996A1 (en) * 2017-12-05 2020-06-25 BioPlx, Inc. Methods and compositions to prevent microbial infection

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999013893A1 (en) * 1997-09-16 1999-03-25 Isis Pharmaceuticals, Inc. Peptide nucleic acids having antibacterial activity
WO1999057281A2 (en) * 1998-05-06 1999-11-11 St. Jude Children's Research Hospital Peptide antibiotics which inhibit the growth of pneumococci, abc transporter and two-component signal transduction system proteins from streptococcus pneumoniae, and methods using the same
WO2001012803A2 (en) * 1999-08-17 2001-02-22 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for restoring antibiotic susceptibility in glycopeptide-resistant enterococcus
WO2001027261A2 (en) * 1998-11-11 2001-04-19 Pantheco A/S Conjugates between a peptides and a nucleic acid analog, such as a pna, lna or a morpholino
WO2002085295A2 (en) * 2001-04-20 2002-10-31 The University Of Iowa Research Foundation Methods and compositions for the modulation of biofilm formation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999013893A1 (en) * 1997-09-16 1999-03-25 Isis Pharmaceuticals, Inc. Peptide nucleic acids having antibacterial activity
WO1999057281A2 (en) * 1998-05-06 1999-11-11 St. Jude Children's Research Hospital Peptide antibiotics which inhibit the growth of pneumococci, abc transporter and two-component signal transduction system proteins from streptococcus pneumoniae, and methods using the same
WO2001027261A2 (en) * 1998-11-11 2001-04-19 Pantheco A/S Conjugates between a peptides and a nucleic acid analog, such as a pna, lna or a morpholino
WO2001012803A2 (en) * 1999-08-17 2001-02-22 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for restoring antibiotic susceptibility in glycopeptide-resistant enterococcus
WO2002085295A2 (en) * 2001-04-20 2002-10-31 The University Of Iowa Research Foundation Methods and compositions for the modulation of biofilm formation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Effect of disruption of a gene encoding an autolysin of Enterococcus faecalis OG1RF", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, November 1998 (1998-11-01), pages 2883 - 2888, XP001132048 *
LEWIS K: "Riddle of biofilm resistance", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 45, no. 4, April 2001 (2001-04-01), pages 999 - 1007, XP002200811, ISSN: 0066-4804 *
MITCHELL P: "ANTIBIOTIC RESISTANCE", PHARMA PROJECTS MAGAZINE, PJB, RICHMOND,, GB, vol. 3, no. 8, June 1998 (1998-06-01), pages 16 - 20, XP000943900, ISSN: 1361-3219 *
NOVAK R ET AL: "PENICILLIN TOLERANCE GENES OF STREPTOCOCCUS PNEUMONIAE: THE ABC- TYPE MANGANESE PERMEASE COMPLEX PSA", MOLECULAR MICROBIOLOGY, BLACKWELL SCIENTIFIC, OXFORD, GB, vol. 29, no. 5, September 1998 (1998-09-01), pages 1285 - 1296, XP000890106, ISSN: 0950-382X *
RODIONOV D. ET AL: "Direct correlation between overproduction of guanosine 3',5' bispyrophosphate (ppGpp) and penicillin tolerance in E. colli", J BACTERIOLOGY, vol. 177, no. 15, August 1995 (1995-08-01), pages 4224 - 4229, XP001127469 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8834514B2 (en) 2006-08-30 2014-09-16 Xennovate Medical Llc Resilient band medical device

Also Published As

Publication number Publication date
AU2001286741A1 (en) 2002-03-04
WO2002015896A2 (en) 2002-02-28

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