WO2002016894A8 - Tdi imaging system for kinetic studies - Google Patents

Tdi imaging system for kinetic studies

Info

Publication number
WO2002016894A8
WO2002016894A8 PCT/US2001/026486 US0126486W WO0216894A8 WO 2002016894 A8 WO2002016894 A8 WO 2002016894A8 US 0126486 W US0126486 W US 0126486W WO 0216894 A8 WO0216894 A8 WO 0216894A8
Authority
WO
WIPO (PCT)
Prior art keywords
output signal
imaging system
light
tdi
synchronized
Prior art date
Application number
PCT/US2001/026486
Other languages
French (fr)
Other versions
WO2002016894A1 (en
Inventor
David Basiji
William Ortyn
Original Assignee
Amnis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amnis Corp filed Critical Amnis Corp
Priority to AU2001288385A priority Critical patent/AU2001288385A1/en
Publication of WO2002016894A1 publication Critical patent/WO2002016894A1/en
Publication of WO2002016894A8 publication Critical patent/WO2002016894A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2803—Investigating the spectrum using photoelectric array detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2823—Imaging spectrometer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium

Abstract

Light from an object (24) such as a cell moving through an imaging system is collected, and imaged onto a time delay integration (TDI) detector (44), producing a pixeled output signal in response to the image of the object (24). The light can be emitted from a luminous object, from a source and scattered by the object, or can be a fluorescent emission by one or more object probes. Light absorbed or reflacted by the object can also produce images for determining specific characteristics of the objects. In one set of embodiments, the movement of the object is synchronized with that of the pixelated output signal, which is controlled by the readout rate of the TDI detector (44). Alternatively, the readout rate of the pixelated output signal is not synchronized with the movement of the object, thereby permitting multiple signals to be produced for each of a plurality of objects over time.
PCT/US2001/026486 2000-08-25 2001-08-24 Tdi imaging system for kinetic studies WO2002016894A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001288385A AU2001288385A1 (en) 2000-08-25 2001-08-24 Tdi imaging system for kinetic studies

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22807900P 2000-08-25 2000-08-25
US60/228,079 2000-08-25
US09/932,838 2001-08-17
US09/932,838 US6608680B2 (en) 2000-08-25 2001-08-17 TDI imaging system for kinetic studies

Publications (2)

Publication Number Publication Date
WO2002016894A1 WO2002016894A1 (en) 2002-02-28
WO2002016894A8 true WO2002016894A8 (en) 2002-07-04

Family

ID=26922031

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026486 WO2002016894A1 (en) 2000-08-25 2001-08-24 Tdi imaging system for kinetic studies

Country Status (3)

Country Link
US (1) US6608680B2 (en)
AU (1) AU2001288385A1 (en)
WO (1) WO2002016894A1 (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8885913B2 (en) 1999-01-25 2014-11-11 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US7450229B2 (en) * 1999-01-25 2008-11-11 Amnis Corporation Methods for analyzing inter-cellular phenomena
US8406498B2 (en) 1999-01-25 2013-03-26 Amnis Corporation Blood and cell analysis using an imaging flow cytometer
US8131053B2 (en) * 1999-01-25 2012-03-06 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
AU2002213157A1 (en) 2000-10-12 2002-04-22 Amnis Corporation System and method for high numeric aperture imaging systems
US7280207B2 (en) 2001-07-25 2007-10-09 Applera Corporation Time-delay integration in a flow cytometry system
CA2463420A1 (en) * 2001-10-24 2003-05-01 Singulex, Inc. Methods for detecting genetic haplotypes by interaction with probes
US20030104439A1 (en) * 2001-11-30 2003-06-05 Finch Rosalynde J. Methods of identifying cellular target molecules
US20060072109A1 (en) * 2004-09-03 2006-04-06 Andrew Bodkin Hyperspectral imaging systems
US8174694B2 (en) * 2001-12-21 2012-05-08 Bodkin Design And Engineering Llc Hyperspectral imaging systems
US7079244B2 (en) * 2002-11-18 2006-07-18 International Remote Imaging Systems, Inc. Particle analyzer with specimen tube in-line mixer
US6825926B2 (en) * 2002-11-19 2004-11-30 International Remote Imaging Systems, Inc. Flow cell for urinalysis diagnostic system and method of making same
WO2005019419A2 (en) * 2003-07-31 2005-03-03 Singulex, Inc. Co-detection of single polypeptide and polynucleotide molecules
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
US8953866B2 (en) 2004-03-16 2015-02-10 Amnis Corporation Method for imaging and differential analysis of cells
US8103080B2 (en) * 2004-03-16 2012-01-24 Amnis Corporation Method for imaging and differential analysis of cells
ATE538138T1 (en) 2004-03-16 2012-01-15 Amnis Corp IMAGING-BASED QUANTIFICATION OF MOLECULAR TRANSLOCATION
US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
EP1805500A4 (en) * 2004-09-28 2008-05-07 Singulex Inc System and method for spectroscopic analysis of single particles
US8685711B2 (en) * 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
WO2007067999A2 (en) * 2005-12-09 2007-06-14 Amnis Corporation Extended depth of field imaging for high speed object analysis
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
WO2007114947A2 (en) 2006-04-04 2007-10-11 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP2158476B8 (en) 2007-05-08 2019-10-09 Trustees of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
CA2709217C (en) 2007-12-19 2021-01-05 Singulex, Inc. Scanning analyzer for single molecule detection and methods of use
US8450069B2 (en) 2009-06-08 2013-05-28 Singulex, Inc. Highly sensitive biomarker panels
US8451524B2 (en) * 2009-09-29 2013-05-28 Amnis Corporation Modifying the output of a laser to achieve a flat top in the laser's Gaussian beam intensity profile
JP2013506418A (en) 2009-09-30 2013-02-28 クアンタポール， インコーポレイテッド Ultrafast sequencing of biological polymers using labeled nanopores
US8817115B1 (en) 2010-05-05 2014-08-26 Amnis Corporation Spatial alignment of image data from a multichannel detector using a reference image
AU2011249908A1 (en) 2010-05-06 2012-11-22 Singulex, Inc. Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis
JP6109744B2 (en) 2010-11-12 2017-04-05 インセルディーエックス・インコーポレーテッド Method and system for predicting whether a subject has a cervical intraepithelial neoplasia (CIN) lesion from a floating sample of cervical cells
CN103180858B (en) 2011-08-25 2016-01-20 索尼公司 The compensation of the motion-related error in mobile micro-entity stream
US8964088B2 (en) 2011-09-28 2015-02-24 Semiconductor Components Industries, Llc Time-delay-and-integrate image sensors having variable intergration times
US9651539B2 (en) 2012-10-28 2017-05-16 Quantapore, Inc. Reducing background fluorescence in MEMS materials by low energy ion beam treatment
US9372143B2 (en) 2013-05-15 2016-06-21 Captl Llc Scanning image flow cytometer
US9862997B2 (en) 2013-05-24 2018-01-09 Quantapore, Inc. Nanopore-based nucleic acid analysis with mixed FRET detection
CN103400345A (en) * 2013-07-18 2013-11-20 西南交通大学 Method for lowering TDI-CCD (time delay integration-charge coupled device) camera image ambiguity
AU2015330841B2 (en) 2014-10-10 2019-08-15 Quantapore, Inc. Nanopore-based polymer analysis with mutually-quenching fluorescent labels
WO2016065339A1 (en) 2014-10-24 2016-04-28 Quantapore, Inc. Efficient optical analysis of polymers using arrays of nanostructures
WO2016100954A1 (en) 2014-12-19 2016-06-23 Captl Llc Flow cytometry using hydrodynamically planar flow
US10036698B2 (en) 2015-06-19 2018-07-31 Captl Llc Time-sequential cytometry
WO2018009346A1 (en) 2016-07-05 2018-01-11 Quantapore, Inc. Optically based nanopore sequencing
SG11201908847TA (en) 2017-03-31 2019-10-30 Life Technologies Corp Apparatuses, systems and methods for imaging flow cytometry
JP7348730B2 (en) 2019-02-22 2023-09-21 シスメックス株式会社 Sample measuring device and sample measuring method

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4786165A (en) 1986-07-10 1988-11-22 Toa Medical Electronics Co., Ltd. Flow cytometry and apparatus therefor
US5159642A (en) 1990-07-13 1992-10-27 Toa Medical Electronics Co., Ltd. Particle image analyzing apparatus
JP3084295B2 (en) 1991-02-27 2000-09-04 シスメックス株式会社 Flow image cytometer
JPH0734012B2 (en) 1991-02-27 1995-04-12 東亜医用電子株式会社 Flow image cytometer
JP3121849B2 (en) 1991-02-27 2001-01-09 シスメックス株式会社 Flow image cytometer
US5548395A (en) 1991-09-20 1996-08-20 Toa Medical Electronics Co., Ltd. Particle analyzer
JP3212647B2 (en) 1991-10-24 2001-09-25 シスメックス株式会社 Imaging flow cytometer
JP3102935B2 (en) 1991-11-20 2000-10-23 シスメックス株式会社 Imaging flow cytometer
US5422712A (en) 1992-04-01 1995-06-06 Toa Medical Electronics Co., Ltd. Apparatus for measuring fluorescent spectra of particles in a flow
JP3145486B2 (en) 1992-06-12 2001-03-12 シスメックス株式会社 Imaging flow cytometer
IL108497A0 (en) 1993-02-01 1994-05-30 Seq Ltd Methods and apparatus for dna sequencing
DE69434551T2 (en) 1993-09-16 2006-06-14 Sysmex Corp Particle analyzer
JP3290786B2 (en) 1993-11-26 2002-06-10 シスメックス株式会社 Particle analyzer
JPH07286953A (en) 1994-04-19 1995-10-31 Toa Medical Electronics Co Ltd Imaging flow sight meter
FI97665C (en) * 1995-11-21 1997-01-27 Planmed Oy Procedures and apparatus for photographing an object
JP3640461B2 (en) 1996-04-03 2005-04-20 シスメックス株式会社 Particle analyzer
US5760899A (en) * 1996-09-04 1998-06-02 Erim International, Inc. High-sensitivity multispectral sensor
US5754291A (en) 1996-09-19 1998-05-19 Molecular Dynamics, Inc. Micro-imaging system
US6256096B1 (en) 1999-01-11 2001-07-03 Softray Flow cytometry apparatus and method
US6249341B1 (en) * 1999-01-25 2001-06-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells

Also Published As

Publication number Publication date
US20020047896A1 (en) 2002-04-25
US6608680B2 (en) 2003-08-19
WO2002016894A1 (en) 2002-02-28
AU2001288385A1 (en) 2002-03-04

Similar Documents

Publication Publication Date Title
WO2002016894A8 (en) Tdi imaging system for kinetic studies
CA2395627A1 (en) Imaging and analyzing parameters of small moving objects such as cells
CN104396226B (en) For provide daytime scene and night scenes improved image system
WO2004031809A3 (en) Optical tomography of small moving objects using time delay and integration imaging
US20210126025A1 (en) Imaging Method and Apparatus
GB2374233B (en) Inspection system with vibration resistant video capture
ATE302978T1 (en) SYSTEM FOR HIGH CONTRAST AND LOW DISTORTION IMAGE CAPTURE
WO2007015784A3 (en) Lobster eye x-ray imaging system and method of fabrication thereof
EP1016881A3 (en) Radiation detecting apparatus
DE69711641T2 (en) VIDEO IMAGING
WO2019178939A1 (en) Pixel acquisition circuit, optical flow sensor, and optical flow and image information acquisition system
JPS5776974A (en) Method and apparatus for read-in of radiant rays picture information
JPS5580039A (en) Integrating sphare type turbidimeter
CN107018388B (en) A kind of ultrahigh speed real-time color calculates the device and method of ghost imaging
TW200719706A (en) Solid-state image sensor and method for producing the same
JPS57204504A (en) Photodetection part of focus detector
WO2006080004A3 (en) Method and system for x-ray radiation imaging
JPS6460156A (en) Method for controlling image pickup device
CA2401614A1 (en) Imaging and analyzing parameters of small moving objects such as cells
EP1213765A3 (en) Solid state imaging device
EP0139441A3 (en) Real time radiographic inspection
Golitsyn et al. The implementation of gated-viewing system based on CCD image sensor
WO2003079047A3 (en) High resolution radiation imaging
JPS564004A (en) System for detecting minute defects of body
JPS56126750A (en) Inspecting device for transmission of radiant ray

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA JP

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: C1

Designated state(s): AU CA JP

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

CFP Corrected version of a pamphlet front page
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP