WO2002016894A8 - Tdi imaging system for kinetic studies - Google Patents
Tdi imaging system for kinetic studiesInfo
- Publication number
- WO2002016894A8 WO2002016894A8 PCT/US2001/026486 US0126486W WO0216894A8 WO 2002016894 A8 WO2002016894 A8 WO 2002016894A8 US 0126486 W US0126486 W US 0126486W WO 0216894 A8 WO0216894 A8 WO 0216894A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- output signal
- imaging system
- light
- tdi
- synchronized
- Prior art date
Links
- 238000003384 imaging method Methods 0.000 title abstract 2
- 230000001360 synchronised effect Effects 0.000 abstract 2
- 230000010354 integration Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/2803—Investigating the spectrum using photoelectric array detector
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/2823—Imaging spectrometer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
Abstract
Light from an object (24) such as a cell moving through an imaging system is collected, and imaged onto a time delay integration (TDI) detector (44), producing a pixeled output signal in response to the image of the object (24). The light can be emitted from a luminous object, from a source and scattered by the object, or can be a fluorescent emission by one or more object probes. Light absorbed or reflacted by the object can also produce images for determining specific characteristics of the objects. In one set of embodiments, the movement of the object is synchronized with that of the pixelated output signal, which is controlled by the readout rate of the TDI detector (44). Alternatively, the readout rate of the pixelated output signal is not synchronized with the movement of the object, thereby permitting multiple signals to be produced for each of a plurality of objects over time.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001288385A AU2001288385A1 (en) | 2000-08-25 | 2001-08-24 | Tdi imaging system for kinetic studies |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22807900P | 2000-08-25 | 2000-08-25 | |
US60/228,079 | 2000-08-25 | ||
US09/932,838 | 2001-08-17 | ||
US09/932,838 US6608680B2 (en) | 2000-08-25 | 2001-08-17 | TDI imaging system for kinetic studies |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002016894A1 WO2002016894A1 (en) | 2002-02-28 |
WO2002016894A8 true WO2002016894A8 (en) | 2002-07-04 |
Family
ID=26922031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/026486 WO2002016894A1 (en) | 2000-08-25 | 2001-08-24 | Tdi imaging system for kinetic studies |
Country Status (3)
Country | Link |
---|---|
US (1) | US6608680B2 (en) |
AU (1) | AU2001288385A1 (en) |
WO (1) | WO2002016894A1 (en) |
Families Citing this family (45)
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US8885913B2 (en) | 1999-01-25 | 2014-11-11 | Amnis Corporation | Detection of circulating tumor cells using imaging flow cytometry |
US7450229B2 (en) * | 1999-01-25 | 2008-11-11 | Amnis Corporation | Methods for analyzing inter-cellular phenomena |
US8406498B2 (en) | 1999-01-25 | 2013-03-26 | Amnis Corporation | Blood and cell analysis using an imaging flow cytometer |
US8131053B2 (en) * | 1999-01-25 | 2012-03-06 | Amnis Corporation | Detection of circulating tumor cells using imaging flow cytometry |
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US7280207B2 (en) | 2001-07-25 | 2007-10-09 | Applera Corporation | Time-delay integration in a flow cytometry system |
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US20030104439A1 (en) * | 2001-11-30 | 2003-06-05 | Finch Rosalynde J. | Methods of identifying cellular target molecules |
US20060072109A1 (en) * | 2004-09-03 | 2006-04-06 | Andrew Bodkin | Hyperspectral imaging systems |
US8174694B2 (en) * | 2001-12-21 | 2012-05-08 | Bodkin Design And Engineering Llc | Hyperspectral imaging systems |
US7079244B2 (en) * | 2002-11-18 | 2006-07-18 | International Remote Imaging Systems, Inc. | Particle analyzer with specimen tube in-line mixer |
US6825926B2 (en) * | 2002-11-19 | 2004-11-30 | International Remote Imaging Systems, Inc. | Flow cell for urinalysis diagnostic system and method of making same |
WO2005019419A2 (en) * | 2003-07-31 | 2005-03-03 | Singulex, Inc. | Co-detection of single polypeptide and polynucleotide molecules |
US20080021674A1 (en) * | 2003-09-30 | 2008-01-24 | Robert Puskas | Methods for Enhancing the Analysis of Particle Detection |
US8953866B2 (en) | 2004-03-16 | 2015-02-10 | Amnis Corporation | Method for imaging and differential analysis of cells |
US8103080B2 (en) * | 2004-03-16 | 2012-01-24 | Amnis Corporation | Method for imaging and differential analysis of cells |
ATE538138T1 (en) | 2004-03-16 | 2012-01-15 | Amnis Corp | IMAGING-BASED QUANTIFICATION OF MOLECULAR TRANSLOCATION |
US9040305B2 (en) * | 2004-09-28 | 2015-05-26 | Singulex, Inc. | Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry |
US7572640B2 (en) * | 2004-09-28 | 2009-08-11 | Singulex, Inc. | Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties |
EP1805500A4 (en) * | 2004-09-28 | 2008-05-07 | Singulex Inc | System and method for spectroscopic analysis of single particles |
US8685711B2 (en) * | 2004-09-28 | 2014-04-01 | Singulex, Inc. | Methods and compositions for highly sensitive detection of molecules |
WO2007067999A2 (en) * | 2005-12-09 | 2007-06-14 | Amnis Corporation | Extended depth of field imaging for high speed object analysis |
US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
WO2007114947A2 (en) | 2006-04-04 | 2007-10-11 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
EP2158476B8 (en) | 2007-05-08 | 2019-10-09 | Trustees of Boston University | Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof |
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US8450069B2 (en) | 2009-06-08 | 2013-05-28 | Singulex, Inc. | Highly sensitive biomarker panels |
US8451524B2 (en) * | 2009-09-29 | 2013-05-28 | Amnis Corporation | Modifying the output of a laser to achieve a flat top in the laser's Gaussian beam intensity profile |
JP2013506418A (en) | 2009-09-30 | 2013-02-28 | クアンタポール, インコーポレイテッド | Ultrafast sequencing of biological polymers using labeled nanopores |
US8817115B1 (en) | 2010-05-05 | 2014-08-26 | Amnis Corporation | Spatial alignment of image data from a multichannel detector using a reference image |
AU2011249908A1 (en) | 2010-05-06 | 2012-11-22 | Singulex, Inc. | Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis |
JP6109744B2 (en) | 2010-11-12 | 2017-04-05 | インセルディーエックス・インコーポレーテッド | Method and system for predicting whether a subject has a cervical intraepithelial neoplasia (CIN) lesion from a floating sample of cervical cells |
CN103180858B (en) | 2011-08-25 | 2016-01-20 | 索尼公司 | The compensation of the motion-related error in mobile micro-entity stream |
US8964088B2 (en) | 2011-09-28 | 2015-02-24 | Semiconductor Components Industries, Llc | Time-delay-and-integrate image sensors having variable intergration times |
US9651539B2 (en) | 2012-10-28 | 2017-05-16 | Quantapore, Inc. | Reducing background fluorescence in MEMS materials by low energy ion beam treatment |
US9372143B2 (en) | 2013-05-15 | 2016-06-21 | Captl Llc | Scanning image flow cytometer |
US9862997B2 (en) | 2013-05-24 | 2018-01-09 | Quantapore, Inc. | Nanopore-based nucleic acid analysis with mixed FRET detection |
CN103400345A (en) * | 2013-07-18 | 2013-11-20 | 西南交通大学 | Method for lowering TDI-CCD (time delay integration-charge coupled device) camera image ambiguity |
AU2015330841B2 (en) | 2014-10-10 | 2019-08-15 | Quantapore, Inc. | Nanopore-based polymer analysis with mutually-quenching fluorescent labels |
WO2016065339A1 (en) | 2014-10-24 | 2016-04-28 | Quantapore, Inc. | Efficient optical analysis of polymers using arrays of nanostructures |
WO2016100954A1 (en) | 2014-12-19 | 2016-06-23 | Captl Llc | Flow cytometry using hydrodynamically planar flow |
US10036698B2 (en) | 2015-06-19 | 2018-07-31 | Captl Llc | Time-sequential cytometry |
WO2018009346A1 (en) | 2016-07-05 | 2018-01-11 | Quantapore, Inc. | Optically based nanopore sequencing |
SG11201908847TA (en) | 2017-03-31 | 2019-10-30 | Life Technologies Corp | Apparatuses, systems and methods for imaging flow cytometry |
JP7348730B2 (en) | 2019-02-22 | 2023-09-21 | シスメックス株式会社 | Sample measuring device and sample measuring method |
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JP3640461B2 (en) | 1996-04-03 | 2005-04-20 | シスメックス株式会社 | Particle analyzer |
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US6249341B1 (en) * | 1999-01-25 | 2001-06-19 | Amnis Corporation | Imaging and analyzing parameters of small moving objects such as cells |
-
2001
- 2001-08-17 US US09/932,838 patent/US6608680B2/en not_active Expired - Fee Related
- 2001-08-24 AU AU2001288385A patent/AU2001288385A1/en not_active Abandoned
- 2001-08-24 WO PCT/US2001/026486 patent/WO2002016894A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20020047896A1 (en) | 2002-04-25 |
US6608680B2 (en) | 2003-08-19 |
WO2002016894A1 (en) | 2002-02-28 |
AU2001288385A1 (en) | 2002-03-04 |
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