WO2002017985A3 - Microneedle structure and production method therefor - Google Patents

Microneedle structure and production method therefor Download PDF

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Publication number
WO2002017985A3
WO2002017985A3 PCT/IL2001/000806 IL0100806W WO0217985A3 WO 2002017985 A3 WO2002017985 A3 WO 2002017985A3 IL 0100806 W IL0100806 W IL 0100806W WO 0217985 A3 WO0217985 A3 WO 0217985A3
Authority
WO
WIPO (PCT)
Prior art keywords
production method
method therefor
protective layer
etching process
microneedle structure
Prior art date
Application number
PCT/IL2001/000806
Other languages
French (fr)
Other versions
WO2002017985A2 (en
Inventor
Yehoshua Yeshurun
Meir Hefetz
Boer Meint De
J W Berenschot
J G E Gardeniers
Original Assignee
Nanopass Ltd
Yehoshua Yeshurun
Meir Hefetz
Boer Meint De
J W Berenschot
J G E Gardeniers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL13813100A external-priority patent/IL138131A0/en
Application filed by Nanopass Ltd, Yehoshua Yeshurun, Meir Hefetz, Boer Meint De, J W Berenschot, J G E Gardeniers filed Critical Nanopass Ltd
Priority to US10/362,835 priority Critical patent/US7648484B2/en
Priority to AU8248901A priority patent/AU8248901A/en
Priority to CA002420859A priority patent/CA2420859C/en
Priority to AU2001282489A priority patent/AU2001282489B2/en
Priority to EP01961111.0A priority patent/EP1330274B1/en
Priority to JP2002522956A priority patent/JP4750347B2/en
Publication of WO2002017985A2 publication Critical patent/WO2002017985A2/en
Publication of WO2002017985A3 publication Critical patent/WO2002017985A3/en
Priority to US12/651,485 priority patent/US7850657B2/en
Priority to US12/958,437 priority patent/US8454844B2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00436—Shaping materials, i.e. techniques for structuring the substrate or the layers on the substrate
    • B81C1/005—Bulk micromachining
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2203/00—Basic microelectromechanical structures
    • B81B2203/03—Static structures
    • B81B2203/0361—Tips, pillars

Abstract

A method for processing a wafer to form a plurality of hollow microneedles projecing from a substrate includes forming, by use of a dry etching process, a number of groups of recessed features, each including at least one slot deployed to form an open shape having an included area and at least one hole located within the included area. The internal surfaces of the holes and the slots are then coated with a protective layer. An anisotropic wet etching process is then performed in such a manner as to remove material from outside the included areas while leaving a projecting feature within each of the included areas. The protective layer is then removed to reveal the microneedles.
PCT/IL2001/000806 2000-08-28 2001-08-28 Microneedle structure and production method therefor WO2002017985A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US10/362,835 US7648484B2 (en) 2000-08-28 2001-08-28 Microneedle structure and production method therefor
AU8248901A AU8248901A (en) 2000-08-28 2001-08-28 Microneedle structure and production method therefor
CA002420859A CA2420859C (en) 2000-08-28 2001-08-28 Microneedle structure and production method therefor
AU2001282489A AU2001282489B2 (en) 2000-08-28 2001-08-28 Microneedle structure and production method therefor
EP01961111.0A EP1330274B1 (en) 2000-08-28 2001-08-28 Microneedle structure and production method therefor
JP2002522956A JP4750347B2 (en) 2000-08-28 2001-08-28 Microneedle structure and manufacturing method thereof
US12/651,485 US7850657B2 (en) 2000-08-28 2010-01-04 Microneedle structure and production method therefor
US12/958,437 US8454844B2 (en) 2000-08-28 2010-12-02 Microneedle structure and production method therefor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IL13813100A IL138131A0 (en) 2000-08-28 2000-08-28 Microneedle structure and production method therefor
IL138131 2000-08-28
US09/677,175 US6533949B1 (en) 2000-08-28 2000-10-02 Microneedle structure and production method therefor
US09/677,175 2000-10-02

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/677,175 Continuation-In-Part US6533949B1 (en) 2000-08-28 2000-10-02 Microneedle structure and production method therefor

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10362835 A-371-Of-International 2001-08-28
US12/651,485 Continuation US7850657B2 (en) 2000-08-28 2010-01-04 Microneedle structure and production method therefor

Publications (2)

Publication Number Publication Date
WO2002017985A2 WO2002017985A2 (en) 2002-03-07
WO2002017985A3 true WO2002017985A3 (en) 2003-01-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2001/000806 WO2002017985A2 (en) 2000-08-28 2001-08-28 Microneedle structure and production method therefor

Country Status (6)

Country Link
US (4) US6533949B1 (en)
EP (1) EP1330274B1 (en)
JP (1) JP4750347B2 (en)
AU (2) AU8248901A (en)
CA (1) CA2420859C (en)
WO (1) WO2002017985A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient

Families Citing this family (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6964804B2 (en) * 2001-02-14 2005-11-15 Shipley Company, L.L.C. Micromachined structures made by combined wet and dry etching
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US20020195417A1 (en) * 2001-04-20 2002-12-26 Steinberg Dan A. Wet and dry etching process on <110> silicon and resulting structures
DE60238119D1 (en) 2001-06-12 2010-12-09 Pelikan Technologies Inc ELECTRIC ACTUATOR ELEMENT FOR A LANZETTE
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
EP1404232B1 (en) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Blood sampling apparatus and method
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7699791B2 (en) 2001-06-12 2010-04-20 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7316700B2 (en) 2001-06-12 2008-01-08 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US7749174B2 (en) 2001-06-12 2010-07-06 Pelikan Technologies, Inc. Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US8740973B2 (en) * 2001-10-26 2014-06-03 Icon Medical Corp. Polymer biodegradable medical device
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
WO2003074102A2 (en) 2002-03-04 2003-09-12 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
CA2478329C (en) * 2002-03-11 2013-04-30 Becton, Dickinson And Company System and method for the manufacture of surgical blades
US7387742B2 (en) * 2002-03-11 2008-06-17 Becton, Dickinson And Company Silicon blades for surgical and non-surgical use
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) * 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
BR0312671A (en) 2002-07-19 2005-04-26 3M Innovative Properties Co Micro-needle device, method for using a micro-needle device, and method for applying a micro-needle device
US7045069B2 (en) * 2002-11-14 2006-05-16 Gennady Ozeryansky Microfabrication method based on metal matrix composite technology
US7265881B2 (en) * 2002-12-20 2007-09-04 Hewlett-Packard Development Company, L.P. Method and apparatus for measuring assembly and alignment errors in sensor assemblies
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
DE10305831B4 (en) 2003-02-12 2007-01-04 Siemens Ag diagnostic device
US20050155955A1 (en) * 2003-03-10 2005-07-21 Daskal Vadim M. Method for reducing glare and creating matte finish of controlled density on a silicon surface
US20090007436A1 (en) * 2003-03-10 2009-01-08 Daskal Vadim M Silicon blades for surgical and non-surgical use
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
US8262614B2 (en) 2003-05-30 2012-09-11 Pelikan Technologies, Inc. Method and apparatus for fluid injection
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
BRPI0413360A (en) * 2003-08-04 2006-10-10 Alza Corp method and device for increasing the flow of transdermal agents
AU2004268616B2 (en) * 2003-08-25 2010-10-07 3M Innovative Properties Company Delivery of immune response modifier compounds
US20050107742A1 (en) * 2003-09-15 2005-05-19 The Regents Of The University Of Michigan Shatter-resistant microprobes
JP2007514457A (en) * 2003-09-17 2007-06-07 ベクトン・ディキンソン・アンド・カンパニー System and method for creating straight and non-linear grooves using routers in silicon and other crystalline materials
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
CN100571643C (en) * 2003-10-31 2009-12-23 阿尔扎公司 The self-driven applicator that is used for microprotrusion array
US7998119B2 (en) * 2003-11-18 2011-08-16 Nano Pass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
EP1699524A4 (en) * 2003-11-18 2009-07-15 Nanopass Technologies Ltd Enhanced penetration system and method for sliding microneedles
US7753888B2 (en) * 2003-11-21 2010-07-13 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
CN100355470C (en) * 2003-12-26 2007-12-19 中国科学院理化技术研究所 Minisize solid silicon needle array chip and its preparation method and use
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
GB0402131D0 (en) * 2004-01-30 2004-03-03 Isis Innovation Delivery method
US8551391B2 (en) * 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
WO2005082596A1 (en) * 2004-02-23 2005-09-09 3M Innovative Properties Company Method of molding for microneedle arrays
US20050256499A1 (en) * 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
JP4500851B2 (en) * 2004-03-12 2010-07-14 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ Method and mold for use in manufacturing microneedles with side holes
US7396484B2 (en) * 2004-04-30 2008-07-08 Becton, Dickinson And Company Methods of fabricating complex blade geometries from silicon wafers and strengthening blade geometries
WO2006011062A2 (en) 2004-05-20 2006-02-02 Albatros Technologies Gmbh & Co. Kg Printable hydrogel for biosensors
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc Method and apparatus for a fluid sampling device
US9775553B2 (en) * 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
TWI246929B (en) * 2004-07-16 2006-01-11 Ind Tech Res Inst Microneedle array device and its fabrication method
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
WO2006022933A2 (en) * 2004-08-05 2006-03-02 Apogee Technologies, Inc. System and method for drug delivery and microfluidic applications using microneedles
ATE490037T1 (en) 2004-08-16 2010-12-15 Functional Microstructures Ltd METHOD FOR PRODUCING A MICRONEEDLE OR A MICROIMPLANT
US7785459B2 (en) 2004-10-22 2010-08-31 Hewlett-Packard Development Company, L.P. Microneedles and methods of fabricating
US7455688B2 (en) * 2004-11-12 2008-11-25 Con Interventional Systems, Inc. Ostial stent
US9339403B2 (en) * 2004-11-12 2016-05-17 Icon Medical Corp. Medical adhesive for medical devices
EP1819379B1 (en) * 2004-11-18 2016-08-31 Nanopass Technologies Ltd. System for delivering fluid into flexible biological barrier
CA2589733C (en) 2004-12-07 2014-02-11 3M Innovative Properties Company Method of molding a microneedle
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US9107899B2 (en) 2005-03-03 2015-08-18 Icon Medical Corporation Metal alloys for medical devices
US7540995B2 (en) 2005-03-03 2009-06-02 Icon Medical Corp. Process for forming an improved metal alloy stent
US20060198869A1 (en) * 2005-03-03 2006-09-07 Icon Medical Corp. Bioabsorable medical devices
US7452502B2 (en) * 2005-03-03 2008-11-18 Icon Medical Corp. Metal alloy for a stent
EP1858440B1 (en) * 2005-03-03 2024-04-24 MiRus LLC Improved metal alloys for medical device
US8323333B2 (en) * 2005-03-03 2012-12-04 Icon Medical Corp. Fragile structure protective coating
WO2006110197A2 (en) * 2005-03-03 2006-10-19 Icon Medical Corp. Polymer biodegradable medical device
JP4793806B2 (en) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 Iontophoresis device
WO2006101459A1 (en) * 2005-03-23 2006-09-28 Agency For Science, Technology And Research Microneedles
EP1869414A4 (en) * 2005-03-29 2010-07-28 Arkal Medical Inc Devices, systems, methods and tools for continuous glucose monitoring
JP2008543528A (en) 2005-06-27 2008-12-04 スリーエム イノベイティブ プロパティズ カンパニー Microneedle cartridge assembly and application method
JPWO2007032446A1 (en) * 2005-09-15 2009-03-19 Ｔｔｉ・エルビュー株式会社 Rod iontophoresis device
US20070073212A1 (en) * 2005-09-28 2007-03-29 Takehiko Matsumura Iontophoresis apparatus and method to deliver active agents to biological interfaces
EP1931420A2 (en) * 2005-09-30 2008-06-18 Tti Ellebeau, Inc. Iontophoresis device to deliver multiple active agents to biological interfaces
WO2007041323A1 (en) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoretic delivery of vesicle-encapsulated active agents
KR20080080087A (en) * 2005-09-30 2008-09-02 티티아이 엘뷰 가부시키가이샤 Transdermal drug delivery systems, devices, and methods employing novel pharmaceutical vehicles
KR20080066712A (en) * 2005-09-30 2008-07-16 티티아이 엘뷰 가부시키가이샤 Functionalized microneedles transdermal drug delivery systems, devices, and methods
JP2009509634A (en) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 Functionalized microneedle transdermal drug delivery system, apparatus and method
US20070093789A1 (en) * 2005-09-30 2007-04-26 Transcutaneous Technologies Inc. Iontophoresis apparatus and method for delivery of angiogenic factors to enhance healing of injured tissue
JP2009509657A (en) * 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 Iontophoresis device and method for delivery of active agents to biological interfaces
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
EP2559448B1 (en) 2005-12-08 2017-05-31 Nanopass Technologies Ltd. Microneedle adapter for dosed drug delivery devices
WO2007070004A2 (en) 2005-12-14 2007-06-21 Silex Microsystems Ab Methods for making micro needles and applications thereof
US20080033338A1 (en) * 2005-12-28 2008-02-07 Smith Gregory A Electroosmotic pump apparatus and method to deliver active agents to biological interfaces
JP2009522011A (en) * 2005-12-30 2009-06-11 Ｔｔｉ・エルビュー株式会社 Iontophoresis system, apparatus and method for delivering an active substance to a biological interface
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US20100168501A1 (en) * 2006-10-02 2010-07-01 Daniel Rogers Burnett Method and apparatus for magnetic induction therapy
US9610459B2 (en) * 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20080004564A1 (en) * 2006-03-30 2008-01-03 Transcutaneous Technologies Inc. Controlled release membrane and methods of use
CN1830496A (en) * 2006-04-10 2006-09-13 清华大学 '-'-shaped structure three-dimensional micre solid, hollow silicone meedle orknife
DE102006028781A1 (en) * 2006-06-23 2007-12-27 Robert Bosch Gmbh Process for making porous microneedles and their use
WO2008007370A2 (en) * 2006-07-11 2008-01-17 Nanopass Technologies Ltd. Dual chamber injector intergrated with micro-needles
US20080015516A1 (en) * 2006-07-12 2008-01-17 Nanopass Technologies Ltd. Microneedle Devices With Controlled Uncapping
WO2008008291A2 (en) * 2006-07-13 2008-01-17 Icon Medical Corp. Stent
WO2008027011A1 (en) * 2006-08-28 2008-03-06 Agency For Science, Technology And Research Microneedles and methods for fabricating microneedles
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
KR20090064422A (en) * 2006-09-05 2009-06-18 티티아이 엘뷰 가부시키가이샤 Transdermal drug delivery systems, devices, and methods using inductive power supplies
WO2008036043A1 (en) * 2006-09-18 2008-03-27 Agency For Science, Technology And Research Needle structures and methods for fabricating needle structures
EP2069013A2 (en) * 2006-10-02 2009-06-17 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US20080091226A1 (en) * 2006-10-17 2008-04-17 Nanopass Technologies Ltd. Microneedle device
EP2061551A2 (en) * 2006-12-01 2009-05-27 TTI ellebeau, Inc. Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices
WO2008114252A2 (en) * 2007-03-18 2008-09-25 Nanopass Technologies Ltd Microneedle structures and corresponding production methods employing a backside wet etch
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
EP2149149A2 (en) * 2007-05-20 2010-02-03 Nanopass Technologies Ltd. Method for producing microneedle structures employing one-sided processing
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
MX2009013118A (en) * 2007-06-14 2010-03-04 Crucell Switzerland Ag Intradermal influenza vaccine.
WO2009064380A2 (en) 2007-11-09 2009-05-22 California Institute Of Technology Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion
GB0802447D0 (en) 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
EP2265324B1 (en) 2008-04-11 2015-01-28 Sanofi-Aventis Deutschland GmbH Integrated analyte measurement system
EP2381972A2 (en) * 2009-01-27 2011-11-02 California Institute Of Technology Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
EP2275164A1 (en) 2009-07-15 2011-01-19 Debiotech S.A. Multichannel micro-needles
CA2768835A1 (en) * 2009-07-23 2011-01-27 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
AU2010313487A1 (en) 2009-10-26 2012-05-24 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
US8398916B2 (en) 2010-03-04 2013-03-19 Icon Medical Corp. Method for forming a tubular medical device
WO2011127207A2 (en) 2010-04-07 2011-10-13 California Institute Of Technology Simple method for producing superhydrophobic carbon nanotube array
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
JP6327852B2 (en) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド Methods and devices for transdermal delivery of parathyroid hormone using microprojection arrays
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
KR101180032B1 (en) 2010-07-12 2012-09-05 인싸이토(주) Method for manufacturing Hollow Microneedle with Controlled External Appearance Characteristics
US8609458B2 (en) 2010-12-10 2013-12-17 California Institute Of Technology Method for producing graphene oxide with tunable gap
WO2012135238A1 (en) 2011-03-29 2012-10-04 California Institute Of Technology Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles
WO2013053022A1 (en) 2011-10-12 2013-04-18 The University Of Queensland Delivery device
US20130110043A1 (en) 2011-10-26 2013-05-02 Nanopass Technologies Ltd. Microneedle Intradermal Drug Delivery Device with Auto-Disable Functionality
US8764681B2 (en) 2011-12-14 2014-07-01 California Institute Of Technology Sharp tip carbon nanotube microneedle devices and their fabrication
EP2806939A2 (en) 2012-01-24 2014-12-03 Nanopass Technologies Ltd. Microneedle adapter for dosed drug delivery devices
WO2013166162A1 (en) 2012-05-01 2013-11-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
US9349543B2 (en) 2012-07-30 2016-05-24 California Institute Of Technology Nano tri-carbon composite systems and manufacture
WO2014059104A1 (en) 2012-10-10 2014-04-17 3M Innovative Properties Company Applicator and method for applying a microneedle device to skin
WO2014058746A1 (en) 2012-10-10 2014-04-17 3M Innovative Properties Company Force-controlled applicator for applying a microneedle device to skin
US9789299B2 (en) 2012-11-16 2017-10-17 3M Innovative Properties Company Force-controlled applicator for applying a microneedle device to skin
CN114176586A (en) 2012-12-14 2022-03-15 明德拉公司 Method and apparatus for detecting and acquiring biomarkers
JP6865524B2 (en) 2012-12-21 2021-04-28 コリウム， インコーポレイテッド Microarrays and usages for delivering therapeutic agents
WO2014105458A1 (en) * 2012-12-27 2014-07-03 3M Innovative Properties Company Article with hollow microneedles and method of making
WO2014110016A1 (en) 2013-01-08 2014-07-17 3M Innovative Properties Company Applicator for applying a microneedle device to skin
US10245422B2 (en) 2013-03-12 2019-04-02 Corium International, Inc. Microprojection applicators and methods of use
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
CN105246458B (en) 2013-03-15 2020-09-15 考里安公司 Microarrays for therapeutic agent delivery and methods of use thereof
CA2903583C (en) 2013-03-15 2021-12-28 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
EP2968751B1 (en) 2013-03-15 2022-11-30 Corium, Inc. Multiple impact microprojection applicators
US20160271380A1 (en) 2013-03-22 2016-09-22 3M Innovative Properties Company Microneedle applicator comprising a counter assembly
JP6494601B2 (en) 2013-05-31 2019-04-03 スリーエム イノベイティブ プロパティズ カンパニー Microneedle injection and injection device and method of use thereof
US9682222B2 (en) 2013-05-31 2017-06-20 3M Innovative Properties Company Microneedle injection apparatus comprising an inverted actuator
SG11201509722PA (en) 2013-05-31 2015-12-30 3M Innovative Properties Co Microneedle injection apparatus comprising a dual cover
US10099043B2 (en) 2013-07-16 2018-10-16 3M Innovative Properties Company Hollow microneedle array article
US10384047B2 (en) 2013-07-16 2019-08-20 3M Innovative Properties Company Hollow microneedle with bevel opening
CN105407957A (en) 2013-07-16 2016-03-16 3M创新有限公司 Article comprising a microneedle
US10232157B2 (en) 2013-07-16 2019-03-19 3M Innovative Properties Company Hollow microneedle with beveled tip
CN106535826A (en) 2014-06-24 2017-03-22 怡康医疗股份有限公司 Improved metal alloys for medical devices
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
WO2016118459A1 (en) 2015-01-21 2016-07-28 3M Innovative Properties Company Microneedle array and method of use
WO2016122915A1 (en) 2015-01-27 2016-08-04 3M Innovative Properties Company Alum-containing coating formulations for microneedle vaccine patches
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
US10828429B2 (en) 2015-10-27 2020-11-10 Nanopass Technologies Ltd. Microneedle device with mechanical guide
CN108430564B (en) * 2015-12-04 2022-01-11 艾希莱恩公司 Microneedle and chip
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
US11766506B2 (en) 2016-03-04 2023-09-26 Mirus Llc Stent device for spinal fusion
KR101942172B1 (en) 2017-01-11 2019-01-24 가천대학교 산학협력단 Micro-needles, mamufacture apparatus thereof and method of mamufacture using them
ES2960937T3 (en) 2017-03-31 2024-03-07 Vaxxas Pty Ltd Device and method for coating surfaces
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
EP3638207A1 (en) 2017-06-15 2020-04-22 Infectious Disease Research Institute Nanostructured lipid carriers and stable emulsions and uses thereof
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
CN111212675B (en) 2017-10-17 2022-01-25 3M创新有限公司 Applicator for applying microneedle arrays to skin
KR20190065003A (en) 2017-12-01 2019-06-11 가천대학교 산학협력단 Micro-needles and method of mamufacture
KR102208178B1 (en) 2017-12-01 2021-01-28 가천대학교 산학협력단 Micro-needles and method of mamufacture
US20210228119A1 (en) 2018-05-16 2021-07-29 Kindeva Drug Delivery L.P. Microneedle biosensor
US10980993B2 (en) 2018-10-31 2021-04-20 Gachon University Of Industry-Academic Cooperation Foundation Microneedle, apparatus for manufacturing microneedle, and method of manufacturing microneedle using apparatus
US10940554B2 (en) 2018-11-30 2021-03-09 International Business Machines Corporation Planar fabrication of micro-needles
WO2021097347A1 (en) 2019-11-15 2021-05-20 Infectious Disease Research Institute Rig-i agonist and adjuvant formulation for tumor treatment
US11291818B2 (en) * 2020-04-01 2022-04-05 Nanopass Technologies Ltd. Microneedle structure for intradermal injection
CA3173941A1 (en) 2020-09-04 2022-03-10 Emily VOIGT Live-attenuated rna hybrid vaccine technology
WO2022051024A1 (en) 2020-09-04 2022-03-10 Infectious Disease Research Institute Genetically-adjuvanted rna vaccines
AU2021337493A1 (en) 2020-09-04 2023-05-18 Access To Advanced Health Institute Co-lyophilized rna and nanostructured lipid carrier
US11717660B2 (en) 2021-07-29 2023-08-08 Nanopass Technologies Ltd. Silicon microneedle structure and production method
WO2024052882A1 (en) 2022-09-09 2024-03-14 Access To Advanced Health Institute Immunogenic vaccine composition incorporating a saponin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064580A1 (en) * 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
WO2001049362A1 (en) * 2000-01-06 2001-07-12 The Regents Of The University Of California Method of forming vertical, hollow needles within a semiconductor substrate
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2409979A (en) * 1946-03-14 1946-10-22 Ralph L Huber Hypodermic needle
US3074403A (en) * 1960-05-17 1963-01-22 American Cyanamid Co Intracutaneous injector with capillary gap
DE2250293A1 (en) * 1972-10-13 1974-04-25 Bayern Freistaat Inoculation stamps for cutaneous smallpox inoculation using dry vaccine
US4561445A (en) * 1983-05-25 1985-12-31 Joseph J. Berke Elongated needle electrode and method of making same
US4969468A (en) * 1986-06-17 1990-11-13 Alfred E. Mann Foundation For Scientific Research Electrode array for use in connection with a living body and method of manufacture
US5468562A (en) * 1991-03-01 1995-11-21 Spire Corporation Metallized polymeric implant with ion embedded coating
US5478328A (en) * 1992-05-22 1995-12-26 Silverman; David G. Methods of minimizing disease transmission by used hypodermic needles, and hypodermic needles adapted for carrying out the method
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
AU4256496A (en) * 1994-12-09 1996-06-26 Novartis Ag Transdermal system
DE19525607A1 (en) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneal drug delivery system
US5801057A (en) 1996-03-22 1998-09-01 Smart; Wilson H. Microsampling device and method of construction
IE80772B1 (en) * 1996-06-10 1999-02-10 Elan Corp Plc Delivery needle
US6629963B2 (en) * 1996-06-20 2003-10-07 Becton, Dickinson And Company Syringe and needle shield assembly and method of sterilizing such assembly
US5928207A (en) 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815820D0 (en) * 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
US7048723B1 (en) * 1998-09-18 2006-05-23 The University Of Utah Research Foundation Surface micromachined microneedles
GB9911609D0 (en) 1999-05-20 1999-07-21 Advanced Biotech Ltd Improved multi-well plates
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6375627B1 (en) * 2000-03-02 2002-04-23 Agilent Technologies, Inc. Physiological fluid extraction with rapid analysis
US6558361B1 (en) 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
EP1311310A4 (en) * 2000-08-21 2004-11-24 Cleveland Clinic Foundation Microneedle array module and method of fabricating the same
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6767341B2 (en) * 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US7753888B2 (en) * 2003-11-21 2010-07-13 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
TWI246929B (en) * 2004-07-16 2006-01-11 Ind Tech Res Inst Microneedle array device and its fabrication method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064580A1 (en) * 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
WO2001049362A1 (en) * 2000-01-06 2001-07-12 The Regents Of The University Of California Method of forming vertical, hollow needles within a semiconductor substrate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHUN K. ET AL.: "An array of hollow microcapillaries for the controlled injection of genetic materials into animal/plant cells", MEMS 1999, January 1999 (1999-01-01), ORLANDO FL, pages 406 - 411, XP010321695 *
See also references of EP1330274A4 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9452280B2 (en) 2007-04-16 2016-09-27 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9498524B2 (en) 2007-04-16 2016-11-22 Corium International, Inc. Method of vaccine delivery via microneedle arrays

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US8454844B2 (en) 2013-06-04
US7850657B2 (en) 2010-12-14
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