WO2002018324A3 - Immunoregulatory compounds, derivatives thereof and their use - Google Patents

Immunoregulatory compounds, derivatives thereof and their use Download PDF

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Publication number
WO2002018324A3
WO2002018324A3 PCT/US2001/026697 US0126697W WO0218324A3 WO 2002018324 A3 WO2002018324 A3 WO 2002018324A3 US 0126697 W US0126697 W US 0126697W WO 0218324 A3 WO0218324 A3 WO 0218324A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
hydrogen
compounds
group
derivatives
Prior art date
Application number
PCT/US2001/026697
Other languages
French (fr)
Other versions
WO2002018324A2 (en
Inventor
Nnochiri N Ekwuribe
Jennifer Riggs-Sauthier
Original Assignee
Nobex Corp
Nnochiri N Ekwuribe
Jennifer Riggs-Sauthier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002420576A priority Critical patent/CA2420576C/en
Priority to IL15453601A priority patent/IL154536A0/en
Application filed by Nobex Corp, Nnochiri N Ekwuribe, Jennifer Riggs-Sauthier filed Critical Nobex Corp
Priority to DK05024822T priority patent/DK1642885T3/en
Priority to AU8531101A priority patent/AU8531101A/en
Priority to MXPA03001787A priority patent/MXPA03001787A/en
Priority to EP01964460A priority patent/EP1313697B1/en
Priority to DE60115465T priority patent/DE60115465T2/en
Priority to AU2001285311A priority patent/AU2001285311B2/en
Priority to JP2002523442A priority patent/JP4163946B2/en
Priority to AT01964460T priority patent/ATE311358T1/en
Publication of WO2002018324A2 publication Critical patent/WO2002018324A2/en
Publication of WO2002018324A3 publication Critical patent/WO2002018324A3/en
Priority to IL154536A priority patent/IL154536A/en
Priority to HK03106194A priority patent/HK1054221A1/en
Priority to AU2005244526A priority patent/AU2005244526B2/en
Priority to IL205420A priority patent/IL205420A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Compounds are disclosed having the structure of Formula (I), where R?1, R3, and R4¿ are independently hydrogen or C¿1? to C4 alkyl, and R?2¿ is (II), where R5 is selected from the group consisting of hydrogen and C¿1? to C4 alkyl, or (III), where R?6, R7 and R8¿ are independently hydrogen or C¿1? to C4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed (IV), where R?9, R10 and R11¿ are independently selected from the group consisting of hydrogen and C¿1? to C4 alkyl, and R?12¿ is selected from the group consisting of hydrogen and -C(O)R13, where R13 is a C¿1? to C6 alkyl or an aryl group.
PCT/US2001/026697 2000-08-29 2001-08-28 Immunoregulatory compounds, derivatives thereof and their use WO2002018324A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP2002523442A JP4163946B2 (en) 2000-08-29 2001-08-28 Immunomodulatory compounds and derivatives thereof and methods of treating diseases using the same
AU2001285311A AU2001285311B2 (en) 2000-08-29 2001-08-28 Immunoregulatory compounds, derivatives thereof and their use
DK05024822T DK1642885T3 (en) 2000-08-29 2001-08-28 Use of a pharmaceutical composition containing a para-aminophenyl acetic acid derivative for the treatment of inflammatory conditions of the gastrointestinal tract
IL15453601A IL154536A0 (en) 2000-08-29 2001-08-28 Immunoregulatory compounds and derivatives and methods of treating diseases therewith
MXPA03001787A MXPA03001787A (en) 2000-08-29 2001-08-28 Immunoregulatory compounds, derivatives thereof and their use.
EP01964460A EP1313697B1 (en) 2000-08-29 2001-08-28 Immunoregulatory compounds, derivatives thereof and their use
AT01964460T ATE311358T1 (en) 2000-08-29 2001-08-28 IMMUNO-REGULATING COMPOUNDS, THEIR DERIVATIVES AND THEIR USE
CA002420576A CA2420576C (en) 2000-08-29 2001-08-28 Immunoregulatory compounds, derivatives thereof and their use
AU8531101A AU8531101A (en) 2000-08-29 2001-08-28 Immunoregulatory compounds and derivatives and methods of treating diseases therewith
DE60115465T DE60115465T2 (en) 2000-08-29 2001-08-28 IMMUNO-REGULATING COMPOUNDS, DERIVATIVES AND THEIR USE
IL154536A IL154536A (en) 2000-08-29 2003-02-19 Immunoregulatory compounds and derivatives
HK03106194A HK1054221A1 (en) 2000-08-29 2003-08-29 Immunoregulatory compounds, derivatives thereof and their use
AU2005244526A AU2005244526B2 (en) 2000-08-29 2005-12-14 Immunoregulatory Compounds and Derivatives and methods of treating diseases therewith
IL205420A IL205420A (en) 2000-08-29 2010-04-28 Immunoregulatory compounds and derivatives, pharmaceutical compositions and use thereof in treating inflammatory conditions of the gastrointestinal tract

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22868300P 2000-08-29 2000-08-29
US60/228,683 2000-08-29

Publications (2)

Publication Number Publication Date
WO2002018324A2 WO2002018324A2 (en) 2002-03-07
WO2002018324A3 true WO2002018324A3 (en) 2002-08-29

Family

ID=22858180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026697 WO2002018324A2 (en) 2000-08-29 2001-08-28 Immunoregulatory compounds, derivatives thereof and their use

Country Status (16)

Country Link
US (5) US6583128B2 (en)
EP (2) EP1642885B1 (en)
JP (1) JP4163946B2 (en)
AT (2) ATE448194T1 (en)
AU (3) AU2001285311B2 (en)
CA (2) CA2420576C (en)
CY (1) CY1110593T1 (en)
DE (2) DE60140491D1 (en)
DK (2) DK1313697T3 (en)
ES (2) ES2333337T3 (en)
HK (2) HK1054221A1 (en)
IL (3) IL154536A0 (en)
MX (1) MXPA03001787A (en)
PT (1) PT1642885E (en)
TW (1) TWI249519B (en)
WO (1) WO2002018324A2 (en)

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