WO2002018444A3 - Erbb4 antagonists - Google Patents

Erbb4 antagonists Download PDF

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Publication number
WO2002018444A3
WO2002018444A3 PCT/US2001/026984 US0126984W WO0218444A3 WO 2002018444 A3 WO2002018444 A3 WO 2002018444A3 US 0126984 W US0126984 W US 0126984W WO 0218444 A3 WO0218444 A3 WO 0218444A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonists
erbb4
migration
smooth muscle
muscle cells
Prior art date
Application number
PCT/US2001/026984
Other languages
French (fr)
Other versions
WO2002018444A2 (en
Inventor
Mary E Gerritsen
Mark X Sliwkowski
Original Assignee
Genentech Inc
Mary E Gerritsen
Mark X Sliwkowski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/362,380 priority Critical patent/US7332579B2/en
Priority to JP2002523958A priority patent/JP2004507559A/en
Application filed by Genentech Inc, Mary E Gerritsen, Mark X Sliwkowski filed Critical Genentech Inc
Priority to IL15449501A priority patent/IL154495A0/en
Priority to AU2001286918A priority patent/AU2001286918B2/en
Priority to CA2420062A priority patent/CA2420062C/en
Priority to EP01966399A priority patent/EP1351744B1/en
Priority to DK01966399T priority patent/DK1351744T3/en
Priority to DE60130797T priority patent/DE60130797T2/en
Priority to AU8691801A priority patent/AU8691801A/en
Publication of WO2002018444A2 publication Critical patent/WO2002018444A2/en
Priority to IL154495A priority patent/IL154495A/en
Publication of WO2002018444A3 publication Critical patent/WO2002018444A3/en
Priority to HK04102271A priority patent/HK1059404A1/en
Priority to US11/581,221 priority patent/US20070092513A1/en
Priority to US12/215,200 priority patent/US7704498B2/en
Priority to US12/753,792 priority patent/US20100190964A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061—Muscle cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.
PCT/US2001/026984 2000-09-01 2001-08-29 Erbb4 antagonists WO2002018444A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
AU8691801A AU8691801A (en) 2000-09-01 2001-08-29 Erbb4 antagonists
DE60130797T DE60130797T2 (en) 2000-09-01 2001-08-29 USE OF SPECIFIC ERBB4 ANTAGONISTS FOR THE TREATMENT OF STENOSIS
IL15449501A IL154495A0 (en) 2000-09-01 2001-08-29 Erbb4 antagonists
JP2002523958A JP2004507559A (en) 2000-09-01 2001-08-29 ErbB4 antagonist
CA2420062A CA2420062C (en) 2000-09-01 2001-08-29 Erbb4 antagonists
EP01966399A EP1351744B1 (en) 2000-09-01 2001-08-29 Use of specific erbb4 antagonists for treating stenosis
DK01966399T DK1351744T3 (en) 2000-09-01 2001-08-29 Use of specific ErbB4 antagonists for the treatment of stenosis
US10/362,380 US7332579B2 (en) 2000-09-01 2001-08-29 Antibodies to human ErbB4
AU2001286918A AU2001286918B2 (en) 2000-09-01 2001-08-29 ErbB4 antagonists
IL154495A IL154495A (en) 2000-09-01 2003-02-17 USE OF AN ANTAGONIST SPECIFIC FOR A NATIVE ErbB4 RECEPTOR IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF STENOSIS
HK04102271A HK1059404A1 (en) 2000-09-01 2004-03-27 Use of specific erbb4 antagonists for treating stenosis
US11/581,221 US20070092513A1 (en) 2000-09-01 2006-10-13 ErbB4 antagonists
US12/215,200 US7704498B2 (en) 2000-09-01 2008-06-24 ErbB4 antagonists
US12/753,792 US20100190964A1 (en) 2000-09-01 2010-04-02 Antibodies to human ErbB4

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22967900P 2000-09-01 2000-09-01
US60/229,679 2000-09-01
US26551601P 2001-01-31 2001-01-31
US60/265,516 2001-01-31
US09/940,101 2001-08-27
US09/940,101 US20020119148A1 (en) 2000-09-01 2001-08-27 ErbB4 antagonists

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/940,101 Continuation US20020119148A1 (en) 2000-09-01 2001-08-27 ErbB4 antagonists

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10362380 A-371-Of-International 2001-08-29
US11/581,221 Continuation US20070092513A1 (en) 2000-09-01 2006-10-13 ErbB4 antagonists

Publications (2)

Publication Number Publication Date
WO2002018444A2 WO2002018444A2 (en) 2002-03-07
WO2002018444A3 true WO2002018444A3 (en) 2003-07-31

Family

ID=27397993

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026984 WO2002018444A2 (en) 2000-09-01 2001-08-29 Erbb4 antagonists

Country Status (12)

Country Link
US (6) US20020119148A1 (en)
EP (1) EP1351744B1 (en)
JP (1) JP2004507559A (en)
AT (1) ATE374642T1 (en)
AU (2) AU2001286918B2 (en)
CA (1) CA2420062C (en)
DE (1) DE60130797T2 (en)
DK (1) DK1351744T3 (en)
ES (1) ES2295202T3 (en)
HK (1) HK1059404A1 (en)
IL (2) IL154495A0 (en)
WO (1) WO2002018444A2 (en)

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US8505468B2 (en) * 2002-11-19 2013-08-13 Sharp Kabushiki Kaisha Substrate accommodating tray
JP4527388B2 (en) * 2003-12-11 2010-08-18 東洋鋼鈑株式会社 Method for detecting interaction between polypeptide and receptor, method for screening for ligand or ligand variant using the method for detection, and diagnostic method for using the method for detection
KR20120064120A (en) 2004-06-01 2012-06-18 제넨테크, 인크. Antibody drug conjugates and methods
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
NZ580115A (en) 2004-09-23 2010-10-29 Genentech Inc Cysteine engineered antibody light chains and conjugates
AU2006220719A1 (en) * 2005-03-07 2006-09-14 Ligacept, Llc Tyrosine kinase inhibitor compositions and methods for manufacturing and using them in the treatment of disease
SG178789A1 (en) * 2007-02-16 2012-03-29 Merrimack Pharmaceuticals Inc Antibodies against erbb3 and uses thereof
JP2011516423A (en) 2008-03-28 2011-05-26 シー レーン バイオテクノロジーズ， エルエルシー Neutralizing molecules against viral antigens
BRPI0917871A2 (en) * 2008-08-15 2017-06-20 Merrimack Pharmaceuticals Inc anti-erbb3 therapeutic agent for use in tumor therapy, methods for predicting tumor responsiveness of an anti-erbb3 therapeutic agent, for selecting anti-erbb3 therapy for a patient, for predicting cell response to treatment with a therapeutic agent , to identify a biomarker, and to prevent administration of an anti-erbb3 cancer drug, and kit to predict cell response to treatment with a therapeutic agent
DK2365987T3 (en) 2008-11-25 2015-01-12 Genentech Inc Isoform specific anti-HER4 antibodies
MA33198B1 (en) * 2009-03-20 2012-04-02 Genentech Inc ANTI-HER DI-SPECIFIC ANTIBODIES
EP2507381A4 (en) 2009-12-04 2016-07-20 Hoffmann La Roche Multispecific antibodies, antibody analogs, compositions, and methods
WO2011097603A1 (en) 2010-02-08 2011-08-11 Regeneron Pharmaceuticals, Inc. Common light chain mouse
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
WO2011107100A1 (en) 2010-03-03 2011-09-09 Aarhus Universitet Methods and compositions for regulation of herv4
US8895001B2 (en) 2010-03-11 2014-11-25 Merrimack Pharmaceuticals, Inc. Use of ErbB3 inhibitors in the treatment of triple negative and basal-like breast cancers
EP2640831A1 (en) 2010-11-17 2013-09-25 Sea Lane Biotechnologies,llc. Influenza virus neutralizing agents that mimic the binding site of an influenza neutralizing antibody
IL273982B2 (en) 2011-08-05 2023-03-01 Regeneron Pharma Humanized universal light chain mice
EP2748197A2 (en) 2011-08-26 2014-07-02 Merrimack Pharmaceuticals, Inc. Tandem fc bispecific antibodies
AR093378A1 (en) 2012-11-08 2015-06-03 Hoffmann La Roche BINDING PROTEINS OF ANTIGEN HER3 OF UNION TO THE FORK b OF HER3
US9725511B2 (en) * 2012-11-08 2017-08-08 Hoffmann-La Roche Inc. Anti-HER3/HER4 antibodies binding to the beta-hairpin of HER3 and the beta-hairpin of HER4
SG11201506451UA (en) 2013-03-06 2015-09-29 Merrimack Pharmaceuticals Inc Anti-c-met tandem fc bispecific antibodies
EP3087394A2 (en) 2013-12-27 2016-11-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
RU2016141307A (en) 2014-03-21 2018-04-24 Регенерон Фармасьютикалз, Инк. EXCELLENT HUMAN ANIMALS THAT MAKE SINGLE-DOMAIN BINDING PROTEINS
FR3020063A1 (en) * 2014-04-16 2015-10-23 Gamamabs Pharma ANTI-HER4 HUMAN ANTIBODY
JP6433511B2 (en) 2014-05-14 2018-12-05 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Anti-HER3 antibody binding to HER3 beta hairpin
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Also Published As

Publication number Publication date
US7704498B2 (en) 2010-04-27
IL154495A0 (en) 2003-09-17
US20070092513A1 (en) 2007-04-26
DK1351744T3 (en) 2008-02-11
IL154495A (en) 2009-12-24
AU8691801A (en) 2002-03-13
WO2002018444A2 (en) 2002-03-07
HK1059404A1 (en) 2004-07-02
EP1351744A2 (en) 2003-10-15
DE60130797T2 (en) 2008-08-07
US20090068205A1 (en) 2009-03-12
EP1351744B1 (en) 2007-10-03
US20040052786A1 (en) 2004-03-18
JP2004507559A (en) 2004-03-11
US20020119148A1 (en) 2002-08-29
CA2420062C (en) 2014-04-01
DE60130797D1 (en) 2007-11-15
ES2295202T3 (en) 2008-04-16
AU2001286918B2 (en) 2006-12-21
US20060093603A1 (en) 2006-05-04
US20100190964A1 (en) 2010-07-29
ATE374642T1 (en) 2007-10-15
US7332579B2 (en) 2008-02-19
CA2420062A1 (en) 2002-03-07

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