WO2002026265A3 - Pegylated interleukin-10 - Google Patents

Pegylated interleukin-10 Download PDF

Info

Publication number
WO2002026265A3
WO2002026265A3 PCT/US2001/042431 US0142431W WO0226265A3 WO 2002026265 A3 WO2002026265 A3 WO 2002026265A3 US 0142431 W US0142431 W US 0142431W WO 0226265 A3 WO0226265 A3 WO 0226265A3
Authority
WO
WIPO (PCT)
Prior art keywords
peg
pegylated
interleukin
mono
pegylated interleukin
Prior art date
Application number
PCT/US2001/042431
Other languages
French (fr)
Other versions
WO2002026265A2 (en
Inventor
Seoju Lee
David C Wylie
Susan V Cannon-Carlson
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to EP01977878A priority Critical patent/EP1324779B1/en
Priority to AT01977878T priority patent/ATE516820T1/en
Priority to AU2001296962A priority patent/AU2001296962A1/en
Publication of WO2002026265A2 publication Critical patent/WO2002026265A2/en
Publication of WO2002026265A3 publication Critical patent/WO2002026265A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10.
PCT/US2001/042431 2000-09-29 2001-09-28 Pegylated interleukin-10 WO2002026265A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01977878A EP1324779B1 (en) 2000-09-29 2001-09-28 Pegylated interleukin-10
AT01977878T ATE516820T1 (en) 2000-09-29 2001-09-28 PEGYLATED INTERLEUKIN 10
AU2001296962A AU2001296962A1 (en) 2000-09-29 2001-09-28 Pegylated interleukin-10

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23659600P 2000-09-29 2000-09-29
US60/236,596 2000-09-29

Publications (2)

Publication Number Publication Date
WO2002026265A2 WO2002026265A2 (en) 2002-04-04
WO2002026265A3 true WO2002026265A3 (en) 2003-01-23

Family

ID=22890150

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/042431 WO2002026265A2 (en) 2000-09-29 2001-09-28 Pegylated interleukin-10

Country Status (7)

Country Link
US (9) US7052686B2 (en)
EP (2) EP1324779B1 (en)
AT (1) ATE516820T1 (en)
AU (1) AU2001296962A1 (en)
ES (1) ES2367891T3 (en)
HK (1) HK1154874A1 (en)
WO (1) WO2002026265A2 (en)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7303760B2 (en) 1999-04-23 2007-12-04 Alza Corporation Method for treating multi-drug resistant tumors
US7238368B2 (en) 1999-04-23 2007-07-03 Alza Corporation Releasable linkage and compositions containing same
US6342244B1 (en) 1999-04-23 2002-01-29 Alza Corporation Releasable linkage and compositions containing same
EP1324779B1 (en) 2000-09-29 2011-07-20 Schering Corporation Pegylated interleukin-10
PL213322B1 (en) * 2002-01-18 2013-02-28 Biogen Idec Inc Polyalkylene polymer compounds and uses thereof
AU2003280315A1 (en) * 2002-11-14 2004-06-03 Maxygen, Inc. Conjugates of interleukin-10 and polymers
US20060127357A1 (en) * 2002-11-29 2006-06-15 Roncarolo Maria G Rapamycin and il-10 for the treatment of immune diseases
EA013535B1 (en) * 2002-12-26 2010-06-30 Маунтин Вью Фамэсьютикэлс, Инк. Polymer conjugate of bioactive component (variants), method for producing and use thereof, pharmaceutical products on the base thereof
US7261882B2 (en) 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
CN100415801C (en) * 2003-10-28 2008-09-03 北京键凯科技有限公司 Polyethylene glycol amino acid N-internal ring carbonyl anhydride active derivatives, and medicinal bonding compound and gel thereof
US20060204512A1 (en) 2004-09-23 2006-09-14 Vasgene Therapeutics, Inc. Polypeptide compounds for inhibiting angiogenesis and tumor growth
JP2008530163A (en) * 2005-02-16 2008-08-07 マイクロメット アクツィエン ゲゼルシャフト Use of activated polymers for the separation of protein and polypeptide multimers
WO2006116948A1 (en) * 2005-04-30 2006-11-09 Chengdu Institute Of Biological Products Interleukin-6 polyethylene glycol conjugate and its preparing method and use
US20180311071A1 (en) 2005-10-21 2018-11-01 Daniel R. BURNETT Method and apparatus for peritoneal oxygenation
CN101534846B (en) 2005-11-07 2014-11-05 印第安纳大学研究及科技有限公司 Glucagon analogs exhibiting physiological solubility and stability
EP1834963A1 (en) * 2006-03-13 2007-09-19 Siegfried Ltd. Di-polymer protein conjugates and processes for their preparation
CN101489569A (en) * 2006-06-12 2009-07-22 席拉坎有限责任公司 Topical treatment for diseases of eye surface
ES2606034T3 (en) * 2006-09-28 2017-03-17 Merck Sharp & Dohme Corp. Pegylated IL-10 for use in the treatment of lymphoma
EP3156415A1 (en) 2006-11-22 2017-04-19 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir
US8669228B2 (en) * 2007-01-05 2014-03-11 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility in physiological pH buffers
ATE516814T1 (en) 2007-02-02 2011-08-15 Bristol Myers Squibb Co 10FN3 DOMAIN FOR THE TREATMENT OF DISEASES ACCOMPANIED BY UNDESIRABLE ANGIOGENESIS
AU2008216265B2 (en) 2007-02-15 2014-04-03 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
WO2009003188A2 (en) * 2007-06-27 2008-12-31 Cedars-Sinai Medical Center N-terminal specific chemical labeling for proteomics applications
US20090094368A1 (en) * 2007-10-08 2009-04-09 Steven Francis Best Instant messaging general queue depth management
JP5771005B2 (en) * 2007-10-30 2015-08-26 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ Glucagon antagonist and compound showing GLP-1 agonist activity
CA2707861A1 (en) 2007-10-30 2009-05-07 Indiana University Research And Technology Corporation Glucagon antagonists
AU2009210570B2 (en) * 2008-01-30 2014-11-20 Indiana University Research And Technology Corporation Ester-based insulin prodrugs
EP2095829A1 (en) * 2008-02-27 2009-09-02 LEK Pharmaceuticals D.D. Selenium containing modifying agents and conjugates
JP2011520961A (en) 2008-05-22 2011-07-21 ブリストル−マイヤーズ スクイブ カンパニー Scaffold domain protein based on multivalent fibronectin
PE20100255A1 (en) 2008-06-17 2010-04-25 Univ Indiana Res & Tech Corp GLUCAGON / GLP-1 RECEPTOR CO-AGONISTS
CN102088989B (en) * 2008-06-17 2014-11-26 印第安纳大学研究及科技有限公司 Glucagon analogs exhibiting enhanced solubility and stability physiological pH buffers
TWI474835B (en) * 2008-06-17 2015-03-01 Univ Indiana Res & Tech Corp Gip-based mixed agonists for treatment of metabolic disorders and obesity
TWI496582B (en) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 Bispecific egfr/igfir binding molecules
CN103601800B (en) * 2008-12-17 2015-10-21 默沙东公司 The production of single and double PEG IL10 and purposes
AU2013205045B2 (en) * 2008-12-17 2015-10-15 Merck Sharp & Dohme Corp. Mono- and di-peg IL-10 production; and uses
JP2012512903A (en) 2008-12-19 2012-06-07 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション Amide glucagon superfamily peptide prodrug
WO2010080609A1 (en) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
US20110237493A1 (en) * 2008-12-19 2011-09-29 Indiana University Research And Technology Corporation Dipeptide linked medicinal agents
JP5789515B2 (en) 2008-12-19 2015-10-07 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ Insulin analogue
US20110293515A1 (en) * 2009-01-13 2011-12-01 The Uab Research Foundation Heterofunctional segment-poly (ethylene glycol) polymers as delivery vehicles
AU2010260058B2 (en) 2009-06-16 2015-09-24 Indiana University Research And Technology Corporation GIP receptor-active glucagon compounds
EP3199551A3 (en) 2009-07-31 2017-10-18 E. R. Squibb & Sons, L.L.C. Fully human antibodies to btla
CA2775287A1 (en) * 2009-09-25 2011-03-31 Vybion, Inc. Polypeptide modification
US8703701B2 (en) 2009-12-18 2014-04-22 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
CA2788304A1 (en) 2010-01-27 2011-08-04 Indiana University Research And Technology Corporation Glucagon antagonist - gip agonist conjugates and compositions for the treatment of metabolic disorders and obesity
KR20130062931A (en) 2010-05-13 2013-06-13 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
WO2011143208A1 (en) 2010-05-13 2011-11-17 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting g protein-coupled receptor activity
CN103180339B (en) 2010-05-26 2016-04-27 百时美施贵宝公司 There is the scaffold protein based on fibronectin of the stability of improvement
WO2011159895A2 (en) 2010-06-16 2011-12-22 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
WO2011163460A1 (en) * 2010-06-24 2011-12-29 Indiana University Research And Technology Corporation Yl-based insulin-like growth factors exhibiting high activity at the insulin receptor
EP2585102B1 (en) 2010-06-24 2015-05-06 Indiana University Research and Technology Corporation Amide-based insulin prodrugs
RU2580317C2 (en) 2010-06-24 2016-04-10 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Peptide pro-drugs of amide glucagon superfamily
EA201390941A1 (en) 2010-12-22 2013-12-30 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн GLUCAGON ANALOGUES, EXPERIENCING ACTIVITY ON GIP RECEPTOR
EP2709669A1 (en) 2011-05-17 2014-03-26 Bristol-Myers Squibb Company Methods for maintaining pegylation of polypeptides
US9309301B2 (en) 2011-06-22 2016-04-12 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
US20140221283A1 (en) 2011-06-22 2014-08-07 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
US20130090294A1 (en) 2011-06-28 2013-04-11 Alternative Innovative Technologies Llc Novel methods of use of hsp70 for increased performance or treatment of hsp70 related disorders
RU2014114849A (en) 2011-10-14 2015-11-20 Алтернатив Инновейтив Текнолоджиз Ллц Degradation-resistant derivatives of proteins of heat shock-70 (btsh70) and methods of their application (options)
JP2015504038A (en) 2011-10-31 2015-02-05 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Fibronectin binding domain with reduced immunogenicity
CA2847246A1 (en) 2011-11-17 2013-05-23 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
RU2685867C2 (en) 2011-12-15 2019-04-23 Алтернатив Инновейтив Текнолоджиз Ллц Hybrid proteins and protein conjugates based on heat shock protein-70 (hsp70) and methods for use thereof (versions)
EP2793932B1 (en) 2011-12-20 2018-10-03 Indiana University Research and Technology Corporation Ctp-based insulin analogs for treatment of diabetes
WO2013149219A2 (en) 2012-03-30 2013-10-03 Sorrento Therapeutics Inc. Fully human antibodies that bind to vegfr2
CN115093480A (en) 2012-05-31 2022-09-23 索伦托药业有限公司 Antigen binding proteins that bind to PD-L1
ES2602486T3 (en) 2012-06-21 2017-02-21 Indiana University Research And Technology Corporation Glucagon analogs showing GIP receptor activity
JP6429771B2 (en) 2012-06-21 2018-11-28 ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Antigen binding protein that binds to c-Met
JP6438391B2 (en) 2012-06-22 2018-12-12 ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Antigen binding protein that binds to CCR2
JP6387008B2 (en) 2012-09-26 2018-09-05 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ Insulin analog dimer
US20150361159A1 (en) 2013-02-01 2015-12-17 Bristol-Myers Squibb Company Fibronectin based scaffold proteins
US20160024169A1 (en) 2013-03-14 2016-01-28 Indiana University Research And Technology Corporation Insulin-incretin conjugates
CN105209054A (en) 2013-04-18 2015-12-30 阿尔莫生物科技股份有限公司 Methods of using interleukin-10 for treating diseases and disorders
US20160068583A1 (en) * 2013-04-24 2016-03-10 Armo Biosciences, Inc. Interleukin-10 Compositions and Uses Thereof
US9823255B2 (en) 2013-06-17 2017-11-21 Armo Biosciences, Inc. Method for assessing protein identity and stability
WO2015031316A1 (en) * 2013-08-30 2015-03-05 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
JP2016535770A (en) 2013-11-01 2016-11-17 スフェリウム バイオメッド エス．エル． Inclusion body for transdermal delivery of therapeutic and cosmetic substances
KR20160079114A (en) 2013-11-11 2016-07-05 아르모 바이오사이언시스 인코포레이티드 Methods of using interleukin-10 for treating diseases and disorders
CN104073482A (en) * 2013-12-30 2014-10-01 江苏众红生物工程创药研究院有限公司 Pegylated tissue kallikrein as well as preparation method and application thereof
US10293043B2 (en) * 2014-06-02 2019-05-21 Armo Biosciences, Inc. Methods of lowering serum cholesterol
JO3663B1 (en) 2014-08-19 2020-08-27 Merck Sharp & Dohme Anti-lag3 antibodies and antigen-binding fragments
WO2016028523A2 (en) 2014-08-22 2016-02-25 Sorrento Therapeutics, Inc. Antigen binding proteins that bind cxcr3
CN108271356A (en) 2014-09-24 2018-07-10 印第安纳大学研究及科技有限公司 Duodenin-insulin conjugate
EP3197912B1 (en) 2014-09-24 2023-01-04 Indiana University Research & Technology Corporation Lipidated amide-based insulin prodrugs
MX2017004838A (en) 2014-10-14 2017-10-16 Armo Biosciences Inc Interleukin-15 compositions and uses thereof.
EP3209320B1 (en) 2014-10-22 2023-03-08 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
WO2016126615A1 (en) 2015-02-03 2016-08-11 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
EP3302547A1 (en) 2015-05-28 2018-04-11 Armo Biosciences, Inc. Pegylated interleukin-10 for use in treating cancer
US20190307849A1 (en) 2015-05-29 2019-10-10 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
JP7053453B2 (en) 2015-08-25 2022-04-12 アルモ・バイオサイエンシーズ・インコーポレイテッド How to use interleukin 10 to treat diseases and disorders
JO3739B1 (en) 2015-11-18 2021-01-31 Merck Sharp & Dohme Ctla4 binders
CA3003777A1 (en) 2015-11-18 2017-05-26 Merck Sharp & Dohme Corp. Pd1/ctla4 binders
TW202216787A (en) 2015-11-18 2022-05-01 美商默沙東藥廠 Pd1 and/or lag3 binders
BR112018012352A2 (en) 2015-12-16 2018-12-11 Merck Sharp & Dohme Corp. anti-lag3 antibodies and antigen binding fragments
CA3008284A1 (en) * 2016-01-05 2017-07-13 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
EP3402512A4 (en) 2016-01-11 2019-09-25 Armo Biosciences, Inc. Interleukin-10 in production of antigen-specific cd8+ t cells and methods of use of same
JP6883590B2 (en) 2016-01-29 2021-06-09 ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Antigen-binding protein that binds to PD-L1
WO2017160599A1 (en) 2016-03-14 2017-09-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of cd300b antagonists to treat sepsis and septic shock
US10610104B2 (en) 2016-12-07 2020-04-07 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
WO2018156602A1 (en) * 2017-02-21 2018-08-30 The Regents Of The University Of Michigan Il-22bp compositions and method for the treatment of disease therewith
US11596670B2 (en) 2017-03-30 2023-03-07 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with IL-10 or an IL-10 agonist
CN111315398A (en) 2017-11-10 2020-06-19 阿尔莫生物科技股份有限公司 Compositions and methods of use of interleukin-10 in combination with an immune checkpoint pathway inhibitor
WO2019245817A1 (en) 2018-06-19 2019-12-26 Armo Biosciences, Inc. Compositions and methods of use of il-10 agents in conjunction with chimeric antigen receptor cell therapy
WO2020106750A1 (en) 2018-11-19 2020-05-28 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
US20220193253A1 (en) * 2019-04-26 2022-06-23 Prolynx Llc Slow-release cytokine conjugates
CN115551530A (en) 2019-08-27 2022-12-30 通尼克斯制药有限公司 Modified TFF2 polypeptides
CN115666704A (en) 2019-12-13 2023-01-31 比奥拉治疗股份有限公司 Ingestible device for delivery of therapeutic agents to the gastrointestinal tract
GB202003428D0 (en) 2020-03-10 2020-04-22 Univ Dundee IL-10 mutiens

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006058A1 (en) * 1993-08-24 1995-03-02 Polymasc Pharmaceuticals Plc Polymer modification
WO1996011953A1 (en) * 1994-10-12 1996-04-25 Amgen Inc. N-terminally chemically modified protein compositions and methods
WO1999032134A1 (en) * 1997-12-19 1999-07-01 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
WO2001058950A1 (en) * 2000-02-11 2001-08-16 Maxygen Aps Improved interleukin 10

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2003A (en) * 1841-03-12 Improvement in horizontal windivhlls
US591974A (en) * 1897-10-19 Bicycle-brake
US3270960A (en) 1964-09-11 1966-09-06 Sperry Rand Corp Fluid sensor
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
JPH0630164B2 (en) * 1985-12-16 1994-04-20 キヤノン株式会社 Optical head device
JPS63152393A (en) 1986-07-03 1988-06-24 Takeda Chem Ind Ltd Glycosyl derivative
US4965195A (en) 1987-10-26 1990-10-23 Immunex Corp. Interleukin-7
US5714585A (en) 1987-10-26 1998-02-03 Sterling Winthrop, Inc. Antibodies that are immunoreactive with interleukin-7
US5032396A (en) 1989-02-17 1991-07-16 Immunex Corporation IL-7 to stimulate platelet production
US6217857B1 (en) 1989-06-28 2001-04-17 Schering Corporation Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof
US5231012A (en) 1989-06-28 1993-07-27 Schering Corporation Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10)
US5229115A (en) 1990-07-26 1993-07-20 Immunex Corporation Adoptive immunotherapy with interleukin-7
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
DE69201128T2 (en) 1991-01-16 1995-05-24 Schering Corp TREATMENT OF NEOPLASTIC DISEASES WITH INTERLEUKIN-10.
ATE124866T1 (en) 1991-01-16 1995-07-15 Schering Corp USE OF INTERLEUKIN-10 IN ADOPTIVE IMMUNOTHERAPY OF CANCER.
US6277635B1 (en) 1992-03-04 2001-08-21 Schering Corporation Use of interleukin-10 to produce a population of suppressor cells
US5552303A (en) 1993-03-08 1996-09-03 Immunex Corporation DNA encoding epithelium-derived T-cell factor
WO1994022473A1 (en) 1993-04-01 1994-10-13 University Of Washington Use of interleukin 7 to improve vaccine potency
US5665345A (en) 1993-05-24 1997-09-09 The United States Of America As Represented By The Department Of Health And Human Services Methods of inhibiting viral replication using IL-10
JPH08507930A (en) 1993-07-26 1996-08-27 シェリング・コーポレーション Human interleukin-10 agonists and antagonists
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5951974A (en) 1993-11-10 1999-09-14 Enzon, Inc. Interferon polymer conjugates
JPH09508116A (en) 1994-01-20 1997-08-19 シェーリング コーポレイション Use of IL-10 to stimulate peripheral blood mononuclear cytolytic activity
US5696234A (en) 1994-08-01 1997-12-09 Schering Corporation Muteins of mammalian cytokine interleukin-13
US6410008B1 (en) 1994-12-12 2002-06-25 Beth Israel Hospital Association Chimeric IL-10 proteins and uses thereof
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5866134A (en) 1995-03-24 1999-02-02 Schering Corporation Method for enhancing the antibody response to specific antigens with Interleukin-10
US5770190A (en) 1995-07-14 1998-06-23 Schering Corporation Method of treatment of acute leukemia with inteleukin-10
GB2304047A (en) 1995-08-09 1997-03-12 Univ Manchester Pharmaceutical compositions containing cytokines
US5744451A (en) * 1995-09-12 1998-04-28 Warner-Lambert Company N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
US5908621A (en) 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
US5759859A (en) 1996-07-15 1998-06-02 United States Of America As Represented By The Secretary Of The Army Sensor and method for detecting trace underground energetic materials
US5989867A (en) 1996-09-23 1999-11-23 Knappe; Andrea DNA encoding IL-10-like homologue; related reagents
ATE255422T1 (en) 1998-01-07 2003-12-15 Debio Rech Pharma Sa DEGRADABLE, HETEROBIFUNCTIONAL POLYETHYLENE GLYCOL ACRYLATES, AND GEL AND CONJUGATES THAT CAN BE PRODUCED THEM
US5908921A (en) * 1998-11-03 1999-06-01 Eastman Kodak Company Method of manufacturing gelatin
US7666400B2 (en) 2005-04-06 2010-02-23 Ibc Pharmaceuticals, Inc. PEGylation by the dock and lock (DNL) technique
AU5827000A (en) 1999-07-16 2001-02-05 Maria Teresa Bejarano Viral il-10 uses
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US20030186386A1 (en) * 2000-02-11 2003-10-02 Hansen Christian Karsten Interleukin 10
EP1324779B1 (en) * 2000-09-29 2011-07-20 Schering Corporation Pegylated interleukin-10
US6838452B2 (en) 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
WO2002085300A2 (en) 2001-04-23 2002-10-31 The Regents Of The University Of California Methods of using interleukin-7 to modulate physiological processes in mammalian pulmonary fibroblasts
EP1276028A1 (en) 2001-07-09 2003-01-15 Telefonaktiebolaget L M Ericsson (Publ) Status indication detection device and method
GB0212648D0 (en) 2002-05-31 2002-07-10 Immunoclin Lab Ltd Treatment with cytokines
EP1391513A1 (en) 2002-08-08 2004-02-25 Cytheris IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof
AU2003280315A1 (en) 2002-11-14 2004-06-03 Maxygen, Inc. Conjugates of interleukin-10 and polymers
US20060127357A1 (en) 2002-11-29 2006-06-15 Roncarolo Maria G Rapamycin and il-10 for the treatment of immune diseases
EA013535B1 (en) 2002-12-26 2010-06-30 Маунтин Вью Фамэсьютикэлс, Инк. Polymer conjugate of bioactive component (variants), method for producing and use thereof, pharmaceutical products on the base thereof
JP4753867B2 (en) 2003-04-15 2011-08-24 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Conjugates containing human IL-18 and substitutional variants thereof
US7261882B2 (en) 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
WO2005033307A1 (en) 2003-09-30 2005-04-14 Kyowa Hakko Kogyo Co., Ltd. Novel refolding method and protein obtained by the method
ATE457353T1 (en) 2003-11-28 2010-02-15 Univ Sydney VIRAL LATENT PHASE INTERLEUKIN-10 (VII-10) AND USES THEREOF
BRPI0418286A (en) 2003-12-30 2007-05-02 Merck Patent Gmbh il-7 fusion proteins
KR20070085886A (en) 2004-12-09 2007-08-27 메르크 파텐트 게엠베하 Il-7 variants with reduced immunogenicity
WO2006094530A1 (en) 2005-03-11 2006-09-14 Siegfried Ltd. Di-polymer protein conjugates and processes for their preparation
WO2006119170A2 (en) 2005-05-02 2006-11-09 Avigen, Inc. Use of cytokine-derived peptides in treatment of pain and neurodegenerative disease
US7749490B2 (en) 2005-05-31 2010-07-06 The Regents Of The University Of Colorado Mutant IL-10
EP1746161A1 (en) 2005-07-20 2007-01-24 Cytheris Glycosylated IL-7, preparation and uses
CA2625208A1 (en) 2005-10-04 2007-04-12 Zymogenetics, Inc. Production and purification of il-29
WO2007061657A2 (en) 2005-11-14 2007-05-31 The Brigham & Women's Hospital, Inc. Interleukin-10 compositions for the treatment of adenocarcinomas
ES2606034T3 (en) 2006-09-28 2017-03-17 Merck Sharp & Dohme Corp. Pegylated IL-10 for use in the treatment of lymphoma
JP5220025B2 (en) 2006-12-04 2013-06-26 プロメディオール， インコーポレイテッド Combination therapy to treat fibrotic diseases
CA2702494A1 (en) 2007-10-19 2009-04-23 The Regents Of The University Of California Compositions and methods for ameliorating cns inflammation, psychosis, delirium, ptsd or ptss
GB0724231D0 (en) 2007-12-12 2008-01-30 Renono Ltd Methods for inhibiting scarring
TW201207383A (en) 2010-06-16 2012-02-16 Abbott Lab Comparison of protein samples
US8759617B2 (en) 2010-09-21 2014-06-24 National Institute Of Agrobiological Sciences Method for extraction and purification of recombinant proteins from transgenic plants
EP2537933A1 (en) 2011-06-24 2012-12-26 Institut National de la Santé et de la Recherche Médicale (INSERM) An IL-15 and IL-15Ralpha sushi domain based immunocytokines
AU2016228555B2 (en) 2015-03-11 2021-12-23 Nektar Therapeutics Conjugates of an IL-7 moiety and a polymer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006058A1 (en) * 1993-08-24 1995-03-02 Polymasc Pharmaceuticals Plc Polymer modification
WO1996011953A1 (en) * 1994-10-12 1996-04-25 Amgen Inc. N-terminally chemically modified protein compositions and methods
WO1999032134A1 (en) * 1997-12-19 1999-07-01 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
WO2001058950A1 (en) * 2000-02-11 2001-08-16 Maxygen Aps Improved interleukin 10

Also Published As

Publication number Publication date
US20020044921A1 (en) 2002-04-18
US20080317707A1 (en) 2008-12-25
EP1324779B1 (en) 2011-07-20
US20160166647A1 (en) 2016-06-16
US20060210534A1 (en) 2006-09-21
US20110305665A1 (en) 2011-12-15
HK1154874A1 (en) 2012-05-04
ATE516820T1 (en) 2011-08-15
US8697045B2 (en) 2014-04-15
ES2367891T3 (en) 2011-11-10
US9238079B2 (en) 2016-01-19
EP1324779A2 (en) 2003-07-09
US20100297069A1 (en) 2010-11-25
EP2295450A1 (en) 2011-03-16
US7052686B2 (en) 2006-05-30
US20180250363A1 (en) 2018-09-06
AU2001296962A1 (en) 2002-04-08
EP2295450B1 (en) 2015-01-28
US10471126B2 (en) 2019-11-12
US20110064690A1 (en) 2011-03-17
WO2002026265A2 (en) 2002-04-04
US9925245B2 (en) 2018-03-27
US20140227223A1 (en) 2014-08-14

Similar Documents

Publication Publication Date Title
WO2002026265A3 (en) Pegylated interleukin-10
WO2001044286A3 (en) Five-helix protein
CY1119848T1 (en) INSULATED TETRAMIC URINATION
EP1085089A3 (en) Human cyclic nucleotide phosphodiesterase
WO2000021574A3 (en) Site-directed dual pegylation of proteins
WO2002014525A3 (en) Expression vector using for animal cell
WO2000007629A3 (en) Peg-urate oxidase conjugates and use thereof
WO2003048334A3 (en) Immunocytokines with modulated selectivity
CA2305013A1 (en) Fusion proteins comprising hiv-1 tat and/or nef proteins
WO1999004820A3 (en) Cytolysis of target cells by superantigen conjugates inducing t-cell activation
WO2003020932A1 (en) Novel secretory proteins and dna thereof
AU2001290312A1 (en) Peg-modified erythropoietin
EP1185545A4 (en) Cd4-independent hiv envelope proteins as vaccines and therapeutics
WO2003048205A3 (en) Novel proteins with il-6 inhibiting activity
WO2003089458A3 (en) Conjugates of membrane translocating agents and pharmaceutically active agents
WO2002060929A3 (en) Polymer conjugates of neublastin and methods of using same
WO1996034964A3 (en) Stable variant hk2 polypeptide
WO2003049699A3 (en) Novel monofunctional polyethylene glycol aldehydes
WO2002044197A3 (en) Cytokine receptor binding peptides
WO2002038612A3 (en) Canine and feline tumour-associated antigen 5t4
CA2340934A1 (en) Novel collectin
MXPA02002489A (en) Monomeric analogues of human insulin.
CA2406884A1 (en) Novel collectins
EP1057490A3 (en) Use of tranexamic acid for the preparation of a human fibrinogen composition
WO2001080902A3 (en) A particulate complex for administering nucleic acid into a cell

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CZ DE DK DM DZ EC EE ES FI GB GD GE HR HU ID IL IN IS JP KG KR KZ LC LK LR LT LU LV MA MD MG MK MN MX MZ NO NZ PH PL PT RO RU SE SG SI SK SL TJ TM TR TT TZ UA UZ VN YU ZA

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2001977878

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001977878

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP