WO2002026316A1 - Dispenser for endermic administration of drug - Google Patents

Dispenser for endermic administration of drug Download PDF

Info

Publication number
WO2002026316A1
WO2002026316A1 PCT/IT2001/000494 IT0100494W WO0226316A1 WO 2002026316 A1 WO2002026316 A1 WO 2002026316A1 IT 0100494 W IT0100494 W IT 0100494W WO 0226316 A1 WO0226316 A1 WO 0226316A1
Authority
WO
WIPO (PCT)
Prior art keywords
dispenser
dispensing
substance
dispensing chamber
dispensing head
Prior art date
Application number
PCT/IT2001/000494
Other languages
French (fr)
Inventor
Edgardo Michelotti
Original Assignee
Servizi Medico-Estetici Italiani-S.M.E.I. S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servizi Medico-Estetici Italiani-S.M.E.I. S.R.L. filed Critical Servizi Medico-Estetici Italiani-S.M.E.I. S.R.L.
Priority to AU2001295884A priority Critical patent/AU2001295884A1/en
Publication of WO2002026316A1 publication Critical patent/WO2002026316A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
    • A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
    • A45D34/041—Appliances specially adapted for applying liquid, e.g. using roller or ball using a roller, a disc or a ball

Definitions

  • the present invention relates to a dispenser and relative dispensing head for endermic administration of a substance containing an active principle . More specifically, the present invention relates to a dispenser and relative dispensing head for endermic administration of a substance containing an active principle by means of ionophoresis, hydroelectrophoresis or any other technique involving the application of energy to the substance to assist penetration of the molecules of the active principle through the skin.
  • a dispenser and relative dispensing head for endermic administration of a substance containing an active principle by means of ionophoresis, hydroelectrophoresis or any other technique involving the application of energy to the substance to assist penetration of the molecules of the active principle through the skin.
  • dispensers for endermic administration of an active principle are currently marketed. Many of them are so-called osmotic-membrane types, i.e. substantially comprise a vessel for the substance containing the active principle to be administered, and which is fitted with an osmotic or semiper eable membrane through which migrate the ions generated by an appropriately generated electric field applied to the substance.
  • osmotic-membrane types i.e. substantially comprise a vessel for the substance containing the active principle to be administered, and which is fitted with an osmotic or semiper eable membrane through which migrate the ions generated by an appropriately generated electric field applied to the substance.
  • roller dispensers i.e. substantially comprising a vessel for the substance containing the active principle to be administered, and a dispensing head formed by a supporting structure and an applicator roller fitted inside the supporting structure and rotating freely about an axis of rotation.
  • the supporting structure defines a dispensing chamber communicating on one side with the vessel through an inlet opening, and on the other side with the outside through an outlet opening.
  • the dispensing chamber is fitted inside with a normally click-on applicator roller, which loosely closes, and projects from the dispensing chamber through, the outlet opening. Adjacent to the applicator roller, the dispensing chamber is also fitted inside with an electrically conducting strip for applying an electric potential to the substance containing the active principle to be administered. More specifically, the conducting strip is connected by a flexible electric conductor to an external electric-energy source, is positioned facing the lateral surface of the applicator roller, and extends parallel to the axis of, and substantially along the whole length of, the roller .
  • roller dispensers also have various drawbacks preventing full benefit of all the advantages available. Firstly, using roller dispensers of the type described above, the substance containing the active principle to be administered must be applied holding the dispenser substantially perpendicularly to the surface to which the substance is applied, thus impairing efficiency and making the dispenser awkward to use .
  • the substance containing the active principle to be administered is not dispensed particularly evenly, and at any rate not adjustably in terms of the amount of substance applied.
  • disassembling and reassembling the component parts of the dispenser, in particular the applicator roller are not always easy, and call for using a tool, in particular a screwdriver, to remove the applicator roller from the supporting structure, so that cleaning the component parts of roller dispensers ' of the type described above is a painstaking, time-consuming job.
  • a dispenser for endermic administration of a substance containing an active principle as claimed in Claim 1.
  • a dispensing head for a dispenser for endermic administration of a substance containing an active principle as claimed in Claim 13.
  • Figure 1 shows an exploded view in perspective of a dispenser in accordance with the present invention
  • Figure 2 shows a cross section of a dispensing head of the Figure 1 dispenser.
  • Number 1 in Figure 1 indicates as a whole a dispenser, in accordance with the present invention, for endermic administration of a substance containing an active principle .
  • Dispenser 1 is substantially elongated along ' a main axis or axis of symmetry A, and substantially comprises a vessel 2 for the substance containing the active principle, and a dispensing head 4 connected releasably to vessel 2.
  • Dispensing head 4 shown in cross section in Figure 2, is made of bioco patible plastic material, and defines internally a substantially cylindrical dispensing chamber 6 coaxial with axis of symmetry A and communicating, on one side, with vessel 2 through a circular inlet opening 8 coaxial with axis of symmetry A, and, on the other side, with the outside through a circular outlet opening 10 also coaxial with axis of symmetry A. More specifically, dispensing head 4 comprises a casing 12; an applicator member 14 for applying the substance; a supporting structure 16 supporting applicator member 14; a retaining ring nut 18 for retaining applicator member 14; and an energy-supply member 20.
  • casing 12 is substantially cup- shaped and defines dispensing chamber 6, which is defined at the bottom by a bottom wall 22 perpendicular to axis of symmetry A and in which inlet opening 8 is formed, and laterally by a cylindrical lateral wall 24 coaxial with axis of symmetry A and having an external thread 25.
  • Casing 12 also comprises a cylindrical, internally threaded, outer collar 26, which extends coaxially with axis of symmetry A, along an extension of inlet opening 8 and in the opposite direction to outlet opening 10, and screws onto a corresponding externally threaded neck portion 28 of vessel 2 to connect dispensing head 4 to vessel 2.
  • a through hole 30 ( Figure 2) is also formed in lateral wall 24 of dispensing chamber 6, has an axis parallel to or slightly inclined with respect to axis of symmetry A, and comes out, on one side, outside dispenser 1, and, on the other side, inside a groove 32 formed in a bottom portion of lateral wall 24 and adjacent to bottom wall 22.
  • Supporting structure 16 is housed, coaxially with axis of symmetry A, inside dispensing chamber 6, and comprises a flat annular base member 34 resting on bottom wall 22 of dispensing chamber 6 and surrounding inlet opening 8; and three substantially elongated supporting members 36 integral with base member 34, projecting, parallel to axis of symmetry A, from base member 34, and equally spaced angularly on base member 34.
  • each supporting member 36 comprises a substantially parallelepiped-shaped base portion 38; and a substantially hemispherical top portion 40 on top of base portion 38.
  • Energy-supply member 20 is interposed interferentially between supporting structure 16 and lateral wall 24 of dispensing chamber 6, and is substantially defined by an electrically conducting ring coaxial with axis of symmetry A and greater in height than base member 34 of supporting structure 16, so that a cylindrical top portion can come into contact with the substance contained, in use, inside dispensing chamber 6. In actual use, an electric potential is applied to energy-supply member 20 by a .
  • flexible conductor 42 connected at one end to an external electric-energy source (not shown) , and having, at the opposite end, an elongated connector 44 which, inserted from the outside inside through hole 30 in lateral wall 24 of dispensing chamber 6, extends partly inside groove 32 and contacts the outer surface of energy-supply member 20.
  • Applicator member 14 is defined by a spherical body housed partly inside dispensing chamber 6, is supported in freely rotating manner by the three supporting members 36 of supporting structure 16, and is retained in this position by retaining ring nut 18, which is substantially cylindrical and comprises a tapered first end portion 46 defining outlet opening 10, and a second end portion 48 having an internal thread 49 engaging the external thread 25 on lateral wall 24 of dispensing chamber 6 to connect retaining ring nut 18 to casing 12.
  • applicator member 14 projects partly outwards of outlet opening 10, and, together with the edge of outlet opening 10, defines a dispensing section 50 ( Figure 2) through which the substance in dispensing chamber 6 flows out for application to the human body.
  • the transverse dimension of dispensing section 50 is adjustable by adjusting the extent to which retaining ring nut 18 is screwed to the casing. More specifically, as retaining ring nut 18 is loosened and tightened, dispensing section 50, and therefore the amount of substance applied to the human body, gradually increases and decreases respectively, when retaining ring nut 18 is screwed right down, dispensing section 50 is closed completely to cut off outflow of the substance to be applied.
  • dispenser 1 using a spherical applicator member 14, the substance containing the active principle can be applied holding dispenser 1 not only perpendicular to but also tilted at any angle with respect to the surface to which the substance is to be applied, thus making dispenser 1 according to the present invention far more efficient and easier to use as compared with roller dispensers .
  • retaining ring nut 18 whose end portion 46, from which spherical applicator member 14 projects, is tapered, so that retaining ring nut 18 slides smoothly over the skin during application, thus preventing minor skin lesions.
  • the substance containing the active principle is applied much more evenly as compared with ' roller dispensers of the type described previously.
  • dispenser 1 provides for accurately adjusting the amount of substance dispensed by simply tightening or loosening retaining ring nut 18.
  • the component parts of dispensing head 4 of dispenser 1 according to the present invention can be disassembled and reassembled extremely easily with no tools required, and can therefore be cleaned quickly and easily.
  • dispenser 1 may be formed in one piece, and energy-supply member 20 be embedded in lateral wall 24 of dispensing chamber 6, thus reducing the number of component parts of dispensing head 4 to be produced and assembled, though only at the expense of forgoing individual replacement of casing 12 or supporting structure 16 when worn, or energy-supply member 20 when oxidized.
  • Dispensing head 4 and its component parts may be formed otherwise than as shown, and in particular may be substantially prismatically, as opposed to circularly, symmetrical .
  • retaining ring nut 18 may be connected to casing 12 otherwise than as shown, and in particular by means of a generic axially adjustable click-on connection, as opposed to threads.

Abstract

The dispenser (1) has a vessel (2) for the substance containing the active principle to be administered, and a dispensing head (4) for dispensing the substance and connected releasably to the vessel (2). The dispensing head (4) defines internally a dispensing chamber (6) communicating, on one side, with the vessel (2) through an inlet opening (8), and, on the other side, with the outside through an outlet opening (10). More specifically, the dispensing head (4) has a cup-shaped casing (12) defining the dispensing chamber (6); a spherical applicator member (14) for applying the substance, and which is housed in freely rotating manner in the dispensing chamber (6) and projects outwards through the outlet opening (10); and supporting structure in the dispensing chamber (16) for supporting the applicator member (14) and housed in the dispensing chamber (6); a retaining ring nut (18) connected to the casing (12) to retain the applicator member (14) in position; and an energy-supply member (20) housed in the dispensing chamber (6) and connected by an electric conductor to an electric-energy source to apply an electric field to the substance containing the active principle to be administered.

Description

DISPENSER FOR ENDERMIC ADMINISTRATION OF
DRUG
TECHNICAL FIELD
The present invention relates to a dispenser and relative dispensing head for endermic administration of a substance containing an active principle . More specifically, the present invention relates to a dispenser and relative dispensing head for endermic administration of a substance containing an active principle by means of ionophoresis, hydroelectrophoresis or any other technique involving the application of energy to the substance to assist penetration of the molecules of the active principle through the skin. BACKGROUND ART
Numerous dispensers for endermic administration of an active principle are currently marketed. Many of them are so-called osmotic-membrane types, i.e. substantially comprise a vessel for the substance containing the active principle to be administered, and which is fitted with an osmotic or semiper eable membrane through which migrate the ions generated by an appropriately generated electric field applied to the substance.
Though widely used, dispensers of this type have numerous drawbacks, which have led to the study of so- called roller dispensers, i.e. substantially comprising a vessel for the substance containing the active principle to be administered, and a dispensing head formed by a supporting structure and an applicator roller fitted inside the supporting structure and rotating freely about an axis of rotation.
More specifically, the supporting structure defines a dispensing chamber communicating on one side with the vessel through an inlet opening, and on the other side with the outside through an outlet opening.
The dispensing chamber is fitted inside with a normally click-on applicator roller, which loosely closes, and projects from the dispensing chamber through, the outlet opening. Adjacent to the applicator roller, the dispensing chamber is also fitted inside with an electrically conducting strip for applying an electric potential to the substance containing the active principle to be administered. More specifically, the conducting strip is connected by a flexible electric conductor to an external electric-energy source, is positioned facing the lateral surface of the applicator roller, and extends parallel to the axis of, and substantially along the whole length of, the roller .
Though an improvement on osmotic-membrane types, roller dispensers also have various drawbacks preventing full benefit of all the advantages available. Firstly, using roller dispensers of the type described above, the substance containing the active principle to be administered must be applied holding the dispenser substantially perpendicularly to the surface to which the substance is applied, thus impairing efficiency and making the dispenser awkward to use .
Secondly, the substance containing the active principle to be administered is not dispensed particularly evenly, and at any rate not adjustably in terms of the amount of substance applied. Thirdly, disassembling and reassembling the component parts of the dispenser, in particular the applicator roller, are not always easy, and call for using a tool, in particular a screwdriver, to remove the applicator roller from the supporting structure, so that cleaning the component parts of roller dispensers' of the type described above is a painstaking, time-consuming job.
DISCLOSURE OF INVENTION
It is an object of the present invention to provide a dispenser designed to eliminate at least some of the aforementioned drawbacks.
According to the present invention, there is provided a dispenser for endermic administration of a substance containing an active principle, as claimed in Claim 1.
According to the present invention, there is also provided a dispensing head for a dispenser for endermic administration of a substance containing an active principle, as claimed in Claim 13.
BRIEF DESCRIPTION OF THE DRAWINGS
A preferred, non-limiting embodiment of the present invention will be described by way of example with reference to the accompanying drawings, in which:
Figure 1 shows an exploded view in perspective of a dispenser in accordance with the present invention;
Figure 2 shows a cross section of a dispensing head of the Figure 1 dispenser. BEST MODE FOR CARRYING OUT THE INVENTION
Number 1 in Figure 1 indicates as a whole a dispenser, in accordance with the present invention, for endermic administration of a substance containing an active principle . Dispenser 1 is substantially elongated along' a main axis or axis of symmetry A, and substantially comprises a vessel 2 for the substance containing the active principle, and a dispensing head 4 connected releasably to vessel 2. Dispensing head 4, shown in cross section in Figure 2, is made of bioco patible plastic material, and defines internally a substantially cylindrical dispensing chamber 6 coaxial with axis of symmetry A and communicating, on one side, with vessel 2 through a circular inlet opening 8 coaxial with axis of symmetry A, and, on the other side, with the outside through a circular outlet opening 10 also coaxial with axis of symmetry A. More specifically, dispensing head 4 comprises a casing 12; an applicator member 14 for applying the substance; a supporting structure 16 supporting applicator member 14; a retaining ring nut 18 for retaining applicator member 14; and an energy-supply member 20.
More specifically, casing 12 is substantially cup- shaped and defines dispensing chamber 6, which is defined at the bottom by a bottom wall 22 perpendicular to axis of symmetry A and in which inlet opening 8 is formed, and laterally by a cylindrical lateral wall 24 coaxial with axis of symmetry A and having an external thread 25.
Casing 12 also comprises a cylindrical, internally threaded, outer collar 26, which extends coaxially with axis of symmetry A, along an extension of inlet opening 8 and in the opposite direction to outlet opening 10, and screws onto a corresponding externally threaded neck portion 28 of vessel 2 to connect dispensing head 4 to vessel 2.
A through hole 30 (Figure 2) is also formed in lateral wall 24 of dispensing chamber 6, has an axis parallel to or slightly inclined with respect to axis of symmetry A, and comes out, on one side, outside dispenser 1, and, on the other side, inside a groove 32 formed in a bottom portion of lateral wall 24 and adjacent to bottom wall 22.
Supporting structure 16 is housed, coaxially with axis of symmetry A, inside dispensing chamber 6, and comprises a flat annular base member 34 resting on bottom wall 22 of dispensing chamber 6 and surrounding inlet opening 8; and three substantially elongated supporting members 36 integral with base member 34, projecting, parallel to axis of symmetry A, from base member 34, and equally spaced angularly on base member 34.
More specifically, each supporting member 36 comprises a substantially parallelepiped-shaped base portion 38; and a substantially hemispherical top portion 40 on top of base portion 38. Energy-supply member 20 is interposed interferentially between supporting structure 16 and lateral wall 24 of dispensing chamber 6, and is substantially defined by an electrically conducting ring coaxial with axis of symmetry A and greater in height than base member 34 of supporting structure 16, so that a cylindrical top portion can come into contact with the substance contained, in use, inside dispensing chamber 6. In actual use, an electric potential is applied to energy-supply member 20 by a . flexible conductor 42 connected at one end to an external electric-energy source (not shown) , and having, at the opposite end, an elongated connector 44 which, inserted from the outside inside through hole 30 in lateral wall 24 of dispensing chamber 6, extends partly inside groove 32 and contacts the outer surface of energy-supply member 20.
Applicator member 14 is defined by a spherical body housed partly inside dispensing chamber 6, is supported in freely rotating manner by the three supporting members 36 of supporting structure 16, and is retained in this position by retaining ring nut 18, which is substantially cylindrical and comprises a tapered first end portion 46 defining outlet opening 10, and a second end portion 48 having an internal thread 49 engaging the external thread 25 on lateral wall 24 of dispensing chamber 6 to connect retaining ring nut 18 to casing 12.
More . specifically, applicator member 14 projects partly outwards of outlet opening 10, and, together with the edge of outlet opening 10, defines a dispensing section 50 (Figure 2) through which the substance in dispensing chamber 6 flows out for application to the human body.
The transverse dimension of dispensing section 50 is adjustable by adjusting the extent to which retaining ring nut 18 is screwed to the casing. More specifically, as retaining ring nut 18 is loosened and tightened, dispensing section 50, and therefore the amount of substance applied to the human body, gradually increases and decreases respectively, when retaining ring nut 18 is screwed right down, dispensing section 50 is closed completely to cut off outflow of the substance to be applied. The advantages of dispenser 1 according to the present invention will be clear from the foregoing description.
In particular, using a spherical applicator member 14, the substance containing the active principle can be applied holding dispenser 1 not only perpendicular to but also tilted at any angle with respect to the surface to which the substance is to be applied, thus making dispenser 1 according to the present invention far more efficient and easier to use as compared with roller dispensers .
The efficiency and ease of use of the dispenser is further improved by the form of retaining ring nut 18, whose end portion 46, from which spherical applicator member 14 projects, is tapered, so that retaining ring nut 18 slides smoothly over the skin during application, thus preventing minor skin lesions.
Using a dispenser in accordance with the present invention, the substance containing the active principle is applied much more evenly as compared with ' roller dispensers of the type described previously.
Also, unlike roller dispensers of the type described previously, dispenser 1 according to the present invention provides for accurately adjusting the amount of substance dispensed by simply tightening or loosening retaining ring nut 18.
By virtue of spherical applicator member 14 being supported at three points on hemispherical top portions 40 of the three supporting members 36 of supporting structure 16, there is practically no wear on either spherical applicator member 14 or hemispherical top portions 40 of the three supporting members 36, so that the average working life of these parts is practically infinite.
The component parts of dispensing head 4 of dispenser 1 according to the present invention can be disassembled and reassembled extremely easily with no tools required, and can therefore be cleaned quickly and easily.
Moreover, the possibility of fully dismantling dispensing head 4 enables individual worn parts to be replaced, as opposed to changing the whole head, thus reducing purchasing cost .
Clearly, changes may be made to dispenser 1 as described and illustrated herein without, however, departing from the scope of the present invention as defined in the accompanying Claims. For example, casing 12 and supporting structure 16 of dispensing head 4 may be formed in one piece, and energy-supply member 20 be embedded in lateral wall 24 of dispensing chamber 6, thus reducing the number of component parts of dispensing head 4 to be produced and assembled, though only at the expense of forgoing individual replacement of casing 12 or supporting structure 16 when worn, or energy-supply member 20 when oxidized. Dispensing head 4 and its component parts may be formed otherwise than as shown, and in particular may be substantially prismatically, as opposed to circularly, symmetrical .
Moreover, retaining ring nut 18 may be connected to casing 12 otherwise than as shown, and in particular by means of a generic axially adjustable click-on connection, as opposed to threads.

Claims

1) A dispenser (1) for endermic administration of a substance containing an active principle, comprising a vessel (2) for said substance; a dispensing head (4) having an applicator member (14) for applying said substance; and means (20) for applying an electric field to said substance; characterized in that said applicator member (14) is substantially spherical. 2) A dispenser as claimed in Claim 1, characterized in that said dispensing head (4) defines internally a dispensing chamber (6) communicating with said vessel (2) through an inlet opening (8) , and with the outside through an outlet opening (10) ; said applicator member (14) being housed partly in said dispensing chamber (6) , and being exposed outwards through said outlet opening (10) .
3) A dispenser as claimed in Claim 2, characterized in that said dispensing head (4) also comprises supporting means (16) housed in said dispensing chamber (6) and supporting said applicator member (14) in freely rotating manner.
4) A dispenser as claimed in Claim 3, characterized in that said dispensing head (4) comprises a substantially cup-shaped casing (12) defining said dispensing chamber (6) , which is defined by a bottom wall
(22) having said inlet opening (8) , and by a lateral wall
(24) ; and in that said supporting means comprise a supporting structure (16) housed in said dispensing chamber (6) and in turn comprising a framelike base member (34) resting on said bottom wall (22) of said dispensing chamber (6) and surrounding said inlet opening (8) ; and a number of substantially elongated supporting members (36) projecting from said base member (34) .
5) A dispenser as claimed in Claim 4, characterized in that said supporting structure (16) comprises three said supporting members (36) equally spaced angularly on said base member (34) .
6) A dispenser as claimed in Claim 4 or 5, characterized in that each of said supporting members (36) comprises a substantially parallelepiped-shaped base portion (38) , and a substantially hemispherical top portion (40) on top of the base portion (38) .
7) A dispenser as claimed in any one of the foregoing Claims, characterized in that said means for applying an electric field to said substance comprise an electrically conducting member (20) housed in said dispensing chamber (6) and connectable to an external electric-energy source.
8) A dispenser as claimed in Claim 7, characterized in that said electrically conducting member (20) is interposed between said lateral wall (24) of said dispensing chamber (6) and said supporting structure (16) .
9) A dispenser as claimed in any one of the foregoing Claims, characterized in that said dispensing head (4) also comprises retaining means (18) for retaining said applicator member (14) in position.
10) A dispenser as claimed in Claim 9, characterized in that said retaining means comprise a retaining ring nut (18) having a first end portion (46) defining said outlet opening (10) ; said outlet opening (10) in turn defining, together with said applicator member (14) , a dispensing section (50) for dispensing said substance; said retaining ring nut (18) also having a second end portion (48) having first connecting means (49) cooperating with second connecting means (25) on said casing (12) to permit adjustment of the axial position of said retaining ring nut (18) with respect to said casing (12) to adjust said dispensing section. 11) A dispenser as claimed in Claim 10, characterized in that said first and second connecting means comprise respective threads (49, 25) .
12) A dispenser as claimed in any one of the foregoing Claims, characterized in that said dispensing head (4) is connected removably to said vessel (2)'.
13) A dispensing head (4) for a dispenser (1) for endermic administration of a substance containing an active principle, as claimed in any one of the foregoing Claims .
PCT/IT2001/000494 2000-09-27 2001-09-26 Dispenser for endermic administration of drug WO2002026316A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001295884A AU2001295884A1 (en) 2000-09-27 2001-09-26 Dispenser for endermic administration of drug

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITTO00A000896 2000-09-27
IT2000TO000896A IT1320262B1 (en) 2000-09-27 2000-09-27 DISPENSING DEVICE FOR THE TRANSDERMIC ADMINISTRATION OF A SUBSTANCE CONTAINING AN ACTIVE PRINCIPLE AND RELATED DISPENSING HEAD.

Publications (1)

Publication Number Publication Date
WO2002026316A1 true WO2002026316A1 (en) 2002-04-04

Family

ID=11458063

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2001/000494 WO2002026316A1 (en) 2000-09-27 2001-09-26 Dispenser for endermic administration of drug

Country Status (3)

Country Link
AU (1) AU2001295884A1 (en)
IT (1) IT1320262B1 (en)
WO (1) WO2002026316A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2372705A (en) * 2000-11-03 2002-09-04 Kieron Loy A hand-held self-administered iontophoretic drug applicator with roller-ball skin electrode
EP2111889A1 (en) * 2008-04-25 2009-10-28 Juan Carlos Font I Mas Roll-on device for electrotherapy machine
ITGO20100004A1 (en) * 2010-05-25 2011-11-26 Fabio Bonifacio ELECTRO-DIFFUSER DEVICE FOR PHYSIOTHERAPY

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
US3677268A (en) * 1969-11-28 1972-07-18 Sherwood Medical Ind Inc Iontophoresis electrode
EP0326398A2 (en) * 1988-01-29 1989-08-02 The Regents Of The University Of California Device for iontophoretic non-invasive sampling or delivery of substances
WO1990006153A1 (en) * 1988-11-28 1990-06-14 Innofinance Általános Innovációs Pénzintézet Rt. Iontophoresis apparatus
US5195953A (en) * 1988-04-21 1993-03-23 Demartini Richard J Method of increasing skin absorption of a drug

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
US3677268A (en) * 1969-11-28 1972-07-18 Sherwood Medical Ind Inc Iontophoresis electrode
EP0326398A2 (en) * 1988-01-29 1989-08-02 The Regents Of The University Of California Device for iontophoretic non-invasive sampling or delivery of substances
US5195953A (en) * 1988-04-21 1993-03-23 Demartini Richard J Method of increasing skin absorption of a drug
WO1990006153A1 (en) * 1988-11-28 1990-06-14 Innofinance Általános Innovációs Pénzintézet Rt. Iontophoresis apparatus

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2372705A (en) * 2000-11-03 2002-09-04 Kieron Loy A hand-held self-administered iontophoretic drug applicator with roller-ball skin electrode
EP2111889A1 (en) * 2008-04-25 2009-10-28 Juan Carlos Font I Mas Roll-on device for electrotherapy machine
ITGO20100004A1 (en) * 2010-05-25 2011-11-26 Fabio Bonifacio ELECTRO-DIFFUSER DEVICE FOR PHYSIOTHERAPY

Also Published As

Publication number Publication date
ITTO20000896A0 (en) 2000-09-27
ITTO20000896A1 (en) 2002-03-27
AU2001295884A1 (en) 2002-04-08
IT1320262B1 (en) 2003-11-26

Similar Documents

Publication Publication Date Title
US5927977A (en) Dental scaler
US4958751A (en) Sub-gingival medicament applicator
US6581804B1 (en) Holder for aerosol dispenser
USD544956S1 (en) Dispenser for dispensing a fluid into a nasal cavity
JPH01153151A (en) Washing apparatus
US4583982A (en) Fluid dispenser
ATE74322T1 (en) DISPENSE PUMP.
AU2001237467A1 (en) Dental hand instrument and tip of the instrument
CA2951553C (en) Nozzle arrangement for flowable substances
WO2004060259A3 (en) Hand held oral irrigator
US4738669A (en) Fluid dispenser using capillary action
US8882720B2 (en) Skin formulation dispenser for use with or as part of a sonic applicator
EP0056019A1 (en) Pump
JP2018532514A (en) Device for applying a formulation that will be distributed to the user's skin by iontophoresis
WO2002026316A1 (en) Dispenser for endermic administration of drug
KR20040011008A (en) Keratin-removal handpiece
US20100032500A1 (en) Multiple configuration shower device
KR101980170B1 (en) High pressure hose anti-torsion connection
IL111371A (en) Rotary water sprinkler including protective cover
SE9702082D0 (en) Eye fluid applicator
CN108602082A (en) There is the distributor of hinged distribution pipe
JP2000177767A (en) Application container
EP0096731A1 (en) Apparatus for aesthetic and electrotherapeutic care, and atomising device
FR2573819A1 (en) Small hand-operated dispensing pump
JP2000308650A (en) Dental device for curing tissue preferably having high- frequency mechanical vibration

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP