WO2002031491A3 - Apparatus and methods for affinity capture tandem mass spectrometry - Google Patents

Apparatus and methods for affinity capture tandem mass spectrometry Download PDF

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Publication number
WO2002031491A3
WO2002031491A3 PCT/US2000/028163 US0028163W WO0231491A3 WO 2002031491 A3 WO2002031491 A3 WO 2002031491A3 US 0028163 W US0028163 W US 0028163W WO 0231491 A3 WO0231491 A3 WO 0231491A3
Authority
WO
WIPO (PCT)
Prior art keywords
tandem mass
affinity capture
methods
mass spectrometry
capture tandem
Prior art date
Application number
PCT/US2000/028163
Other languages
French (fr)
Other versions
WO2002031491A2 (en
Inventor
Scot Weinberger
Werner Ens
Alexander Laboda
Victor Spicer
Raymond G Bryan
Ken Standing
Pete Tornatore
Original Assignee
Ciphergen Biosystems Inc
Scot Weinberger
Werner Ens
Alexander Laboda
Victor Spicer
Raymond G Bryan
Ken Standing
Pete Tornatore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciphergen Biosystems Inc, Scot Weinberger, Werner Ens, Alexander Laboda, Victor Spicer, Raymond G Bryan, Ken Standing, Pete Tornatore filed Critical Ciphergen Biosystems Inc
Priority to CA002425456A priority Critical patent/CA2425456A1/en
Priority to IL15493200A priority patent/IL154932A0/en
Priority to EP00972093A priority patent/EP1327256A2/en
Priority to JP2002534826A priority patent/JP2004524511A/en
Priority to AU2001210807A priority patent/AU2001210807A1/en
Priority to PCT/US2000/028163 priority patent/WO2002031491A2/en
Priority to KR10-2003-7005172A priority patent/KR20040010541A/en
Priority to CNA008199590A priority patent/CN1502116A/en
Priority to US10/095,259 priority patent/US20020195555A1/en
Publication of WO2002031491A2 publication Critical patent/WO2002031491A2/en
Publication of WO2002031491A3 publication Critical patent/WO2002031491A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Optics & Photonics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

The invention provides an analytical instrument comprising an affinity capture probe interface, a laser desorption ionization source, and a tandem mass spectrometer. Also presented are new methods for protein discovery and identification and for characterization of molecular interactions that utilize the instrument of the present invention.
PCT/US2000/028163 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry WO2002031491A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA002425456A CA2425456A1 (en) 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry
IL15493200A IL154932A0 (en) 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry
EP00972093A EP1327256A2 (en) 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry
JP2002534826A JP2004524511A (en) 2000-10-11 2000-10-11 Apparatus and method for affinity capture tandem mass spectrometry
AU2001210807A AU2001210807A1 (en) 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry
PCT/US2000/028163 WO2002031491A2 (en) 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry
KR10-2003-7005172A KR20040010541A (en) 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry
CNA008199590A CN1502116A (en) 2000-10-11 2000-10-11 Compatible capture tandem mass spectrographic analysis equipment and method
US10/095,259 US20020195555A1 (en) 2000-10-11 2002-03-08 Apparatus and methods for affinity capture tandem mass spectrometry

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/028163 WO2002031491A2 (en) 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/095,259 Continuation US20020195555A1 (en) 2000-10-11 2002-03-08 Apparatus and methods for affinity capture tandem mass spectrometry

Publications (2)

Publication Number Publication Date
WO2002031491A2 WO2002031491A2 (en) 2002-04-18
WO2002031491A3 true WO2002031491A3 (en) 2003-01-09

Family

ID=21741880

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028163 WO2002031491A2 (en) 2000-10-11 2000-10-11 Apparatus and methods for affinity capture tandem mass spectrometry

Country Status (8)

Country Link
EP (1) EP1327256A2 (en)
JP (1) JP2004524511A (en)
KR (1) KR20040010541A (en)
CN (1) CN1502116A (en)
AU (1) AU2001210807A1 (en)
CA (1) CA2425456A1 (en)
IL (1) IL154932A0 (en)
WO (1) WO2002031491A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10125258A1 (en) 2001-05-23 2003-01-09 November Ag Molekulare Medizin Method for determining the binding behavior of ligands that specifically bind to target molecules
AU2002358219A1 (en) * 2001-12-21 2003-07-15 Sense Proteomic Limited Protein analysis using mass spectrometry
US7064319B2 (en) * 2003-03-31 2006-06-20 Hitachi High-Technologies Corporation Mass spectrometer
JP4605344B2 (en) * 2003-06-10 2011-01-05 直久 友杉 Test method for patients with Sjogren's syndrome
JP4522910B2 (en) * 2005-05-30 2010-08-11 株式会社日立ハイテクノロジーズ Mass spectrometry method and mass spectrometer
KR100805775B1 (en) * 2005-08-08 2008-02-21 한국기초과학지원연구원 An additive scoring method for modified polypeptide
CN106055895B (en) * 2010-09-15 2021-02-19 Dh科技发展私人贸易有限公司 Data independent acquisition of product ion spectra and reference library matching
US9202677B2 (en) * 2012-05-18 2015-12-01 Dh Technologies Development Pte. Ltd. Systems and methods for using interleaving window widths in tandem mass spectrometry
KR101559101B1 (en) * 2013-11-28 2015-10-12 한국기초과학지원연구원 Polypeptide markers for cancer diagnosis derived from blood sample and methods for the diagnosis of cancers using the same
CN113049663B (en) * 2021-01-27 2023-10-20 中国科学院成都生物研究所 Device for dumping one-dimensional wire sample and analyzing mass spectrum and application method
CN115184530B (en) * 2022-08-19 2023-11-24 北京中医药大学 Multistage online energy resolution mass spectrometry and application thereof in precise structural identification

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BLAWAS A S ET AL: "Protein patterning", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 19, no. 7-9, 5 April 1998 (1998-04-05), pages 595 - 609, XP004120826, ISSN: 0142-9612 *
J. R. YATES: "Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database", ANALYTICAL CHEMISTRY., vol. 67, 15 April 1995 (1995-04-15), AMERICAN CHEMICAL SOCIETY. COLUMBUS., US, pages 1426 - 1436, XP002209924, ISSN: 0003-2700 *
OKANO K ET AL: "Position-specific release of DNA from a chip by using photothermal denaturation", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 64, no. 1-3, June 2000 (2000-06-01), pages 88 - 94, XP004199291, ISSN: 0925-4005 *
YAN-HUI LIU: "Use of a nitrocellulose film substrate in matrix-assisted laser desorption / ionization mass spectrometry for DNA mapping and screening", ANALYTICAL CHEMISTRY., vol. 67, 1 October 1995 (1995-10-01), AMERICAN CHEMICAL SOCIETY. COLUMBUS., US, pages 3482 - 3490, XP002209923, ISSN: 0003-2700 *

Also Published As

Publication number Publication date
AU2001210807A1 (en) 2002-04-22
IL154932A0 (en) 2003-10-31
JP2004524511A (en) 2004-08-12
CA2425456A1 (en) 2002-04-18
WO2002031491A2 (en) 2002-04-18
KR20040010541A (en) 2004-01-31
CN1502116A (en) 2004-06-02
EP1327256A2 (en) 2003-07-16

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