WO2002034711A1 - Biaryl compounds as serine protease inhibitors - Google Patents
Biaryl compounds as serine protease inhibitors Download PDFInfo
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- WO2002034711A1 WO2002034711A1 PCT/US2001/032582 US0132582W WO0234711A1 WO 2002034711 A1 WO2002034711 A1 WO 2002034711A1 US 0132582 W US0132582 W US 0132582W WO 0234711 A1 WO0234711 A1 WO 0234711A1
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- 0 COc1cccc(C=O)c1* Chemical compound COc1cccc(C=O)c1* 0.000 description 7
- LWPFHZMAQZTNHT-UHFFFAOYSA-N CC(c(cc1)cc(N)c1-c(c(C(C)=O)c1)ccc1O)=O Chemical compound CC(c(cc1)cc(N)c1-c(c(C(C)=O)c1)ccc1O)=O LWPFHZMAQZTNHT-UHFFFAOYSA-N 0.000 description 1
- PZGVOPPZHROXRK-UHFFFAOYSA-N CCOc(cc1)ccc1C(NC(OC(C)(C)C)=O)=N Chemical compound CCOc(cc1)ccc1C(NC(OC(C)(C)C)=O)=N PZGVOPPZHROXRK-UHFFFAOYSA-N 0.000 description 1
- WMPDAIZRQDCGFH-UHFFFAOYSA-N COc1cc(C=O)ccc1 Chemical compound COc1cc(C=O)ccc1 WMPDAIZRQDCGFH-UHFFFAOYSA-N 0.000 description 1
- FTYOGLDPNBZSQC-UHFFFAOYSA-N Cc1c(CO)cc[o]1 Chemical compound Cc1c(CO)cc[o]1 FTYOGLDPNBZSQC-UHFFFAOYSA-N 0.000 description 1
- OXUZEENWOFWDJS-UHFFFAOYSA-N Cc1c(COc2ccccc2)[o]cc1CO Chemical compound Cc1c(COc2ccccc2)[o]cc1CO OXUZEENWOFWDJS-UHFFFAOYSA-N 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
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- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
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- C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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- C07C259/20—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines with at least one nitrogen atom of hydroxamidine groups bound to another nitrogen atom
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- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract
Description
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
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MXPA03009130A MXPA03009130A (en) | 2000-10-20 | 2001-10-22 | Biaryl compounds as serine protease inhibitors. |
AT01981772T ATE438615T1 (en) | 2001-04-06 | 2001-10-22 | BIARYL COMPOUNDS AS SERINE PROTEASE INHIBITORS |
IL15520201A IL155202A0 (en) | 2000-10-20 | 2001-10-22 | Biaryl compounds as serine protease inhibitors |
NZ526003A NZ526003A (en) | 2000-10-20 | 2001-10-22 | Biaryl compounds as serine protease inhibitors |
CA2426430A CA2426430C (en) | 2000-10-20 | 2001-10-22 | Biaryl compounds as serine protease inhibitors |
DK01981772T DK1383731T3 (en) | 2000-10-20 | 2001-10-22 | Biaryl compounds as serine protease inhibitors |
AU2002213393A AU2002213393B2 (en) | 2000-10-20 | 2001-10-22 | Biaryl compounds as serine protease inhibitors |
DE60139510T DE60139510D1 (en) | 2001-04-06 | 2001-10-22 | BIARYL COMPOUNDS AS SERINE PROTEASE INHIBITORS |
AU1339302A AU1339302A (en) | 2000-10-20 | 2001-10-22 | Biaryl compounds as serine protease inhibitors |
JP2002537705A JP4342178B2 (en) | 2001-04-06 | 2001-10-22 | Biaryl compounds as serine protease inhibitors |
EP01981772A EP1383731B1 (en) | 2001-04-06 | 2001-10-22 | Biaryl compounds as serine protease inhibitors |
US10/127,460 US6699994B1 (en) | 2001-04-06 | 2002-04-23 | Biaryl compounds as serine protease inhibitors |
IL155202A IL155202A (en) | 2001-04-06 | 2003-04-02 | Biaryl compounds as serine protease inhibitors |
US10/738,027 US6936719B2 (en) | 2001-04-06 | 2003-12-18 | Biaryl compounds as serine protease inhibitors |
HK04105585.6A HK1062676A1 (en) | 2000-10-20 | 2004-07-28 | Biaryl compounds as serine protease inhibitors |
IL222773A IL222773B (en) | 2001-04-06 | 2012-10-30 | Biaryl compounds, pharmaceutical compositions comprising the same, use of such compounds in the manufacture of medicaments and in vitro methods and devices using such compounds |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24184800P | 2000-10-20 | 2000-10-20 | |
US60/241,848 | 2000-10-20 | ||
US28173501P | 2001-04-06 | 2001-04-06 | |
US60/281,735 | 2001-04-06 |
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US10/127,460 Continuation-In-Part US6699994B1 (en) | 2001-04-06 | 2002-04-23 | Biaryl compounds as serine protease inhibitors |
Publications (1)
Publication Number | Publication Date |
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WO2002034711A1 true WO2002034711A1 (en) | 2002-05-02 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/032582 WO2002034711A1 (en) | 2000-10-20 | 2001-10-22 | Biaryl compounds as serine protease inhibitors |
Country Status (8)
Country | Link |
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AU (2) | AU2002213393B2 (en) |
CA (1) | CA2426430C (en) |
DK (1) | DK1383731T3 (en) |
HK (1) | HK1062676A1 (en) |
IL (1) | IL155202A0 (en) |
MX (1) | MXPA03009130A (en) |
NZ (1) | NZ526003A (en) |
WO (1) | WO2002034711A1 (en) |
Cited By (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002037937A2 (en) * | 2000-11-07 | 2002-05-16 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
WO2002042273A2 (en) * | 2000-11-07 | 2002-05-30 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
WO2003011858A1 (en) * | 2001-07-30 | 2003-02-13 | Bayer Healthcare Ag | Substituted isoindoles and e use thereof |
EP1388341A1 (en) * | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
EP1394147A1 (en) * | 2001-06-04 | 2004-03-03 | Eisai Co., Ltd. | Carboxylic acid derivative and medicine comprising salt or ester of the same |
WO2004048335A2 (en) * | 2002-11-25 | 2004-06-10 | F. Hoffmann-La Roche Ag | Mandelic acid derivatives |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US6833140B2 (en) * | 2001-06-11 | 2004-12-21 | Xenoport, Inc. | Orally administered dosage forms of GABA analog prodrugs having reduced toxicity |
US6906192B2 (en) | 2000-11-07 | 2005-06-14 | Bristol Myers Squibb Company | Processes for the preparation of acid derivatives useful as serine protease inhibitors |
FR2871157A1 (en) * | 2004-06-04 | 2005-12-09 | Aventis Pharma Sa | BIARYL AROMATIC PRODUCTS, COMPOSITIONS CONTAINING SAME AND USE THEREOF |
US7122559B2 (en) | 2003-02-11 | 2006-10-17 | Bristol-Myers Squibb Company | Phenylglycine derivatives useful as serine protease inhibitors |
US7144895B2 (en) | 2003-02-11 | 2006-12-05 | Bristol-Myers Squibb Co. | Benzene acetamide compounds useful as serine protease inhibitors |
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Also Published As
Publication number | Publication date |
---|---|
NZ526003A (en) | 2005-09-30 |
AU2002213393B2 (en) | 2007-02-15 |
IL155202A0 (en) | 2003-11-23 |
DK1383731T3 (en) | 2009-12-07 |
CA2426430C (en) | 2014-10-07 |
MXPA03009130A (en) | 2004-02-26 |
CA2426430A1 (en) | 2002-05-02 |
AU1339302A (en) | 2002-05-06 |
HK1062676A1 (en) | 2004-11-19 |
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