WO2002035241A3 - High throughput screening for protein formulations - Google Patents

High throughput screening for protein formulations Download PDF

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Publication number
WO2002035241A3
WO2002035241A3 PCT/US2001/050835 US0150835W WO0235241A3 WO 2002035241 A3 WO2002035241 A3 WO 2002035241A3 US 0150835 W US0150835 W US 0150835W WO 0235241 A3 WO0235241 A3 WO 0235241A3
Authority
WO
WIPO (PCT)
Prior art keywords
high throughput
throughput screening
protein formulations
protein
formulations
Prior art date
Application number
PCT/US2001/050835
Other languages
French (fr)
Other versions
WO2002035241A2 (en
Inventor
Alexey L Margolin
Original Assignee
Altus Biologics Inc
Alexey L Margolin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altus Biologics Inc, Alexey L Margolin filed Critical Altus Biologics Inc
Priority to AU2002231339A priority Critical patent/AU2002231339A1/en
Publication of WO2002035241A2 publication Critical patent/WO2002035241A2/en
Publication of WO2002035241A3 publication Critical patent/WO2002035241A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B01J2219/00587—High throughput processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00756—Compositions, e.g. coatings, crystals, formulations
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

This invention relates to methods for rapidly optimizing a protein formulation. This invention provides formulations libraries and methods for high throughput screening of a protein formulations library to obtain protein formulations characterized by protein stability.
PCT/US2001/050835 2000-10-23 2001-10-23 High throughput screening for protein formulations WO2002035241A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002231339A AU2002231339A1 (en) 2000-10-23 2001-10-23 High throughput screening for protein formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24260300P 2000-10-23 2000-10-23
US60/242,603 2000-10-23

Publications (2)

Publication Number Publication Date
WO2002035241A2 WO2002035241A2 (en) 2002-05-02
WO2002035241A3 true WO2002035241A3 (en) 2003-05-15

Family

ID=22915454

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/050835 WO2002035241A2 (en) 2000-10-23 2001-10-23 High throughput screening for protein formulations

Country Status (2)

Country Link
AU (1) AU2002231339A1 (en)
WO (1) WO2002035241A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030231984A1 (en) * 2002-05-07 2003-12-18 Bright Frank V. Method to rapidly prepare and screen formulations and compositions containing same
CN116211794A (en) * 2022-12-13 2023-06-06 上海探实生物科技有限公司 High-flux protein pharmaceutical preparation, screening method and kit

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192743A (en) * 1992-01-16 1993-03-09 Genentech, Inc. Reconstitutable lyophilized protein formulation
WO1999042608A1 (en) * 1998-02-24 1999-08-26 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
WO2000057183A1 (en) * 1999-03-23 2000-09-28 Biovation Limited Protein isolation and analysis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192743A (en) * 1992-01-16 1993-03-09 Genentech, Inc. Reconstitutable lyophilized protein formulation
WO1999042608A1 (en) * 1998-02-24 1999-08-26 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
WO2000057183A1 (en) * 1999-03-23 2000-09-28 Biovation Limited Protein isolation and analysis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ALLISON S DEAN ET AL: "Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran.", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 89, no. 2, February 2000 (2000-02-01), pages 199 - 214, XP002225454, ISSN: 0022-3549 *
COSTANTINO HENRY R ET AL: "Effect of mannitol crystallization on the stability and aerosol performance of a spray-dried pharmaceutical protein, recombinant humanized anti-IgE monoclonal antibody.", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 87, no. 11, November 1998 (1998-11-01), pages 1406 - 1411, XP002225455, ISSN: 0022-3549 *
GRIEBENOW KAI ET AL: "Lyophilization-induced reversible changes in the secondary structure of proteins.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 92, no. 24, 1995, 1995, pages 10969 - 10976, XP002225453, ISSN: 0027-8424 *
KATAKAM M ET AL: "Aggregation of insulin and its prevention by carbohydrate excipients.", PDA JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY / PDA. UNITED STATES 1995 JUL-AUG, vol. 49, no. 4, July 1995 (1995-07-01), pages 160 - 165, XP009003026, ISSN: 1079-7440 *
MCINTOSH KYLIE A ET AL: "The application of capillary electrophoresis for monitoring effects of excipients on protein conformation.", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 16, no. 6, February 1998 (1998-02-01), pages 1097 - 1105, XP002225456, ISSN: 0731-7085 *

Also Published As

Publication number Publication date
AU2002231339A1 (en) 2002-05-06
WO2002035241A2 (en) 2002-05-02

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