WO2002043770A3 - Homing peptide multimers, their preparation and uses - Google Patents

Homing peptide multimers, their preparation and uses Download PDF

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Publication number
WO2002043770A3
WO2002043770A3 PCT/US2001/044154 US0144154W WO0243770A3 WO 2002043770 A3 WO2002043770 A3 WO 2002043770A3 US 0144154 W US0144154 W US 0144154W WO 0243770 A3 WO0243770 A3 WO 0243770A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
homing peptide
peptide multimers
multimers
homing
Prior art date
Application number
PCT/US2001/044154
Other languages
French (fr)
Other versions
WO2002043770A2 (en
Inventor
Samuel J Danishefsky
Lawrence C Fritz
Original Assignee
Conforma Therapeutic Corp
Samuel J Danishefsky
Lawrence C Fritz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conforma Therapeutic Corp, Samuel J Danishefsky, Lawrence C Fritz filed Critical Conforma Therapeutic Corp
Priority to US10/433,212 priority Critical patent/US20040058865A1/en
Priority to AU2002217863A priority patent/AU2002217863A1/en
Publication of WO2002043770A2 publication Critical patent/WO2002043770A2/en
Publication of WO2002043770A3 publication Critical patent/WO2002043770A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/36—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents adapted to be used for non-packaging purposes after removal of contents
    • B65D81/365—Containers, or parts thereof, simulating or being incorporated into other items, e.g. puppet, animal, vehicle, building, dumb bells
    • B65D81/366—Containers, or parts thereof, simulating or being incorporated into other items, e.g. puppet, animal, vehicle, building, dumb bells the container closure only being provided with a three dimensional figure, e.g. chess piece, animal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid

Abstract

Synthetic multimeric ligands that provide for enhanced cell-, and organ- specific targeting are described and claimed, as are methods of their preparation and use.
PCT/US2001/044154 2000-12-01 2001-11-26 Homing peptide multimers, their preparation and uses WO2002043770A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/433,212 US20040058865A1 (en) 2001-11-26 2001-11-26 Homing peptide multimers, their preparation and uses
AU2002217863A AU2002217863A1 (en) 2000-12-01 2001-11-26 Homing peptide multimers, their preparation and uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25077800P 2000-12-01 2000-12-01
US60/250,778 2000-12-01

Publications (2)

Publication Number Publication Date
WO2002043770A2 WO2002043770A2 (en) 2002-06-06
WO2002043770A3 true WO2002043770A3 (en) 2003-11-06

Family

ID=22949102

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044154 WO2002043770A2 (en) 2000-12-01 2001-11-26 Homing peptide multimers, their preparation and uses

Country Status (3)

Country Link
US (1) US20020066687A1 (en)
AU (1) AU2002217863A1 (en)
WO (1) WO2002043770A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040163972A1 (en) * 2003-01-23 2004-08-26 Kevin Buckley Key hiding device
US20060227541A1 (en) * 2005-04-12 2006-10-12 Reichlin Joseph A Jr Floating candle holding device and method of use
USD975888S1 (en) * 2019-12-30 2023-01-17 Gertrude M. Legard Combination candle holder and drink coaster

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011686A (en) * 1987-09-21 1991-04-30 Creative Biomolecules, Inc. Thrombus specific conjugates
WO1996020236A1 (en) * 1994-12-23 1996-07-04 Wisconsin Alumni Research Foundation Polyglycomers
WO1996024675A1 (en) * 1995-02-10 1996-08-15 University Of Saskatchewan GnRH-LEUKOTOXIN CHIMERAS
WO1996041813A2 (en) * 1994-11-09 1996-12-27 Offord Robin E Functionalized polymers for site-specific attachment
WO1997007398A1 (en) * 1995-08-11 1997-02-27 Dade International Inc. Polypeptide-dendrimer complexes
WO1997015668A2 (en) * 1995-10-23 1997-05-01 Board Of Regents, The University Of Texas System Methods and compositions comprising glut-2 and glut-2 chimeras
WO1998006848A1 (en) * 1996-08-09 1998-02-19 University Of Saskatchewan GnRH-LEUKOTOXIN CHIMERAS
WO1999059633A1 (en) * 1998-05-20 1999-11-25 Immunomedics, Inc. Therapeutics using a bispecific anti-hla class ii invariant chain x anti-pathogen antibody
US6121236A (en) * 1998-03-24 2000-09-19 The Children's Medical Center Corporation Multivalent ligands which modulate angiogenesis
WO2001047960A1 (en) * 1999-12-24 2001-07-05 Phogen Limited Uses of transport proteins for controlling cell cycle

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011686A (en) * 1987-09-21 1991-04-30 Creative Biomolecules, Inc. Thrombus specific conjugates
WO1996041813A2 (en) * 1994-11-09 1996-12-27 Offord Robin E Functionalized polymers for site-specific attachment
WO1996020236A1 (en) * 1994-12-23 1996-07-04 Wisconsin Alumni Research Foundation Polyglycomers
WO1996024675A1 (en) * 1995-02-10 1996-08-15 University Of Saskatchewan GnRH-LEUKOTOXIN CHIMERAS
WO1997007398A1 (en) * 1995-08-11 1997-02-27 Dade International Inc. Polypeptide-dendrimer complexes
WO1997015668A2 (en) * 1995-10-23 1997-05-01 Board Of Regents, The University Of Texas System Methods and compositions comprising glut-2 and glut-2 chimeras
WO1998006848A1 (en) * 1996-08-09 1998-02-19 University Of Saskatchewan GnRH-LEUKOTOXIN CHIMERAS
US6121236A (en) * 1998-03-24 2000-09-19 The Children's Medical Center Corporation Multivalent ligands which modulate angiogenesis
WO1999059633A1 (en) * 1998-05-20 1999-11-25 Immunomedics, Inc. Therapeutics using a bispecific anti-hla class ii invariant chain x anti-pathogen antibody
US6458933B1 (en) * 1998-05-20 2002-10-01 Immunomedics, Inc. Therapeutic using a bispecific antibody
WO2001047960A1 (en) * 1999-12-24 2001-07-05 Phogen Limited Uses of transport proteins for controlling cell cycle

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BLACKWELL H E ET AL: "NEW APPROACHES TO OLEFIN CROSS-METATHESIS", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 122, no. 1, 12 January 2000 (2000-01-12), pages 58 - 71, XP000891075, ISSN: 0002-7863 *
GUO L H ET AL: "DIRECT UN-MEDIATED ELECTROCHEMISTRY OF THE ENZYME P-CRESOLMETHYLHYDROXYLASE", JOURNAL OF ELECTROANALYTICAL CHEMISTRY AND INTERFACIAL ELECTROCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 266, no. 2, 25 July 1989 (1989-07-25), pages 379 - 396, XP002038924, ISSN: 0022-0728 *
MIYAURA N ET AL: "PALLADIUM-CATALYZED INTER- AND INTRAMOLECULAR CROSS-COUPLING REACTIONS OF B-ALKYL-9-BORABICYCLOU3.3.1NONANE DERIVATIVES WITH 1-HALO-1-ALKENES OR HALOARENES. SYNTHESES OF FUNCTIONALIZED ALKENES, ARENES, AND CYCLOALKENES VIA A HYDROBORATION-COUPLING SEQUENCE", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 111, no. 1, 1989, pages 314 - 321, XP000650210, ISSN: 0002-7863 *
STILLE J K: "THE PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS OF ORGANOTIN REAGENTS WITH ORGANIC ELECTROPHILES", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, VERLAG CHEMIE. WEINHEIM, DE, vol. 25, 1986, pages 508 - 524, XP000872970, ISSN: 0570-0833 *

Also Published As

Publication number Publication date
WO2002043770A2 (en) 2002-06-06
AU2002217863A1 (en) 2002-06-11
US20020066687A1 (en) 2002-06-06

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