WO2002043864A3 - Devices and methods for biochip multiplexing - Google Patents
Devices and methods for biochip multiplexing Download PDFInfo
- Publication number
- WO2002043864A3 WO2002043864A3 PCT/US2001/044364 US0144364W WO0243864A3 WO 2002043864 A3 WO2002043864 A3 WO 2002043864A3 US 0144364 W US0144364 W US 0144364W WO 0243864 A3 WO0243864 A3 WO 0243864A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- devices
- biochip
- methods
- nucleic acid
- allow
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00871—Communications between instruments or with remote terminals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/021—Identification, e.g. bar codes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0605—Valves, specific forms thereof check valves
- B01L2400/0611—Valves, specific forms thereof check valves duck bill valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0661—Valves, specific forms thereof with moving parts shape memory polymer valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N2001/021—Correlating sampling sites with geographical information, e.g. GPS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00158—Elements containing microarrays, i.e. "biochip"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00326—Analysers with modular structure
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
Abstract
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002427669A CA2427669A1 (en) | 2000-11-03 | 2001-11-05 | Devices and methods for biochip multiplexing |
JP2002545830A JP2004515231A (en) | 2000-11-03 | 2001-11-05 | Apparatus and method for multiplexing biochips |
AU2002239354A AU2002239354A1 (en) | 2000-11-03 | 2001-11-05 | Devices and methods for biochip multiplexing |
EP01987105A EP1331999A2 (en) | 2000-11-03 | 2001-11-05 | Devices and methods for biochip multiplexing |
US10/412,660 US20040053290A1 (en) | 2000-01-11 | 2003-04-11 | Devices and methods for biochip multiplexing |
AU2005244524A AU2005244524A1 (en) | 2000-11-03 | 2005-12-14 | Devices and methods for biochip multiplexing |
US11/532,872 US20070098600A1 (en) | 1999-04-21 | 2006-09-18 | Devices and methods for biochip multiplexing |
US11/982,368 US20110180425A1 (en) | 1999-04-21 | 2007-10-31 | Devices and methods for biochip multiplexing |
US11/982,403 US20090057147A1 (en) | 1999-04-21 | 2007-10-31 | Devices and methods for biochip multiplexing |
US11/982,334 US20100285981A1 (en) | 1999-04-21 | 2007-10-31 | Devices and methods for biochip multiplexing |
US11/982,408 US20080242553A1 (en) | 1999-04-21 | 2007-10-31 | Devices and methods for biochip multiplexing |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24584000P | 2000-11-03 | 2000-11-03 | |
US60/145,840 | 2000-11-03 | ||
USPCT/US01/01150 | 2001-01-11 | ||
PCT/US2001/001150 WO2001054813A2 (en) | 2000-01-11 | 2001-01-11 | Devices and methods for biochip multiplexing |
US09/760,384 | 2001-01-11 | ||
US09/760,384 US7312087B2 (en) | 2000-01-11 | 2001-01-11 | Devices and methods for biochip multiplexing |
US09/904,175 US20020177135A1 (en) | 1999-07-27 | 2001-07-11 | Devices and methods for biochip multiplexing |
US09/904,175 | 2001-07-11 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/904,175 Continuation-In-Part US20020177135A1 (en) | 1999-04-21 | 2001-07-11 | Devices and methods for biochip multiplexing |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US19371202A Continuation-In-Part | 1999-04-21 | 2002-07-11 | |
US10/412,660 Continuation-In-Part US20040053290A1 (en) | 1999-04-21 | 2003-04-11 | Devices and methods for biochip multiplexing |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002043864A2 WO2002043864A2 (en) | 2002-06-06 |
WO2002043864A3 true WO2002043864A3 (en) | 2002-08-01 |
Family
ID=56290216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/044364 WO2002043864A2 (en) | 1999-04-21 | 2001-11-05 | Devices and methods for biochip multiplexing |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1331999A2 (en) |
JP (1) | JP2004515231A (en) |
AU (1) | AU2002239354A1 (en) |
CA (1) | CA2427669A1 (en) |
WO (1) | WO2002043864A2 (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8388908B2 (en) | 2009-06-02 | 2013-03-05 | Integenx Inc. | Fluidic devices with diaphragm valves |
US8431390B2 (en) | 2004-09-15 | 2013-04-30 | Integenx Inc. | Systems of sample processing having a macro-micro interface |
US8476063B2 (en) | 2004-09-15 | 2013-07-02 | Integenx Inc. | Microfluidic devices |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
US8557518B2 (en) | 2007-02-05 | 2013-10-15 | Integenx Inc. | Microfluidic and nanofluidic devices, systems, and applications |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
US8672532B2 (en) | 2008-12-31 | 2014-03-18 | Integenx Inc. | Microfluidic methods |
US8748165B2 (en) | 2008-01-22 | 2014-06-10 | Integenx Inc. | Methods for generating short tandem repeat (STR) profiles |
US8763642B2 (en) | 2010-08-20 | 2014-07-01 | Integenx Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
US8841116B2 (en) | 2006-10-25 | 2014-09-23 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated DNA analysis system using same |
US9121058B2 (en) | 2010-08-20 | 2015-09-01 | Integenx Inc. | Linear valve arrays |
US9151746B2 (en) | 1999-04-21 | 2015-10-06 | Osmetech Technology, Inc. | Use of microfluidic systems in the electrochemical detection of target analytes |
US11845081B2 (en) | 2007-07-13 | 2023-12-19 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000024941A1 (en) | 1998-10-27 | 2000-05-04 | Clinical Micro Sensors, Inc. | Detection of target analytes using particles and electrodes |
US6875619B2 (en) | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
US7338760B2 (en) | 2001-10-26 | 2008-03-04 | Ntu Ventures Private Limited | Sample preparation integrated chip |
KR100450818B1 (en) * | 2002-03-09 | 2004-10-01 | 삼성전자주식회사 | Multi chamber PCR chip |
EP1385006A3 (en) * | 2002-07-24 | 2004-09-01 | F. Hoffmann-La Roche Ag | System and cartridge for processing a biological sample |
EP1419821A1 (en) * | 2002-11-14 | 2004-05-19 | F. Hoffmann-La Roche Ag | Method, system and reaction vessel for processing a biological sample contained in a liquid |
EP1594694A4 (en) | 2002-12-30 | 2010-01-20 | Univ California | Methods and apparatus for pathogen detection and analysis |
CN100504372C (en) * | 2003-02-14 | 2009-06-24 | 爱科来株式会社 | Analyzing tool with knob part |
DE10318139B4 (en) * | 2003-04-18 | 2005-02-17 | PRO DESIGN Gesellschaft für Produktentwicklung mbH | Self-configurable biochip |
JP4038575B2 (en) * | 2003-07-25 | 2008-01-30 | 独立行政法人産業技術総合研究所 | Biosensor, biosensor device or biosensor storage method |
KR101165860B1 (en) | 2003-10-16 | 2012-07-13 | 하이 캉 라이프 코포레이션 리미티드 | Apparatus and methods for detecting nucleic acid in biological samples |
US7390622B2 (en) * | 2003-10-16 | 2008-06-24 | Hai Kang Life Corporation Limited | Apparatus and methods for detecting nucleic acid in biological samples |
JP4750412B2 (en) * | 2003-12-25 | 2011-08-17 | モレックス インコーポレイテド | Biologically derived molecules, dioxins and endocrine disrupting substance detection apparatus and detection method using the apparatus |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
EP1799348A2 (en) * | 2004-08-04 | 2007-06-27 | Spinx, Inc. | Devices and methods for interfacing microfluidic devices with fluid handling devices |
JP4583937B2 (en) * | 2005-01-07 | 2010-11-17 | 積水化学工業株式会社 | Method for electrochemical measurement of arsenic ions |
JP4714475B2 (en) * | 2005-02-15 | 2011-06-29 | 株式会社島津製作所 | Reaction vessel, gene polymorphism detection method and apparatus |
JP2006223126A (en) * | 2005-02-15 | 2006-08-31 | Shimadzu Corp | Reaction vessel, method and apparatus for detecting genetic polymorphism and method and apparatus for diagnosis |
JP2006242925A (en) | 2005-03-07 | 2006-09-14 | Seiko Epson Corp | Electrode substrate, detector equipped with the substrate, kit including the detector, detection method using the kit |
JP4660662B2 (en) * | 2005-09-06 | 2011-03-30 | アークレイ株式会社 | cartridge |
US7723120B2 (en) | 2005-10-26 | 2010-05-25 | General Electric Company | Optical sensor array system and method for parallel processing of chemical and biochemical information |
US8133741B2 (en) | 2005-10-26 | 2012-03-13 | General Electric Company | Methods and systems for delivery of fluidic samples to sensor arrays |
US9023278B2 (en) * | 2006-01-12 | 2015-05-05 | Micah James Atkin | Instrumentation systems and methods |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
WO2007112114A2 (en) | 2006-03-24 | 2007-10-04 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
EP1886727A1 (en) * | 2006-07-14 | 2008-02-13 | Roche Diagnostics GmbH | Analytical device |
EP1878495A1 (en) * | 2006-07-14 | 2008-01-16 | Roche Diagnostics GmbH | Analytical device for thermally treating a fluid and/or monitoring a property thereof |
US20090291505A1 (en) * | 2006-07-14 | 2009-11-26 | Roche Molecular System, Inc. | Analytical Device for Thermally Treating a Fluid and/or Monitoring a Property Thereof |
JP4751302B2 (en) * | 2006-11-21 | 2011-08-17 | 株式会社日立製作所 | Potential difference sensor and analytical element |
US8317492B2 (en) * | 2007-02-27 | 2012-11-27 | Deka Products Limited Partnership | Pumping cassette |
US20090107335A1 (en) | 2007-02-27 | 2009-04-30 | Deka Products Limited Partnership | Air trap for a medical infusion device |
US7883898B2 (en) | 2007-05-07 | 2011-02-08 | General Electric Company | Method and apparatus for measuring pH of low alkalinity solutions |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
EP2028488B1 (en) * | 2007-08-02 | 2015-02-25 | F. Hoffmann-La Roche AG | Transfer unit for test elements |
JP2009085829A (en) * | 2007-10-01 | 2009-04-23 | Nec Corp | Biomaterial measuring device |
WO2012142516A1 (en) | 2011-04-15 | 2012-10-18 | Becton, Dickinson And Company | Scanning real-time microfluidic thermo-cycler and methods for synchronized thermocycling and scanning optical detection |
WO2013067202A1 (en) | 2011-11-04 | 2013-05-10 | Handylab, Inc. | Polynucleotide sample preparation device |
WO2014022700A2 (en) * | 2012-08-01 | 2014-02-06 | Prakash Ranjit A | Functionally integrated device for multiplex genetic identification and method for separation and detection of dna fragments |
US20140200167A1 (en) | 2012-08-01 | 2014-07-17 | Nanomdx, Inc. | Functionally integrated device for multiplex genetic identification |
CN107051604B (en) | 2012-08-30 | 2019-07-05 | 生命技术公司 | Vertical grip device |
DE102014205728B3 (en) * | 2014-03-27 | 2015-03-05 | Robert Bosch Gmbh | A chip laboratory cartridge for a microfluidic system for analyzing a sample of biological material, a microfluidic system for analyzing a sample of biological material, and a method and apparatus for analyzing a sample of biological material |
GB201510723D0 (en) * | 2015-06-18 | 2015-08-05 | Alere Switzerland Gmbh | High throughput isothermal nucleic acid amplification |
JP7012301B2 (en) * | 2017-09-12 | 2022-02-14 | 株式会社八光電機 | Drug detection system |
JP7303623B2 (en) * | 2018-12-07 | 2023-07-05 | 積水化学工業株式会社 | inspection tool |
DE102022209418A1 (en) * | 2022-09-09 | 2024-03-14 | Robert Bosch Gesellschaft mit beschränkter Haftung | Microfluidic device and method for its operation |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5519635A (en) * | 1993-09-20 | 1996-05-21 | Hitachi Ltd. | Apparatus for chemical analysis with detachable analytical units |
WO1997041425A1 (en) * | 1996-04-25 | 1997-11-06 | Pence, Inc. | Biosensor device and method |
WO1998005424A1 (en) * | 1996-08-02 | 1998-02-12 | Caliper Technologies Corporation | Analytical system and method |
WO1998057159A1 (en) * | 1997-06-12 | 1998-12-17 | Clinical Micro Sensors, Inc. | Electronic methods for the detection of analytes |
US5866345A (en) * | 1992-05-01 | 1999-02-02 | The Trustees Of The University Of Pennsylvania | Apparatus for the detection of an analyte utilizing mesoscale flow systems |
WO1999033559A1 (en) * | 1997-12-24 | 1999-07-08 | Cepheid | Integrated fluid manipulation cartridge |
US6114122A (en) * | 1996-03-26 | 2000-09-05 | Affymetrix, Inc. | Fluidics station with a mounting system and method of using |
WO2000062931A1 (en) * | 1999-04-21 | 2000-10-26 | Clinical Micro Sensors, Inc. | The use of microfluidic systems in the electrochemical detection of target analytes |
-
2001
- 2001-11-05 WO PCT/US2001/044364 patent/WO2002043864A2/en active Application Filing
- 2001-11-05 AU AU2002239354A patent/AU2002239354A1/en not_active Abandoned
- 2001-11-05 CA CA002427669A patent/CA2427669A1/en not_active Abandoned
- 2001-11-05 JP JP2002545830A patent/JP2004515231A/en active Pending
- 2001-11-05 EP EP01987105A patent/EP1331999A2/en not_active Withdrawn
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5866345A (en) * | 1992-05-01 | 1999-02-02 | The Trustees Of The University Of Pennsylvania | Apparatus for the detection of an analyte utilizing mesoscale flow systems |
US5519635A (en) * | 1993-09-20 | 1996-05-21 | Hitachi Ltd. | Apparatus for chemical analysis with detachable analytical units |
US6114122A (en) * | 1996-03-26 | 2000-09-05 | Affymetrix, Inc. | Fluidics station with a mounting system and method of using |
WO1997041425A1 (en) * | 1996-04-25 | 1997-11-06 | Pence, Inc. | Biosensor device and method |
WO1998005424A1 (en) * | 1996-08-02 | 1998-02-12 | Caliper Technologies Corporation | Analytical system and method |
WO1998057159A1 (en) * | 1997-06-12 | 1998-12-17 | Clinical Micro Sensors, Inc. | Electronic methods for the detection of analytes |
WO1999033559A1 (en) * | 1997-12-24 | 1999-07-08 | Cepheid | Integrated fluid manipulation cartridge |
WO2000062931A1 (en) * | 1999-04-21 | 2000-10-26 | Clinical Micro Sensors, Inc. | The use of microfluidic systems in the electrochemical detection of target analytes |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9557295B2 (en) | 1999-04-21 | 2017-01-31 | Osmetech Technology, Inc. | Use of microfluidic systems in the electrochemical detection of target analytes |
US9151746B2 (en) | 1999-04-21 | 2015-10-06 | Osmetech Technology, Inc. | Use of microfluidic systems in the electrochemical detection of target analytes |
US8431390B2 (en) | 2004-09-15 | 2013-04-30 | Integenx Inc. | Systems of sample processing having a macro-micro interface |
US8431340B2 (en) | 2004-09-15 | 2013-04-30 | Integenx Inc. | Methods for processing and analyzing nucleic acid samples |
US8476063B2 (en) | 2004-09-15 | 2013-07-02 | Integenx Inc. | Microfluidic devices |
US8551714B2 (en) | 2004-09-15 | 2013-10-08 | Integenx Inc. | Microfluidic devices |
US8841116B2 (en) | 2006-10-25 | 2014-09-23 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated DNA analysis system using same |
US8557518B2 (en) | 2007-02-05 | 2013-10-15 | Integenx Inc. | Microfluidic and nanofluidic devices, systems, and applications |
US11845081B2 (en) | 2007-07-13 | 2023-12-19 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8748165B2 (en) | 2008-01-22 | 2014-06-10 | Integenx Inc. | Methods for generating short tandem repeat (STR) profiles |
US8672532B2 (en) | 2008-12-31 | 2014-03-18 | Integenx Inc. | Microfluidic methods |
US8388908B2 (en) | 2009-06-02 | 2013-03-05 | Integenx Inc. | Fluidic devices with diaphragm valves |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
US9121058B2 (en) | 2010-08-20 | 2015-09-01 | Integenx Inc. | Linear valve arrays |
US8763642B2 (en) | 2010-08-20 | 2014-07-01 | Integenx Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
Also Published As
Publication number | Publication date |
---|---|
EP1331999A2 (en) | 2003-08-06 |
JP2004515231A (en) | 2004-05-27 |
AU2002239354A1 (en) | 2002-06-11 |
WO2002043864A2 (en) | 2002-06-06 |
CA2427669A1 (en) | 2002-06-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2002043864A3 (en) | Devices and methods for biochip multiplexing | |
EP1828381B1 (en) | Template directed split and mix systhesis of small molecule libraries | |
US6586211B1 (en) | Method for producing polymers | |
JP2004501665A5 (en) | ||
WO2003056030A3 (en) | Methods and systems of nucleic acid sequencing | |
WO2005063372A3 (en) | Device and method for pressure and flow control in parallel reactors | |
IL145459A (en) | Individual addressable micro-electromagnetic unit array chips | |
EP1473084A3 (en) | Biochemical reaction cartridge | |
US20080125330A1 (en) | Real-Time Pcr Detection of Microorganisms Using an Integrated Microfluidics Platform | |
EP0683790A4 (en) | Automated synthesis of oligonucleotides. | |
WO2005066343A1 (en) | Nucleic acid purification chip | |
US20100159582A1 (en) | Disposable multiplex polymerase chain reaction (pcr) chip and device | |
WO2003078659A3 (en) | Microcapsules with controlable permeability encapsulating a nucleic acid amplification reaction mixture and their use as reaction compartments for parallels reactions | |
EP2436778A3 (en) | Photocleavable fluorescent nucleotides for DNA sequencing on chip constructed by site-specific coupling chemistry | |
WO2002094846A2 (en) | Method for in situ, on-chip chemical synthesis | |
WO2005028629A3 (en) | Whole genome expression analysis system | |
EP1574586A3 (en) | Method and apparatus for amplifying nucleic acids | |
DE60224033D1 (en) | COMBINATORY CHEMICAL REACTION SYSTEM | |
CN105723203B (en) | Magnetic Isolation | |
US20140274809A1 (en) | Multi-well manifold assembly system for oligonucleotide synthesis | |
EP0822401A3 (en) | Hydraulic system for a hematology analytical instrument | |
WO2003043712A8 (en) | Column comprising dual flow plates | |
WO2004088280A3 (en) | Method and apparatus for improved gas detection | |
WO2003015896A3 (en) | Apparatus for and method of trapping products in exhaust gas | |
WO2002092221A8 (en) | A system for performing experiments, in particular for high throughput experimentation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2002239354 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2427669 Country of ref document: CA Ref document number: 2002545830 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001987105 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2001987105 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |