WO2002047578A1 - Implant, procede pour introduire un element de renforcement et procede de production d'implant - Google Patents

Implant, procede pour introduire un element de renforcement et procede de production d'implant Download PDF

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Publication number
WO2002047578A1
WO2002047578A1 PCT/DE2001/004722 DE0104722W WO0247578A1 WO 2002047578 A1 WO2002047578 A1 WO 2002047578A1 DE 0104722 W DE0104722 W DE 0104722W WO 0247578 A1 WO0247578 A1 WO 0247578A1
Authority
WO
WIPO (PCT)
Prior art keywords
implant
tissue
guide means
openings
reinforcing element
Prior art date
Application number
PCT/DE2001/004722
Other languages
German (de)
English (en)
Inventor
Kornel Tordy
Friedhelm Limbeck
Janine Tordy
Original Assignee
Kornel Tordy
Friedhelm Limbeck
Janine Tordy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE20022228U external-priority patent/DE20022228U1/de
Application filed by Kornel Tordy, Friedhelm Limbeck, Janine Tordy filed Critical Kornel Tordy
Priority to EP01995601A priority Critical patent/EP1345553A1/fr
Priority to US10/450,688 priority patent/US20040049289A1/en
Priority to JP2002549156A priority patent/JP2004515306A/ja
Priority to AU2002226295A priority patent/AU2002226295A1/en
Publication of WO2002047578A1 publication Critical patent/WO2002047578A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L27/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
    • C08L27/02—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L27/12—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers not modified by chemical after-treatment containing fluorine atoms
    • C08L27/18—Homopolymers or copolymers or tetrafluoroethene

Definitions

  • Implant method for inserting a reinforcing element and method for producing an implant
  • the invention relates to an implant made of a tissue-compatible microporous material, a method for introducing a reinforcing element into a soft structure surrounded by a casing and a method for producing an implant from a blank.
  • nets, braided ribbons and pillows are known in particular for surgical use and can be implanted.
  • polyamides or silicones are generally used as materials.
  • these have the disadvantage that they do not grow sufficiently with the tissue due to their constellation. This leads to incompatibilities, such as encapsulation until the corresponding implant is rejected.
  • the implants are mostly sewn to the tissue so that they do not slip.
  • pillow implants in particular, this is aggravated by the fact that the size of these implants has to be determined and ordered before the surgical intervention, so that another surgical intervention is disadvantageously necessary if it becomes apparent during the operation that the intended implant is not of the required size equivalent. Since surgical intervention is always risks, a second surgical intervention is a major disadvantage.
  • implants made of a tissue-compatible microporous material are well known from the prior art and are used, for example, in different variations for cosmetic surgery or for accident surgery, e.g. B. offered as a tissue replacement.
  • Expanded polytetrafluoroethylene (e-PTFE) is used in particular.
  • the object of the invention is to provide an implant which connects to a tissue as quickly as possible and which is nevertheless sufficiently compatible with the tissue.
  • the object of the invention is achieved by an implant made of a tissue-compatible microporous material which has at least one stable opening. With such an arrangement, a tissue that comes into contact with the implant can grow into the stable opening of the implant relatively quickly.
  • the tissue-compatible microporous material advantageously comprises labile openings. This is particularly advantageous since, in addition to the stable openings, which serve for the rapid ingrowth of cell tissue, almost any area of the implant is suitable for cell tissue to grow in, in particular in the medium or long term.
  • the cell tissue that grows rapidly into the stable opening causes a particularly intimate connection between the tissue-compatible microporous material of the implant and the cell tissue arranged around the implant.
  • the implant according to the invention achieves considerable weight savings in comparison to implants that have been customary to date, such as silicone, table salt, soybean oil.
  • leakage of the content of an implant is excluded with regard to the implant according to the invention.
  • the implant does not suffer any serious injuries due to pressure or negative pressure.
  • the implant is hardly destroyed by stab or other injuries.
  • the implant is made from an expanded polytetrafluoroethylene (e-PTFE).
  • e-PTFE expanded polytetrafluoroethylene
  • an implant made of e-PTFE is very soft and elastic, pressure sores advantageously rarely or not at all occur. This is particularly advantageous in areas such as nerves, bones, vessels, which means that later pain in particular is virtually excluded.
  • a microporous material is advantageously provided, the material of which is or can be expanded to such an extent that a tissue and / or a vessel can grow through the microporous material itself and thus the implant has a very intimate connection with the Tissue comes in.
  • the microporous material made of an expanded polytetrafluoroethylene and having stable openings has a ratio of preferably only 14% material and 86% air, in particular due to its porous structure.
  • the microporosity or the unstable holes ensure that tissue can penetrate or grow into the material in the medium or long term.
  • the implant with the stable openings is suitable to fill up even the smallest tissue and / or nodal distances (both benign and malignant), which are easily visible, for example, after an operation through the sagging skin due to a lack of tissue, since the implant is preferably cut to any length and thus Almost any missing tissue, the shape and size of which has not yet been determined before surgery, can be replaced.
  • a tangle can be formed from the implant, which can be used instead of the removed tissue.
  • the band-shaped implant which is shaped into a ball or a similar three-dimensional arrangement, thus forms a lattice structure that tissue can permanently penetrate.
  • the implant according to the invention has a monosubstance which preferably does not contain any filling, the disadvantage of a diffusion out of liquids of conventional implants advantageously not being present.
  • the implant according to the invention can be used not only in human medicine but also in veterinary medicine as a supporting element or as a tissue replacement.
  • At least one stable opening has a minimum diameter of 30 ⁇ m or 50 ⁇ m, which is essentially perpendicular to the implant surface, preferably a minimum diameter of 1 mm. on- has. This ensures that a tissue grows particularly quickly into the microporous material of the implant.
  • the openings can be chosen so large that tissues or similar structures penetrate these openings after the implant has been introduced to such an extent that they come into contact with the body's own tissue or with other body's structures.
  • the resulting adhesions immediately stabilize the implant in the body.
  • the contact also promotes a possible growing together, which then takes place much faster. It is also conceivable that - especially in the case of more stable or harder structures - it takes a little longer for them to penetrate or grow into the relatively large openings themselves. Nevertheless, this happens much faster than is the case with the smallest or unstable openings.
  • At least one stable opening has a diameter of less than 5 mm, preferably perpendicular to the implant surface, preferably less than or equal to 4 mm.
  • the stable openings of the microporous material are opened in such a way that their minimum diameters are larger than the minimum diameters of the unstable openings. hereby the risk can be reduced that a recently inserted implant is displaced by an unfavorable movement or, for example, by a coughing process, such that a new surgical intervention is necessary.
  • the stable openings of the implant according to the invention remain so wide open at all application-related loads that a tissue surrounding the microporous material can advantageously grow rapidly into the stable openings and thus at least ensure basic fixation of the implant within the tissue as quickly as possible.
  • the risk of slipping can be greatly reduced soon after the surgical intervention.
  • the size of the stable openings or the microstructure can be adapted to the respective application in the sense of the invention, wherein the stable openings should be large enough for a quick penetration of the respective tissue and the microstructure should be sufficiently firm for the necessary loads and sufficiently wide for a long-term ingrowth of the tissue.
  • the stable openings can have almost any technically feasible hole shape. It is particularly advantageous if at least one stable opening has a circular or oval shape.
  • the stable openings can be arranged at any distance from one another, it being found that it is advantageous if the stable openings are at a distance of at least 0.5 mm, preferably a distance of at least 1 mm, from one another.
  • the stable openings can generally be arranged in almost any arrangement on the implant.
  • the implant is tubular or band-shaped.
  • the implant is preferably designed as an e-polytetrafluoroethylene tape.
  • the implant can vary in terms of its width, height or shape, a rectangular shape with 1 mm and 10 mm width being preferred.
  • the implant can be provided as a tissue replacement, preferably as a tape on a roll.
  • An oval belt can be advantageous here, since it provides volume in a suitable manner.
  • a rectangular band which is easier to process, is particularly suitable for production.
  • a tape as a tissue replacement is preferred to have a rectangular shape with a height of 1.5 mm and a width of 4 mm.
  • the implant in the form of a band can be introduced freely into a conglomerate by a small incision or by one or more small incisions, thereby making it possible, among other things, to produce a loose implant of any size.
  • the implant has a connecting device to which, for example, a fixed component can be easily attached for guiding.
  • the connecting device can be attached to the implant intraoperatively or can already be arranged on the implant at the factory.
  • the connecting device has means for positive connection.
  • a good durable connection can be quickly established.
  • the connecting device can have a thread. This ensures, for example, that almost any component can be quickly and easily attached to the implant. The component only needs a counter thread corresponding to the thread of the connecting device.
  • the connecting device can also have means for non-positive connection.
  • connection device of the implant can be implemented using a large number of technical devices, such as plug or clamp connections. It goes without saying that such a connecting device, in particular if it is already connected to the implant at the factory, is also advantageous independently of the other features of the invention, in order to ensure a reliable insertion of an implant quickly and reliably.
  • a further embodiment variant provides that a guide means is attached to the connection device with which the implant can be guided, in particular, through a tissue.
  • the guide means makes it possible, for example, in an operative application to cure urinary incontinence, advantageously to guide the implant through the tissue of the body without serious injuries.
  • the guide means preferably has no tactile and / or visible transition relative to the connecting device of the implant.
  • the guide means can be a blunt needle or a pilot pin, for example.
  • a blunt needle enables the implant to be inserted in the shortest possible time during an incontinence operation, the risk of tissue and / or vascular injury, for example injuries to the bladder and urethra, being greatly minimized.
  • the guide means is curved.
  • the guide means has a coupling device which communicates with the connecting device of the implant.
  • the connecting device of the implant has an external thread and the coupling device of the guide means has an internal thread corresponding to the external thread, so that the guide means can be attached to the implant in a particularly simple manner.
  • the guide means is concave, preferably spherical, at the end opposite the coupling device.
  • a relatively rough structuring of this end only injures the tissue to a reasonable extent.
  • the average radius of curvature of the tip should not be below 50 ⁇ , preferably above 100 ⁇ or 300 ⁇ . lie around Avoid injuries if possible.
  • the mean radius of curvature means a radius of a semicircle that can be reached from one side of the tip and then hit on the other side, in which both sides and the tip itself lie on this semicircle, while the other components of the tip are outside or are arranged on this semicircle.
  • the concave end is polished to minimize the risk of injury.
  • the risk of tissue or vascular injuries can also be minimized if the coupling device of the guide means and the connecting device of the implant have an identical outside diameter. In this way, an almost seamless connection between the guide means and the implant can be established. Among other things, this considerably facilitates guiding the implant according to the invention through a body, since no transitions between the guiding means and the implant are a hindrance when guiding through a tissue.
  • a protective tube or a protective sheath between the implant and a tissue that is pierced can be dispensed with.
  • the guide means has a vibration device.
  • a high pressure need not be exerted on the filling agent, as was previously the case, in order to ses to move through the body, rather the implant moves almost independently through the tissue of the body due to the vibrations of the guide means.
  • this further reduces the risk of injury to internal organs, such as a bladder or blood vessels.
  • this significantly shortens the operating time.
  • the implant can be inserted in less than 20 minutes during an operation to insert a vaginal ligament, possibly even under local anesthesia.
  • the vibration device can be attached externally to the guide means as well as arranged internally in the guide means.
  • the vibrating device can vibrate the guide means directly or by means of a flexible extension.
  • the vibration device is preferably arranged in the region of the coupling device or in the vicinity of the coupling device of the guide means, so that the latter can be inserted without further ado.
  • the guide means is constructed in such a way that it can be used a second time at least after a first use.
  • the connecting device and / or the guide means and / or the coupling device of the guide means is preferably made of V4A. This makes them extremely durable and easy to sterilize. In addition, this material has already been tried and tested in medical technology.
  • the term “labile opening” means pores of the microporous material which, in the worst case, close completely or to such an extent when the load is introduced into the microporous material that at least temporarily there is no cell tissue in the unstable openings can grow in.
  • stable opening is understood to mean those pores of the microporous material which, when an application-related load is introduced into the microporous material, retain a minimum diameter even in the event of an unfavorable load introduction, so that they enter the stable openings almost at all times a cell tissue can penetrate or ingrow.
  • the microporous material is an expanded polytetrafluoroethylene (e-PTFE).
  • e-PTFE expanded polytetrafluoroethylene
  • the fibrils can be expanded almost arbitrarily and thus a differently structured microporous material can be produced simply and inexpensively.
  • e-PTFE has so far been completely inconspicuous, particularly with regard to medical applications with regard to intolerance or allergies.
  • the object of the invention is also achieved by a method for introducing a reinforcing element into a soft structure surrounded by an envelope, in which the reinforcing element, starting from a first region of the envelope, into the soft structure, Strengthening element up to a second area of the casing through the soft structure and out there, and in which the casing in the second area is made permeable to the reinforcing element from the outside and the reinforcing element is then guided through the second area to the outside.
  • the reinforcing element is previously located in the second area of the casing from the outside, so that the casing can be opened in a targeted manner at this point.
  • the reinforcing element is formed on the second region in order to make the casing permeable.
  • the fact that the reinforcing element or at least part of it is imaged on the sheath makes it very easy to determine from the outside where the sheath the reinforcing element is located. As a result, the location of the casing for the reinforcing element can be made permeable in a targeted manner from the outside.
  • the method is suitable, for example, with regard to use in connection with aerosols surrounded by an envelope.
  • Other soft materials which are surrounded by a harder shell and which are to be reinforced by a reinforcing element can also be treated in this way.
  • this method is also suitable for pulling an implant into a body.
  • the casing or skin is first opened at a first point in such a way that the reinforcing element or an implant, if necessary with the aid of take the guide means in the material or in the body and is driven through this or this until the shell or the skin is reached at a second location.
  • the reinforcement means, the implant or the guide means can be localized and the shell or skin can be opened again from the outside, for example by a cut.
  • the object of the invention is achieved by a method for producing an implant from a blank, the blank being shaped intraoperatively into an implant. For example, since the extent of tissue removal can almost never be determined in advance of an operation, it is now possible to adjust the implant intraoperatively to the extent of tissue removal.
  • the blank is cut to length intraoperatively to form an implant.
  • the implant directly during an operation, for example for introducing a tissue replacement, it is advantageous if the implant can be adapted exactly to the operative conditions by the blank can be cut to length intraoperatively. In the case of a vaginal ligament, for example, this can happen - possibly even after days - when the implant has already been inserted.
  • FIG. 1 shows a schematic view of a first arrangement variant of stable openings of an implant
  • FIG. 2 shows a schematic view of a second arrangement variant of stable openings of an implant
  • FIG. 3 shows schematic cross sections of some implants
  • FIG. 4 shows a schematic illustration of an implant with a guide means and a vibration means
  • Figure 5 is a schematic representation of another implant with a connecting device.
  • the implant 1 shown in FIG. 1 is made from a flat strip 2.
  • the flat strip 2 in this case comprises a large number of holes 3, 4, 5, 6, 7 and 8, which are made as stable openings in the implant 1.
  • Holes 3 to 8 are each arranged essentially at the same distance from one another in a longitudinal extent 9 of flat strip 2.
  • the implant 10 has a plurality of holes 13, 14, 15, 16, 17 and 18 offset from one another in a longitudinal orientation 12 on its body 11, which is designed in the form of a flat band.
  • the holes 13 to 18 are also in the longitudinal direction 12 on the body 11 of the implant 10, but the holes 13, 15 and 17 are closer to a side ten area 19 of the implant 10, whereas the holes 14, 16 and 18 are rather arranged in a side area 20 of the implant 10.
  • FIG. 3 shows cross sections 21, 22, 23, 24 and 24 A of different implants.
  • the cross section 21 corresponds to an oval band
  • the cross section 22 corresponds to a flat band.
  • the cross section 23 has a circular shape
  • the cross section 24 is rectangular, in particular square.
  • the reference number 24 A denotes a hose. On the one hand, this can be designed to be inherently rigid or, in itself, unstable.
  • the implant 25 shown in FIG. 4 comprises an expanded polytetrafluoroethylene band 26, which is arranged with a stainless steel screw 27 on an internal thread 28 of a bent needle 29.
  • the expanded polytetrafluoroethylene tape 26 has a large number of unstable openings 30 (numbered here only by way of example) and a large number of stable openings 31 (also numbered only by way of example).
  • the curved needle 29 comprises a polished spherical tip 33 in the area of its tip 32. Any rounded tip that has an average radius of curvature greater than 50 ⁇ , preferably greater than 300 ⁇ , can be used as the tip.
  • the implant 25 or its bent needle 29 has a vibrator 35 in an area 34, which is preferably arranged in the vicinity of the internal thread 28.
  • the needle 29 is in particular in the area of the polished spherical tip 33 set in vibration such that the implant 25 can advantageously be moved in the pushing direction 36 by a tissue 36A.
  • a skin 36 B which is arranged around the tissue 36 A, is pierced, if necessary. This can be done using known methods, such as a small incision, so that a pointed needle that can pierce the skin independently can be dispensed with.
  • the guide means or the implant 25 can then also be guided out again by leading it to the skin 36B and localizing it there.
  • the guide means or the implant 25 can then be removed by a small incision.
  • the vibrator 35 transmits vibrations to the needle 29 of the implant 25 by means of an extension 37.
  • the implant 38 (FIG. 5) comprises a plurality of stable openings 39 (numbered here only as an example) and at one end 40 a screw 41 which is clamped with its area 42 to a polytetrafluoroethylene tape 43 of the implant 38.

Abstract

L'invention vise à mettre au point un implant induisant le plus rapidement possible une jonction avec un tissu, tout en étant suffisamment compatible avec ledit tissu. A cet effet, il est prévu un implant réalisé dans un matériau microporeux compatible avec le tissu, présentant au moins une ouverture stable.
PCT/DE2001/004722 2000-12-16 2001-12-14 Implant, procede pour introduire un element de renforcement et procede de production d'implant WO2002047578A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01995601A EP1345553A1 (fr) 2000-12-16 2001-12-14 Implant, procede pour introduire un element de renforcement et procede de production d'implant
US10/450,688 US20040049289A1 (en) 2000-12-16 2001-12-14 Implant, method for inserting a reinforcing element, and method for producing an implant
JP2002549156A JP2004515306A (ja) 2000-12-16 2001-12-14 インプラント、補強要素の導入手順、およびインプラントの製造プロセス
AU2002226295A AU2002226295A1 (en) 2000-12-16 2001-12-14 Implant, method for inserting a reinforcing element, and method for producing animplant

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE10062691.2 2000-12-16
DE20022228U DE20022228U1 (de) 2000-12-16 2000-12-16 Gelochtes e-PTFE Band für chirurgische Implantate
DE10062691 2000-12-16
DE20022228.7 2000-12-16
DE10156592 2001-11-20
DE10156594 2001-11-20
DE10156592.5 2001-11-20
DE10156594.1 2001-11-20

Publications (1)

Publication Number Publication Date
WO2002047578A1 true WO2002047578A1 (fr) 2002-06-20

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ID=27437911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/004722 WO2002047578A1 (fr) 2000-12-16 2001-12-14 Implant, procede pour introduire un element de renforcement et procede de production d'implant

Country Status (5)

Country Link
EP (1) EP1345553A1 (fr)
JP (1) JP2004515306A (fr)
CN (1) CN1489449A (fr)
AU (1) AU2002226295A1 (fr)
WO (1) WO2002047578A1 (fr)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122155A (en) * 1990-10-11 1992-06-16 Eberbach Mark A Hernia repair apparatus and method of use
US5290217A (en) * 1991-10-10 1994-03-01 Earl K. Sipes Method and apparatus for hernia repair
WO1994019029A1 (fr) * 1993-02-18 1994-09-01 W.L. Gore & Associates, Inc. Matiere en feuille stratifiee servant de piece pour la reparation de tissus vivants
WO1995030374A1 (fr) * 1994-05-06 1995-11-16 Origin Medsystems, Inc. Appareil et procede pour positionner une piece
FR2741523A1 (fr) * 1995-11-23 1997-05-30 Prothia Sarl Dispositif de retrait de produits implantables
WO1999016381A1 (fr) * 1997-10-01 1999-04-08 Boston Scientific Limited Reconstitution de la structure perineale
US5922026A (en) * 1997-05-01 1999-07-13 Origin Medsystems, Inc. Surgical method and prosthetic strip therefor
US5972007A (en) * 1997-10-31 1999-10-26 Ethicon Endo-Surgery, Inc. Energy-base method applied to prosthetics for repairing tissue defects

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122155A (en) * 1990-10-11 1992-06-16 Eberbach Mark A Hernia repair apparatus and method of use
US5290217A (en) * 1991-10-10 1994-03-01 Earl K. Sipes Method and apparatus for hernia repair
WO1994019029A1 (fr) * 1993-02-18 1994-09-01 W.L. Gore & Associates, Inc. Matiere en feuille stratifiee servant de piece pour la reparation de tissus vivants
WO1995030374A1 (fr) * 1994-05-06 1995-11-16 Origin Medsystems, Inc. Appareil et procede pour positionner une piece
FR2741523A1 (fr) * 1995-11-23 1997-05-30 Prothia Sarl Dispositif de retrait de produits implantables
US5922026A (en) * 1997-05-01 1999-07-13 Origin Medsystems, Inc. Surgical method and prosthetic strip therefor
WO1999016381A1 (fr) * 1997-10-01 1999-04-08 Boston Scientific Limited Reconstitution de la structure perineale
US5972007A (en) * 1997-10-31 1999-10-26 Ethicon Endo-Surgery, Inc. Energy-base method applied to prosthetics for repairing tissue defects

Also Published As

Publication number Publication date
JP2004515306A (ja) 2004-05-27
EP1345553A1 (fr) 2003-09-24
AU2002226295A1 (en) 2002-06-24
CN1489449A (zh) 2004-04-14

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