WO2002057252A3 - Heterocyclic sulfonamide inhibitors of beta amyloid production - Google Patents
Heterocyclic sulfonamide inhibitors of beta amyloid production Download PDFInfo
- Publication number
- WO2002057252A3 WO2002057252A3 PCT/US2001/048375 US0148375W WO02057252A3 WO 2002057252 A3 WO2002057252 A3 WO 2002057252A3 US 0148375 W US0148375 W US 0148375W WO 02057252 A3 WO02057252 A3 WO 02057252A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- beta amyloid
- amyloid production
- heterocyclic sulfonamide
- sulfonamide inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Abstract
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0116063-0A BR0116063A (en) | 2000-12-13 | 2001-12-11 | Heterocyclically Sulfonamide Inhibitors of Beta Amyloid Production and Its Uses |
IL15626801A IL156268A0 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
JP2002557933A JP2004517892A (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of β-amyloid production |
SI200130604T SI1341779T1 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
NZ526213A NZ526213A (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
MXPA03005255A MXPA03005255A (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production. |
CA2436526A CA2436526C (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
HU0303857A HUP0303857A3 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulifonamide inhibitors of beta amyloid production |
EP01993277A EP1341779B1 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
KR1020037007928A KR100869061B1 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
AU2002245123A AU2002245123B2 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
EA200300674A EA009035B1 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
DE60121032T DE60121032T2 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic Sulphonamides as Inhibitors of Beta-Amyloid Production |
IL156268A IL156268A (en) | 2000-12-13 | 2003-06-02 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
NO20032645A NO328885B1 (en) | 2000-12-13 | 2003-06-11 | Heterocyclic sulfonamide inhibitors of <beta> -amyloid production, pharmaceutical composition comprising such a compound and the use of the compounds |
HK04101538A HK1059619A1 (en) | 2000-12-13 | 2004-03-02 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
CY20061101305T CY1105441T1 (en) | 2000-12-13 | 2006-09-14 | ETEOCYCLIC SULFONAMIDE INHIBITORS OF BETA-AMYLOID PRODUCTION |
IL188853A IL188853A0 (en) | 2000-12-13 | 2008-01-17 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25510500P | 2000-12-13 | 2000-12-13 | |
US60/255,105 | 2000-12-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002057252A2 WO2002057252A2 (en) | 2002-07-25 |
WO2002057252A3 true WO2002057252A3 (en) | 2002-12-12 |
Family
ID=22966854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/048375 WO2002057252A2 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
Country Status (28)
Country | Link |
---|---|
US (5) | US6610734B2 (en) |
EP (1) | EP1341779B1 (en) |
JP (2) | JP2004517892A (en) |
KR (1) | KR100869061B1 (en) |
CN (2) | CN1263750C (en) |
AR (1) | AR035516A1 (en) |
AT (1) | ATE330950T1 (en) |
AU (1) | AU2002245123B2 (en) |
BR (1) | BR0116063A (en) |
CA (1) | CA2436526C (en) |
CY (1) | CY1105441T1 (en) |
DE (1) | DE60121032T2 (en) |
DK (1) | DK1341779T3 (en) |
EA (1) | EA009035B1 (en) |
ES (1) | ES2267853T3 (en) |
HK (1) | HK1059619A1 (en) |
HU (1) | HUP0303857A3 (en) |
IL (3) | IL156268A0 (en) |
MX (1) | MXPA03005255A (en) |
NO (1) | NO328885B1 (en) |
NZ (2) | NZ526213A (en) |
PL (1) | PL365950A1 (en) |
PT (1) | PT1341779E (en) |
SG (1) | SG128491A1 (en) |
SI (1) | SI1341779T1 (en) |
TW (1) | TWI235155B (en) |
WO (1) | WO2002057252A2 (en) |
ZA (1) | ZA200304135B (en) |
Cited By (1)
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---|---|---|---|---|
US9139520B2 (en) | 2007-12-21 | 2015-09-22 | Ligand Pharmaceuticals Incorporated | Selective androgen receptor modulators (SARMs) and uses thereof |
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JP2003528076A (en) * | 2000-03-20 | 2003-09-24 | メルク シャープ エンド ドーム リミテッド | Sulfonamide-substituted bridged bicycloalkyl derivatives |
NZ526213A (en) * | 2000-12-13 | 2005-05-27 | Wyeth Corp | Heterocyclic sulfonamide inhibitors of beta amyloid production |
US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
BR0214863A (en) * | 2001-12-11 | 2004-12-14 | Wyeth Corp | Process for the synthesis of chirally pure beta-amino alcohols |
RU2321394C2 (en) * | 2002-06-11 | 2008-04-10 | Уайт | Substituted phenylsulfonamide inhibitors of beta-amyloid secretion |
DE60329316D1 (en) * | 2002-11-12 | 2009-10-29 | Merck & Co Inc | PHENYL ACARBOXAMIDE AS A BETA SEKRETASE INHIBITOR FOR THE TREATMENT OF ALZHEIMER |
WO2004092155A1 (en) * | 2003-03-31 | 2004-10-28 | Wyeth | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
KR20060066057A (en) * | 2003-06-30 | 2006-06-15 | 다이이찌 세이야꾸 가부시기가이샤 | Heterocyclic methyl sulfone derivative |
CA2552558A1 (en) * | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
WO2006078753A1 (en) | 2005-01-18 | 2006-07-27 | Elan Pharmaceuticals, Inc. | N-substituted heterocyclic sulfonamides |
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RU2008129797A (en) * | 2006-02-17 | 2010-03-27 | Вайет (Us) | METHODS FOR PRODUCING SULFONAMIDE-SUBSTITUTED ALCOHOLS AND THEIR INTERMEDIATE COMPOUNDS |
CA2649396A1 (en) * | 2006-04-21 | 2007-11-08 | Wyeth | Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof |
US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
US7476762B2 (en) * | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
TW200808740A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof |
TW200808741A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts |
TW200811144A (en) * | 2006-06-09 | 2008-03-01 | Wyeth Corp | Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline |
WO2008059238A1 (en) * | 2006-11-17 | 2008-05-22 | Astrazeneca Ab | Benzenesulfonamide compounds as edg-1 antagonists useful in the treatment of cancer |
WO2008064320A2 (en) * | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity |
US20080262228A1 (en) * | 2006-11-28 | 2008-10-23 | Wyeth | Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof |
CL2008000119A1 (en) * | 2007-01-16 | 2008-05-16 | Wyeth Corp | COMPOUNDS DERIVED FROM PIRAZOL, ANTAGONISTS OF THE NICOTINIC ACETILCOLINE RECEIVER; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF DISEASES SUCH AS SENILE DEMENTIA, ALZHEIMER AND SCHIZOPHRENIA. |
EP2121633A2 (en) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
AR067534A1 (en) * | 2007-07-16 | 2009-10-14 | Wyeth Corp | PROCESS FOR THE PREPARATION OF TRIFLUOROALQUIL - PHENYL SULFONAMIDS AND HETEROCICLIC SULFONAMIDS |
CL2008002059A1 (en) * | 2007-07-16 | 2008-11-14 | Wyeth Corp | Method of preparation of heterocyclic sulfonamides; intermediate compounds used in the described method; and the methods of preparing said intermediaries. |
EP2193117A1 (en) * | 2007-07-16 | 2010-06-09 | Wyeth a Corporation of the State of Delaware | Inhibitors of beta amyloid production |
AR070120A1 (en) * | 2008-01-11 | 2010-03-17 | Wyeth Corp | DERIVATIVES OF ARIL SULFONAMIDE CONTAINING O-SULFATE AND O-PHOSPHATE, USEFUL AS BETA-AMYLOID INHIBITORS, PREPARATION PROCESS OF THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
WO2009128057A2 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
EP3586839A1 (en) | 2008-07-28 | 2020-01-01 | Blanchette Rockefeller Neurosciences, Institute | Pkc-activating compounds for the treatment of neurodegenerative diseases |
JP2013514287A (en) | 2009-12-17 | 2013-04-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Inhibitors of sphingosine kinase |
US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
CN105142627B (en) | 2013-01-18 | 2019-06-21 | 卡尔迪奥克斯尔制药公司 | Medical composition comprising nitroxyl donors |
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-
2001
- 2001-12-11 NZ NZ526213A patent/NZ526213A/en unknown
- 2001-12-11 CA CA2436526A patent/CA2436526C/en not_active Expired - Fee Related
- 2001-12-11 AT AT01993277T patent/ATE330950T1/en active
- 2001-12-11 KR KR1020037007928A patent/KR100869061B1/en not_active IP Right Cessation
- 2001-12-11 WO PCT/US2001/048375 patent/WO2002057252A2/en active Application Filing
- 2001-12-11 NZ NZ538100A patent/NZ538100A/en unknown
- 2001-12-11 CN CNB018205186A patent/CN1263750C/en not_active Expired - Fee Related
- 2001-12-11 IL IL15626801A patent/IL156268A0/en active IP Right Review Request
- 2001-12-11 DE DE60121032T patent/DE60121032T2/en not_active Expired - Lifetime
- 2001-12-11 AU AU2002245123A patent/AU2002245123B2/en not_active Ceased
- 2001-12-11 PL PL01365950A patent/PL365950A1/en not_active IP Right Cessation
- 2001-12-11 EP EP01993277A patent/EP1341779B1/en not_active Expired - Lifetime
- 2001-12-11 JP JP2002557933A patent/JP2004517892A/en not_active Withdrawn
- 2001-12-11 SG SG200503628A patent/SG128491A1/en unknown
- 2001-12-11 EA EA200300674A patent/EA009035B1/en not_active IP Right Cessation
- 2001-12-11 ES ES01993277T patent/ES2267853T3/en not_active Expired - Lifetime
- 2001-12-11 CN CNA2005100035919A patent/CN1800176A/en active Pending
- 2001-12-11 US US10/014,304 patent/US6610734B2/en not_active Expired - Fee Related
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EP1088821A1 (en) * | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives |
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Cited By (1)
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US9139520B2 (en) | 2007-12-21 | 2015-09-22 | Ligand Pharmaceuticals Incorporated | Selective androgen receptor modulators (SARMs) and uses thereof |
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