WO2002058718A3 - Use of compositions containing pdgf-bb for promoting angiogenesis - Google Patents

Use of compositions containing pdgf-bb for promoting angiogenesis Download PDF

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Publication number
WO2002058718A3
WO2002058718A3 PCT/US2002/001666 US0201666W WO02058718A3 WO 2002058718 A3 WO2002058718 A3 WO 2002058718A3 US 0201666 W US0201666 W US 0201666W WO 02058718 A3 WO02058718 A3 WO 02058718A3
Authority
WO
WIPO (PCT)
Prior art keywords
promoting angiogenesis
compositions containing
containing pdgf
pdgf
factors
Prior art date
Application number
PCT/US2002/001666
Other languages
French (fr)
Other versions
WO2002058718A2 (en
Inventor
Robert Pawliuk
Philippe Leboulch
Original Assignee
Genetix Pharmaceuticals Inc
Robert Pawliuk
Philippe Leboulch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetix Pharmaceuticals Inc, Robert Pawliuk, Philippe Leboulch filed Critical Genetix Pharmaceuticals Inc
Priority to CA002436076A priority Critical patent/CA2436076A1/en
Priority to JP2002559052A priority patent/JP4434584B2/en
Priority to AU2002247007A priority patent/AU2002247007B2/en
Priority to EP02714757A priority patent/EP1355659A2/en
Priority to US10/198,917 priority patent/US20030139333A1/en
Publication of WO2002058718A2 publication Critical patent/WO2002058718A2/en
Publication of WO2002058718A3 publication Critical patent/WO2002058718A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

Methods of promoting angiogenesis by delivering angiogenic factors are disclosed. The factors can be delivered as a gradient to a localized area of tissue to direct vascular growth.
PCT/US2002/001666 2001-01-26 2002-01-18 Use of compositions containing pdgf-bb for promoting angiogenesis WO2002058718A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002436076A CA2436076A1 (en) 2001-01-26 2002-01-18 Use of compositions containing pdgf-bb for promoting angiogenesis
JP2002559052A JP4434584B2 (en) 2001-01-26 2002-01-18 Methods and compositions for promoting angiogenesis
AU2002247007A AU2002247007B2 (en) 2001-01-26 2002-01-18 Use of compositions containing PDGF-BB for promoting angiogenesis
EP02714757A EP1355659A2 (en) 2001-01-26 2002-01-18 Use of compositions containing pdgf-bb for promoting angiogenesis
US10/198,917 US20030139333A1 (en) 2002-01-18 2002-07-19 Methods and compositions for promoting angiogenesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26445701P 2001-01-26 2001-01-26
US60/264,457 2001-01-26

Publications (2)

Publication Number Publication Date
WO2002058718A2 WO2002058718A2 (en) 2002-08-01
WO2002058718A3 true WO2002058718A3 (en) 2003-04-17

Family

ID=23006154

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/001666 WO2002058718A2 (en) 2001-01-26 2002-01-18 Use of compositions containing pdgf-bb for promoting angiogenesis

Country Status (5)

Country Link
EP (1) EP1355659A2 (en)
JP (1) JP4434584B2 (en)
AU (1) AU2002247007B2 (en)
CA (1) CA2436076A1 (en)
WO (1) WO2002058718A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020072489A1 (en) * 1998-10-13 2002-06-13 Whitehouse Martha J. Angiogenically effective unit dose of FGF-2 and method of use
JP2005168654A (en) * 2003-12-09 2005-06-30 Kissei Pharmaceut Co Ltd Growth factor-bonded low molecular weight modified heparin
FR2891149B1 (en) 2005-09-26 2007-11-30 Biodex Sarl PHARMACEUTICAL COMPOSITION WITH A HEALING ACTION COMPRISING A SOLUBLE DEXTRANE DERIVATIVE AND A PLATELET DERIVED GROWTH FACTOR.
EP1948210A4 (en) * 2005-11-08 2010-07-14 Found Biomedical Res & Innov Method of treatment for ischemic heart disease
FR2914191A1 (en) * 2007-03-29 2008-10-03 Proteins & Peptides Man ANGIOGENIC COMPOSITION
CN102196822A (en) * 2008-09-26 2011-09-21 阿道恰公司 Complex consisting of polysaccharide and an HBP
WO2010078624A1 (en) * 2009-01-07 2010-07-15 Vegenics Limited Materials and methods for the treatment of hypertension
GB201504665D0 (en) * 2015-03-19 2015-05-06 Cell Therapy Ltd Composition

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990000060A1 (en) * 1988-06-30 1990-01-11 Collagen Corporation Collagen wound healing matrices and process for their production
WO1991016009A1 (en) * 1990-04-17 1991-10-31 Curative Technologies, Inc. Coating prosthetic surfaces with mammalian cells
US5128321A (en) * 1986-08-13 1992-07-07 Zymogenetics, Inc. PDGF analogs and methods of use
WO1994025056A2 (en) * 1993-04-29 1994-11-10 Washington University Use of platelet-derived growth factor to improve collateral circulation
WO1997012601A2 (en) * 1995-10-06 1997-04-10 Ethicon, Inc. Gel formulations containing growth factors
WO2000041732A1 (en) * 1999-01-19 2000-07-20 The Children's Hospital Of Philadelphia Hydrogel compositions for controlled delivery of virus vectors and methods of use thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128321A (en) * 1986-08-13 1992-07-07 Zymogenetics, Inc. PDGF analogs and methods of use
WO1990000060A1 (en) * 1988-06-30 1990-01-11 Collagen Corporation Collagen wound healing matrices and process for their production
WO1991016009A1 (en) * 1990-04-17 1991-10-31 Curative Technologies, Inc. Coating prosthetic surfaces with mammalian cells
WO1994025056A2 (en) * 1993-04-29 1994-11-10 Washington University Use of platelet-derived growth factor to improve collateral circulation
WO1997012601A2 (en) * 1995-10-06 1997-04-10 Ethicon, Inc. Gel formulations containing growth factors
WO2000041732A1 (en) * 1999-01-19 2000-07-20 The Children's Hospital Of Philadelphia Hydrogel compositions for controlled delivery of virus vectors and methods of use thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
EDELMAN E.R. ET AL.: "Controlled and modulated release of basic fibroblast growth factor.", BIOMATERIALS, vol. 12, no. 7, September 1991 (1991-09-01), pages 619 - 626, XP000226106 *
FRANK K R ET AL: "CONTROLLED RELEASE OF BIOACTIVE GROWTH FACTORS FROM A BIODEGRADABLE DELIVERY SYSTEM", PHARMACEUTICAL RESEARCH, NEW YORK, NY, US, vol. 11, no. 10, October 1994 (1994-10-01), pages S88,ANBIOTEC2070, XP001068790, ISSN: 0724-8741 *
KAWAI K ET AL: "Accelerated tissue regeneration through incorporation of basic fibroblast growth factor-impregnated gelatin microspheres into artificial dermis - targeted delivery systems", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 21, no. 5, March 2000 (2000-03-01), pages 489 - 499, XP004185546, ISSN: 0142-9612 *
LIECHTY K.W. ET AL.: "Adenoviral-mediated overexpression of platelet-derived growth factor-B corrects ischemic impaired wound healing.", J. INVEST. DERMATOL., vol. 113, no. 3, September 1999 (1999-09-01), pages 375 - 383, XP002211469 *
PARK Y J ET AL: "Controlled release of platelet-derived growth factor-BB from chondroitin sulfate-chitosan sponge for guided bone regeneration", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 67, no. 2-3, July 2000 (2000-07-01), pages 385 - 394, XP004199184, ISSN: 0168-3659 *
PARK Y.J.: "Controlled release of PDGF from porous poly(L-lactide) membranes for guided tissue regeneration.", J. CONTROLLED RELEASE., vol. 51, 1998, pages 201 - 211, XP004113628 *
STEED D L ET AL: "CLINICAL EVALUATION OF RECOMBINANT HUMAN PLATELET-DERIVED GROWTH FACTOR FOR THE TREATMENT OF LOWER EXTREMITY DIABETIC ULCERS", JOURNAL OF VASCULAR SURGERY, C.V. MOSBY CO., ST. LOUIS, MO, US, vol. 1, no. 21, January 1995 (1995-01-01), pages 71 - 81, XP001088899, ISSN: 0741-5214 *
YLÄ-HERTTUALA S. AND MARTIN J.F.: "Cardiovascular gene therapy", LANCET, vol. 355, 15 January 2000 (2000-01-15), pages 213 - 222, XP002211470 *

Also Published As

Publication number Publication date
AU2002247007B2 (en) 2006-12-07
EP1355659A2 (en) 2003-10-29
WO2002058718A2 (en) 2002-08-01
JP2005506279A (en) 2005-03-03
JP4434584B2 (en) 2010-03-17
CA2436076A1 (en) 2002-08-01

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