WO2002060336A1 - Automated inhalation toxicology exposure system - Google Patents

Abstract

A method to exposing an animal to an inhalant; acquiring near real time measurement of at least respiration during said exposing; and calculating a received dose of the inhalant in response to the near real time measurement of the at least respiration during said exposing. The method further includes to automatically controlling an environment of an inhalant chamber; automatically controlling a concentration of an inhalant in the inhalant chamber, and displaying near real time measurement data related to an animal in an inhalant chamber.

Description

AUTOMATED INHALATION TOXICOLOGY EXPOSURE SYSTEM

CROSS-REFERENCES TO RELATED APPLICATIONS

This patent application hereby claims priority from and incorporates by reference in its entirety pending U.S. Utility Patent Application No. 09/919,741, filed July 31, 2001, entitled AUTOMATED INHALATION TOXICOLOGY EXPOSURE SYSTEM, and naming Chad J. Roy and Justin M. Hartings as inventors. This patent application hereby incorporates by reference in its entirety the pending U.S. Provisional Patent Application No. 60/267,233, filed January 31, 2001, entitled AUTOMATED INHALATION TOXICOLOGY EXPOSURE SYSTEM, and naming Chad J. Roy and Justin M. Hartings as inventors; this patent application also claims the benefit of the foregoing-referenced Provisional Patent Application No. 60/267,233 under the auspices of 35 U.S.C. 119(e).

BACKGROUND OF THE INVENTION

Field of the Invention The present application relates, in general, to inhalant systems.

Description of the Related Art

Inhalation exposure studies are generally performed using inhalant systems. In an inhalation exposure study, an animal is usually exposed to an organic or inorganic inhalant within the confined space of an inhalant chamber forming part of an inhalant system.

In the related art, an inhalant system is typically one that provides mechanisms for exposing an animal to an inhalant. The inventors named herein ("inventors") have noticed several deficiencies and/or unmet needs associated with related-art inhalant systems, a few of which will now be set forth (other related-art deficiencies and/or unmet needs will become apparent in the detailed description below). The inventors have discovered that related-art inhalant systems tend to provide poor reproducibility of scientific experiments. The inventors have noted that delivery of inhalants, environmental control, and monitoring in related-art inhalant systems is generally poorly controlled and/or monitored (e.g., by a human engaging in real-time manipulation of valves and motors and/or near real-time viewing and recordation of data presented on displays). Accordingly, insofar as human actions tend to be notoriously difficult to reproduce, the inventors have concluded that related-art inhalant systems tend to provide poor reproducibility. That is, precision and accuracy of inhalation experiments suffer because the users of related-art inhalant systems are neither able to exactly reproduce or actively record deviations of both intrinsic and extrinsic factors from experiment to experiment.

Insofar as inhalant systems are generally used to perform scientific experiments, it is desirable that the inhalant systems provide high reproducibility of scientific experiments so that experimental claims can be checked and validated. Unfortunately, related-art inhalant systems do not provide high reproducibility of scientific experiments. Accordingly, it is apparent that a need exists for inhalant systems that provide high reproducibility of scientific experiments, and that at present this need is going unmet in the related art.

In addition to the foregoing, the inventors have discovered that related- art inhalant systems do not incorporate near real-time measurement of respiratory function of test animals for purposes of dosimetry. That is, in general, related-art methods of inhalant dose calculation rely on physiologic trends based on historical data related to animals similar to those under test. Insofar as physiology varies from animal to animal, the inventors have recognized that it would be advantageous to have methods and systems, which provide, among other things, inhalant systems capable of determining inhalant dosage via near real-time acquisition of respiration of a test animal. Unfortunately, related-art inhalant systems are not, in general, capable of determining inhalant dosage via near real-time acquisition of respiration of a test animal. Accordingly, it is apparent that a need exists for inhalant systems capable of determining inhalant dosage via near real-time acquisition of respiration of a test animal. BRIEF SUMMARY OF THE INVENTION

The inventors have devised methods and systems, which provide, among other things, inhalant systems capable of achieving high reproducibility of scientific experiments. In addition, the inventors have devised methods and systems, which provide, among other things, inhalant systems capable of determining inhalant dosage via near real-time acquisition of respiration of a test animal.

In one embodiment, a method includes but is not limited to exposing an animal to an inhalant; acquiring near real time measurement of at least respiration during said exposing; and calculating a received dose of the inhalant in response to the near real time measurement of the at least respiration during said exposing.

In one embodiment, a method includes but is not limited to automatically controlling an environment of an inhalant chamber; and automatically controlling a concentration of an inhalant in the inhalant chamber.

In one embodiment, a method includes but is not limited to displaying near real time measurement data related to an animal in an inhalant chamber.

In addition to the foregoing, other method embodiments are described in the claims, drawings, and text forming a part of the present application.

In one or more various embodiments, related systems include but are not limited to circuitry and/or programming for effecting the foregoing-described method embodiments; the circuitry and/or programming can be virtually any combination of hardware, software, and/or firmware configured to effect the foregoing-described method embodiments depending upon the design choices of the system designer. In one embodiment, a system includes but is not limited to at least one inhalant chamber; and at least one animal respiration sensor integral with the at least one inhalant chamber. The foregoing is a summary and thus contains, by necessity; simplifications, generalizations and omissions of detail; consequently, those skilled in the art will appreciate that the summary is illustrative only and is NOT intended to be in any way limiting. Other aspects, inventive features, and advantages of the devices and or processes described herein, as defined solely by the claims, will become apparent in the non-limiting detailed description set forth herein. BRIEF DESCRIPTION OF SEVERAL VIEWS OF THE DRAWINGS

The foregoing aspects and many of the attendant advantages of this invention will become more readily appreciated as the same become better understood by reference to the following detailed description, when taken in conjunction with the accompanying drawings, wherein:

Figure 1 shows a high level pictographic representation of inhalant exposure and monitoring system 100.

Figure 2 shows the start of the process of exposing an animal to an inhalant. Figure 3 shows that in one implementation method step 202 can include method step 300.

Figure 4 depicts that in one implementation method step 202 can include method step 400.

Figure 5 shows that in one implementation method step 204 can include method step 500.

Figure 6 depicts that in one implementation method step 500 can include method steps 600 and 602.

Figure 7 shows that in one implementation method step 204 can include method step 700. Figure 8 shows that in one implementation method step 206 can include method step 800, while in another implementation method step 206 can include method step 802.

Figure 9 shows a process that depicts automatically controls an environment of an inhalant chamber. Figure 10 shows that in one implementation method step 902 can include method step 1000.

Figure 11 depicts that in one implementation method step 1000 can include method step 1100.

Figure 12 shows that in one implementation method step 902 can include method step 1200. Figure 13 depicts that in one implementation method step 902 can include method step 1300.

Figure 14 depicts that in one implementation method step 902 can include method step 1400. Figure 15 shows that in one alternate implementation the process includes additional method step 1500.

Figure 16 shows that in one implementation method step 1500 can include method step 1600, while in another implementation method step 1500 can include method step 1602. Figure 17 depicts a process that displays near real time measurement data related to an animal in the inhalant chamber.

Figure 18 shows that in one implementation method step 1702 can include method step 1800, while in another implementation method step 1702 can include method step 1802, while in yet another implementation method step 1702 can include method step 1804.

The use of the same reference symbols in different drawings indicates similar or identical items.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

With reference now to Figure 1, shown is a high level pictographic representation of inhalant exposure and monitoring system 100. Depicted is inhalant toxicology exposure system 100. Illustrated is animal 102 contained within inhalant chamber 104. Shown integral with inhalant chamber 104 is sensor 106, which is intended to be indicative of one or more types of sensors integral with various parts of inhalant toxicology exposure system 100. For example, sensor 106 is meant to be indicative of a variety of different types of sensors, such as temperature sensors, humidity sensors, particle count sensors, gas concentration sensors, etcetera, and even though sensor 106 is shown integral with inhalant chamber 104, sensor 106 is meant to be indicative of sensors positioned throughout various parts of inhalant toxicology exposure system 100. Further with respect to Figure 1, depicted is input airflow driver 108 (e.g., an air pump) connected to drive air through input air hose 110 and into inhalant chamber 104. Illustrated is inhalant reservoir 112 (e.g., a reservoir for inhalants such as biological aerosols) that feeds nebulizer 114, and allows nebulizer 114 to deposit an inhalant into input air hose 110. Nebulizer 114 and inhalant reservoir 112 are meant to be collectively indicative of a variety of different types of organic or inorganic substance dispensing units, such as wet aerosol dispensing units, a dry aerosol dispensing units, a gaseous substance dispensing units, mist dispensing units, a fog dispensing units a fume dispensing units, and an airborne substance dispensing units, etc.), and even though nebulizer 114 is shown integral with input air hose 110, nebulizer 114 and inhalant reservoir 112 are meant to be collectively indicative of dispensing units positioned throughout various parts of inhalant toxicology exposure system 100. Further depicted is input airflow sensor 116, which detects input airflow volume, and even though input airflow sensor 116 is shown integral with input air hose 110, input airflow sensor 116 is meant to be indicative of input airflow sensors positioned throughout various parts of inhalant toxicology exposure system 100, where such various parts are in the air inflow path.

Further with respect to Figure 1, depicted is output airflow driver 118 (e.g., a fan, or a vacuum pump) connected to drive air through output air hose 120 and into exhaust sink 122 (e.g., a chlorine bleach reservoir sufficient to kill/neutralize organic inhalants such as biological aerosols). Illustrated is output airflow sensor 124, which detects output airflow volume, airflow and even though output airflow sensor 124 is shown integral with output air hose 120, output airflow sensor 124 is meant to be indicative of output airflow sensors positioned throughout various parts of inhalant toxicology exposure system 100, where such various parts are in the air outflow path.

Further with respect to Figure 1, shown integral with inhalant chamber 104 is driver 126, which is intended to be indicative of one or more types of drivers integral with various parts of inhalant toxicology exposure system 100. For example, driver 126 is meant to be indicative of a variety of different types of drivers, such as temperature drivers (e.g., heaters and/or coolers), humidity drivers (e.g., humidifiers and/or dehumidifiers), inhalant concentration drivers (e.g., the various types of organic and inorganic dispensing units described herein), etc. and even though driver 126 is shown integral with inhalant chamber 104, driver 126 is meant to be indicative of drivers positioned throughout various parts of inhalant toxicology exposure system 100. Lastly with respect to Figure 1, shown is that the various sensors and drivers of inhalant toxicology and exposure system are operably connected (e.g., via electrical connections capable of carrying digital and/or analog information) with interface card 128. Depicted is that interface card 128 is operably connected with data processing system 130 which includes system unit housing 132, video display device 134 (shown as displaying a graphical user interface (GUI) 135), keyboard 136, and mouse 138. In one implementation, one or more control programs 140 reside within and run on data processing system 130, where such one or more control programs control the various sensors and drivers shown in order to effect the processes described herein. Data processing system 130 may be implemented utilizing any suitable computer such as a DELL portable computer system, a product of Dell Computer Corporation, located in Round Rock, Texas; Dell is a trademark of Dell Computer Corporation.

Following are a series of flowcharts depicting implementations of processes. For ease of understanding, the flowcharts are organized such that the initial flowcharts present implementations via an overall "big picture" viewpoint and thereafter the following flowcharts present alternate implementations and/or expansions of the "big picture" flowcharts as either substeps or additional steps building on one or more earlier-presented flowcharts. Those having ordinary skill in the art will appreciate that the style of presentation utilized herein (e.g., beginning with a presentation of a flowchart(s) presenting an overall view and thereafter providing additions to and/or further details in subsequent flowcharts) generally allows for a rapid and easy understanding of the various process implementations.

With reference now to Figure 2, shown is an implementation of a high- level logic flowchart depicting a process. Method step 200 shows the start of the process. Method step 202 depicts exposing an animal to an inhalant (e.g., exposing an animal of a type drawn from a gas-breathing-members-of-phylum-chordata group which includes an avian, a rodent, a primate, a feline, a canine, a porcine, an equine). In one device implementation, method step 202 is achieved by introducing an inhalant (e.g., an aerosolized form of a pathogen, such as anthrax or smallpox) from an inhalant reservoir (e.g., inhalant reservoir 112) into an inhalant chamber (e.g., inhalant chamber 104) containing all or part of an animal.

Method step 204 illustrates acquiring near real time measurement of at least respiration during said exposing. In one device implementation, method step 204 is achieved by via a respiration sensor (e.g., a pressure sensor implementation of sensor 106) integral with an inhalant chamber (e.g., inhalant chamber 104). Method step 206 shows calculating a received dose of the inhalant in response to the near real time measurement of the at least respiration during said exposing. In one device implementation, method step 206 is achieved via a processor (e.g., a processor internal to data processing system 130) running software that calculates a dose of the inhalant received by the animal, where such calculation is based at least in part on the near real time measurement of respiration. Method step 208 illustrates the end of the process. For additional examples of the process of Figure 2 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. With reference now to Figure 3, shown is an implementation of the high- level logic flowchart shown in Figure 2. Depicted in Figure 3 is that in one implementation method step 202 can include method step 300. Illustrated is that in one implementation exposing an animal to an inhalant can include, but is not limited to, dispersing either an organic or inorganic substance (e.g., dispersing a substance having a form selected from an inhalant-form group including but not limited to a wet aerosol form, a dry aerosol form, a gaseous substance form, mist form, a fog form, a fume form, and an airborne substance form). In one device implementation, method step 300 is achieved by activation of a nebulizer (e.g., nebulizer 114) that feeds an input airflow (e.g., input airflow flowing from input air hose 110 into inhalant chamber 104) into an inhalant chamber (e.g. , inhalant chamber 104). For additional examples of the process of Figure 3 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 3 function substantially as described elsewhere herein. With reference now to Figure 4, shown is an implementation of the high- level logic flowchart shown in Figure 2. Depicted in Figure 4 is that in one implementation method step 202 can include method step 400. Illustrated is that in one implementation exposing an animal to an inhalant can include, but is not limited to, dispersing the inhalant into an inhalant chamber (e.g., dispersing the inhalant into an inhalant chamber having a configuration selected from an exposure-target group including but not limited to a configuration to house a nose of the animal, a configuration to house a head of the animal, a configuration to house a part of the animal, and a configuration to house the entire animal; however, with respect to the foregoing, those skilled in the art will appreciate that the part of the animal that expands/contracts appreciably during respiration is preferably substantially isolated from the inhalant-chamber space where pressure measurement is taken, so that the expansion/contraction of the part of the animal that expands/contracts appreciably during respiration does not unduly interfere with the pressure measurement (e.g., if the inhalant chamber houses the entire animal, a second enclosure could be used to enclose and isolate the animal's thoracic cage from the space of the inhalant chamber where the pressure is to be measured.). In one device implementation, method step 400 is achieved by activation of a nebulizer (e.g., nebulizer 114) which feeds an input airflow (e.g., input airflow flowing from input air hose 110 into inhalant chamber 104) into an inhalant chamber (e.g., inhalant chamber 104) constructed to enclose either the nose, head, part, or all of the animal in a fashion such that gaseous input and egress from the inhalant chamber are controlled.

For additional examples of the process of Figure 4 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 4 function substantially as described elsewhere herein. With reference now to Figure 5, shown is an implementation of the high- level logic flowchart shown in Figure 2. Depicted in Figure 5 is that in one implementation method step 204 can include method step 500. Illustrated is that in one implementation acquiring near real time measurement of at least respiration during said exposing can include, but is not limited to, calculating the at least respiration via detecting at least one change in an inhalant chamber pressure (e.g., by acquiring pressure readings at about 30x per second). In one device implementation, method step 500 is achieved via a processor (e.g., a processor internal to data processing system 130) running software which calculates either or both inspiration and expiration by an animal in response to a pressure reading detected by a pressure transducer (e.g., a pressure sensor implementation of sensor 106) integral with an inhalation chamber (e.g., inhalation chamber 104).

Those skilled in the art will recognize that the change in the inhalant chamber pressure caused by the animal's respiratory function could also be measured indirectly by detecting a change in pressure in a second enclosure which isolates the animal's thoracic cage.

For additional examples of the process of Figure 5 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 5 function substantially as described elsewhere herein.

With reference now to Figure 6, shown is an implementation of the high- level logic flowchart shown in Figure 5. Depicted in Figure 6 is that in one implementation method step 500 can include method steps 600 and 602. Illustrated is that in one implementation calculating the at least respiration via detecting at least one change in a chamber pressure can include, but is not limited to, converting the at least one change in the inhalant chamber pressure into at least one change in an inhalant chamber volume via use of the Ideal Gas Law. In one device implementation, method step 600 is achieved via a processor (e.g., a processor internal to data processing system 130) running software, which calculates either or both inspiration and expiration by an animal in response to a pressure reading detected by a pressure transducer (a pressure sensor implementation of sensor 106) integral with an inhalation chamber (e.g., inhalation chamber 104), via use of the Ideal Gas Law (e.g., PV = nRT, where p is the pressure, V is the volume, n is the number of moles, R is the gas constant, and T is the temperature.). Further illustrated is that in one implementation calculating the at least respiration via detecting at least one change in a chamber pressure can include, but is not limited to, calculating the respiration from the at least one change in the inhalant chamber volume. In one device implementation, method step 602 is achieved via a processor (e.g., a processor internal to data processing system 130) running software, which calculates either or both inspiration and expiration by an animal in response to the calculated change in volume such as was described in relation to method step 600.

For additional examples of the process of Figure 6 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 6 function substantially as described elsewhere herein. With reference now to Figure 7, shown is an implementation of the high- level logic flowchart shown in Figure 2. Depicted in Figure 7 is that in one implementation method step 204 can include method step 700. Illustrated is that in one implementation acquiring near real time measurement of at least respiration during said exposing can include, but is not limited to, acquiring near real time measurement of at least one exposing parameter selected from an exposing- parameter group including humidity, temperature, pressure, flow volume, and inhalant concentration. In one device implementation, method step 700 is achieved via a processor (e.g., a processor internal to data processing system 130) running software, which monitors and collects data from humidity, pressure, flow volume, and/or inhalant concentration sensors (e.g., humidity sensor, pressure sensor, flow volume sensor, and inhalant concentration sensor, etc. implementations of sensor 106) integral with an inhalation chamber (e.g., inhalation chamber 106).

For additional examples of the process of Figure 7 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 7 function substantially as described elsewhere herein.

With reference now to Figure 8, shown are alternate implementations of the high-level logic flowchart shown in Figure 2. Depicted in Figure 8 is that in one implementation method step 206 can include method step 800, while in another implementation method step 206 can include method step 802. Illustrated in method step 800 is that in one implementation calculating a received dose of the inhalant in response to the near real time measurement of the at least respiration during said exposing can include, but is not limited to, multiplying a measured inhalant concentration by a volume inhaled by an animal. In one device implementation, method step 800 is achieved via a processor (e.g., a processor internal to data processing system 130) running software which uses measured data in conjunction with a calculated volume of air inhaled by an animal in an inhalant concentration sensor 104). Depicted in method step 802 is that in another implementation calculating a received dose of the inhalant in response to the near real time measurement of the at least respiration during said exposing can include, but is not limited to, multiplying an inferred inhalant concentration by a volume inhaled by an animal. In one device implementation, method step 800 is achieved via a processor (e.g., a processor internal to data processing system 130) running software which uses inferred data (e.g., data inferred from directions to a nebulizer to dispense a certain aerosol concentration) in conjunction with a calculated volume of air inhaled by an animal in an inhalant concentration sensor 104).

For additional examples of the process of Figure 8 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 8 function substantially as described elsewhere herein.

With reference now to Figure 9, shown is an implementation of a high- level logic flowchart depicting a process. Method step 900 shows the start of the process. Method step 902 depicts automatically controlling an environment of an inhalant chamber. Method step 904 illustrates automatically controlling a concentration of an inhalant in the inhalant chamber. Method step 906 shows the end of the process.

For examples of the process of Figure 9, please see the discussion here. For additional examples of the process of Figure 9 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233.

With reference now to Figure 10, shown is an implementation of the high-level logic flowchart shown in Figure 9. Depicted in Figure 10 is that in one implementation method step 902 can include method step 1000. Illustrated is that in one implementation automatically controlling an environment of an inhalant chamber can include, but is not limited to, maintaining one or more environmental factors via feedback control wherein said one or more environmental factors are selected from an environmental-factor group including but not limited to pressure, temperature, humidity, airflow in to the inhalant chamber, and airflow out of the inhalant chamber. In one device implementation, method step 1000 is achieved via control software running on a processor (e.g., a processor internal to data processing system 130), where the control software maintains the one or more environmental factors at levels specified via user input to a graphical user interface.

For additional examples of the process of Figure 10 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 10 function substantially as described elsewhere herein.

With reference now to Figure 11 , shown is an implementation of the high-level logic flowchart shown in Figure 10. Depicted in Figure 11 is that in one implementation method step 1000 can include method step 1100. Illustrated is that in one implementation maintaining one or more environmental factors via feedback control wherein said one or more environmental factors are selected from an environmental-factor group including but not limited to pressure, temperature, humidity, airflow in to the inhalant chamber, and airflow out of the inhalant chamber can include, but is not limited to, controlling the one or more environmental factors via monitoring one or more environmental sensors selected from an environmental-sensor group including a pressure sensor, a temperature sensor, a humidity sensor, an input airflow sensor, and an output airflow sensor (e.g., controlling the one or more environmental factors via one or more Proportional Integral Derivative (PID) controllers respectively receiving input from the one or more environmental sensors and respectively adjusting one or more environmental drivers selected from the environmental-driver group including a pressure driver, a temperature driver, a humidity driver, an input airflow driver, and an output airflow driver). In one device implementation, method step 1100 is achieved via control software running on a processor (e.g., a processor internal to data processing system 130), where the control software collects data from one or more environmental sensors and uses one or more PID algorithms to adjust one or more devices which drive the one or more environmental factors.

For additional examples of the process of Figure 11 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 11 function substantially as described elsewhere herein.

With reference now to Figure 12, shown is an implementation of the high-level logic flowchart shown in Figure 9. Depicted in Figure 12 is that in one implementation method step 902 can include method step 1200. Illustrated is that in one implementation automatically controlling an environment of an inhalant chamber can include, but is not limited to, dispersing either an organic or inorganic substance via electronic control of one or more inhalant dissemination devices (e.g., dispersing a substance having a form selected from an inhalant-form group including but not limited to a wet aerosol form, a dry aerosol form, a gaseous substance form, mist form, a fog form, a fume form, and an airborne substance form). In one device implementation, method step 1200 is achieved by activation of a nebulizer (e.g., nebulizer 114) that feeds an input airflow (e.g., input airflow flowing from input air hose 110 into inhalant chamber 10) into an inhalant chamber (e.g., inhalant chamber 104).

For additional examples of the process of Figure 12 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 12 function substantially as described elsewhere herein.

With reference now to Figure 13, shown is an implementation of the high-level logic flowchart shown in Figure 9. Depicted in Figure 13 is that in one implementation method step 902 can include method step 1300. Illustrated is that in one implementation automatically controlling an environment of an inhalant chamber can include, but is not limited to, dispersing either an organic or inorganic substance via electronic control of one or more inhalant dissemination devices (e.g., controlling the one or more inhalant dissemination devices via one or more Proportional Integral Derivative (PID) controllers respectively receiving input from one or more dissemination- related sensors selected from the dissemination-related-sensor group including but not limited to a chamber pressure monitor, an inhalant-concentration sensor, and a gas sensor). In one device implementation, method step 1300 is achieved via control software running on a processor (e.g., a processor internal to data processing system 130), where the control software collects data from one or more dissemination-related sensors (e.g., various and sundry implementations of sensor(s) 106) and uses one or more PID algorithms to adjust one or more one or more inhalant dissemination devices (e.g., one or more implementations of the drivers and/or dissemination devices described herein).

For additional examples of the process of Figure 13 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 13 function substantially as described elsewhere herein.

With reference now to Figure 14, shown is an implementation of the high-level logic flowchart shown in Figure 9. Depicted in Figure 14 is that in one implementation method step 904 can include method step 1400. Illustrated is that in one implementation automatically controlling a concentration of an inhalant in the inhalant chamber, but is not limited to, controlling a flow rate either into or out of the inhalant chamber in response to a specified discernment of the inhalant (e.g., controlling the flow rate either into or out of the inhalant chamber via one or more Proportional Integral Derivative (PID) controllers respectively receiving input from one or more concentration-related sensors selected from a concentration-related-sensor group including a chamber pressure monitor, an inhalant-concentration sensor, a gas sensor, an input airflow sensor, and an output airflow sensor). In one device implementation, method step 1400 is achieved via control software running on a processor (e.g., a processor internal to data processing system 130), where the control software collects data from one or more concentration-related sensors (e.g., various and sundry concentration-related implementations of sensor(s) 106) and uses one or more PID algorithms to adjust one or more flow rate control devices (one or more implementations of the drivers and/or dissemination devices described herein). For additional examples of the process of Figure 14 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 14 function substantially as described elsewhere herein.

With reference now to Figure 15, shown is an alternate implementation of the high-level logic flowchart of Figure 9. Shown is that in one alternate implementation the process includes additional method step 1500. Method step 1500 depicts displaying near real time measurement data related to an animal in the inhalant chamber. In one device implementation, method step 1500 is achieved via display of the near real time measurement data via a Graphical User Interface (e.g., GUI 135) displayed on a screen (e.g. , display device 134) of a computer (e.g. , data processing system 130).

For additional examples of the process of Figure 15 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 15 function substantially as described elsewhere herein. With reference now to Figure 16, shown are alternate implementations of the high-level logic flowchart shown in Figure 15. Depicted in Figure 16 is that in one implementation method step 1500 can include method step 1600, while in another implementation method step 1500 can include method step 1602. Illustrated in method step 1600 is that in one implementation displaying near real time measurement data related to an animal in the inhalant chamber can include, but is not limited to, displaying one or more animal-related factors wherein said one or more animal-related factors are selected from the animal-related-factor group including respiration data and dosimetry data. In one device implementation, method step 1600 is achieved via display of the one or more animal-related factors a Graphical User Interface (e.g., GUI 135) displayed on a screen (e.g., display device 134) of a computer (e.g., data processing system 130).

Further depicted in method step 1602 is that in another implementation displaying near real time measurement data related to an animal in the inhalant chamber can include, but is not limited to, displaying one or more environmental factors wherein said one or more environmental factors are selected from an environmental-factor group including but not limited to pressure, temperature, humidity, and airflow into the inhalant chamber, and airflow out of the inhalant chamber. In one device implementation, method step 1602 is achieved via display of the one or more environmental factors a Graphical User Interface (e.g., GUI 135) displayed on a screen (e.g. , display device 134) of a computer (e.g. , data processing system 130).

For additional examples of the process of Figure 16 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 16 function substantially as described elsewhere herein. With reference now to Figure 17, shown is a high-level logic flowchart depicting a process. Method step 1700 depicts the start of the process. Method step 1702 illustrates displaying near real time measurement data related to an animal in the inhalant chamber. In one device implementation, method step 1700 is achieved via display of the near real time measurement data a Graphical User Interface (e.g., GUI 135) displayed on a screen (e.g., display device 134) of a computer (e.g., data processing system 130). Method step 1704 shows the end of the process.

For additional examples of the process of Figure 17 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. With reference now to Figure 18, shown are alternate implementations of the high-level logic flowchart shown in Figure 17. Depicted in Figure 18 is that in one implementation method step 1702 can include method step 1800, while in another implementation method step 1702 can include method step 1802, while in yet another implementation method step 1702 can include method step 1804. Illustrated in method step 1800 is that in one implementation displaying near real time measurement data related to an animal in the inhalant chamber can include, but is not limited to, displaying one or more animal-related factors wherein said one or more animal-related factors are selected from the animal-related-factor group including respiration data and dosimetry data. In one device implementation, method step 1600 is achieved via display of the one or more animal-related factors a Graphical User Interface (e.g., GUI 135) displayed on a screen (e.g., display device 134) of a computer (e.g., data processing system 130).

Further depicted in method step 1804 is that in another implementation displaying near real time measurement data related to an animal in the inhalant chamber can include, but is not limited to, displaying one or more environmental factors wherein said one or more environmental factors are selected from an environmental-factor group including but not limited to pressure, temperature, humidity, and airflow into the inhalant chamber, and airflow out of the inhalant chamber. In one device implementation, method step 1802 is achieved via display of the one or more environmental factors a Graphical User Interface (e.g., GUI 135) displayed on a screen (e.g., display device 134) of a computer (e.g., data processing system 130).

Yet further depicted in method step 1804 is that in another implementation displaying near real time measurement data related to an animal in the inhalant chamber can include, but is not limited to, displaying one or more inhalant- related factors wherein said one or more inhalant-related factors are selected from the inhalant-related-factor group including but not limited to rate of inhalant discernment and inhalant concentration. In one device implementation, method step 1804 is achieved via display of the one or more environmental factors a Graphical User Interface (e.g., GUI 135) displayed on a screen (e.g., display device 134) of a computer (e.g., data processing system 130). For additional examples of the process of Figure 18 and device implementations thereof, please see herein incorporated by reference Provisional Patent Application No. 60/267,233. The remaining method steps of Figure 18 function substantially as described elsewhere herein. Those having ordinary skill in the art will appreciate that in the discussion herein the same factors and/or sensors have sometimes appeared in different categories of sensors (e.g., the same sensors categorized as environmental sensors or inhalant-concentration sensors). Those skilled in the art will appreciate that this is because in some instances the factors and/or sensors have been designated as environmental (e.g., hold humidity constant at 66%) which usually (but not always) mitigates the ability to use such factors and/or sensors to control dispersement. The converse is also true. Hence, those having ordinary skill in the art will recognize that the categorization of a particular factor and/or sensor will depend upon the context of use of the factor and/or sensor. That is, if one designates that "something" be held constant or variable in an environment, one typically loses the ability to disseminate on the basis of that "something," and vice versa.

Those having ordinary skill in the art will recognize that the state of the art has progressed to the point where there is little distinction left between hardware and software implementations of aspects of systems; the use of hardware or software is generally (but not always, in that in certain contexts the choice between hardware and software can become significant) a design choice representing cost vs. efficiency tradeoffs. Those having ordinary skill in the art will appreciate that there are various vehicles by which processes and/or systems described herein can be effected (e.g., hardware, software, and/or firmware), and that the preferred vehicle will vary with the context in which the processes are deployed. For example, if an implementer determines that speed and accuracy are paramount, the implementer may opt for a hardware and/or firmware vehicle; alternatively, if flexibility is paramount, the implementer may opt for a solely software implementation; or, yet again alternatively, the implementer may opt for some combination of hardware, software, and/or firmware. Hence, there are several possible vehicles by which the processes described herein may be effected, none of which is inherently superior to the other in that any vehicle to be utilized is a choice dependent upon the context in which the vehicle will be deployed and the specific concerns (e.g. , speed, flexibility, or predictability) of the implementer, any of which may vary. The foregoing detailed description has set forth various embodiments of the devices and/or processes via the use of block diagrams, flowcharts, and examples. Insofar as such block diagrams, flowcharts, and examples contain one or more functions and/or operations, it will be understood as notorious by those within the art that each function and/or operation within such block diagrams, flowcharts, or examples can be implemented, individually and/or collectively, by a wide range of hardware, software, firmware, or any combination thereof. In one embodiment, the present invention may be implemented via Application Specific Integrated Circuits (ASICs). However, those skilled in the art will recognize that the embodiments disclosed herein, in whole or in part, can be equivalently implemented in standard Integrated Circuits, as one or more computer programs running on one or more computers (e.g., as one or more server programs running on one or more computer systems), as one or more programs running on one or more processors (e.g., as one or more thin client programs running on one or more processors), as firmware, or as virtually any combination thereof, and that designing the circuitry and/or writing the code for the software or firmware would be well within the skill of one of ordinary skill in the art in light of this disclosure. In addition, those skilled in the art will appreciate that the mechanisms of the present invention are capable of being distributed as a program product in a variety of forms, and that an illustrative embodiment of the present invention applies equally regardless of the particular type of signal bearing media used to actually carry out the distribution. Examples of a signal bearing media include, but are not limited to, the following: recordable type media such as floppy disks, hard disk drives, CD ROMs, digital tape, and transmission type media such as digital and analogue communication links using TDM or IP based communication links (e.g., packet links).

In a general sense, those skilled in the art will recognize that the various embodiments described herein which can be implemented, individually and/or collectively, by a wide range of hardware, software, firmware, or any combination thereof can be viewed as being composed of various types of "electrical circuitry." Consequently, as used herein "electrical circuitry" includes, but is not limited to, electrical circuitry having at least one discrete electrical circuit, electrical circuitry having at least one integrated circuit, electrical circuitry having at least one application specific integrated circuit, electrical circuitry forming a general purpose computing device configurable by a computer program (e.g., a general purpose computer configurable by a computer program or a microprocessor configurable by a computer program), electrical circuitry forming a memory device (e.g., any and all forms of random access memory), and electrical circuitry forming a communications device (e.g., a modem, communications switch, or optical-electrical equipment).

Those skilled in the art will recognize that it is common within the art to describe devices and/or processes in the fashion set forth herein, and thereafter use standard engineering practices to integrate such described devices and/or processes into data processing systems. That is, the devices and/or processes described herein can be integrated into a data processing system via a reasonable amount of experimentation. Figure 1 shows an example representation of a data processing system into which at least a part of the herein described devices and/or processes may be integrated with a reasonable amount of experimentation. With reference now again to Figure 1, depicted is a pictorial representation of a conventional data processing system in which portions of the illustrative embodiments of the devices and/or processes described herein may be implemented. It should be noted that a graphical user interface systems (e.g., Microsoft Windows 98 or Microsoft Windows NT operating systems) and methods can be utilized with the data processing system depicted in Figure 1. Data processing system 130 is depicted which includes system unit housing 132, video display device 134, keyboard 136, mouse 138, and microphone (not shown). Data processing system 130 may be implemented utilizing any suitable computer such as a DELL portable computer system, a product of Dell Computer Corporation, located in Round Rock, Texas; Dell is a trademark of Dell Computer Corporation. The foregoing described embodiments depict different components contained within, or connected with, different other components. It is to be understood that such depicted architectures are merely exemplary, and that in fact many other architectures can be implemented which achieve the same functionality. In a conceptual sense, any arrangement of components to achieve the same functionality is effectively "associated" such that the desired functionality is achieved. Hence, any two components herein combined to achieve a particular functionality can be seen as "associated with" each other such that the desired functionality is achieved, irrespective of architectures or intermedial components. Likewise, any two components so associated can also be viewed as being "operably connected," or "operably coupled," to each other to achieve the desired functionality.

While particular embodiments of the present invention have been shown and described, it will be obvious to those skilled in the art that, based upon the teachings herein, changes and modifications may be made without departing from this invention and its broader aspects and, therefore, the appended claims are to encompass within their scope all such changes and modifications as are within the true spirit and scope of this invention. Furthermore, it is to be understood that the invention is solely defined by the appended claims. It will be understood by those within the art that, in general, terms used herein, and especially in the appended claims (e.g., bodies of the appended claims) are generally intended as "open" terms (e.g., the term "including" should be interpreted as "including but not limited to," the term "having" should be interpreted as "having at least," the term "includes" should be interpreted as "includes but is not limited to," etc.). It will be further understood by those within the art that if a specific number of an introduced claim element is intended, such an intent will be explicitly recited in the claim, and in the absence of such recitation no such intent is present. For example, as an aid to understanding, the following appended claims may contain usage of the introductory phrases "at least one" and "one or more" to introduce claim elements. However, the use of such phrases should not be construed to imply that the introduction of a claim element by the indefinite articles "a" or "an" limits any particular claim containing such introduced claim element to inventions containing only one such element, even when the same claim includes the introductory phrases "one or more" or "at least one" and indefinite articles such as "a" or "an"; the same holds true for the use of definite articles used to introduce claim elements. In addition, even if a specific number of an introduced claim element is explicitly recited, those skilled in the art will recognize that such recitation should typically be interpreted to mean at least the recited number (e.g., the bare recitation of "two elements," without other modifiers, typically means at least two elements, or two or more elements).

Claims

CLAIMS The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. A method comprising: exposing an animal to an inhalant; acquiring near real time measurement of at least respiration during said exposing; and calculating a received dose of the inhalant in response to the near real time measurement of the at least respiration during said exposing.

2. The method of claim 1 wherein said exposing an animal to an inhalant comprises: dispersing either an organic or inorganic substance.

3. The method of claim 2 wherein said dispersing either an organic or inorganic substance comprises: dispersing a substance having a form selected from an inhalant-form group including a wet aerosol form, a dry aerosol form, a gaseous substance form, mist form, a fog form, a fume form, and an airborne substance form.

4. The method of claim 1 wherein said exposing an animal to an inhalant comprises: dispersing the inhalant into an inhalant chamber.

5. The method of claim 4 wherein said dispersing the inhalant into an inhalant chamber comprises: dispersing the inhalant into an inhalant chamber having a configuration selected' from an exposure-target group including a configuration to house a nose of the animal, a configuration to house a head of the animal, a configuration to house a part of the animal, and a configuration to house the entire animal.

6. The method of claim 1 wherein said exposing an animal to an inhalant comprises: exposing the animal drawn from a gas-breathing-members-of-phylum- chordata group which includes an avian, a rodent, a primate, a feline, a canine, a porcine, an equine.

7. The method of claim 1 wherein said acquiring near real time measurement of at least respiration during said exposing comprises: calculating the at least respiration via detecting at least one change in an inhalant chamber pressure.

8. The method of claim 7 wherein said calculating the respiration via at least one change in an inhalant chamber pressure comprises: converting the at least one change in the inhalant chamber pressure into at least one change in an inhalant chamber volume via use of the Ideal Gas Law; and calculating the respiration from the at least one change in the inhalant chamber volume.

9. The method of claim 1 wherein said acquiring near real time measurement of at least respiration during said exposing comprises: acquiring near real time measurement of at least one exposing parameter selected from an exposing-parameter group including humidity, temperature, pressure, flow volume, and inhalant concentration.

10. The method of claim 1 wherein said calculating a received dose of the inhalant in response to the near real time measurement of the at least respiration during said exposing comprises: multiplying a measured inhalant concentration by a volume inhaled by an animal.

11. The method of claim 1 wherein said calculating a received dose of the inhalant in response to the near real time measurement of the at least respiration during said exposing comprises: multiplying an inferred inhalant concentration by a volume inhaled by an animal.

12. A system comprising : means for exposing an animal to an inhalant; means for acquiring near real time measurement of at least respiration during said exposing; and means for calculating a received dose of the inhalant in response to the near real time measurement of the at least respiration during said exposing.

13. The system of claim 12 wherein said means for exposing an animal to an inhalant comprises: means for dispersing either an organic or inorganic substance.

14. The system of claim 13 wherein said means for dispersing either an organic or inorganic substance comprises: means for dispersing a substance having a form selected from an inhalant- form group including a wet aerosol form, a dry aerosol form, a gaseous substance form, mist form, a fog form, a fume form, and an airborne substance form.

15. The system of claim 12 wherein said means for exposing an animal to an inhalant comprises: means for dispersing the inhalant into an inhalant chamber.

16. The system of claim 15 wherein said means for dispersing the inhalant into an inhalant chamber comprises: means for dispersing the inhalant into an inhalant chamber having a configuration selected from an exposure-target group including a configuration to house a nose of the animal, a configuration to house a head of the animal, a configuration to house a part of the animal, and a configuration to house the entire animal.

17. The system of claim 12 wherein said means for exposing an animal to an inhalant comprises: means for exposing the animal drawn from a gas-breathing-members-of- phylum-chordata group, which includes an avian, a rodent, a primate, a feline, a canine, a porcine, an equine.

18. The system of claim 12 wherein said means for acquiring near real time measurement of at least respiration during said means for exposing comprises: means for calculating the at least respiration via detecting at least one change in an inhalant chamber pressure.

19. The system of claim 18 wherein said means for calculating the respiration via at least one change in an inhalant chamber pressure comprises: means for converting the at least one change in the inhalant chamber pressure into at least one change in an inhalant chamber volume via use of the Ideal Gas Law; and means for calculating the respiration from the at least one change in the inhalant chamber volume.

20. The system of claim 12 wherein said means for acquiring near real time measurement of at least respiration during said means for exposing comprises: means for acquiring near real time measurement of at least one exposing parameter selected from an exposing-parameter group including humidity, temperature, pressure, flow volume, and inhalant concentration.

21. The system of claim 12 wherein said means for calculating a received dose of the inhalant in response to the near real time measurement of the at least respiration during said means for exposing comprises: means for multiplying a measured inhalant concentration by a volume inhaled by an animal.

22. The system of claim 12 wherein said means for calculating a received dose of the inhalant in response to the near real time measurement of the at least respiration during said means for exposing comprises: means for multiplying an inferred inhalant concentration by a volume inhaled by an animal.

23. A method comprising: automatically controlling an environment of an inhalant chamber; and automatically controlling a concentration of an inhalant in the inhalant chamber.

24. The method of claim 23 wherein said automatically controlling an environment of an inhalant chamber comprises: maintaining one or more environmental factors via feedback control wherein said one or more environmental factors are selected from an environmental-factor group including pressure, temperature, humidity, airflow in to the inhalant chamber, and airflow out of the inhalant chamber.

25. The method of claim 24 wherein said maintaining one or more environmental factors via feedback control comprises: controlling the one or more environmental factors via monitoring one or more environmental sensors selected from an environmental-sensor group including a pressure sensor, a temperature sensor, a humidity sensor, an input airflow sensor, and an output airflow sensor.

26. The method of claim 25 wherein said controlling the one or more environmental factors via monitoring one or more environmental sensors comprises: controlling the one or more environmental factors via one or more Proportional Integral Derivative controllers respectively receiving input from the one or more environmental sensors and respectively adjusting one or more environmental drivers selected from the environmental-driver group including a pressure driver, a temperature driver, a humidity driver, an input airflow driver, and an output airflow driver.

27. The method of claim 23 wherein said automatically controlling a concentration of an inhalant in the inhalant chamber comprises: dispersing either an organic or inorganic substance via electronic control of one or more inhalant dissemination devices.

28. The method of claim 27 wherein said dispersing either an organic or inorganic substance via electronic control of one or more inhalant dissemination devices comprises: dispersing a substance having a form selected from an inhalant-form group including a wet aerosol form, a dry aerosol form, a gaseous substance form, mist form, a fog form, a fume form, and an airborne substance form.

29. The method of claim 27 wherein said dispersing either an organic or inorganic substance via electronic control of one or more inhalant dissemination devices comprises: controlling the one or more inhalant dissemination devices via one or more Proportional Integral Derivative controllers respectively receiving input from one or more dissemination-related sensors selected from the dissemination-related-sensor group including a chamber pressure monitor, an inhalant-concentration sensor, and a gas sensor.

30. The method of claim 23 wherein said automatically controlling a concentration of an inhalant in the inhalant chamber comprises: controlling a flow rate either into or out of the inhalant chamber in response to a specified dispensement of the inhalant.

31. The method of claim 30 wherein said controlling a flow rate either into or out of the inhalant chamber in response to a specified dispensement of the inhalant comprises: controlling the flow rate either into or out of the inhalant chamber via one or more Proportional Integral Derivative controllers respectively receiving input from one or more concentration-related sensors selected from a concentration-related-sensor group including a chamber pressure monitor, an inhalant-concentration sensor, a gas sensor, an input airflow sensor, and an output airflow sensor.

32. The method of claim 23 further comprising: displaying near real time measurement data related to an animal in the inhalant chamber.

33. The method of claim 32 wherein said displaying near real time measurement data related to an animal in an inhalant chamber comprises: displaying one or more animal-related factors wherein said one or more animal-related factors are selected from the animal-related-factor group including to respiration data, and dosimetry data.

34. The method of claim 32 wherein said displaying near real time measurement data related to an animal in an inhalant chamber comprises: displaying one or more environmental factors wherein said one or more environmental factors are selected from an environmental-factor group including pressure, temperature, humidity, and airflow into the inhalant chamber, and airflow out of the inhalant chamber.

35. A system comprising: means for automatically controlling an environment of an inhalant chamber; and means for automatically controlling a concentration of an inhalant in the inhalant chamber.

36. The system of claim 35 wherein said means for automatically controlling an environment of an inhalant chamber comprises: means for maintaining one or more environmental factors via feedback control wherein said one or more environmental factors are selected from an environmental-factor group including pressure, temperature, humidity, airflow in to the inhalant chamber, and airflow out of the inhalant chamber.

37. The system of claim 36 wherein said means for maintaining one or more environmental factors via feedback control comprises: means for controlling the one or more environmental factors via monitoring one or more environmental sensors selected from an environmental-sensor group including a pressure sensor, a temperature sensor, a humidity sensor, an input airflow sensor, and an output airflow sensor.

38. The system of claim 37 wherein said means for controlling the one or more environmental factors via monitoring one or more environmental sensors comprises: means for controlling the one or more environmental factors via one or more Proportional Integral Derivative controllers respectively receiving input from the one or more environmental sensors and respectively adjusting one or more environmental drivers selected from the environmental-driver group including a pressure driver, a temperature driver, a humidity driver, an input airflow driver, and an output airflow driver.

39. The system of claim 35 wherein said means for automatically controlling a concentration of an inhalant in the inhalant chamber comprises: means for dispersing either an organic or inorganic substance via electronic control of one or more inhalant dissemination devices.

40. The system of claim 39 wherein said means for dispersing either an organic or inorganic substance via electronic control of one or more inhalant dissemination devices comprises: means for dispersing a substance having a form selected from an inhalant- form group including a wet aerosol form, a dry aerosol form, a gaseous substance form, mist form, a fog form, a fume form, and an airborne substance form.

41. The system of claim 39 wherein said means for dispersing either an organic or inorganic substance via electronic control of one or more inhalant dissemination devices comprises: means for controlling the one or more inhalant dissemination devices via one or more Proportional Integral Derivative controllers respectively receiving input from one or more dissemination-related sensors selected from the dissemination-related-sensor group including a chamber pressure monitor, an inhalant-concentration sensor, and a gas sensor.

42. The system of claim 35 wherein said means for automatically controlling a concentration of an inhalant in the inhalant chamber comprises: means for controlling a flow rate either into or out of the inhalant chamber in response to a specified dispensement of the inhalant.

43. The system of claim 42 wherein said means for controlling a flow rate either into or out of the inhalant chamber in response to a specified dispensement of the inhalant comprises: means for controlling the flow rate either into or out of the inhalant chamber via one or more Proportional Integral Derivative controllers respectively receiving input from one or more concentration-related sensors selected from a concentration-related-sensor group including a chamber pressure monitor, an inhalant-concentration sensor, a gas sensor, an input airflow sensor, and an output airflow sensor.

44. The system of claim 35 further comprising: means for displaying near real time measurement data related to an animal in the inhalant chamber.

45. The system of claim 44 wherein said means for displaying near real time measurement data related to an animal in an inhalant chamber comprises: means for displaying one or more animal-related factors wherein said one or more animal-related factors are selected from the animal-related-factor group including to respiration data, and dosimetry data.

46. The system of claim 44 wherein said means for displaying near real time measurement data related to an animal in an inhalant chamber comprises: means for displaying one or more environmental factors wherein said one or more environmental factors are selected from an environmental-factor group including pressure, temperature, humidity, and airflow into the inhalant chamber, and airflow out of the inhalant chamber.

47. A method comprising: displaying near real time measurement data related to an animal in an inhalant chamber.

48. The method of claim 47 wherein said displaying near real time measurement data related to an animal in an inhalant chamber comprises: displaying one or more animal-related factors wherein said one or more animal-related factors are selected from an animal-related-factor group including respiration data, and dosimetry data.

49. The method of claim 47 wherein said displaying near real time measurement data related to an animal in an inhalant chamber comprises: displaying one or more environmental factors wherein said one or more environmental factors are selected from the environmental-factor group including pressure, temperature, humidity, and airflow into the inhalant chamber, and airflow out of the inhalant chamber.

50. The method of claim 47 wherein said displaying near real time measurement data related to an animal in an inhalant chamber comprises: displaying one or more inhalant-related factors wherein said one or more inhalant-related factors are selected from the inhalant-related-factor group including rate of inhalant dispensement and inhalant concentration.

51. A system comprising: means for displaying near real time measurement data related to an animal in an inhalant chamber.

52. The system of claim 51 wherein said means for displaying near real time measurement data related to an animal in an inhalant chamber comprises: means for displaying one or more animal-related factors wherein said means for one or more animal-related factors are selected from an animal-related-factor group including respiration data, and dosimetry data.

53. The system of claim 51 wherein said means for displaying near real time measurement data related to an animal in an inhalant chamber comprises: means for displaying one or more environmental factors wherein said means for one or more environmental factors are selected from the environmental-factor group including pressure, temperature, humidity, and airflow into the inhalant chamber, and airflow out of the inhalant chamber.

54. The system of claim 51 wherein said means for displaying near real time measurement data related to an animal in an inhalant chamber comprises: means for displaying one or more inhalant-related factors wherein said one or more inhalant-related factors are selected from the inhalant-related-factor group including rate of inhalant dispensement and inhalant concentration.

55. A system comprising: at least one inhalant chamber; and at least one animal respiration sensor integral with the at least one inhalant chamber.

56. The system of claim 55 wherein the at least one inhalant chamber comprises: the at least one inhalant chamber configured to accept at least a part of an animal wherein the at least a part of the animal is selected from the animal-part group including the animal's head, the animal's nose, a portion of the animal, and the animal in its entirety.

57. The system of claim 55 wherein the at least one inhalant chamber comprises: the at least one inhalant chamber constructed from non-porous materials.

58. The system of claim 55 wherein the at least one animal respiration sensor integral with the at least one inhalant chamber comprises: at least one pressure transducer integral with the at least one inhalant chamber.

59. The system of claim 55 wherein the at least one animal respiration sensor integral with the at least one inhalant chamber comprises: the at least one animal respiration sensor operably coupled to circuitry wherein the circuitry includes one or more electrical circuits selected from the electrical-circuit group including electrical circuits having at least one discrete electrical circuit, electrical circuits having at least one integrated circuit, electrical circuits having at least one application specific integrated circuit, and electrical circuits providing at least one general purpose computing device configurable by a computer program, and electrical circuits providing a communications device.

60. The system of claim 55 wherein the at least one inhalant chamber comprises: at least one sensor integral with the at least one inhalant chamber wherein the at least one sensor is selected from the sensor group including a pressure sensor, a temperature sensor, a humidity sensor, an input airflow sensor, an output airflow sensor, an inhalant dispensement sensor, a pressure sensor, and an inhalant-concentration sensor.

61. The system of claim 60 wherein the at least one sensor integral with the at least one inhalant chamber comprises: the at least one sensor operably coupled to circuitry wherein the circuitry includes one or more electrical circuits selected from the electrical-circuit group including electrical circuits having at least one discrete electrical circuit, electrical circuits having at least one integrated circuit, electrical circuits having at least one application specific integrated circuit, electrical circuits providing at least one general purpose computing device configurable by a computer program, and electrical circuits providing a communications device.

62. The system of claim 61 wherein the electrical circuits providing at least one general purpose computing device configurable by a computer program comprise: electrical circuits providing a memory wherein the memory contains control software which interfaces with the at least one sensor and provides control or recording functions.

63. The system of claim 55 wherein the at least one inhalant chamber comprises: at least one environmental control device operably coupled with the at least one inhalant chamber wherein the at least one environmental control device is selected from the environmental-control-device group including at least one humidifier, at least one input airflow device, at least one output airflow device, at least one device to heat the inhalant chamber, and at least one device to cool the inhalant chamber.

64. The system of claim 63 wherein the at least one environmental control device operably coupled with the at least one inhalant chamber comprises: the at least one environmental control device operably coupled to circuitry wherein the circuitry includes one or more electrical circuits selected from the electrical- circuit group including electrical circuits having at least one discrete electrical circuit, electrical circuits having at least one integrated circuit, electrical circuits having at least one application specific integrated circuit, and electrical circuits providing at least one general purpose computing device configurable by a computer program, and electrical circuits providing a communications device.

65. The system of claim 64 wherein the electrical circuits providing at least one general purpose computing device configurable by a computer program comprise: electrical circuits providing a memory wherein the memory contains control software which interfaces with the at least one environmental control device and provides control or recording functions.