WO2002064187A3 - Systems, methods, and compositions for achieving closure of vascular puncture sites - Google Patents

Systems, methods, and compositions for achieving closure of vascular puncture sites Download PDF

Info

Publication number
WO2002064187A3
WO2002064187A3 PCT/US2002/003733 US0203733W WO02064187A3 WO 2002064187 A3 WO2002064187 A3 WO 2002064187A3 US 0203733 W US0203733 W US 0203733W WO 02064187 A3 WO02064187 A3 WO 02064187A3
Authority
WO
WIPO (PCT)
Prior art keywords
systems
methods
compositions
vascular puncture
puncture sites
Prior art date
Application number
PCT/US2002/003733
Other languages
French (fr)
Other versions
WO2002064187A2 (en
Inventor
Charles F Milo
Olexander Hnojewyj
Timothy J Mccoy
Bruce S Addis
Original Assignee
Neomend Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neomend Inc filed Critical Neomend Inc
Priority to AU2002236986A priority Critical patent/AU2002236986A1/en
Publication of WO2002064187A2 publication Critical patent/WO2002064187A2/en
Publication of WO2002064187A3 publication Critical patent/WO2002064187A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004(bio)absorbable, (bio)resorbable, resorptive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491Surgical glue applicators
    • A61B2017/00495Surgical glue applicators for two-component glue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00637Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for sealing trocar wounds through abdominal wall
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00646Type of implements
    • A61B2017/00659Type of implements located only on one side of the opening

Abstract

Systems and methods convey a closure material into a catheter to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components which, upon mixing, undergo a reaction to form a solid closure material composition. The systems and methods assure ease of delivery and effective mixing of the components to create an in situ barrier at the puncture site.
PCT/US2002/003733 2001-02-09 2002-02-08 Systems, methods, and compositions for achieving closure of vascular puncture sites WO2002064187A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002236986A AU2002236986A1 (en) 2001-02-09 2002-02-08 Systems, methods, and compositions for achieving closure of vascular puncture sites

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/780,843 2001-02-09
US09/780,843 US6949114B2 (en) 1998-11-06 2001-02-09 Systems, methods, and compositions for achieving closure of vascular puncture sites

Publications (2)

Publication Number Publication Date
WO2002064187A2 WO2002064187A2 (en) 2002-08-22
WO2002064187A3 true WO2002064187A3 (en) 2003-04-10

Family

ID=25120872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/003733 WO2002064187A2 (en) 2001-02-09 2002-02-08 Systems, methods, and compositions for achieving closure of vascular puncture sites

Country Status (3)

Country Link
US (1) US6949114B2 (en)
AU (1) AU2002236986A1 (en)
WO (1) WO2002064187A2 (en)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040176801A1 (en) * 1997-03-12 2004-09-09 Neomend, Inc. Pretreatment method for enhancing tissue adhesion
US7335220B2 (en) 2004-11-05 2008-02-26 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US7351249B2 (en) * 1998-11-06 2008-04-01 Neomend, Inc. Systems, methods, and compositions for achieving closure of suture sites
EP1526812B1 (en) * 2002-08-01 2007-01-17 Abbott Laboratories Vascular Enterprises Limited Apparatus for sealing a puncture by causing a reduction in the circumference of the puncture
US20040122362A1 (en) * 2002-09-10 2004-06-24 Houser Russell A. Pseudo aneurysm repair system
US7331979B2 (en) * 2003-06-04 2008-02-19 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US9289195B2 (en) 2003-06-04 2016-03-22 Access Closure, Inc. Auto-retraction apparatus and methods for sealing a vascular puncture
US20050149117A1 (en) * 2003-12-24 2005-07-07 Farhad Khosravi Apparatus and methods for delivering sealing materials during a percutaneous procedure to facilitate hemostasis
US7641647B2 (en) * 2003-12-29 2010-01-05 Boston Scientific Scimed, Inc. Medical device with modified marker band
US20080154303A1 (en) * 2006-12-21 2008-06-26 Cardiva Medical, Inc. Hemostasis-enhancing device and method for its use
US20050267520A1 (en) 2004-05-12 2005-12-01 Modesitt D B Access and closure device and method
US20050281739A1 (en) * 2004-06-16 2005-12-22 Glen Gong Imaging damaged lung tissue using compositions
US7608579B2 (en) * 2004-06-16 2009-10-27 Pneumrx, Inc. Lung volume reduction using glue compositions
US7553810B2 (en) * 2004-06-16 2009-06-30 Pneumrx, Inc. Lung volume reduction using glue composition
US20050281798A1 (en) * 2004-06-16 2005-12-22 Glen Gong Targeting sites of damaged lung tissue using composition
US20050281799A1 (en) * 2004-06-16 2005-12-22 Glen Gong Targeting damaged lung tissue using compositions
US7678767B2 (en) 2004-06-16 2010-03-16 Pneumrx, Inc. Glue compositions for lung volume reduction
US20050281740A1 (en) * 2004-06-16 2005-12-22 Glen Gong Imaging damaged lung tissue
JP5113519B2 (en) 2004-07-08 2013-01-09 ヌームアールエックス・インコーポレーテッド Treatment device, treatment method and material for pleural effusion
US7678133B2 (en) 2004-07-10 2010-03-16 Arstasis, Inc. Biological tissue closure device and method
US8348971B2 (en) * 2004-08-27 2013-01-08 Accessclosure, Inc. Apparatus and methods for facilitating hemostasis within a vascular puncture
US8262693B2 (en) 2004-11-05 2012-09-11 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US8882787B2 (en) 2005-03-02 2014-11-11 St. Jude Medical, Cardiology Division, Inc. Tissue anchor apparatus
US7806856B2 (en) 2005-04-22 2010-10-05 Accessclosure, Inc. Apparatus and method for temporary hemostasis
US8002742B2 (en) * 2005-04-22 2011-08-23 Accessclosure, Inc. Apparatus and methods for sealing a puncture in tissue
WO2006117766A2 (en) * 2005-04-29 2006-11-09 Zerusa Limited An interventional medical closure device
AU2006247355B2 (en) 2005-05-12 2013-01-10 Arstasis, Inc. Access and closure device and method
US8123693B2 (en) * 2005-06-20 2012-02-28 Conceptus, Inc. Methods and devices for determining lumen occlusion
EP1901796B1 (en) 2005-07-08 2020-11-11 C. R. Bard, Inc. Implantable medical device delivery apparatus
JP5253170B2 (en) * 2005-10-05 2013-07-31 ローマ リンダ ユニヴァーシティ メディカル センター Vascular wound closure device and method
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
US7472589B2 (en) * 2005-11-07 2009-01-06 Halliburton Energy Services, Inc. Single phase fluid sampling apparatus and method for use of same
US8617204B2 (en) 2006-09-13 2013-12-31 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US8062262B2 (en) * 2006-10-05 2011-11-22 Becton, Dickinson And Company Extravascular system in-line venting
US9066885B2 (en) * 2007-03-16 2015-06-30 University Of Maryland, College Park Advanced functional biocompatible polymeric matrix containing nano-compartments
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
US8092837B2 (en) * 2007-04-27 2012-01-10 Biomet Manufacturing Corp Fibrin based glue with functionalized hydrophilic polymer protein binding agent
US20080306439A1 (en) * 2007-06-08 2008-12-11 Nelson M Bud Devices for mixing and applying a fluid composition
WO2008152617A2 (en) * 2007-06-15 2008-12-18 Zerusa Limited A closure device
US7993367B2 (en) 2007-09-28 2011-08-09 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
WO2009059217A2 (en) 2007-11-02 2009-05-07 Incept, Llc Apparatus and methods for sealing a vascular puncture
CN101449987B (en) * 2007-11-29 2010-06-09 许尚栋 Sacculus conveyer
US8029533B2 (en) 2008-04-04 2011-10-04 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US9364206B2 (en) 2008-04-04 2016-06-14 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
CN102159126A (en) 2008-07-21 2011-08-17 阿尔斯塔西斯公司 Devices, methods, and kits for forming tracts in tissue
AU2009288440B2 (en) 2008-08-26 2015-04-23 St Jude Medical, Inc. Device and sealing component for sealing punctures
JP2012508618A (en) 2008-11-12 2012-04-12 アクセスクロージャー,インク. Device and method for closing a vascular puncture
US8403822B2 (en) * 2009-02-20 2013-03-26 Cytyc Corporation Passive vent for brachytherapy balloon catheters
EP2424596B1 (en) * 2009-04-30 2024-02-28 Hyperbranch Medical Technology, Inc. Applicator system for the delivery of surgical sealants
JP5684239B2 (en) 2009-05-04 2015-03-11 インセプト・リミテッド・ライアビリティ・カンパニーIncept Llc Biomaterial for track and puncture closure
US8383044B2 (en) 2009-07-09 2013-02-26 Becton, Dickinson And Company Blood sampling device
US8845682B2 (en) 2009-10-13 2014-09-30 E-Pacing, Inc. Vasculature closure devices and methods
US9498271B2 (en) * 2009-10-29 2016-11-22 Cook Medical Technologies Llc Coaxial needle cannula with distal spiral mixer and side ports for fluid injection
EP2498820B1 (en) 2009-11-13 2019-01-09 University of Maryland, College Park Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds
EP2519161B1 (en) 2009-12-30 2020-04-29 Vivasure Medical Limited Closure system
WO2011119360A1 (en) * 2010-03-23 2011-09-29 Hyperbranch Medical Technology, Inc. Disposable syringe applicators for multi-component formulations, and methods of use thereof
US20120109190A1 (en) * 2010-05-06 2012-05-03 Cvdevices, Llc (A California Limited Liability Company) Devices, systems, and methods for closing an aperture in a bodily tissue
US8664199B2 (en) 2010-08-13 2014-03-04 University Of Maryland, College Park Method and system for reversal of interactions between hydrophobically modified biopolymers and vesicles or cell membranes
WO2012075457A2 (en) 2010-12-02 2012-06-07 University Of Maryland, College Park Method and system for capture and use of intact vesicles on electrodeposited hydrophobically modified biopolymer films
EP2658453B1 (en) 2010-12-30 2020-04-29 Vivasure Medical Limited Surgical closure systems
ES2870965T3 (en) 2011-01-19 2021-10-28 Access Closure Inc Procedures to seal a vascular puncture
US9820728B2 (en) 2011-01-19 2017-11-21 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8894613B2 (en) 2011-01-22 2014-11-25 Hideo Koike Catheter attachment and method
US9386968B2 (en) 2011-05-11 2016-07-12 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8747428B2 (en) * 2012-01-12 2014-06-10 Fischell Innovations, Llc Carotid sheath with entry and tracking rapid exchange dilators and method of use
EP2819586A2 (en) 2012-02-29 2015-01-07 Vivasure Medical Limited Percutaneous perforation closure systems, devices, and methods
US8721680B2 (en) 2012-03-23 2014-05-13 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US9757105B2 (en) 2012-03-23 2017-09-12 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US20130317438A1 (en) 2012-05-25 2013-11-28 Arstasis, Inc. Vascular access configuration
US20130317481A1 (en) 2012-05-25 2013-11-28 Arstasis, Inc. Vascular access configuration
CA2914610C (en) 2013-03-13 2022-08-02 University Of Maryland Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
US9850013B2 (en) 2013-03-15 2017-12-26 Vivasure Medical Limited Loading devices and methods for percutaneous perforation closure systems
US9707319B2 (en) * 2013-06-20 2017-07-18 Nordson Corporation Device and method for improving hydration of a biomaterial
EP3021762B1 (en) 2013-07-15 2020-03-04 E-Pacing, Inc. Vasculature closure devices
US10420888B2 (en) * 2013-09-03 2019-09-24 Max Arocha Double-chamber mixing syringe and method of use
WO2015153828A1 (en) 2014-04-04 2015-10-08 Hyperbranch Medical Technology, Inc. Extended tip spray applicator for two-component surgical selant, and methods of use thereof
US9295752B1 (en) 2014-09-30 2016-03-29 Covidien Lp Bioadhesive for occluding vessels
MA40946A (en) 2014-11-14 2017-09-19 Access Closure Inc APPARATUS AND METHODS FOR MAKING A VASCULAR PUNCTURE WATERTIGHT
US10433826B2 (en) 2014-12-15 2019-10-08 Vivasure Medical Limited Closure apparatus with flexible sealable member and flexible support member
EP3232939B1 (en) 2014-12-15 2020-09-23 Vivasure Medical Limited Implantable sealable member with mesh layer
USD843573S1 (en) 2015-11-13 2019-03-19 Access Closure, Inc. Vascular closure apparatus
USD847988S1 (en) 2015-11-13 2019-05-07 Access Closure, Inc. Handle grip
USD865166S1 (en) 2015-11-13 2019-10-29 Access Closure, Inc. Sheath adapter
CN108697414B (en) 2015-12-15 2022-02-01 维瓦舒尔医疗设备有限公司 Arteriotomy closure device with slotted shoe to achieve advantageous pressure distribution
US10603446B2 (en) * 2017-04-03 2020-03-31 Becton, Dickinson And Company IV catheter with integral extension set and a spring powered needle safety

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5951589A (en) * 1997-02-11 1999-09-14 Biointerventional Corporation Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464468A (en) 1968-03-29 1984-08-07 Agence Nationale De Valorisation De La Recherche (Anvar) Immobilization of active protein by cross-linking to inactive protein
IL47468A (en) 1975-06-12 1979-05-31 Rehovot Res Prod Process for the cross-linking of proteins using water soluble cross-linking agents
CH625702A5 (en) 1977-01-18 1981-10-15 Delalande Sa
US4839345A (en) 1985-03-09 1989-06-13 Nippon Oil And Fats Co., Ltd. Hydrated adhesive gel and method for preparing the same
US5051406A (en) 1987-03-04 1991-09-24 Nippon Hypox Laboratories Incorporated Pharmaceutical composition using albumin as a carrier and process for producing the same
US5936035A (en) 1988-11-21 1999-08-10 Cohesion Technologies, Inc. Biocompatible adhesive compositions
US5087244A (en) * 1989-01-31 1992-02-11 C. R. Bard, Inc. Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen
DE8910856U1 (en) * 1989-09-12 1989-11-30 Schneider (Europe) Ag, Zuerich, Ch
US5318524A (en) 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
US5071417A (en) 1990-06-15 1991-12-10 Rare Earth Medical Lasers, Inc. Laser fusion of biological materials
US5391183A (en) 1990-09-21 1995-02-21 Datascope Investment Corp Device and method sealing puncture wounds
US5108421A (en) 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5419765A (en) 1990-12-27 1995-05-30 Novoste Corporation Wound treating device and method for treating wounds
US5129882A (en) 1990-12-27 1992-07-14 Novoste Corporation Wound clotting device and method of using same
CA2103727A1 (en) 1991-02-13 1992-08-14 Philip N. Sawyer Filler material for use in tissue welding
US5676689A (en) 1991-11-08 1997-10-14 Kensey Nash Corporation Hemostatic puncture closure system including vessel location device and method of use
US5282827A (en) 1991-11-08 1994-02-01 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
ES2153378T3 (en) 1992-02-28 2001-03-01 Univ Texas PHOTOPOLIMERIZABLE BIODEGRADABLE HYDROGELS AS FABRIC CONTACT MATERIALS AND CONTROLLED DISCHARGE CARRIER.
US5403278A (en) 1992-04-15 1995-04-04 Datascope Investment Corp. Device and method for treating hematomas and false aneurysms
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5269755A (en) * 1992-09-11 1993-12-14 Sherwood Medical Company Catheter with outer membrane medicament delivery system
US5520885A (en) 1993-01-19 1996-05-28 Thermogenesis Corporation Fibrinogen processing apparatus, method and container
US5279565A (en) * 1993-02-03 1994-01-18 Localmed, Inc. Intravascular treatment apparatus and method
US5800373A (en) 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
WO1994021320A1 (en) * 1993-03-15 1994-09-29 Advanced Cardiovascular Systems, Inc. Fluid delivery catheter
US5383896A (en) 1993-05-25 1995-01-24 Gershony; Gary Vascular sealing device
US5951583A (en) 1993-05-25 1999-09-14 Vascular Solutions, Inc. Thrombin and collagen procoagulant and process for making the same
US5626601A (en) 1995-10-27 1997-05-06 Gary Gershony Vascular sealing apparatus and method
US5759194A (en) 1993-09-28 1998-06-02 Hemodynamics, Inc. Vascular patch applicator
US5843124A (en) 1993-09-28 1998-12-01 Hemodynamics, Inc. Surface opening adhesive sealer
US5383899A (en) 1993-09-28 1995-01-24 Hammerslag; Julius G. Method of using a surface opening adhesive sealer
US5653730A (en) 1993-09-28 1997-08-05 Hemodynamics, Inc. Surface opening adhesive sealer
US5462529A (en) * 1993-09-29 1995-10-31 Technology Development Center Adjustable treatment chamber catheter
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
EP0705298B1 (en) 1993-12-01 2002-03-27 Bioartificial Gel Technologies Inc. Albumin based hydrogel
US5583114A (en) 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
AU700903B2 (en) 1994-10-12 1999-01-14 Focal, Inc. Targeted delivery via biodegradable polymers
FR2726571B1 (en) 1994-11-03 1997-08-08 Izoret Georges BIOLOGICAL GLUE, PREPARATION METHOD AND APPLICATION DEVICE FOR BIOLOGICAL GLUE, AND HARDENERS FOR BIOLOGICAL GLUE
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
ATE330644T1 (en) 1995-12-18 2006-07-15 Angiotech Biomaterials Corp CROSS-LINKED POLYMER MATERIALS AND METHODS FOR USE THEREOF
CN1213316A (en) 1996-03-11 1999-04-07 富克尔公司 Polymeric delivery of radionuclides and radiopharmaceuticals
US6022336A (en) * 1996-05-20 2000-02-08 Percusurge, Inc. Catheter system for emboli containment
US5791352A (en) 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
US20020064546A1 (en) 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US5782860A (en) * 1997-02-11 1998-07-21 Biointerventional Corporation Closure device for percutaneous occlusion of puncture sites and tracts in the human body and method
US6217549B1 (en) * 1997-02-28 2001-04-17 Lumend, Inc. Methods and apparatus for treating vascular occlusions
US6371975B2 (en) * 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
US5990237A (en) 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
ZA987019B (en) 1997-08-06 1999-06-04 Focal Inc Hemostatic tissue sealants
US6217527B1 (en) * 1998-09-30 2001-04-17 Lumend, Inc. Methods and apparatus for crossing vascular occlusions
US6231546B1 (en) * 1998-01-13 2001-05-15 Lumend, Inc. Methods and apparatus for crossing total occlusions in blood vessels
US6398798B2 (en) * 1998-02-28 2002-06-04 Lumend, Inc. Catheter system for treating a vascular occlusion
EP1061954B1 (en) 1998-03-12 2004-06-09 Nektar Therapeutics Al, Corporation Poly(ethylene glycol) derivatives with proximal reactive groups
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
DE69943297D1 (en) 1998-08-14 2011-05-05 Incept Llc APPARATUS FOR IN-SITU-EDUCATION OF HYDROGELS
US6179862B1 (en) 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6022361A (en) 1998-10-09 2000-02-08 Biointerventional Corporation Device for introducing and polymerizing polymeric biomaterials in the human body and method
EP1137373A4 (en) 1998-12-04 2004-05-19 Chandrashekhar P Pathak Biocompatible crosslinked polymers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5951589A (en) * 1997-02-11 1999-09-14 Biointerventional Corporation Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels

Also Published As

Publication number Publication date
WO2002064187A2 (en) 2002-08-22
US6949114B2 (en) 2005-09-27
US20010047187A1 (en) 2001-11-29
AU2002236986A1 (en) 2002-08-28

Similar Documents

Publication Publication Date Title
WO2002064187A3 (en) Systems, methods, and compositions for achieving closure of vascular puncture sites
WO2002064186A3 (en) Systems, methods, and compositions for achieving closure of vascular puncture sites
WO2006074044A3 (en) Method and apparatus for percutaneous wound sealing
WO2002024114A3 (en) Resorbable anastomosis stents and plugs
WO2004052336A3 (en) High viscosity liquid controlled delivery system and medical or surgical device
WO2002087416A3 (en) Method and apparatus for delivering materials to the body
WO2005016257A3 (en) Process of making flowable hemostatic compositions and devices containing such compositions
DK1162916T3 (en) Method and device for mixing and applying components having different viscosities, such as tissue adhesives
MX2009003737A (en) Injectable depot composition and it's process of preparation.
WO2003051442A3 (en) Catheter for endoluminal delivery of therapeutic agents that minimizes loss of therapeutic
WO2006055216A3 (en) Vulnerable plaque treatment
WO2005002510A3 (en) Deployable multifunctional hemostatic agent
WO2002056937A3 (en) Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites
WO2001049327A3 (en) Bioactive and osteoprorotic bone cement
EP0911039A3 (en) Drug-resin complexes stabilized by chelating agents
WO2000040203A3 (en) Polymeric delivery agents and delivery agent compounds
WO2001081581A3 (en) Compositions and methods for the therapy and diagnosis of acne vulgaris
WO1998000172A3 (en) Compositions and methods for altering the biodistribution of biological agents
WO2001068138A3 (en) Intradermal-penetration agents for topical local anesthetic administration
WO1998037872A3 (en) Transdermal drug delivery system for the administration of tamsulosin, and related compositions and methods of use
WO2005007115A3 (en) Pharmaceutical composition for inhibiting acid secretion
WO2000013531A3 (en) Composition comprising a viscosity modulating polymer material and its use
BRPI0511574A (en) composition, method of depositing a sugar polyester on a substrate, and use of a composition
WO1998008505A8 (en) Pharmaceutical compounds
WO2001013933A3 (en) Agents for the enhanced oxygen delivery in mammals

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP