WO2002066983A3 - Bioassay device for detecting molecular events - Google Patents

Bioassay device for detecting molecular events Download PDF

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Publication number
WO2002066983A3
WO2002066983A3 PCT/US2002/003143 US0203143W WO02066983A3 WO 2002066983 A3 WO2002066983 A3 WO 2002066983A3 US 0203143 W US0203143 W US 0203143W WO 02066983 A3 WO02066983 A3 WO 02066983A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
detector
transmission line
magic
detector includes
Prior art date
Application number
PCT/US2002/003143
Other languages
French (fr)
Other versions
WO2002066983A2 (en
Inventor
Hong Peng
Mark A Phodes
Kurt D Kramer
Christopher K Fuller
Original Assignee
Signature Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signature Bioscience Inc filed Critical Signature Bioscience Inc
Publication of WO2002066983A2 publication Critical patent/WO2002066983A2/en
Publication of WO2002066983A3 publication Critical patent/WO2002066983A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N22/00—Investigating or analysing materials by the use of microwaves or radio waves, i.e. electromagnetic waves with a wavelength of one millimetre or more
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

A bioassay device operable to detect the presence or absence of molecular events within a test sample is presented in four embodiments: a coplanar waveguide detector, a stripline detector, a magic-t detector, and a microstrip detector. The coplanar waveguide detector includes a center gap operable to contact the sample and to electromagnetically couple an incident test signal between the sample and transmission line. The stripline detector includes a sample chamber operable to contain at least a portion of the supplied sample and to electromagnetically couple an incident at least a portion of the supplied sample and to electromagnetically couple an incident test signal between the contained sample and the transmission line. The magic-t detector includes a magic-t coupler and first and second test sample loads electromagnetically coupled thereto. The microstrip detector includes a transmission line, ground plane metallization and a flow channel formed between, and vertically aligned with, the transmission line and ground plane.
PCT/US2002/003143 2001-02-01 2002-01-30 Bioassay device for detecting molecular events WO2002066983A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77571801A 2001-02-01 2001-02-01
US09/775,718 2001-02-01

Publications (2)

Publication Number Publication Date
WO2002066983A2 WO2002066983A2 (en) 2002-08-29
WO2002066983A3 true WO2002066983A3 (en) 2003-05-01

Family

ID=25105265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/003143 WO2002066983A2 (en) 2001-02-01 2002-01-30 Bioassay device for detecting molecular events

Country Status (1)

Country Link
WO (1) WO2002066983A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7951583B2 (en) 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US8675199B2 (en) 2006-03-10 2014-03-18 Plc Diagnostics, Inc. Waveguide-based detection system with scanning light source
US8747751B2 (en) 2008-06-16 2014-06-10 Plc Diagnostics, Inc. System and method for nucleic acids sequencing by phased synthesis

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4154388B2 (en) * 2004-12-27 2008-09-24 キヤノン株式会社 Detection device for detecting the state of electromagnetic waves transmitted through an object
WO2006107972A2 (en) * 2005-04-05 2006-10-12 Cornell Research Foundation, Inc. Permittivity based detection of immunobiological specific bindings in a capacitive cell of coplanar waveguide or microstrip layout using a microwave
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
WO2014048799A2 (en) * 2012-09-25 2014-04-03 Sony Corporation Sensor arrangement for non-invasive measurements of dielectric permittivity of liquids
US9949679B2 (en) * 2012-12-07 2018-04-24 Ascilion Ab Microfabricated sensor and a method of sensing the level of a component in bodily fluid
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402917A2 (en) * 1989-06-15 1990-12-19 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
EP0519250A2 (en) * 1991-06-10 1992-12-23 Miles Inc. Microparticle-labeled binding assay analyzed by microwave spectroscopy
WO1997039343A1 (en) * 1996-04-17 1997-10-23 British Nuclear Fuels Plc Biosensors
US5961832A (en) * 1994-10-22 1999-10-05 Central Research Laboratories Limited Method and apparatus for diffusive transfer between immiscible fluids
WO2000045160A1 (en) * 1999-02-01 2000-08-03 Signature Bioscience Inc. Method and apparatus for detecting molecular binding events
WO2001020329A2 (en) * 1999-08-02 2001-03-22 Signature Bioscience, Inc. Test systems and sensors for detecting molecular binding events
WO2001027610A2 (en) * 1999-10-13 2001-04-19 Signature Bioscience, Inc. System and method for detecting and identifying molecular events in a test sample

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402917A2 (en) * 1989-06-15 1990-12-19 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
EP0519250A2 (en) * 1991-06-10 1992-12-23 Miles Inc. Microparticle-labeled binding assay analyzed by microwave spectroscopy
US5961832A (en) * 1994-10-22 1999-10-05 Central Research Laboratories Limited Method and apparatus for diffusive transfer between immiscible fluids
WO1997039343A1 (en) * 1996-04-17 1997-10-23 British Nuclear Fuels Plc Biosensors
WO2000045160A1 (en) * 1999-02-01 2000-08-03 Signature Bioscience Inc. Method and apparatus for detecting molecular binding events
WO2001020329A2 (en) * 1999-08-02 2001-03-22 Signature Bioscience, Inc. Test systems and sensors for detecting molecular binding events
WO2001027610A2 (en) * 1999-10-13 2001-04-19 Signature Bioscience, Inc. System and method for detecting and identifying molecular events in a test sample

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7951583B2 (en) 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US8187866B2 (en) 2006-03-10 2012-05-29 Plc Diagnostics, Inc. Optical scanning system
US8675199B2 (en) 2006-03-10 2014-03-18 Plc Diagnostics, Inc. Waveguide-based detection system with scanning light source
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US8747751B2 (en) 2008-06-16 2014-06-10 Plc Diagnostics, Inc. System and method for nucleic acids sequencing by phased synthesis

Also Published As

Publication number Publication date
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