WO2002068600A3 - Endogenous and non-endogenous versions of human g protein-coupled receptors - Google Patents

Endogenous and non-endogenous versions of human g protein-coupled receptors Download PDF

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Publication number
WO2002068600A3
WO2002068600A3 PCT/US2002/005625 US0205625W WO02068600A3 WO 2002068600 A3 WO2002068600 A3 WO 2002068600A3 US 0205625 W US0205625 W US 0205625W WO 02068600 A3 WO02068600 A3 WO 02068600A3
Authority
WO
WIPO (PCT)
Prior art keywords
endogenous
human
protein
versions
coupled receptors
Prior art date
Application number
PCT/US2002/005625
Other languages
French (fr)
Other versions
WO2002068600A2 (en
Inventor
Chen W Liaw
Derek T Chalmers
Dominic P Behan
Dominique Maciejewski-Lenior
James N Leonard
I-Lin Lin
Daniel Ortuno
Original Assignee
Arena Pharm Inc
Chen W Liaw
Derek T Chalmers
Dominic P Behan
Dominique Maciejewski-Lenior
James N Leonard
I-Lin Lin
Daniel Ortuno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc, Chen W Liaw, Derek T Chalmers, Dominic P Behan, Dominique Maciejewski-Lenior, James N Leonard, I-Lin Lin, Daniel Ortuno filed Critical Arena Pharm Inc
Priority to JP2002568696A priority Critical patent/JP2004526441A/en
Priority to EP02717500A priority patent/EP1412372A4/en
Priority to CA002439383A priority patent/CA2439383A1/en
Publication of WO2002068600A2 publication Critical patent/WO2002068600A2/en
Publication of WO2002068600A3 publication Critical patent/WO2002068600A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Abstract

The invention disclosed in this patent docuemnt relates to transmembrane receptors, more particularly to a human G protein-coupled receptor and to mutated (non-endogenous) versions of the human GPCRs for evidence activity.
PCT/US2002/005625 2001-02-26 2002-02-26 Endogenous and non-endogenous versions of human g protein-coupled receptors WO2002068600A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2002568696A JP2004526441A (en) 2001-02-26 2002-02-26 Endogenous and non-endogenous human G protein-coupled receptors
EP02717500A EP1412372A4 (en) 2001-02-26 2002-02-26 Endogenous and non-endogenous versions of human g protein-coupled receptors
CA002439383A CA2439383A1 (en) 2001-02-26 2002-02-26 Endogenous and non-endogenous versions of human g protein-coupled receptors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27191301P 2001-02-26 2001-02-26
US60/271,913 2001-02-26

Publications (2)

Publication Number Publication Date
WO2002068600A2 WO2002068600A2 (en) 2002-09-06
WO2002068600A3 true WO2002068600A3 (en) 2004-02-26

Family

ID=23037612

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/005625 WO2002068600A2 (en) 2001-02-26 2002-02-26 Endogenous and non-endogenous versions of human g protein-coupled receptors

Country Status (5)

Country Link
EP (1) EP1412372A4 (en)
JP (1) JP2004526441A (en)
CN (1) CN1516706A (en)
CA (1) CA2439383A1 (en)
WO (1) WO2002068600A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9212228B2 (en) 2005-11-24 2015-12-15 Ganymed Pharmaceuticals Ag Monoclonal antibodies against claudin-18 for treatment of cancer
US9512232B2 (en) 2012-05-09 2016-12-06 Ganymed Pharmaceuticals Ag Antibodies against Claudin 18.2 useful in cancer diagnosis

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115375B2 (en) 2000-11-14 2006-10-03 Bristol-Myers Squibb Methods of diagnosing renal tumors by determining the expression level of RNA encoding the HGPRBMY18 polypeptide
WO2004013638A1 (en) * 2002-07-31 2004-02-12 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human g-protein coupled receptor 45 (gpr45)
AU2003250128A1 (en) * 2002-08-01 2004-02-23 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 37 (gpr37)
DE10254601A1 (en) * 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Gene products differentially expressed in tumors and their use
AU2004220864B2 (en) * 2003-03-17 2011-05-26 Arena Pharmaceuticals Inc. Modulators of G Protein-Coupled Formyl peptide receptor-like 2 and their therapeutic use against cell death-related disorders
US7517661B2 (en) 2003-04-23 2009-04-14 Takeda Pharmaceutical Company Limited Methods of screening for ligands for FPRL2
JP4533655B2 (en) * 2003-04-23 2010-09-01 武田薬品工業株式会社 New screening method
WO2005059546A2 (en) * 2003-12-12 2005-06-30 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 35 (gpr35)
DE102004024617A1 (en) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentially expressed in tumors gene products and their use
WO2006005588A1 (en) * 2004-07-12 2006-01-19 Geneprot, Inc. Polypeptide species useful for the treatment of neurological disorders
JP4772684B2 (en) * 2004-08-30 2011-09-14 武田薬品工業株式会社 Screening method
ATE544854T1 (en) * 2007-03-22 2012-02-15 Heptares Therapeutics Ltd MUTANT G-PROTEIN-COUPLED RECEPTORS AND SELECTION METHODS THEREOF
GB0724051D0 (en) 2007-12-08 2008-01-16 Medical Res Council Mutant proteins and methods for producing them
GB0724860D0 (en) 2007-12-20 2008-01-30 Heptares Therapeutics Ltd Screening
GB0802474D0 (en) 2008-02-11 2008-03-19 Heptares Therapeutics Ltd Mutant proteins and methods for selecting them
GB0910725D0 (en) 2009-06-22 2009-08-05 Heptares Therapeutics Ltd Mutant proteins and methods for producing them
KR20240033145A (en) 2012-11-13 2024-03-12 비온테크 에스이 Agents for treatment of claudin expressing cancer diseases
GB201601690D0 (en) 2016-01-29 2016-03-16 Heptares Therapeutics Ltd G proteins

Citations (1)

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Publication number Priority date Publication date Assignee Title
US6159705A (en) * 1996-09-24 2000-12-12 Cadus Pharmaceutical Corporation Recombinant yeast cells for identifying receptor effectors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555339B1 (en) * 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159705A (en) * 1996-09-24 2000-12-12 Cadus Pharmaceutical Corporation Recombinant yeast cells for identifying receptor effectors

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] 4 January 1999 (1999-01-04), LAMERDIN J.E. ET AL.: "Homo sapiens chromosome 18, cosmid F23276, complete sequence", XP002971904, Database accession no. (AC06272) *
DATABASE GENBANK [online] 7 November 1998 (1998-11-07), LAMERDIN J.E. ET AL.: "Homo sapiens chromosome 19, cosmid R2872, complete sequence", XP002971903, Database accession no. (AC005946) *
DATABASE GENBANK [online] 8 November 1994 (1994-11-08), DURSTIN M. ET AL.: "Human N-formyl receptor-like protein (FPRL2) gene, complete cds", XP002971902, Database accession no. (HUMFRPL2) *
DATABASE PIR 73 [online] 30 September 1993 (1993-09-30), BAO L. ET AL.: "FMLP-related receptor 2-human", XP002971905, Database accession no. (C42009) *
DATABASE SWISSPROT [online] 1 May 1992 (1992-05-01), BAO L. ET AL.: "FML2-Human", XP002971901, Database accession no. (P25089) *
See also references of EP1412372A4 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9212228B2 (en) 2005-11-24 2015-12-15 Ganymed Pharmaceuticals Ag Monoclonal antibodies against claudin-18 for treatment of cancer
US9499609B2 (en) 2005-11-24 2016-11-22 Ganymed Pharmaceuticals Ag Monoclonal antibodies against claudin-18 for treatment of cancer
US9512232B2 (en) 2012-05-09 2016-12-06 Ganymed Pharmaceuticals Ag Antibodies against Claudin 18.2 useful in cancer diagnosis

Also Published As

Publication number Publication date
JP2004526441A (en) 2004-09-02
CN1516706A (en) 2004-07-28
EP1412372A4 (en) 2005-08-24
EP1412372A2 (en) 2004-04-28
CA2439383A1 (en) 2002-09-06
WO2002068600A2 (en) 2002-09-06

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