WO2002070039A2 - Intravascular device for treatment of hypertension - Google Patents

Intravascular device for treatment of hypertension Download PDF

Info

Publication number
WO2002070039A2
WO2002070039A2 PCT/US2002/006929 US0206929W WO02070039A2 WO 2002070039 A2 WO2002070039 A2 WO 2002070039A2 US 0206929 W US0206929 W US 0206929W WO 02070039 A2 WO02070039 A2 WO 02070039A2
Authority
WO
WIPO (PCT)
Prior art keywords
pump
blood pressure
artery
blood flow
renal artery
Prior art date
Application number
PCT/US2002/006929
Other languages
French (fr)
Other versions
WO2002070039A8 (en
WO2002070039A3 (en
Inventor
Richard Y. Lin
Gholam Reza Zadno-Azizi
Erica Rogers
Original Assignee
Three Arch Partners
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Three Arch Partners filed Critical Three Arch Partners
Priority to AU2002250250A priority Critical patent/AU2002250250A1/en
Publication of WO2002070039A2 publication Critical patent/WO2002070039A2/en
Publication of WO2002070039A3 publication Critical patent/WO2002070039A3/en
Publication of WO2002070039A8 publication Critical patent/WO2002070039A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/403—Details relating to driving for non-positive displacement blood pumps
    • A61M60/408—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
    • A61M60/411—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
    • A61M60/414—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted by a rotating cable, e.g. for blood pumps mounted on a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/135—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/135—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting
    • A61M60/139—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting inside the aorta, e.g. intra-aortic balloon pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/31—Medical purposes thereof other than the enhancement of the cardiac output for enhancement of in vivo organ perfusion, e.g. retroperfusion
    • A61M60/33—Medical purposes thereof other than the enhancement of the cardiac output for enhancement of in vivo organ perfusion, e.g. retroperfusion of kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/585—User interfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/833—Occluders for preventing backflow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/861—Connections or anchorings for connecting or anchoring pumps or pumping devices to parts of the patient's body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3507—Communication with implanted devices, e.g. external control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1078—Urinary tract
    • A61M2210/1082—Kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices

Definitions

  • the invention relates to devices used in the treatment of essential hypertension. More particularly, the invention relates to an intrarenal pump that produces a decrease in blood pressure via hormonal modulation.
  • Hypertension is a primary or contributing cause in more than 10% of deaths in the United States. Hypertension is a disease often overlooked and inefficiently managed. According to the American Heart Association, about 44% of men and women age 55-64 have hypertension. Sixty percent of men and women age 65-74 are hypertensive, and after age 75, 64% of men and 77% of women have hypertension. Men are at increased risk for development of hypertension prior to age 55. After age 55, women have a slightly increased risk, and after age 75, women are at a much greater risk of developing hypertension. Hypertension is generally defined as a systolic blood pressure of greater than 140 mm Hg, or a diastolic blood pressure of 90 mm Hg or more.
  • Systolic blood pressure is the transmural pressure within arteries during the contraction of the left ventricle.
  • Diastolic pressure is pressure within arteries during relaxation of the left ventricle. Elevated diastolic blood pressure reflects high continuous, static pressure on arterial walls, while an elevated systolic blood pressure intermittently stresses the arterial walls with increased pressure during each heart beat.
  • Essential, or primary, hypertension accounts for approximately 90% of cases of hypertension, and the cause is unknown.
  • Hypertension is often called a "silent killer.” Symptoms of elevated blood pressure are rare unless the pressure is extremely high. Target organ damage can be the first manifestation of hypertension and occurs primarily in the heart, brain, eyes, and kidney.
  • Organs can be damaged by labile and chronic hypertension, or by acute episodes of severe hypertension.
  • Hypertension is a major risk factor for the development of arteriosclerosis.
  • vascular damage develops as a result of chronically elevated blood pressure.
  • high blood pressure can contribute to the buildup of arteriosclerotic plaque within vessel walls. This plaque accumulation can hinder a vessel's ability to react to hormonal and neurogenic stimuli.
  • elevated blood pressure can cause rupture of thin-walled vessels.
  • the exposure of inflammatory material within the vessel walls to procoagulant factors in the blood leads to thrombus (clot) formation.
  • thrombus clot
  • This unstable environment provides a physiologic basis for angina (chest pain caused by inadequate oxygen delivery to the heart), myocardial infarction (heart attack), peripheral vascular disease, ischemic neuropathy, transient ischemic attacks (TIAs), and stroke.
  • Age is the strongest identifiable factor related to elevated blood pressure.
  • Epithelial tissue declines in elasticity as people age. Blood vessels become less flexible, and their response to numerous regulatory substances is reduced. This suggests a decline in the effectiveness of endogenous mechanisms of blood pressure control with age.
  • Blood pressure is normally regulated by compensatory mechanisms that respond to changes in cardiac demand. Blood pressure is mathematically equivalent to the product of cardiac output and total peripheral resistance in the vasculature. Cardiac output, in turn, is the product of cardiac stroke volume and heart rate. An increase in cardiac output (i.e., the volume of blood expelled from the heart each minute) results in a compensatory decrease in total peripheral resistance, caused by dilation of arterioles (vasodilation). Conversely, a decreased cardiac output normally leads to a compensatory increase in total peripheral resistance through vasoconstriction. In normal circumstances, this compensation occurs to maintain a normal blood pressure.
  • the sympathetic nervous system can act on the heart and blood vessels by direct nerve transmission and through the release of catecholamine hormones, including epinephrine and norepinephrine.
  • catecholamines stimulate alpha and beta adrenergic receptors throughout the body.
  • the most prevalent receptors are alpha- 1 receptors, located in blood vessels.
  • Beta-1 receptors are similar to alpha- 1 receptors, except that beta-1 receptors are located primarily in the heart. Medications that block these adrenergic receptor sites decrease blood pressure.
  • Alpha- 1 receptor blockade causes blood vessels to dilate.
  • Beta-1 receptor blockade causes myocardial contractility and heart rate to decrease, thereby decreasing cardiac output.
  • Alpha-2 receptors located in the brain stem can be stimulated to reduce catecholamine release as part of a negative feedback mechanism. Medications that bind to these receptors can cause a decrease in the amount of catecholamines released, thereby lowering blood pressure.
  • renin-angiotensin-aldosterone a complex compensatory blood pressure system located principally in the kidney. Whenever blood pressure, blood volume, or arterial sodium concentration decreases, renin is released by the kidney to ensure adequate renal perfusion.
  • the renin-angiotensin system is triggered when the granular cells of the juxtaglomerular apparatus release renin in response to various stimuli, including norepinephrine release from sympathetic innervation of the kidney, reduced stretch of juxtaglomerular cells, and reduced flow of sodium to the macula densa cells of the juxtaglomerular apparatus, located in the distal tubule of the nephron.
  • Renin is an enzyme that acts on angiotensinogen, also known as renin substrate, to produce angiotensin I.
  • Angiotensin I is then converted to angiotensin ⁇ through the action of angiotensin converting enzyme (ACE).
  • ACE angiotensin converting enzyme
  • Angiotensin ⁇ is a potent vasoconstrictor that quickly increases total vascular resistance (total peripheral resistance) as a way of keeping vital organs adequately perfused.
  • Angiotensin II also stimulates the production of the hormone aldosterone from the adrenal cortex.
  • Aldosterone in turn, causes renal retention of sodium chloride at the level of the distal convoluted tubule and, to a lesser extent, the collecting duct, helping to maintain fluid balance and blood pressure homeostasis. Aldosterone also produces renal loss of hydrogen and potassium ions. In the presence of aldosterone, up to 99.5% of all ingested sodium is retained through renal tubular reabsorption. In the absence of aldosterone, a continued obligatory loss of approximately 20 mg of sodium per day occurs until blood pressure falls, and symptoms, such as fainting (syncope), may result.
  • ACE inhibitors angiotensin converting enzyme inhibitors
  • ARBs angiotensin II receptor blockers
  • Some aspects of the invention include an apparatus for reducing blood pressure, comprising an intravascular pump configured to be placed within an artery.
  • the pump is configured to increase antegrade blood flow in a renal artery, thereby producing a reduction in blood pressure.
  • the intravascular pump is placed in a renal artery.
  • it can be placed in the aorta.
  • the intravascular pump further comprises a control mechanism in communication with the pump, whereby a user can adjust the mechanism producing a change in the antegrade blood flow through the pump.
  • the intravascular pump further comprises a radiofrequency transmitter, wherein the user can adjust the mechanism remotely via the radiofrequency transmitter, thereby producing a change in the antegrade blood flow through the pump.
  • the intravascular pump further comprises an inductive coupling controller, wherein the user can adjust the mechanism remotely via the inductive coupling controller, thereby producing a change in the antegrade blood flow through the pump.
  • Some aspects of the invention include a method for reducing blood pressure, comprising placing an intravascular pump in an artery.
  • the pump is configured to increase antegrade blood flow in a renal artery, thereby producing a reduction in blood pressure.
  • the intravascular pump is placed in a renal artery. In other embodiments, it can be placed in the aorta.
  • the method further comprises adjusting a control mechanism that is in communication with the pump, whereby said adjusting causes a change in the antegrade blood flow through the pump.
  • the method further comprises using a radiofrequency transmitter to adjust the mechanism remotely, thereby producing a change in the antegrade blood flow through the pump.
  • the method further comprises using an inductive coupling controller to adjust the mechanism remotely, thereby producing a change in the antegrade blood flow through the pump.
  • Figure 1 is a schematic frontal view of an intravascular pump placed within the renal artery.
  • Figure 2 is a schematic frontal view of an intravascular pump with a balloon fixation member placed within the renal artery.
  • an intravascular pump 2 is shown, which may, for example, be placed within the renal artery or aorta or other suitable artery via percutaneous catheter 6 or via an open surgical procedure.
  • a percutaneous catheter 6 may be placed via the femoral artery into the common iliac area artery 8, then fed up the aorta 10 and into a renal artery 4.
  • the pump 2 may then be situated within the renal artery 4 by any suitable fixation method.
  • suitable fixation method include inflation of a balloon 14, as shown in Figure 2, as well as other fixation methods known to those skilled in the art.
  • the pump 2 causes an increase in forward (downstream or antegrade) flow through the renal artery 4 and into the kidney 12.
  • This increased flow is perceived at the level of the macula densa of the kidney 12 as increased volume and sodium delivery to the macula densa and the juxtaglomerular apparatus.
  • This increased delivery of sodium to the macula densa results in suppression of renin production and release from the granular cells of the juxtaglomerular apparatus, with consequent reduction in angiotensin II and aldosterone levels.
  • This decreased aldosterone and angiotensin TJ production leads to a reduction in blood pressure.
  • the intravascular pump 2 may be surgically placed directly or indirectly into the renal artery 4, the aorta 10, or other suitable artery, with or without the need for placement via a percutaneous catheter 6.
  • FIG. 2 illustrates another embodiment. Again shown is the catheter 6 ascending from the aorta 10 into the renal artery 4.
  • a balloon 14 or other appropriate expander may be located around the periphery of, or adjacent to, the pump 2.
  • the balloon 14 can be inflated, or the expander otherwise expanded, to cause the pump 2 to be situated securely within the renal artery 4. This allows for minimal lateral and axial movement of the pump 2 within the renal artery 4.
  • the pump 2 may be any suitable fluid pump known to those of skill in the art to produce an increase in blood flow in the renal artery 4 above the physiologic rate of flow.
  • This pump 2 may have an internal rotary propeller, diagonal fan or propeller, or other suitable mechanism.
  • the pump 2 may be powered at the proximal end of the catheter, and even outside the patient.
  • a drive shaft for the pump 2 may be located within the body of the catheter 6, to which the pump 2 is attached. Alternatively, the power source may be self-contained within the pump 2 itself, or its housing, or adjacent thereto
  • the pump 2 may operate continuously or in some embodiments, intermittently, as befits the need of the patient in optimally lowering blood pressure.
  • the pump 2 may, in certain embodiments, be programmable to operate at various intervals and/or speeds.
  • the programming of the pump 2 may be accomplished before and/or after implantation in the patient.
  • the programming may be accomplished by an external electromagnetic coupling device (not shown) such as a hand-held radiofrequency transmitter that may be held by a physician over the patient's body during the programming of pump variables, such as on-off intervals and pump speed.
  • a microelectrode, radiofrequency catheter, or other energy releasing device is placed within the renal artery 4 and into the substance of the kidney 12, with the tip of the microelectrode or other device in close proximity to the macula densa and juxtaglomerular apparatus.
  • This device then stimulates the macula densa and juxtaglomerular apparatus with an electrical current or other type of energy transmission, such as radiofrequency transmission.
  • This energy stimulation causes a suppression of renin release from the juxtaglomerular apparatus, leading to decreased sodium chloride and water retention by the kidney, and a consequent reduction in blood pressure.
  • This microelectrode or micro-RF transmitter may be powered outside the patient, with an electrical wire running through a catheter body and supplying electrical power to the microelectrode, or other suitable actuator or transducer at the distal end of the catheter 6.
  • An appropriate power source such as a battery, may also be located outside of the patient's body.
  • the microelectrode or micro-RF transmitter may be powered by a battery, which may be located, for example, within the microelectrode or micro-RF transmitter device.
  • an appropriate power source such as a battery; may also be located outside of the patient's body and power may be delivered to the device through inductive coupling, in any of various ways well known to those skilled in the art.

Abstract

Some aspects include a mechanical pump (3) which is placed in the renal artery (4) by means of a percutaneous catheter (6), surgical implantation, or other appropriate means. This pump increases blood flow through the renal artery to the kidney (12). This increased bloodflow is perceived at the level of the macula densa as increased sodium delivery to the macula densa and the juxtaglomerular apparatus, resulting in suppression of renin production from the juxtaglomerular apparatus, with consequent reduction in angiotensin II production and aldosterone levels. This decreased aldosterone and decreased angiotensin II production lead to a reduction in blood pressure.

Description

INTRAVASCULARDEVICE FOR TREATMENT OF HYPERTENSION
Background of the Invention The invention relates to devices used in the treatment of essential hypertension. More particularly, the invention relates to an intrarenal pump that produces a decrease in blood pressure via hormonal modulation.
High blood pressure, or hypertension, is a primary or contributing cause in more than 10% of deaths in the United States. Hypertension is a disease often overlooked and inefficiently managed. According to the American Heart Association, about 44% of men and women age 55-64 have hypertension. Sixty percent of men and women age 65-74 are hypertensive, and after age 75, 64% of men and 77% of women have hypertension. Men are at increased risk for development of hypertension prior to age 55. After age 55, women have a slightly increased risk, and after age 75, women are at a much greater risk of developing hypertension. Hypertension is generally defined as a systolic blood pressure of greater than 140 mm Hg, or a diastolic blood pressure of 90 mm Hg or more. Systolic blood pressure is the transmural pressure within arteries during the contraction of the left ventricle. Diastolic pressure is pressure within arteries during relaxation of the left ventricle. Elevated diastolic blood pressure reflects high continuous, static pressure on arterial walls, while an elevated systolic blood pressure intermittently stresses the arterial walls with increased pressure during each heart beat. Essential, or primary, hypertension accounts for approximately 90% of cases of hypertension, and the cause is unknown.
Hypertension is often called a "silent killer." Symptoms of elevated blood pressure are rare unless the pressure is extremely high. Target organ damage can be the first manifestation of hypertension and occurs primarily in the heart, brain, eyes, and kidney.
Organs can be damaged by labile and chronic hypertension, or by acute episodes of severe hypertension.
Hypertension is a major risk factor for the development of arteriosclerosis.
Vascular damage develops as a result of chronically elevated blood pressure. In early stages of arteriosclerosis, high blood pressure can contribute to the buildup of arteriosclerotic plaque within vessel walls. This plaque accumulation can hinder a vessel's ability to react to hormonal and neurogenic stimuli. Furthermore, elevated blood pressure can cause rupture of thin-walled vessels. The exposure of inflammatory material within the vessel walls to procoagulant factors in the blood leads to thrombus (clot) formation. This unstable environment provides a physiologic basis for angina (chest pain caused by inadequate oxygen delivery to the heart), myocardial infarction (heart attack), peripheral vascular disease, ischemic neuropathy, transient ischemic attacks (TIAs), and stroke.
Epidemiological and experimental data link increased sodium intake to development of hypertension in some patients. The presence of high intracellular sodium results in increased vascular tone. Restricting sodium intake can sometimes result in the lowering of blood pressure by decreasing vascular tone. Age is the strongest identifiable factor related to elevated blood pressure. Epithelial tissue declines in elasticity as people age. Blood vessels become less flexible, and their response to numerous regulatory substances is reduced. This suggests a decline in the effectiveness of endogenous mechanisms of blood pressure control with age.
Blood pressure is normally regulated by compensatory mechanisms that respond to changes in cardiac demand. Blood pressure is mathematically equivalent to the product of cardiac output and total peripheral resistance in the vasculature. Cardiac output, in turn, is the product of cardiac stroke volume and heart rate. An increase in cardiac output (i.e., the volume of blood expelled from the heart each minute) results in a compensatory decrease in total peripheral resistance, caused by dilation of arterioles (vasodilation). Conversely, a decreased cardiac output normally leads to a compensatory increase in total peripheral resistance through vasoconstriction. In normal circumstances, this compensation occurs to maintain a normal blood pressure.
A complex interplay exists in the body between mechanisms of blood pressure regulation. Baroreceptors and chemoreceptors located throughout the body react quickly, via the sympathetic and parasympathetic nervous systems, to produce changes in vascular tone and changes in the oxygenation of blood to maintain homeostasis. Hormonal and fluid balance systems in the body also maintain and control blood pressure. Such hormones include angiotensin π, vasopressin (antidiuretic hormone), bradykinin, endothelium-derived relaxing factor, epinephrine, norepinephrine, atrial natriuretic peptide, thyroid hormone, and the adrenal cortical hormones, such as aldosterone and cortisol.
Two systems closely involved with blood pressure control are the renin-angiotensin- aldosterone system and the sympathetic nervous system. The sympathetic nervous system can act on the heart and blood vessels by direct nerve transmission and through the release of catecholamine hormones, including epinephrine and norepinephrine. The catecholamines stimulate alpha and beta adrenergic receptors throughout the body. The most prevalent receptors are alpha- 1 receptors, located in blood vessels. Beta-1 receptors are similar to alpha- 1 receptors, except that beta-1 receptors are located primarily in the heart. Medications that block these adrenergic receptor sites decrease blood pressure. Alpha- 1 receptor blockade causes blood vessels to dilate. Beta-1 receptor blockade causes myocardial contractility and heart rate to decrease, thereby decreasing cardiac output. Alpha-2 receptors located in the brain stem can be stimulated to reduce catecholamine release as part of a negative feedback mechanism. Medications that bind to these receptors can cause a decrease in the amount of catecholamines released, thereby lowering blood pressure.
One of the major hormonal and fluid balance systems in the body that maintains blood pressure is the renin-angiotensin-aldosterone, a complex compensatory blood pressure system located principally in the kidney. Whenever blood pressure, blood volume, or arterial sodium concentration decreases, renin is released by the kidney to ensure adequate renal perfusion. The renin-angiotensin system is triggered when the granular cells of the juxtaglomerular apparatus release renin in response to various stimuli, including norepinephrine release from sympathetic innervation of the kidney, reduced stretch of juxtaglomerular cells, and reduced flow of sodium to the macula densa cells of the juxtaglomerular apparatus, located in the distal tubule of the nephron.
Renin is an enzyme that acts on angiotensinogen, also known as renin substrate, to produce angiotensin I. Angiotensin I is then converted to angiotensin π through the action of angiotensin converting enzyme (ACE). Angiotensin π is a potent vasoconstrictor that quickly increases total vascular resistance (total peripheral resistance) as a way of keeping vital organs adequately perfused. Angiotensin II also stimulates the production of the hormone aldosterone from the adrenal cortex.
Aldosterone, in turn, causes renal retention of sodium chloride at the level of the distal convoluted tubule and, to a lesser extent, the collecting duct, helping to maintain fluid balance and blood pressure homeostasis. Aldosterone also produces renal loss of hydrogen and potassium ions. In the presence of aldosterone, up to 99.5% of all ingested sodium is retained through renal tubular reabsorption. In the absence of aldosterone, a continued obligatory loss of approximately 20 mg of sodium per day occurs until blood pressure falls, and symptoms, such as fainting (syncope), may result.
It is well established that by reducing the activity of the renin-angiotensin system, blood pressure may be lowered. As a result of this knowledge, angiotensin converting enzyme inhibitors (ACE inhibitors) and angiotensin II receptor blockers (ARBs) have become important and beneficial drugs in the treatment of hypertension.
Summary of the Invention
Some aspects of the invention include an apparatus for reducing blood pressure, comprising an intravascular pump configured to be placed within an artery. The pump is configured to increase antegrade blood flow in a renal artery, thereby producing a reduction in blood pressure. In some embodiments, the intravascular pump is placed in a renal artery.
In other embodiments, it can be placed in the aorta.
In some embodiments, the intravascular pump further comprises a control mechanism in communication with the pump, whereby a user can adjust the mechanism producing a change in the antegrade blood flow through the pump.
In yet other embodiments, the intravascular pump further comprises a radiofrequency transmitter, wherein the user can adjust the mechanism remotely via the radiofrequency transmitter, thereby producing a change in the antegrade blood flow through the pump. In another embodiment, the intravascular pump further comprises an inductive coupling controller, wherein the user can adjust the mechanism remotely via the inductive coupling controller, thereby producing a change in the antegrade blood flow through the pump.
Some aspects of the invention include a method for reducing blood pressure, comprising placing an intravascular pump in an artery. The pump is configured to increase antegrade blood flow in a renal artery, thereby producing a reduction in blood pressure. In some embodiments, the intravascular pump is placed in a renal artery. In other embodiments, it can be placed in the aorta.
In some embodiments, the method further comprises adjusting a control mechanism that is in communication with the pump, whereby said adjusting causes a change in the antegrade blood flow through the pump. In some embodiments, the method further comprises using a radiofrequency transmitter to adjust the mechanism remotely, thereby producing a change in the antegrade blood flow through the pump.
In some embodiments, the method further comprises using an inductive coupling controller to adjust the mechanism remotely, thereby producing a change in the antegrade blood flow through the pump.
Brief Description of the Drawings Figure 1 is a schematic frontal view of an intravascular pump placed within the renal artery. Figure 2 is a schematic frontal view of an intravascular pump with a balloon fixation member placed within the renal artery.
Detailed Description of Preferred Embodiments
Referring to Figure 1 , an intravascular pump 2 is shown, which may, for example, be placed within the renal artery or aorta or other suitable artery via percutaneous catheter 6 or via an open surgical procedure. Such a percutaneous catheter 6 may be placed via the femoral artery into the common iliac area artery 8, then fed up the aorta 10 and into a renal artery 4. The pump 2 may then be situated within the renal artery 4 by any suitable fixation method. Such methods include inflation of a balloon 14, as shown in Figure 2, as well as other fixation methods known to those skilled in the art. The pump 2 causes an increase in forward (downstream or antegrade) flow through the renal artery 4 and into the kidney 12. This increased flow is perceived at the level of the macula densa of the kidney 12 as increased volume and sodium delivery to the macula densa and the juxtaglomerular apparatus. This increased delivery of sodium to the macula densa results in suppression of renin production and release from the granular cells of the juxtaglomerular apparatus, with consequent reduction in angiotensin II and aldosterone levels. This decreased aldosterone and angiotensin TJ production leads to a reduction in blood pressure.
Alternatively, the intravascular pump 2 may be surgically placed directly or indirectly into the renal artery 4, the aorta 10, or other suitable artery, with or without the need for placement via a percutaneous catheter 6.
Figure 2 illustrates another embodiment. Again shown is the catheter 6 ascending from the aorta 10 into the renal artery 4. A balloon 14 or other appropriate expander may be located around the periphery of, or adjacent to, the pump 2. The balloon 14 can be inflated, or the expander otherwise expanded, to cause the pump 2 to be situated securely within the renal artery 4. This allows for minimal lateral and axial movement of the pump 2 within the renal artery 4. The pump 2 may be any suitable fluid pump known to those of skill in the art to produce an increase in blood flow in the renal artery 4 above the physiologic rate of flow. This pump 2 may have an internal rotary propeller, diagonal fan or propeller, or other suitable mechanism. The pump 2 may be powered at the proximal end of the catheter, and even outside the patient. A drive shaft for the pump 2 may be located within the body of the catheter 6, to which the pump 2 is attached. Alternatively, the power source may be self-contained within the pump 2 itself, or its housing, or adjacent thereto.
The pump 2 may operate continuously or in some embodiments, intermittently, as befits the need of the patient in optimally lowering blood pressure. The pump 2 may, in certain embodiments, be programmable to operate at various intervals and/or speeds. The programming of the pump 2 may be accomplished before and/or after implantation in the patient. In certain embodiments, the programming may be accomplished by an external electromagnetic coupling device (not shown) such as a hand-held radiofrequency transmitter that may be held by a physician over the patient's body during the programming of pump variables, such as on-off intervals and pump speed. In another aspect (not shown), a microelectrode, radiofrequency catheter, or other energy releasing device is placed within the renal artery 4 and into the substance of the kidney 12, with the tip of the microelectrode or other device in close proximity to the macula densa and juxtaglomerular apparatus. This device then stimulates the macula densa and juxtaglomerular apparatus with an electrical current or other type of energy transmission, such as radiofrequency transmission. This energy stimulation causes a suppression of renin release from the juxtaglomerular apparatus, leading to decreased sodium chloride and water retention by the kidney, and a consequent reduction in blood pressure.
This microelectrode or micro-RF transmitter may be powered outside the patient, with an electrical wire running through a catheter body and supplying electrical power to the microelectrode, or other suitable actuator or transducer at the distal end of the catheter 6. An appropriate power source, such as a battery, may also be located outside of the patient's body. Alternatively, the microelectrode or micro-RF transmitter may be powered by a battery, which may be located, for example, within the microelectrode or micro-RF transmitter device. In other embodiments, an appropriate power source, such as a battery; may also be located outside of the patient's body and power may be delivered to the device through inductive coupling, in any of various ways well known to those skilled in the art.
While certain aspects and embodiments of the invention have been described, these have been presented by way of example only, and are not intended to limit the scope of the invention. Indeed, the novel methods and systems described herein may be embodied in a variety of other forms without departing from the spirit thereof. The accompanying claims and their equivalents are intended to cover such forms or modifications as would fall within the scope and spirit of the invention.

Claims

WHAT IS CLAIMED IS:
1. An apparatus for reducing blood pressure, comprising: an intravascular pump configured to be placed within an artery, the pump configured to increase antegrade blood flow in a renal artery, thereby producing a reduction in blood pressure.
2. The apparatus of Claim 1 , wherein the artery is a renal artery.
3. The apparatus of Claim 1 , wherein the artery is an aorta.
4. The apparatus of Claim 1, further comprising a control mechanism in communication with the pump, whereby a user can adjust the control mechanism producing a change in the antegrade blood flow through the pump.
5. The apparatus of Claim 4, further comprising a radiofrequency transmitter, wherein the user can adjust the control mechanism remotely via the radiofrequency transmitter, thereby producing a change in the antegrade blood flow through the pump.
6. The apparatus of Claim 4, further comprising a inductive coupling controller, wherein the user can adjust the mechanism remotely via the inductive coupling controller, thereby producing a change in the antegrade blood flow through the pump.
7. An method for reducing blood pressure, comprising: placing an intravascular pump in an artery, the pump configured to increase antegrade blood flow in a renal artery, thereby producing a reduction in blood pressure.
8. The method of Claim 7, further comprising adjusting a control mechanism that is in communication with the pump, whereby said adjusting causes a change in the antegrade blood flow through the pump.
9. The method of Claim 1, wherein the artery is a renal artery.
10. The method of Claim 7, wherein the artery is an aorta.
11. The method of Claim 8, further comprising using a radiofrequency transmitter to adjust the control mechanism remotely, thereby producing a change in the antegrade blood flow through the pump.
12. The method of Claim 8, further comprising using an inductive coupling controller to adjust the control mechanism remotely, thereby producing a change in the antegrade blood flow through the pump.
PCT/US2002/006929 2001-03-01 2002-03-01 Intravascular device for treatment of hypertension WO2002070039A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002250250A AU2002250250A1 (en) 2001-03-01 2002-03-01 Intravascular device for treatment of hypertension

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27263401P 2001-03-01 2001-03-01
US60/272,634 2001-03-01

Publications (3)

Publication Number Publication Date
WO2002070039A2 true WO2002070039A2 (en) 2002-09-12
WO2002070039A3 WO2002070039A3 (en) 2003-05-01
WO2002070039A8 WO2002070039A8 (en) 2003-10-30

Family

ID=23040634

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/006929 WO2002070039A2 (en) 2001-03-01 2002-03-01 Intravascular device for treatment of hypertension

Country Status (2)

Country Link
AU (1) AU2002250250A1 (en)
WO (1) WO2002070039A2 (en)

Cited By (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037348A1 (en) * 2003-10-15 2005-04-28 Orqis Medical Corporation Implantable heart assist system and method of applying same
US7485104B2 (en) 2000-10-30 2009-02-03 Cvrx, Inc. Systems and methods for controlling renovascular perfusion
US8118724B2 (en) 2003-09-18 2012-02-21 Thoratec Corporation Rotary blood pump
US8224437B2 (en) 2003-10-22 2012-07-17 Cvrx, Inc. Baroreflex activation for sedation and sleep
US8712531B2 (en) 2000-09-27 2014-04-29 Cvrx, Inc. Automatic baroreflex modulation responsive to adverse event
US8852163B2 (en) 2002-04-08 2014-10-07 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation via drugs and neuromodulatory agents and associated systems and methods
US8876815B2 (en) 2011-12-09 2014-11-04 Metavention, Inc. Energy delivery devices for hepatic neuromodulation
US9072527B2 (en) 2002-04-08 2015-07-07 Medtronic Ardian Luxembourg S.A.R.L. Apparatuses and methods for renal neuromodulation
US9131978B2 (en) 2002-04-08 2015-09-15 Medtronic Ardian Luxembourg S.A.R.L. Methods for bilateral renal neuromodulation
US20160022890A1 (en) * 2013-03-13 2016-01-28 Magenta Medical Ltd. Renal pump
CN105473089A (en) * 2013-06-05 2016-04-06 麦特文申公司 Modulation of targeted nerve fibers
US9512852B2 (en) 2006-03-31 2016-12-06 Thoratec Corporation Rotary blood pump
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US9675740B2 (en) 2012-05-14 2017-06-13 Tc1 Llc Impeller for catheter pump
US9675739B2 (en) 2015-01-22 2017-06-13 Tc1 Llc Motor assembly with heat exchanger for catheter pump
US9675738B2 (en) 2015-01-22 2017-06-13 Tc1 Llc Attachment mechanisms for motor of catheter pump
US9707035B2 (en) 2002-04-08 2017-07-18 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9717833B2 (en) 2004-09-17 2017-08-01 The Penn State Research Foundation Heart assist device with expandable impeller pump
US9743983B2 (en) 2002-04-08 2017-08-29 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of patients
US9757193B2 (en) 2002-04-08 2017-09-12 Medtronic Ardian Luxembourg S.A.R.L. Balloon catheter apparatus for renal neuromodulation
US9770543B2 (en) 2015-01-22 2017-09-26 Tc1 Llc Reduced rotational mass motor assembly for catheter pump
US9827356B2 (en) 2014-04-15 2017-11-28 Tc1 Llc Catheter pump with access ports
US9827040B2 (en) 2002-04-08 2017-11-28 Medtronic Adrian Luxembourg S.a.r.l. Methods and apparatus for intravascularly-induced neuromodulation
US9872947B2 (en) 2012-05-14 2018-01-23 Tc1 Llc Sheath system for catheter pump
US9907890B2 (en) 2015-04-16 2018-03-06 Tc1 Llc Catheter pump with positioning brace
US9962475B2 (en) 2011-01-06 2018-05-08 Tc1 Llc Percutaneous heart pump
US9968611B2 (en) 2002-04-08 2018-05-15 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for renal nerve blocking
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10029037B2 (en) 2014-04-15 2018-07-24 Tc1 Llc Sensors for catheter pumps
US10034708B2 (en) 2002-04-08 2018-07-31 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for thermally-induced renal neuromodulation
US10039596B2 (en) 2002-04-08 2018-08-07 Medtronic Ardian Luxembourg S.A.R.L. Apparatus for renal neuromodulation via an intra-to-extravascular approach
US10071192B2 (en) 2013-03-15 2018-09-11 Tc1 Llp Catheter pump assembly including a stator
US10080864B2 (en) 2012-10-19 2018-09-25 Medtronic Ardian Luxembourg S.A.R.L. Packaging for catheter treatment devices and associated devices, systems, and methods
US10086121B2 (en) 2012-07-03 2018-10-02 Tc1 Llc Catheter pump
US10105475B2 (en) 2014-04-15 2018-10-23 Tc1 Llc Catheter pump introducer systems and methods
US10117980B2 (en) 2012-05-14 2018-11-06 Tc1 Llc Distal bearing support
US10124195B2 (en) 2002-04-08 2018-11-13 Medtronic Ardian Luxembourg S.A.R.L. Methods for thermally-induced renal neuromodulation
US10130792B2 (en) 2002-04-08 2018-11-20 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation using neuromodulatory agents or drugs
US10179020B2 (en) 2010-10-25 2019-01-15 Medtronic Ardian Luxembourg S.A.R.L. Devices, systems and methods for evaluation and feedback of neuromodulation treatment
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10213580B2 (en) 2013-12-11 2019-02-26 Magenta Medical Ltd Curved catheter
US10215187B2 (en) 2004-09-17 2019-02-26 Tc1 Llc Expandable impeller pump
US10299918B2 (en) 2012-06-06 2019-05-28 Magenta Medical Ltd. Vena-caval device
US10363349B2 (en) 2014-04-15 2019-07-30 Tc1 Llp Heart pump providing adjustable outflow
US10449279B2 (en) 2014-08-18 2019-10-22 Tc1 Llc Guide features for percutaneous catheter pump
US10525178B2 (en) 2013-03-15 2020-01-07 Tc1 Llc Catheter pump assembly including a stator
US10524859B2 (en) 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
US10537385B2 (en) 2008-12-31 2020-01-21 Medtronic Ardian Luxembourg S.A.R.L. Intravascular, thermally-induced renal neuromodulation for treatment of polycystic ovary syndrome or infertility
US10537734B2 (en) 2004-10-05 2020-01-21 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for multi-vessel renal neuromodulation
US10576193B2 (en) 2012-07-03 2020-03-03 Tc1 Llc Motor assembly for catheter pump
US10583231B2 (en) 2013-03-13 2020-03-10 Magenta Medical Ltd. Blood pump
US10583232B2 (en) 2014-04-15 2020-03-10 Tc1 Llc Catheter pump with off-set motor position
US10632241B2 (en) 2013-03-13 2020-04-28 Tc1 Llc Fluid handling system
US10722631B2 (en) 2018-02-01 2020-07-28 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US10874455B2 (en) 2012-03-08 2020-12-29 Medtronic Ardian Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
US10881770B2 (en) 2018-01-10 2021-01-05 Magenta Medical Ltd. Impeller for blood pump
US10893927B2 (en) 2018-03-29 2021-01-19 Magenta Medical Ltd. Inferior vena cava blood-flow implant
US11033728B2 (en) 2013-03-13 2021-06-15 Tc1 Llc Fluid handling system
US11033727B2 (en) 2016-11-23 2021-06-15 Magenta Medical Ltd. Blood pumps
US11039915B2 (en) 2016-09-29 2021-06-22 Magenta Medical Ltd. Blood vessel tube
US11077294B2 (en) 2013-03-13 2021-08-03 Tc1 Llc Sheath assembly for catheter pump
US11147967B2 (en) 2017-10-18 2021-10-19 Boston Scientific Neuromodulation Corporation Modulation of aldosterone via adrenal gland stimulation
US11160970B2 (en) 2016-07-21 2021-11-02 Tc1 Llc Fluid seals for catheter pump motor assembly
US11185677B2 (en) 2017-06-07 2021-11-30 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11191944B2 (en) 2019-01-24 2021-12-07 Magenta Medical Ltd. Distal tip element for a ventricular assist device
US11219756B2 (en) 2012-07-03 2022-01-11 Tc1 Llc Motor assembly for catheter pump
US11229786B2 (en) 2012-05-14 2022-01-25 Tc1 Llc Impeller for catheter pump
US11235138B2 (en) 2015-09-25 2022-02-01 Procyrion, Inc. Non-occluding intravascular blood pump providing reduced hemolysis
US11241569B2 (en) 2004-08-13 2022-02-08 Procyrion, Inc. Method and apparatus for long-term assisting a left ventricle to pump blood
US11260212B2 (en) 2016-10-25 2022-03-01 Magenta Medical Ltd. Ventricular assist device
US11291826B2 (en) 2018-01-10 2022-04-05 Magenta Medical Ltd. Axially-elongatable frame and impeller
US11291824B2 (en) 2015-05-18 2022-04-05 Magenta Medical Ltd. Blood pump
US11324940B2 (en) 2019-12-03 2022-05-10 Procyrion, Inc. Blood pumps
US11338140B2 (en) 2012-03-08 2022-05-24 Medtronic Ardian Luxembourg S.A.R.L. Monitoring of neuromodulation using biomarkers
US11351359B2 (en) 2019-12-13 2022-06-07 Procyrion, Inc. Support structures for intravascular blood pumps
US11368081B2 (en) 2018-01-24 2022-06-21 Kardion Gmbh Magnetic coupling element with a magnetic bearing function
US11491322B2 (en) 2016-07-21 2022-11-08 Tc1 Llc Gas-filled chamber for catheter pump motor assembly
US11511103B2 (en) 2017-11-13 2022-11-29 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11534304B2 (en) 2017-10-06 2022-12-27 Troy Thornton Device for renal decongestion
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
US11754075B2 (en) 2018-07-10 2023-09-12 Kardion Gmbh Impeller for an implantable, vascular support system
US11944805B2 (en) 2020-01-31 2024-04-02 Kardion Gmbh Pump for delivering a fluid and method of manufacturing a pump
US11964119B2 (en) 2021-02-18 2024-04-23 Tc1 Llc Sheath assembly for catheter pump

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8086314B1 (en) 2000-09-27 2011-12-27 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US9327067B2 (en) 2012-05-14 2016-05-03 Thoratec Corporation Impeller for catheter pump

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136025A (en) * 1999-07-27 2000-10-24 Barbut; Denise R. Endoscopic arterial pumps for treatment of cardiac insufficiency and venous pumps for right-sided cardiac support

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136025A (en) * 1999-07-27 2000-10-24 Barbut; Denise R. Endoscopic arterial pumps for treatment of cardiac insufficiency and venous pumps for right-sided cardiac support

Cited By (211)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8712531B2 (en) 2000-09-27 2014-04-29 Cvrx, Inc. Automatic baroreflex modulation responsive to adverse event
US9427583B2 (en) 2000-09-27 2016-08-30 Cvrx, Inc. Electrode structures and methods for their use in cardiovascular reflex control
US9044609B2 (en) 2000-09-27 2015-06-02 Cvrx, Inc. Electrode structures and methods for their use in cardiovascular reflex control
US8880190B2 (en) 2000-09-27 2014-11-04 Cvrx, Inc. Electrode structures and methods for their use in cardiovascular reflex control
US7485104B2 (en) 2000-10-30 2009-02-03 Cvrx, Inc. Systems and methods for controlling renovascular perfusion
US10293190B2 (en) 2002-04-08 2019-05-21 Medtronic Ardian Luxembourg S.A.R.L. Thermally-induced renal neuromodulation and associated systems and methods
US10130792B2 (en) 2002-04-08 2018-11-20 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation using neuromodulatory agents or drugs
US8852163B2 (en) 2002-04-08 2014-10-07 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation via drugs and neuromodulatory agents and associated systems and methods
US11033328B2 (en) 2002-04-08 2021-06-15 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US10039596B2 (en) 2002-04-08 2018-08-07 Medtronic Ardian Luxembourg S.A.R.L. Apparatus for renal neuromodulation via an intra-to-extravascular approach
US10272246B2 (en) 2002-04-08 2019-04-30 Medtronic Adrian Luxembourg S.a.r.l Methods for extravascular renal neuromodulation
US10850091B2 (en) 2002-04-08 2020-12-01 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for bilateral renal neuromodulation
US10111707B2 (en) 2002-04-08 2018-10-30 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of human patients
US10124195B2 (en) 2002-04-08 2018-11-13 Medtronic Ardian Luxembourg S.A.R.L. Methods for thermally-induced renal neuromodulation
US9072527B2 (en) 2002-04-08 2015-07-07 Medtronic Ardian Luxembourg S.A.R.L. Apparatuses and methods for renal neuromodulation
US9968611B2 (en) 2002-04-08 2018-05-15 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for renal nerve blocking
US9707035B2 (en) 2002-04-08 2017-07-18 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10441356B2 (en) 2002-04-08 2019-10-15 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal neuromodulation via neuromodulatory agents
US9131978B2 (en) 2002-04-08 2015-09-15 Medtronic Ardian Luxembourg S.A.R.L. Methods for bilateral renal neuromodulation
US10420606B2 (en) 2002-04-08 2019-09-24 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US10376312B2 (en) 2002-04-08 2019-08-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for monopolar renal neuromodulation
US9956410B2 (en) 2002-04-08 2018-05-01 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US10376311B2 (en) 2002-04-08 2019-08-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravascularly-induced neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US10376516B2 (en) 2002-04-08 2019-08-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for renal nerve blocking
US9675413B2 (en) 2002-04-08 2017-06-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US10034708B2 (en) 2002-04-08 2018-07-31 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for thermally-induced renal neuromodulation
US10105180B2 (en) 2002-04-08 2018-10-23 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravascularly-induced neuromodulation
US10179028B2 (en) 2002-04-08 2019-01-15 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating patients via renal neuromodulation
US9757192B2 (en) 2002-04-08 2017-09-12 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of patients
US9731132B2 (en) 2002-04-08 2017-08-15 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal neuromodulation
US9743983B2 (en) 2002-04-08 2017-08-29 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of patients
US9907611B2 (en) 2002-04-08 2018-03-06 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of patients
US9757193B2 (en) 2002-04-08 2017-09-12 Medtronic Ardian Luxembourg S.A.R.L. Balloon catheter apparatus for renal neuromodulation
US10245429B2 (en) 2002-04-08 2019-04-02 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US9814873B2 (en) 2002-04-08 2017-11-14 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for bilateral renal neuromodulation
US10179235B2 (en) 2002-04-08 2019-01-15 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for bilateral renal neuromodulation
US9827041B2 (en) 2002-04-08 2017-11-28 Medtronic Ardian Luxembourg S.A.R.L. Balloon catheter apparatuses for renal denervation
US9827040B2 (en) 2002-04-08 2017-11-28 Medtronic Adrian Luxembourg S.a.r.l. Methods and apparatus for intravascularly-induced neuromodulation
US10179027B2 (en) 2002-04-08 2019-01-15 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable baskets for renal neuromodulation and associated systems and methods
US9895195B2 (en) 2002-04-08 2018-02-20 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8118724B2 (en) 2003-09-18 2012-02-21 Thoratec Corporation Rotary blood pump
US8684902B2 (en) 2003-09-18 2014-04-01 Thoratec Corporation Rotary blood pump
WO2005037348A1 (en) * 2003-10-15 2005-04-28 Orqis Medical Corporation Implantable heart assist system and method of applying same
US8755907B2 (en) 2003-10-22 2014-06-17 Cvrx, Inc. Devices and methods for electrode implantation
US8224437B2 (en) 2003-10-22 2012-07-17 Cvrx, Inc. Baroreflex activation for sedation and sleep
US11642511B2 (en) 2004-08-13 2023-05-09 Procyrion, Inc. Method and apparatus for long-term assisting a left ventricle to pump blood
US11241569B2 (en) 2004-08-13 2022-02-08 Procyrion, Inc. Method and apparatus for long-term assisting a left ventricle to pump blood
US10215187B2 (en) 2004-09-17 2019-02-26 Tc1 Llc Expandable impeller pump
US9717833B2 (en) 2004-09-17 2017-08-01 The Penn State Research Foundation Heart assist device with expandable impeller pump
US11434921B2 (en) 2004-09-17 2022-09-06 Tc1 Llc Expandable impeller pump
US11428236B2 (en) 2004-09-17 2022-08-30 Tc1 Llc Expandable impeller pump
US10537734B2 (en) 2004-10-05 2020-01-21 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for multi-vessel renal neuromodulation
EP2868344A1 (en) * 2004-10-05 2015-05-06 Medtronic Ardian Luxembourg S.à.r.l. Apparatus for renal neuromodulation
US10149932B2 (en) 2006-03-23 2018-12-11 The Penn State Research Foundation Heart assist device with expandable impeller pump
US11708833B2 (en) 2006-03-23 2023-07-25 The Penn State Research Foundation Heart assist device with expandable impeller pump
US10864309B2 (en) 2006-03-23 2020-12-15 The Penn State Research Foundation Heart assist device with expandable impeller pump
US9512852B2 (en) 2006-03-31 2016-12-06 Thoratec Corporation Rotary blood pump
US10537385B2 (en) 2008-12-31 2020-01-21 Medtronic Ardian Luxembourg S.A.R.L. Intravascular, thermally-induced renal neuromodulation for treatment of polycystic ovary syndrome or infertility
US10561460B2 (en) 2008-12-31 2020-02-18 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation systems and methods for treatment of sexual dysfunction
US10179020B2 (en) 2010-10-25 2019-01-15 Medtronic Ardian Luxembourg S.A.R.L. Devices, systems and methods for evaluation and feedback of neuromodulation treatment
US9962475B2 (en) 2011-01-06 2018-05-08 Tc1 Llc Percutaneous heart pump
US10960116B2 (en) 2011-01-06 2021-03-30 Tci Llc Percutaneous heart pump
US9114124B2 (en) 2011-12-09 2015-08-25 Metavention, Inc. Modulation of nerves innervating the liver
US9999461B2 (en) 2011-12-09 2018-06-19 Metavention, Inc. Therapeutic denervation of nerves surrounding a hepatic vessel
US10070911B2 (en) 2011-12-09 2018-09-11 Metavention, Inc. Neuromodulation methods to alter glucose levels
US10617460B2 (en) 2011-12-09 2020-04-14 Metavention, Inc. Neuromodulation for metabolic conditions or syndromes
US10064674B2 (en) 2011-12-09 2018-09-04 Metavention, Inc. Methods of modulating nerves of the hepatic plexus
US10856926B2 (en) 2011-12-09 2020-12-08 Metavention, Inc. Neuromodulation for metabolic conditions or syndromes
US8876815B2 (en) 2011-12-09 2014-11-04 Metavention, Inc. Energy delivery devices for hepatic neuromodulation
US8894639B2 (en) 2011-12-09 2014-11-25 Metavention, Inc. Hepatic artery nerve modulation methods
US9089542B2 (en) 2011-12-09 2015-07-28 Metavention, Inc. Hepatic neuromodulation using microwave energy
US9114123B2 (en) 2011-12-09 2015-08-25 Metavention, Inc. Hepatic neuromodulation using fluids or chemical agents
US9011422B2 (en) 2011-12-09 2015-04-21 Metavention, Inc. Hepatic neuromodulation to treat fatty liver conditions
US10543034B2 (en) 2011-12-09 2020-01-28 Metavention, Inc. Modulation of nerves innervating the liver
US10874455B2 (en) 2012-03-08 2020-12-29 Medtronic Ardian Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
US11338140B2 (en) 2012-03-08 2022-05-24 Medtronic Ardian Luxembourg S.A.R.L. Monitoring of neuromodulation using biomarkers
US9675740B2 (en) 2012-05-14 2017-06-13 Tc1 Llc Impeller for catheter pump
US11357967B2 (en) 2012-05-14 2022-06-14 Tc1 Llc Impeller for catheter pump
US11260213B2 (en) 2012-05-14 2022-03-01 Tc1 Llc Impeller for catheter pump
US11229786B2 (en) 2012-05-14 2022-01-25 Tc1 Llc Impeller for catheter pump
US10117980B2 (en) 2012-05-14 2018-11-06 Tc1 Llc Distal bearing support
US9872947B2 (en) 2012-05-14 2018-01-23 Tc1 Llc Sheath system for catheter pump
US10765789B2 (en) 2012-05-14 2020-09-08 Tc1 Llc Impeller for catheter pump
US11311712B2 (en) 2012-05-14 2022-04-26 Tc1 Llc Impeller for catheter pump
US10039872B2 (en) 2012-05-14 2018-08-07 Tc1 Llc Impeller for catheter pump
US10299918B2 (en) 2012-06-06 2019-05-28 Magenta Medical Ltd. Vena-caval device
US11160654B2 (en) 2012-06-06 2021-11-02 Magenta Medical Ltd. Vena-caval device
US11839540B2 (en) 2012-06-06 2023-12-12 Magenta Medical Ltd Vena-caval apparatus and methods
US11058865B2 (en) 2012-07-03 2021-07-13 Tc1 Llc Catheter pump
US11944801B2 (en) 2012-07-03 2024-04-02 Tc1 Llc Motor assembly for catheter pump
US11944802B2 (en) 2012-07-03 2024-04-02 Tc1 Llc Motor assembly for catheter pump
US11925796B2 (en) 2012-07-03 2024-03-12 Tc1 Llc Motor assembly for catheter pump
US11925797B2 (en) 2012-07-03 2024-03-12 Tc1 Llc Motor assembly for catheter pump
US11219756B2 (en) 2012-07-03 2022-01-11 Tc1 Llc Motor assembly for catheter pump
US10576193B2 (en) 2012-07-03 2020-03-03 Tc1 Llc Motor assembly for catheter pump
US11654276B2 (en) 2012-07-03 2023-05-23 Tc1 Llc Catheter pump
US11660441B2 (en) 2012-07-03 2023-05-30 Tc1 Llc Catheter pump
US10086121B2 (en) 2012-07-03 2018-10-02 Tc1 Llc Catheter pump
US11833342B2 (en) 2012-07-03 2023-12-05 Tc1 Llc Motor assembly for catheter pump
US10080864B2 (en) 2012-10-19 2018-09-25 Medtronic Ardian Luxembourg S.A.R.L. Packaging for catheter treatment devices and associated devices, systems, and methods
US9913937B2 (en) 2013-03-13 2018-03-13 Magenta Medical Ltd. Renal pump
US11298521B2 (en) 2013-03-13 2022-04-12 Magenta Medical Ltd. Methods of manufacturing an impeller
US11298520B2 (en) 2013-03-13 2022-04-12 Magenta Medical Ltd. Impeller for use with axial shaft
US10632241B2 (en) 2013-03-13 2020-04-28 Tc1 Llc Fluid handling system
US10583231B2 (en) 2013-03-13 2020-03-10 Magenta Medical Ltd. Blood pump
US11052238B2 (en) 2013-03-13 2021-07-06 Magenta Medical Ltd. Vena-caval sleeve
US11484701B2 (en) 2013-03-13 2022-11-01 Magenta Medical Ltd. Vena-caval occlusion element
US20160022890A1 (en) * 2013-03-13 2016-01-28 Magenta Medical Ltd. Renal pump
US10363350B2 (en) 2013-03-13 2019-07-30 Magenta Medical Ltd. Blood pump
US10864310B2 (en) 2013-03-13 2020-12-15 Magenta Medical Ltd. Impeller for use in blood pump
US11547845B2 (en) 2013-03-13 2023-01-10 Tc1 Llc Fluid handling system
US11883274B2 (en) 2013-03-13 2024-01-30 Magenta Medical Ltd. Vena-caval blood pump
US11648391B2 (en) 2013-03-13 2023-05-16 Magenta Medical Ltd. Blood pump
AU2014229150B2 (en) * 2013-03-13 2018-02-22 Magenta Medical Ltd. Renal pump
US11850414B2 (en) 2013-03-13 2023-12-26 Tc1 Llc Fluid handling system
US11077294B2 (en) 2013-03-13 2021-08-03 Tc1 Llc Sheath assembly for catheter pump
US11033728B2 (en) 2013-03-13 2021-06-15 Tc1 Llc Fluid handling system
US10039874B2 (en) * 2013-03-13 2018-08-07 Magenta Medical Ltd. Renal pump
US11850415B2 (en) 2013-03-13 2023-12-26 Magenta Medical Ltd. Blood pump
US10786610B2 (en) 2013-03-15 2020-09-29 Tc1 Llc Catheter pump assembly including a stator
US10071192B2 (en) 2013-03-15 2018-09-11 Tc1 Llp Catheter pump assembly including a stator
US10525178B2 (en) 2013-03-15 2020-01-07 Tc1 Llc Catheter pump assembly including a stator
CN105473089A (en) * 2013-06-05 2016-04-06 麦特文申公司 Modulation of targeted nerve fibers
US10213580B2 (en) 2013-12-11 2019-02-26 Magenta Medical Ltd Curved catheter
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10576192B2 (en) 2014-04-15 2020-03-03 Tc1 Llc Catheter pump with access ports
US11478628B2 (en) 2014-04-15 2022-10-25 Tc1 Llc Heart pump providing adjustable outflow
US10363349B2 (en) 2014-04-15 2019-07-30 Tc1 Llp Heart pump providing adjustable outflow
US10105475B2 (en) 2014-04-15 2018-10-23 Tc1 Llc Catheter pump introducer systems and methods
US11786720B2 (en) 2014-04-15 2023-10-17 Tc1 Llc Catheter pump with off-set motor position
US9827356B2 (en) 2014-04-15 2017-11-28 Tc1 Llc Catheter pump with access ports
US10709829B2 (en) 2014-04-15 2020-07-14 Tc1 Llc Catheter pump introducer systems and methods
US10864308B2 (en) 2014-04-15 2020-12-15 Tc1 Llc Sensors for catheter pumps
US10583232B2 (en) 2014-04-15 2020-03-10 Tc1 Llc Catheter pump with off-set motor position
US11331470B2 (en) 2014-04-15 2022-05-17 Tc1 Llc Catheter pump with access ports
US10029037B2 (en) 2014-04-15 2018-07-24 Tc1 Llc Sensors for catheter pumps
US11173297B2 (en) 2014-04-15 2021-11-16 Tc1 Llc Catheter pump with off-set motor position
US10449279B2 (en) 2014-08-18 2019-10-22 Tc1 Llc Guide features for percutaneous catheter pump
US11911579B2 (en) 2015-01-22 2024-02-27 Tc1 Llc Reduced rotational mass motor assembly for catheter pump
US10737005B2 (en) 2015-01-22 2020-08-11 Tc1 Llc Motor assembly with heat exchanger for catheter pump
US9675739B2 (en) 2015-01-22 2017-06-13 Tc1 Llc Motor assembly with heat exchanger for catheter pump
US9987404B2 (en) 2015-01-22 2018-06-05 Tc1 Llc Motor assembly with heat exchanger for catheter pump
US10709830B2 (en) 2015-01-22 2020-07-14 Tc1 Llc Reduced rotational mass motor assembly for catheter pump
US9770543B2 (en) 2015-01-22 2017-09-26 Tc1 Llc Reduced rotational mass motor assembly for catheter pump
US9675738B2 (en) 2015-01-22 2017-06-13 Tc1 Llc Attachment mechanisms for motor of catheter pump
US11759612B2 (en) 2015-01-22 2023-09-19 Tc1 Llc Reduced rotational mass motor assembly for catheter pump
US11497896B2 (en) 2015-01-22 2022-11-15 Tc1 Llc Reduced rotational mass motor assembly for catheter pump
US9907890B2 (en) 2015-04-16 2018-03-06 Tc1 Llc Catheter pump with positioning brace
US11291824B2 (en) 2015-05-18 2022-04-05 Magenta Medical Ltd. Blood pump
US11648387B2 (en) 2015-05-18 2023-05-16 Magenta Medical Ltd. Blood pump
US11235138B2 (en) 2015-09-25 2022-02-01 Procyrion, Inc. Non-occluding intravascular blood pump providing reduced hemolysis
US10524859B2 (en) 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
US11925795B2 (en) 2016-07-21 2024-03-12 Tc1 Llc Fluid seals for catheter pump motor assembly
US11160970B2 (en) 2016-07-21 2021-11-02 Tc1 Llc Fluid seals for catheter pump motor assembly
US11918800B2 (en) 2016-07-21 2024-03-05 Tc1 Llc Gas-filled chamber for catheter pump motor assembly
US11491322B2 (en) 2016-07-21 2022-11-08 Tc1 Llc Gas-filled chamber for catheter pump motor assembly
US11039915B2 (en) 2016-09-29 2021-06-22 Magenta Medical Ltd. Blood vessel tube
US11291825B2 (en) 2016-10-25 2022-04-05 Magenta Medical Ltd. Ventricular assist device
US11260212B2 (en) 2016-10-25 2022-03-01 Magenta Medical Ltd. Ventricular assist device
US11839754B2 (en) 2016-10-25 2023-12-12 Magenta Medical Ltd Ventricular assist device
US11648392B2 (en) 2016-11-23 2023-05-16 Magenta Medical Ltd. Blood pumps
US11033727B2 (en) 2016-11-23 2021-06-15 Magenta Medical Ltd. Blood pumps
US11717670B2 (en) 2017-06-07 2023-08-08 Shifamed Holdings, LLP Intravascular fluid movement devices, systems, and methods of use
US11185677B2 (en) 2017-06-07 2021-11-30 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11534304B2 (en) 2017-10-06 2022-12-27 Troy Thornton Device for renal decongestion
US11147967B2 (en) 2017-10-18 2021-10-19 Boston Scientific Neuromodulation Corporation Modulation of aldosterone via adrenal gland stimulation
US11511103B2 (en) 2017-11-13 2022-11-29 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11806116B2 (en) 2018-01-10 2023-11-07 Magenta Medical Ltd. Sensor for blood pump
US11185679B2 (en) 2018-01-10 2021-11-30 Magenta Medical Ltd. Blood-pressure-measurement tube
US11950889B2 (en) 2018-01-10 2024-04-09 Magenta Medical Ltd. Ventricular assist device
US10994120B2 (en) 2018-01-10 2021-05-04 Magenta Medical Ltd. Ventricular assist device
US11944413B2 (en) 2018-01-10 2024-04-02 Magenta Medical Ltd. Ventricular assist device
US10905808B2 (en) 2018-01-10 2021-02-02 Magenta Medical Ltd. Drive cable for use with a blood pump
US11684275B2 (en) 2018-01-10 2023-06-27 Magenta Medical Ltd. Distal tip element for blood pump
US11690521B2 (en) 2018-01-10 2023-07-04 Magenta Medical Ltd. Impeller for blood pump
US11185680B2 (en) 2018-01-10 2021-11-30 Magenta Medical Ltd. Ventricular assist device
US11844592B2 (en) 2018-01-10 2023-12-19 Magenta Medical Ltd. Impeller and frame for blood pump
US11806117B2 (en) 2018-01-10 2023-11-07 Magenta Medical Ltd. Drive cable for blood pump
US10881770B2 (en) 2018-01-10 2021-01-05 Magenta Medical Ltd. Impeller for blood pump
US11291826B2 (en) 2018-01-10 2022-04-05 Magenta Medical Ltd. Axially-elongatable frame and impeller
US11368081B2 (en) 2018-01-24 2022-06-21 Kardion Gmbh Magnetic coupling element with a magnetic bearing function
US11804767B2 (en) 2018-01-24 2023-10-31 Kardion Gmbh Magnetic coupling element with a magnetic bearing function
US11229784B2 (en) 2018-02-01 2022-01-25 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US10722631B2 (en) 2018-02-01 2020-07-28 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US10893927B2 (en) 2018-03-29 2021-01-19 Magenta Medical Ltd. Inferior vena cava blood-flow implant
US11754075B2 (en) 2018-07-10 2023-09-12 Kardion Gmbh Impeller for an implantable, vascular support system
US11298523B2 (en) 2019-01-24 2022-04-12 Magenta Medical Ltd. Impeller housing
US11471663B2 (en) 2019-01-24 2022-10-18 Magenta Medical Ltd. Frame for blood pump
US11944800B2 (en) 2019-01-24 2024-04-02 Magenta Medical Ltd. Atraumatic balloon for blood pump
US11484699B2 (en) 2019-01-24 2022-11-01 Magenta Medical Ltd. Welding overtube
US11285309B2 (en) 2019-01-24 2022-03-29 Magenta Medical Ltd. Ventricular assist device with stabilized impeller
US11666747B2 (en) 2019-01-24 2023-06-06 Magenta Medical Ltd. Manufacturing an impeller
US11191944B2 (en) 2019-01-24 2021-12-07 Magenta Medical Ltd. Distal tip element for a ventricular assist device
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
US11857777B2 (en) 2019-12-03 2024-01-02 Procyrion, Inc. Blood pumps
US11452859B2 (en) 2019-12-03 2022-09-27 Procyrion, Inc. Blood pumps
US11324940B2 (en) 2019-12-03 2022-05-10 Procyrion, Inc. Blood pumps
US11779751B2 (en) 2019-12-03 2023-10-10 Procyrion, Inc. Blood pumps
US11517736B2 (en) 2019-12-03 2022-12-06 Procyrion, Inc. Blood pumps
US11471665B2 (en) 2019-12-13 2022-10-18 Procyrion, Inc. Support structures for intravascular blood pumps
US11697017B2 (en) 2019-12-13 2023-07-11 Procyrion, Inc. Support structures for intravascular blood pumps
US11351359B2 (en) 2019-12-13 2022-06-07 Procyrion, Inc. Support structures for intravascular blood pumps
US11571559B2 (en) 2019-12-13 2023-02-07 Procyrion, Inc. Support structures for intravascular blood pumps
US11944805B2 (en) 2020-01-31 2024-04-02 Kardion Gmbh Pump for delivering a fluid and method of manufacturing a pump
US11964145B2 (en) 2020-07-13 2024-04-23 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use
US11964143B2 (en) 2020-10-23 2024-04-23 Magenta Medical Ltd. Flexible drive cable with rigid axial shaft
US11964119B2 (en) 2021-02-18 2024-04-23 Tc1 Llc Sheath assembly for catheter pump

Also Published As

Publication number Publication date
AU2002250250A1 (en) 2002-09-19
WO2002070039A8 (en) 2003-10-30
WO2002070039A3 (en) 2003-05-01

Similar Documents

Publication Publication Date Title
WO2002070039A2 (en) Intravascular device for treatment of hypertension
US8934968B2 (en) Neurostimulation and coronary artery disease treatment
US10179028B2 (en) Methods for treating patients via renal neuromodulation
US8121684B2 (en) Method and apparatus for minimizing post-infarct ventricular remodeling
Weber et al. Intraaortic balloon counterpulsation: A review of physiological principles, clinical results, and device safety
US7481759B2 (en) Systems and methods for treatment of coronary artery disease
US9498624B2 (en) Stimulation of the urinary system
US8612001B2 (en) Method and apparatus for minimizing post-infarct ventricular remodeling
JP5015768B2 (en) Stimulation regimen for cardiovascular reflex control
US7758531B2 (en) Method and apparatus for treatment of congestive heart disease
US8425454B2 (en) Device and method for modulating renal function
US7244225B2 (en) Devices and methods for non-invasively improving blood circulation
US6287608B1 (en) Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney by infusion of a vasodilator
Braunwald et al. Carotid sinus nerve stimulation in the treatment of angina pectoris and supraventricular tachycardia.
US20090318749A1 (en) Method and apparatus for pacing and intermittent ischemia
Boulain et al. Efficacy of epinephrine therapy in shock complicating pulmonary embolism
AU2015202019B2 (en) Systems for regulation of blood pressure and heart rate
Williams Profound bradycardia and hypotension following spinal anaesthesia in a patient receiving an ACE inhibitor: an important ‘drug’interaction?
Gunnar et al. Shock in acute myocardial infarction: evolution of physiologic therapy
Rady Possible mechanisms for the interaction of peripheral somatic nerve stimulation, tissue injury, and hemorrhage in the pathophysiology of traumatic shock
Rimoldi et al. Reduced cardiovascular sympathetic excitatory responses during iloprost infusion in conscious dogs
Geha et al. Bilateral carotid nerve stimulation in the treatment of angina pectoris
Albert Advanced systolic heart failure: emerging pathophysiology and current management
Barger Regulation of blood pressure: interaction of the renin-angiotensin-aldosterone system, the autonomic nervous system, and sodium balance
PULEY et al. CARDIOLOGY Rounds

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ CZ DE DE DK DK DM DZ EC EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 37/2002 DUE TO A TECHNICAL PROBLEM AT THE TIME OF INTERNATIONAL PUBLICATION, SOME INFORMATION WAS MISSING (81). THE MISSING INFORMATION NOW APPEARS IN THE CORRECTED VERSION.

Free format text: IN PCT GAZETTE 37/2002 DUE TO A TECHNICAL PROBLEM AT THE TIME OF INTERNATIONAL PUBLICATION, SOME INFORMATION WAS MISSING (81). THE MISSING INFORMATION NOW APPEARS IN THE CORRECTED VERSION.

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP