WO2002070043A1 - Fluid injection apparatus with improved contrast visualization - Google Patents
Fluid injection apparatus with improved contrast visualization Download PDFInfo
- Publication number
- WO2002070043A1 WO2002070043A1 PCT/US2001/023645 US0123645W WO02070043A1 WO 2002070043 A1 WO2002070043 A1 WO 2002070043A1 US 0123645 W US0123645 W US 0123645W WO 02070043 A1 WO02070043 A1 WO 02070043A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fluid
- catheter
- manifold
- syringe
- manually operated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/44—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1407—Infusion of two or more substances
- A61M5/1408—Infusion of two or more substances in parallel, e.g. manifolds, sequencing valves
Definitions
- the invention generally relates to fluid injection apparatus and, more particularly, relates to manually operated syringes.
- Angiography is a procedure used in the detection and treatment of abnormalities or restrictions in blood vessels.
- a radiographic image of a vascular structure is obtained by injecting radiopaque fluid or contrast through a catheter into a vein or artery.
- Vascular structure fluidically connected with the vein or artery in which the injection occurs is filled with the contrast material.
- X-rays are then passed through the region of the body in which the contrast material was injected, with the x-rays being absorbed by the contrast material, creating a radiographic outline or image of the blood vessel containing the contrast material.
- the x-ray image of the blood vessels filled with the contrast material is usually recorded onto film or videotape and then displayed on a fluoroscope monitor.
- the speed with which the injection of contrast occurs enhances the resulting radiographic image because the speed of injection counteracts the flow of blood through the vessels that continually carries or flushes the contrast away.
- the faster the injection of contrast means a higher concentration of the contrast during the x-ray imaging and therefore a higher radiopacity of the blood vessels. Due to the high viscosity of the contrast material, and the flow resistance in the catheter and other fluid channels, the force required for rapid injection of a contrast is relatively high.
- a power injector is typically used because manual syringes cannot be operated with sufficiently high flow rate due to the inability to apply enough manual force on the syringe plunger.
- the power injector is operated by first setting a flow rate and an injection volume. The operator then activates the system by pressing a button on a hand controller which actuates a motor or the like for injecting the contrast. Examples of such power injectors are disclosed in U.S. Patent Nos. 5,515,851 and 5,916,165.
- a manual syringe is that the operator is provided with more direct control of the injection. For example, if resistance is encountered during the injection process, the operator can detect the resistance due to an increase in the pressure, and thus the force required to manually depress the plunger.
- a fluid injection apparatus adapted to inject fluid which comprises an input device, a catheter, and an improved visualization device.
- the catheter is in fluid communication with the input device.
- the improved visualization device is adapted to increase the speed with which fluid may be injected.
- a method of manually injecting fluid comprises the steps of retracting a plunger from a syringe cylinder and drawing fluid into the cylinder, depressing the plunger into the cylinder forcing the fluid out an outlet of the cylinder, increasing the speed with which fluid may be injected, and injecting the fluid into a patient.
- a manually operated fluid injection apparatus which comprises a syringe, a manifold, a fluid line, a catheter, a source of fluid, and a heater.
- the syringe includes a movable plunger, while the manifold includes a plurality of inlet ports in first and second ends.
- the syringe is connected to the first end of the manifold.
- the catheter is connected to the second end of the manifold.
- the source of fluid is in communication with one of the manifold inlet ports via the fluid line, while the heater is operatively associated with one of the syringe, manifold, fluid line, catheter, or source of fluid.
- a manually operated fluid injection apparatus which comprises a syringe, a manifold, a fluid line, a catheter, a source of fluid, and an expandable ring.
- the syringe includes a movable plunger, while the manifold includes a plurality of inlet ports in first and second ends.
- the syringe is connected to the first end of the manifold.
- the catheter is connected to the second end of the manifold.
- the source of fluid is in communication with one of the manifold inlet ports via the fluid line, while the expandable ring is associated with the catheter and is expandable after catheter insertion and prior to injection to constrict blood flow.
- a manually operated fluid injection system which comprises a manipulable input device, and a heater associated with the input device and adapted to increase the temperature of fluid prior to injection.
- a manually operated fluid injection system which comprises a manipulable input device, a catheter connected to the input device, and an expandable member associated with the catheter and adapted to expand after the catheter is inserted into a patient to restrict blood flow during injection.
- FIG. 1 is a schematic representation of a manual fluid injection apparatus constructed in accordance with the teachings of the invention
- FIG. 2 is a block diagram of an alternative embodiment of a fluid injection apparatus constructed in accordance with the teachings of the invention.
- FIG. 3 is a flow chart of a sample sequence of steps which may be taken by a fluid injection system constructed in accordance with the teachings of the invention.
- a manually operated fluid injection apparatus constructed in accordance with the teachings of the invention is generally depicted by reference numeral 20.
- the apparatus 20 is depicted in reference to a manually operated apparatus 20 for the injection of radiopaque contrast from a supply 22 to a patient (not shown).
- teachings of the invention can be used for the injection of other fluids as well, and in power-assisted, or automatic injection systems as well.
- the apparatus 20 includes a manually operated syringe 24, a manifold 26, a first fluid line 28, a second fluid line 30, a catheter 32, and an improved visualization device 34.
- the syringe 24 includes a cylinder 36 in which a plunger 38 is disposed for translational movement.
- the plunger 38 includes a thumb ring 40, as well as a rubber or otherwise elastomeric stopper 42 engaging an inner circumferential surface 44 of the cylinder 36.
- First and second finger rings 46 and 48 extend from the cylinder 36 to facilitate operation of the syringe 24 in conjunction with the thumb ring 40.
- the cylinder 36 includes a reduced diameter outlet 50 connected to a first end 52 of the manifold 26. A threaded or other suitable coupling 54 is provided for attachment therebetween.
- the manifold 26 includes the first end 52, a second end 56, and a plurality of valved inlet ports 58a, b, and c. As shown in FIG. 1 , inlet port 58c is connected to the first fluid line 28 for receipt of contrast from the supply 22. The second inlet port 58b, is connected to a source of saline 60 by way of the second fluid line 30. The third inlet port 58a, is shown connected to a pressure transducer 64. The second end 56 of the manifold 26 is connected
- the first fluid line 28, connecting the source of contrast 22 to the manifold 26, may include a valve 66 as well as a vent 68.
- the valve 66 which may be provided in the form of a stop cock, is provided to control flow of contrast from the source of contrast 22 to the manifold 26.
- the vent 68 is provided to aerate any air or gas within the first fluid line 28.
- the catheter 32 includes a proximal end 70, and a distal end 72. As shown in FIG. 2, in an alternative embodiment the distal end 72 of the catheter 32 may be provided with an expandable ring 74, the importance of which will be discussed in further detail herein.
- the expandable ring 74 may be provided in the form of an elastomeric hollow ring which upon introduction of compressed air or the like, may expand to increase the diameter of the catheter 32.
- the improved visualization device 34 is shown proximate the catheter 32.
- the improved visualization device 34 may be provided in the form of a heater, or may include the expandable ring 74.
- the heater 76 can be provided in a variety of radiant, convective and conductive forms, including conventional heating coils which, upon electrical actuation, elevate temperature to thereby increase the temperature of the catheter 32 and thus the temperature of the contrast within the catheter 32.
- the heater 76 may be provided in the form of conduits or tubes wrapped around the catheter 32 or other parts of the apparatus 20 and through which a relatively warm fluid is passed for heating of the contrast.
- the heater 76 may be embedded directly in the apparatus 20.
- resistor coils or other heating devices may be provided in the body of the syringe 24, the manifold 26, the first fluid line 28, the second fluid line 30, or the catheter 32.
- the inventor has found that it is beneficial to provide the heater 76 as close to the end of the catheter 32 inserted into the patient as possible to lessen the cooling effects of traveling through the apparatus 20.
- the improved visualization devices 34 are provided to increase the speed with which the contrast may be injected to thereby minimize the effect of blood flow washing the contrast away and lessening the visual radiographic image generated.
- the speed is increased by elevating the temperature of the contrast, which in turn decreases its density and decreases its viscosity. Accordingly, the contrast is more easily injected.
- the size of the catheter 32 is increased after placement within the vascular structure of the patient. In so doing, blood flow is restricted through the vascular structure, momentarily, while the contrast is injected. The contrast therefore is injected with less mixing with blood flow and less dilution of the contrast.
- the expandable ring can be deflated and the catheter 32 can be removed thereby allowing blood flow to return to normal.
- the heater 76 and the expandable ring 74 may be combined in the same system or apparatus 20. In operation, the apparatus 20 may be used to inject fluid into a patient with increased speed. As shown in FIG. 3, which is a sample depiction of
- step 78 fluid flow is communicated from the source of contrast 22, through the manifold 26 and to the outlet 50 of the syringe 24.
- the contrast 22 is able to enter the cylinder 36 of the syringe 24 upon retraction of the plunger 38, as indicated by step 80. More specifically, the retraction of the plunger 38 within the cylinder 36 creates a vacuum within the cylinder 36, thereby drawing the contrast into the syringe 24.
- the plunger 38 may be retracted a distance sufficient to fill the cylinder 36 to the appropriate volume.
- a series of indicia or graduations may be provided on the side of the cylinder to facilitate such operation.
- the plunger 38 is reciprocated back into the cylinder 36 as indicated by step 82.
- the contrast 22 is forced from the cylinder 36 into the manifold 26, through the catheter 32, and into the patient.
- the contrast fluid 22 is heated, as indicated by step 84. In so doing, the density and viscosity of the contrast 22 are decreased, and the force required by the user to depress the plunger 38 is decreased, and the speed of injection is increased.
- the catheter 32 may be expanded in conjunction with the heating step 84. In so doing, the catheter 32 restricts blood flow through the vascular structure in which the catheter 32 is placed.
- the contrast 22 can therefore be injected into the patient in step 88 with lessened interference and dilution from blood flow. Once the contrast 22 is fully injected, the catheter can be deflated and removed. It is to understood that the expansion of the catheter step 86 may be conducted in the absence of the heating step 84, and similarly, that the heating of the contrast 84 can be conducted in the absence of the catheter expansion step 86.
- teachings of the invention may be utilized to provide a manual fluid injection apparatus and method which reduces the force required by an operator to manually inject fluid into a patient, increases the speed of injection, and improves the contrast visualization on the resulting radiographic image.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60121474T DE60121474D1 (en) | 2001-03-01 | 2001-07-27 | FLUIDINJECTION DEVICE WITH IMPROVED CONTRAST VISUALIZATION |
JP2002569213A JP2004526494A (en) | 2001-03-01 | 2001-07-27 | Fluid injection device with improved contrast visualization |
EP01957283A EP1363686B1 (en) | 2001-03-01 | 2001-07-27 | Fluid injection apparatus with improved contrast visualization |
CA002438399A CA2438399A1 (en) | 2001-03-01 | 2001-07-27 | Fluid injection apparatus with improved contrast visualization |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/797,473 US6699232B2 (en) | 2001-03-01 | 2001-03-01 | Fluid injection apparatus with improved contrast visualization |
US09/797,473 | 2001-03-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002070043A1 true WO2002070043A1 (en) | 2002-09-12 |
Family
ID=25170926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/023645 WO2002070043A1 (en) | 2001-03-01 | 2001-07-27 | Fluid injection apparatus with improved contrast visualization |
Country Status (7)
Country | Link |
---|---|
US (2) | US6699232B2 (en) |
EP (1) | EP1363686B1 (en) |
JP (1) | JP2004526494A (en) |
AT (1) | ATE332718T1 (en) |
CA (1) | CA2438399A1 (en) |
DE (1) | DE60121474D1 (en) |
WO (1) | WO2002070043A1 (en) |
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BRPI0717978A2 (en) * | 2006-10-18 | 2013-11-12 | Terumo Corp | MEDICAL DEVICES |
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- 2001-07-27 CA CA002438399A patent/CA2438399A1/en not_active Abandoned
- 2001-07-27 DE DE60121474T patent/DE60121474D1/en not_active Expired - Fee Related
- 2001-07-27 WO PCT/US2001/023645 patent/WO2002070043A1/en active IP Right Grant
- 2001-07-27 JP JP2002569213A patent/JP2004526494A/en active Pending
- 2001-07-27 AT AT01957283T patent/ATE332718T1/en not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
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EP1363686A1 (en) | 2003-11-26 |
ATE332718T1 (en) | 2006-08-15 |
US20040167401A1 (en) | 2004-08-26 |
EP1363686B1 (en) | 2006-07-12 |
US20020123737A1 (en) | 2002-09-05 |
CA2438399A1 (en) | 2002-09-12 |
US6699232B2 (en) | 2004-03-02 |
JP2004526494A (en) | 2004-09-02 |
DE60121474D1 (en) | 2006-08-24 |
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