WO2002083063A3 - Method of improving systemic exposure of subcutaneously administered therapeutic proteins - Google Patents

Method of improving systemic exposure of subcutaneously administered therapeutic proteins Download PDF

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Publication number
WO2002083063A3
WO2002083063A3 PCT/US2001/051617 US0151617W WO02083063A3 WO 2002083063 A3 WO2002083063 A3 WO 2002083063A3 US 0151617 W US0151617 W US 0151617W WO 02083063 A3 WO02083063 A3 WO 02083063A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic proteins
systemic exposure
subcutaneously administered
administered therapeutic
improving systemic
Prior art date
Application number
PCT/US2001/051617
Other languages
French (fr)
Other versions
WO2002083063A2 (en
Inventor
Charles B Davis
Amarnath Sharma
Original Assignee
Smithkline Beecham Corp
Charles B Davis
Amarnath Sharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Charles B Davis, Amarnath Sharma filed Critical Smithkline Beecham Corp
Priority to US10/415,738 priority Critical patent/US20040042999A1/en
Priority to JP2002580868A priority patent/JP2004532843A/en
Priority to EP01273890A priority patent/EP1353622A4/en
Priority to AU2001297793A priority patent/AU2001297793A1/en
Publication of WO2002083063A2 publication Critical patent/WO2002083063A2/en
Publication of WO2002083063A3 publication Critical patent/WO2002083063A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

A method of improving systemic exposure of subcutaneously administering therapeutic proteins.
PCT/US2001/051617 2000-11-03 2001-11-01 Method of improving systemic exposure of subcutaneously administered therapeutic proteins WO2002083063A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/415,738 US20040042999A1 (en) 2001-11-01 2001-11-01 Method of improving systemic exposure of subcutaneously administered therapeutic proteins
JP2002580868A JP2004532843A (en) 2000-11-03 2001-11-01 Method for improving systemic exposure of therapeutic protein for subcutaneous administration
EP01273890A EP1353622A4 (en) 2000-11-03 2001-11-01 Method of improving systemic exposure of subcutaneously administered therapeutic proteins
AU2001297793A AU2001297793A1 (en) 2000-11-03 2001-11-01 Method of improving systemic exposure of subcutaneously administered therapeutic proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24561800P 2000-11-03 2000-11-03
US60/245,618 2000-11-03

Publications (2)

Publication Number Publication Date
WO2002083063A2 WO2002083063A2 (en) 2002-10-24
WO2002083063A3 true WO2002083063A3 (en) 2003-08-28

Family

ID=22927410

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/051617 WO2002083063A2 (en) 2000-11-03 2001-11-01 Method of improving systemic exposure of subcutaneously administered therapeutic proteins

Country Status (4)

Country Link
EP (1) EP1353622A4 (en)
JP (1) JP2004532843A (en)
AU (1) AU2001297793A1 (en)
WO (1) WO2002083063A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008033499A2 (en) * 2006-09-14 2008-03-20 The Trustees Of The University Of Pennsylvania Modulation of regulatory t cells by human il-18

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
EP0712913A1 (en) * 1994-11-17 1996-05-22 Canon Kabushiki Kaisha Ink-jet color recording process and ink set therefor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6600020B1 (en) * 1997-08-07 2003-07-29 Toray Industries, Inc. Canine interleukin 18 polypeptide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
EP0712913A1 (en) * 1994-11-17 1996-05-22 Canon Kabushiki Kaisha Ink-jet color recording process and ink set therefor

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 43, no. 6, 1 January 1997 (1997-01-01), pages 361 - 367 *
CYTOKINE, vol. 11, no. 8, August 1999 (1999-08-01), pages 593 - 599 *
DATABASE MEDLINE [online] January 1997 (1997-01-01), MICALLEF: "IN VIVO ANTITUMOR EFFECTS OF MURINE INTERFERON-GAMMA-INDUCING FA TOR/INTERLEUKIN-18 IN MICE BEARING SYGENEIC METH A SARCOMA MALIGNANT ASCITES", XP002964696, Database accession no. 97220033 *
DATABASE MEDLINE [online] TANAKA-KATAOKA: "IN VIVO ANTIVIRAL EFFECT OF INTERLEUKIN 18 IN A MOUSE OF VACCINIA VIRUS INFECTION", XP002964671, Database accession no. 99365045 *
MASTROENI: "INTERLEUKIN 18 CONTRIBUTES TO HOST RESISTANCE AND GAMMA INTERFERON PRODUCTION IN MICE INFECTED WITH VIRULENT SALMONELLA TYPHIMURIUM", INFECTION AND IMMUNITY, vol. 67, no. 2, February 1999 (1999-02-01), pages 478 - 483, XP002964670 *
OHKUSU: "POTENTIALITY OF INTERLEUKIN-18 AS A USEFUL REAGENT FOR TREATMENT AND PREVENTION OF LEISHMANIA MAJOR INFECTION", INFECTION AND IMMUNITY, vol. 68, no. 5, May 2000 (2000-05-01), pages 2449 - 2456, XP002964672 *
See also references of EP1353622A4 *

Also Published As

Publication number Publication date
AU2001297793A1 (en) 2002-10-28
EP1353622A2 (en) 2003-10-22
EP1353622A4 (en) 2005-06-22
WO2002083063A2 (en) 2002-10-24
JP2004532843A (en) 2004-10-28

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