WO2002085451A3 - Handheld apparatus for transdermal drug delivery and analyte extraction - Google Patents

Handheld apparatus for transdermal drug delivery and analyte extraction Download PDF

Info

Publication number
WO2002085451A3
WO2002085451A3 PCT/IL2002/000319 IL0200319W WO02085451A3 WO 2002085451 A3 WO2002085451 A3 WO 2002085451A3 IL 0200319 W IL0200319 W IL 0200319W WO 02085451 A3 WO02085451 A3 WO 02085451A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
skin
transdermal drug
handheld apparatus
analyte extraction
Prior art date
Application number
PCT/IL2002/000319
Other languages
French (fr)
Other versions
WO2002085451A2 (en
Inventor
Zohar Avrahami
Ze Ev Sohn
Original Assignee
Transpharma Ltd
Zohar Avrahami
Ze Ev Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transpharma Ltd, Zohar Avrahami, Ze Ev Sohn filed Critical Transpharma Ltd
Priority to CA002445118A priority Critical patent/CA2445118A1/en
Priority to JP2002583024A priority patent/JP4262985B2/en
Priority to IL15858202A priority patent/IL158582A0/en
Priority to EP02764094A priority patent/EP1397178A2/en
Priority to AU2002307781A priority patent/AU2002307781B2/en
Publication of WO2002085451A2 publication Critical patent/WO2002085451A2/en
Publication of WO2002085451A3 publication Critical patent/WO2002085451A3/en
Priority to IL158582A priority patent/IL158582A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

Abstract

A device (20) is provided for treating skin (22) on the body of a subject. The device includes a plurality of electrodes (60), which are adapted to be placed in contact with the skin and then moved across the skin while maintaining electrical contact with the skin. The device additionally includes a power source (52), which is adapted to apply a current between two or more of the plurality of electrodes at the same time as the electrodes are being moved across the skin.
PCT/IL2002/000319 2001-04-23 2002-04-22 Handheld apparatus for transdermal drug delivery and analyte extraction WO2002085451A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002445118A CA2445118A1 (en) 2001-04-23 2002-04-22 Handheld apparatus and method for transdermal drug delivery and analyte extraction
JP2002583024A JP4262985B2 (en) 2001-04-23 2002-04-22 Hand-held device and method for transdermal drug delivery and analyte extraction
IL15858202A IL158582A0 (en) 2001-04-23 2002-04-22 Handheld apparatus and method for transdermal drug delivery and analyte extraction
EP02764094A EP1397178A2 (en) 2001-04-23 2002-04-22 Handheld apparatus and method for transdermal drug delivery and analyte extraction
AU2002307781A AU2002307781B2 (en) 2001-04-23 2002-04-22 Handheld apparatus for transdermal drug delivery and analyte extraction
IL158582A IL158582A (en) 2001-04-23 2003-10-23 Handheld apparatus for transdermal drug delivery and analyte extraction

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/840,522 US6708060B1 (en) 1998-11-09 2001-04-23 Handheld apparatus and method for transdermal drug delivery and analyte extraction
US09/840,522 2001-04-23

Publications (2)

Publication Number Publication Date
WO2002085451A2 WO2002085451A2 (en) 2002-10-31
WO2002085451A3 true WO2002085451A3 (en) 2003-05-08

Family

ID=25282592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2002/000319 WO2002085451A2 (en) 2001-04-23 2002-04-22 Handheld apparatus for transdermal drug delivery and analyte extraction

Country Status (9)

Country Link
US (2) US6708060B1 (en)
EP (2) EP1502622B1 (en)
JP (1) JP4262985B2 (en)
AT (1) ATE434464T1 (en)
AU (1) AU2002307781B2 (en)
CA (1) CA2445118A1 (en)
DE (1) DE60232747D1 (en)
IL (1) IL158582A0 (en)
WO (1) WO2002085451A2 (en)

Families Citing this family (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7537605B2 (en) * 1993-10-04 2009-05-26 Huan-Chen Li Medical device for treating skin itch and rash
US6792306B2 (en) * 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
ATE438418T1 (en) 2001-05-01 2009-08-15 Av Topchiev Inst Petrochemical HYDROGEL COMPOSITIONS
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US6803420B2 (en) * 2001-05-01 2004-10-12 Corium International Two-phase, water-absorbent bioadhesive composition
US8541021B2 (en) * 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
DE10151471A1 (en) * 2001-10-18 2003-05-15 Disetronic Licensing Ag Injection device with energy storage
US8116860B2 (en) 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
AU2003265226A1 (en) 2002-03-11 2003-12-19 Altea Therapeutics Corporation Transdermal drug delivery device, method and use
AU2003226605A1 (en) * 2002-04-19 2003-11-03 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
US6975902B2 (en) * 2002-06-28 2005-12-13 Alza Corporation Reservoir and a series of related reservoirs for use in an electrotransport drug delivery device and devices comprised thereof
IL152575A (en) 2002-10-31 2008-12-29 Transpharma Medical Ltd Transdermal delivery system for water insoluble drugs
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd Transdermal delivery system for dried particulate or lyophilized medications
US7383084B2 (en) * 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US8133505B2 (en) * 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152573A (en) 2002-10-31 2009-11-18 Transpharma Medical Ltd Transdermal delivery system for anti-emetic medication
US7662404B2 (en) * 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
JP4381705B2 (en) * 2003-03-26 2009-12-09 シスメックス株式会社 Transcutaneous analyte extraction system and analysis system, and transcutaneous analyte extraction method and analysis method
US7137979B2 (en) 2003-05-31 2006-11-21 Tyrell, Inc. Methods and devices for the treatment of skin lesions
US8016810B2 (en) * 2003-06-23 2011-09-13 Transpharma Medical Ltd. Transdermal delivery system for cosmetic agents
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
IL159273A0 (en) * 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
IL160033A0 (en) * 2004-01-25 2004-06-20 Transpharma Medical Ltd Transdermal delivery system for polynucleotides
WO2005074894A1 (en) 2004-01-30 2005-08-18 Corium International Rapidly dissolving film for delivery of an active agent
AU2005231443B2 (en) * 2004-04-01 2012-02-23 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
US8690865B2 (en) * 2004-05-28 2014-04-08 Georgia Tech Research Corporation Methods and devices for thermal treatment
EP1768742A4 (en) * 2004-07-06 2007-10-17 Transpharma Medical Ltd Delivery system for transdermal immunization
CN103497713B (en) * 2004-08-05 2018-07-17 考里安国际公司 Adhesive composition
US20060047281A1 (en) * 2004-09-01 2006-03-02 Syneron Medical Ltd. Method and system for invasive skin treatment
US20060089637A1 (en) 2004-10-14 2006-04-27 Werneth Randell L Ablation catheter
CA2587780A1 (en) * 2004-11-18 2006-05-26 Transpharma Medical Ltd. Combined micro-channel generation and iontophoresis for transdermal delivery of pharmaceutical agents
US8371307B2 (en) 2005-02-08 2013-02-12 Koninklijke Philips Electronics N.V. Methods and devices for the treatment of airway obstruction, sleep apnea and snoring
US8096303B2 (en) 2005-02-08 2012-01-17 Koninklijke Philips Electronics N.V Airway implants and methods and devices for insertion and retrieval
US8730031B2 (en) 2005-04-28 2014-05-20 Proteus Digital Health, Inc. Communication system using an implantable device
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
US9198608B2 (en) 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
US8912908B2 (en) 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
AU2006247109A1 (en) * 2005-05-18 2006-11-23 Zeno Corporation Treatment device and method for treating skin lesions through application of heat
US20080274166A1 (en) * 2005-06-10 2008-11-06 Transpharma Medical Ltd. Patch for Transdermal Drug Delivery
TWI419717B (en) 2005-06-17 2013-12-21 Altea Therapeutics Corp Permeant delivery system and methods for use thereof
US20070009542A1 (en) 2005-07-05 2007-01-11 Galit Levin Method and device for transdermal immunization
WO2007028035A2 (en) 2005-09-01 2007-03-08 Proteus Biomedical, Inc. Implantable zero-wire communications system
US20070078502A1 (en) * 2005-10-05 2007-04-05 Thermage, Inc. Method and apparatus for estimating a local impedance factor
US7957815B2 (en) * 2005-10-11 2011-06-07 Thermage, Inc. Electrode assembly and handpiece with adjustable system impedance, and methods of operating an energy-based medical system to treat tissue
US8702691B2 (en) * 2005-10-19 2014-04-22 Thermage, Inc. Treatment apparatus and methods for delivering energy at multiple selectable depths in tissue
JP5522939B2 (en) 2005-11-02 2014-06-18 トランスファーマ メディカル リミテッド Human growth hormone patch formulation
EA017290B1 (en) 2005-11-28 2012-11-30 Домейн Раша Инвестментс Лимитед Ganaxolone-based formulations
US7634314B2 (en) * 2005-11-30 2009-12-15 Ak Beauty Enterprises, Llc Powered stimulation device
US20070128420A1 (en) * 2005-12-07 2007-06-07 Mariam Maghribi Hybrid composite for biological tissue interface devices
WO2007109194A2 (en) * 2006-03-17 2007-09-27 Bovie Medical Apparatus and method for skin tightening and corrective forming
US20080234626A1 (en) * 2006-04-26 2008-09-25 Chelak Todd M Multi-stage microporation device
CN105468895A (en) 2006-05-02 2016-04-06 普罗透斯数字保健公司 Patient customized therapeutic regimens
US20070259316A1 (en) * 2006-05-08 2007-11-08 Tyrell, Inc. Treatment device and method for treating or preventing periodontal disease through application of heat
US20080008978A1 (en) * 2006-05-08 2008-01-10 Tyrell, Inc. Treatment device and method for treating or preventing periodontal disease through application of heat
US8246611B2 (en) * 2006-06-14 2012-08-21 Candela Corporation Treatment of skin by spatial modulation of thermal heating
WO2008066617A2 (en) 2006-10-17 2008-06-05 Proteus Biomedical, Inc. Low voltage oscillator for medical devices
EP2083680B1 (en) 2006-10-25 2016-08-10 Proteus Digital Health, Inc. Controlled activation ingestible identifier
EP2069004A4 (en) 2006-11-20 2014-07-09 Proteus Digital Health Inc Active signal processing personal health signal receivers
JP2010510988A (en) 2006-11-28 2010-04-08 マリナス ファーマシューティカルズ Nanoparticle formulation, method for producing the same and use thereof
WO2008091983A2 (en) * 2007-01-25 2008-07-31 Thermage, Inc. Treatment apparatus and methods for inducing microburn patterns in tissue
MY165532A (en) * 2007-02-01 2018-04-02 Proteus Digital Health Inc Ingestible event marker systems
CA2676280C (en) 2007-02-14 2018-05-22 Proteus Biomedical, Inc. In-body power source having high surface area electrode
EP2124725A1 (en) * 2007-03-09 2009-12-02 Proteus Biomedical, Inc. In-body device having a multi-directional transmitter
US9270025B2 (en) 2007-03-09 2016-02-23 Proteus Digital Health, Inc. In-body device having deployable antenna
WO2008131072A1 (en) * 2007-04-17 2008-10-30 Transport Pharmaceuticals, Inc. Current density detection and control system and method for an electrokinetic delivery of medicaments
US20080269735A1 (en) * 2007-04-26 2008-10-30 Agustina Vila Echague Optical array for treating biological tissue
US8540632B2 (en) * 2007-05-24 2013-09-24 Proteus Digital Health, Inc. Low profile antenna for in body device
WO2009009661A1 (en) * 2007-07-10 2009-01-15 Thermage, Inc. Treatment apparatus and methods for delivering high frequency energy across large tissue areas
DK2192946T3 (en) 2007-09-25 2022-11-21 Otsuka Pharma Co Ltd In-body device with virtual dipole signal amplification
WO2009047774A2 (en) * 2007-10-09 2009-04-16 Transpharma Ltd. Magnetic patch coupling
CA2696227A1 (en) * 2007-10-17 2009-04-23 Transpharma Medical Ltd. Dissolution rate verification
WO2009057112A2 (en) * 2007-10-29 2009-05-07 Transpharma Medical, Ltd. Vertical patch drying
ES2661739T3 (en) * 2007-11-27 2018-04-03 Proteus Digital Health, Inc. Transcorporeal communication systems that employ communication channels
KR101287351B1 (en) 2007-12-05 2013-07-23 시네론 메디컬 리미티드 A carrier for use in a skin treatment apparatus
US20090149930A1 (en) * 2007-12-07 2009-06-11 Thermage, Inc. Apparatus and methods for cooling a treatment apparatus configured to non-invasively deliver electromagnetic energy to a patient's tissue
EP2561819B1 (en) 2008-01-17 2015-01-07 Syneron Medical Ltd. Hair removal apparatus for personal use
WO2009093230A2 (en) * 2008-01-24 2009-07-30 Syneron Medical Ltd. A device, apparatus, and method of adipose tissue treatment
MY161533A (en) 2008-03-05 2017-04-28 Proteus Digital Health Inc Multi-mode communication ingestible event markers and systems, and methods of using the same
KR101674492B1 (en) 2008-03-31 2016-11-09 닛토덴코 가부시키가이샤 Permeant delivery system and methods for use thereof
US8515553B2 (en) * 2008-04-28 2013-08-20 Thermage, Inc. Methods and apparatus for predictively controlling the temperature of a coolant delivered to a treatment device
US8121704B2 (en) * 2008-06-19 2012-02-21 Thermage, Inc. Leakage-resistant tissue treatment apparatus and methods of using same
US8285392B2 (en) * 2008-06-19 2012-10-09 Thermage, Inc. Leakage-resistant tissue treatment apparatus and methods of using such tissue treatment apparatus
SG195535A1 (en) 2008-07-08 2013-12-30 Proteus Digital Health Inc Ingestible event marker data framework
US9314293B2 (en) * 2008-07-16 2016-04-19 Syneron Medical Ltd RF electrode for aesthetic and body shaping devices and method of using same
US20100017750A1 (en) * 2008-07-16 2010-01-21 Avner Rosenberg User interface
KR101214453B1 (en) 2008-08-13 2012-12-24 프로테우스 디지털 헬스, 인코포레이티드 Ingestible circuitry
DE102008039844A1 (en) * 2008-08-27 2010-03-04 Fresenius Medical Care Deutschland Gmbh Probe with at least two electrodes for impedance measurement, arrangement and method for this purpose
WO2010029552A1 (en) * 2008-09-10 2010-03-18 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
WO2010032235A1 (en) 2008-09-21 2010-03-25 Syneron Medical Ltd. A method and apparatus for personal skin treatment
JP2012505717A (en) * 2008-10-14 2012-03-08 プロテウス バイオメディカル インコーポレイテッド Method and system for incorporating physiological data into a gaming environment
WO2010057049A2 (en) 2008-11-13 2010-05-20 Proteus Biomedical, Inc. Ingestible therapy activator system and method
EP2346391A4 (en) * 2008-11-18 2012-08-15 Proteus Biomedical Inc Sensing system, device, and method for therapy modulation
US8357150B2 (en) 2009-07-20 2013-01-22 Syneron Medical Ltd. Method and apparatus for fractional skin treatment
CN102271578B (en) 2008-12-11 2013-12-04 普罗秋斯数字健康公司 Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same
TWI424832B (en) 2008-12-15 2014-02-01 Proteus Digital Health Inc Body-associated receiver and method
US9439566B2 (en) 2008-12-15 2016-09-13 Proteus Digital Health, Inc. Re-wearable wireless device
US9659423B2 (en) 2008-12-15 2017-05-23 Proteus Digital Health, Inc. Personal authentication apparatus system and method
AU2010203625A1 (en) 2009-01-06 2011-07-21 Proteus Digital Health, Inc. Ingestion-related biofeedback and personalized medical therapy method and system
TWI602561B (en) 2009-01-06 2017-10-21 波提亞斯數位康健公司 Pharmaceutical dosages delivery system
AU2010204986B2 (en) 2009-01-14 2016-06-02 Corium International, Inc. Transdermal administration of tamsulosin
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
US9278230B2 (en) * 2009-02-25 2016-03-08 Syneron Medical Ltd Electrical skin rejuvenation
WO2010111403A2 (en) 2009-03-25 2010-09-30 Proteus Biomedical, Inc. Probablistic pharmacokinetic and pharmacodynamic modeling
CN102458236B (en) * 2009-04-28 2016-01-27 普罗秋斯数字健康公司 The Ingestible event marker of high reliability and using method thereof
WO2010132331A2 (en) 2009-05-12 2010-11-18 Proteus Biomedical, Inc. Ingestible event markers comprising an ingestible component
WO2011005894A1 (en) * 2009-07-07 2011-01-13 Naya Touch, Inc. Dermal roller with therapeutic microstructures
US8558563B2 (en) 2009-08-21 2013-10-15 Proteus Digital Health, Inc. Apparatus and method for measuring biochemical parameters
TWI517050B (en) 2009-11-04 2016-01-11 普羅托斯數位健康公司 System for supply chain management
US9770560B2 (en) 2009-11-12 2017-09-26 Pourang Bral Means and method to administer injections with little or no pain
US10226586B2 (en) 2011-05-26 2019-03-12 Pourang Bral Means and method to painlessly puncture skin
US10973994B2 (en) 2013-09-16 2021-04-13 Pourang Bral Means and method to invade skin, mucosa, and underlying tissues with little or no pain
UA109424C2 (en) 2009-12-02 2015-08-25 PHARMACEUTICAL PRODUCT, PHARMACEUTICAL TABLE WITH ELECTRONIC MARKER AND METHOD OF MANUFACTURING PHARMACEUTICAL TABLETS
US20110172659A1 (en) * 2010-01-13 2011-07-14 Vivant Medical, Inc. Ablation Device With User Interface at Device Handle, System Including Same, and Method of Ablating Tissue Using Same
JP5841951B2 (en) 2010-02-01 2016-01-13 プロテウス デジタル ヘルス, インコーポレイテッド Data collection system
WO2011127252A2 (en) 2010-04-07 2011-10-13 Proteus Biomedical, Inc. Miniature ingestible device
TWI557672B (en) 2010-05-19 2016-11-11 波提亞斯數位康健公司 Computer system and computer-implemented method to track medication from manufacturer to a patient, apparatus and method for confirming delivery of medication to a patient, patient interface device
JP2014504902A (en) 2010-11-22 2014-02-27 プロテウス デジタル ヘルス, インコーポレイテッド Ingestible device with medicinal product
US9439599B2 (en) 2011-03-11 2016-09-13 Proteus Digital Health, Inc. Wearable personal body associated device with various physical configurations
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
WO2015112603A1 (en) 2014-01-21 2015-07-30 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
BR112014001397A2 (en) 2011-07-21 2017-02-21 Proteus Biomedical Inc device, system and method of mobile communication
JP5963412B2 (en) * 2011-09-14 2016-08-03 日立マクセル株式会社 Beauty equipment
US9235683B2 (en) 2011-11-09 2016-01-12 Proteus Digital Health, Inc. Apparatus, system, and method for managing adherence to a regimen
LT3677252T (en) 2012-03-19 2023-10-10 Cidara Therapeutics, Inc. Dosing regimens for echinocandin class compounds
BR112014027514A2 (en) 2012-05-07 2017-06-27 Koninklijke Philips Nv method of treating a raised aspect of skin tissue in mammalian skin tissue; system for treating radiofrequency energy skin tissue; and roll for a system
DE102012209008B4 (en) * 2012-05-29 2015-02-05 Wellcomet Gmbh Apparatus for generating treatment waves
WO2014018454A1 (en) 2012-07-23 2014-01-30 Proteus Digital Health, Inc. Techniques for manufacturing ingestible event markers comprising an ingestible component
JP5580383B2 (en) * 2012-10-05 2014-08-27 株式会社 資生堂 Beauty device, energization method and recording medium
JP5869736B2 (en) 2012-10-18 2016-02-24 プロテウス デジタル ヘルス, インコーポレイテッド Apparatus, system, and method for adaptively optimizing power dissipation and broadcast power in a power supply for a communication device
US20140194949A1 (en) * 2013-01-04 2014-07-10 Brian D. Wichner Multiplex Electrodes for Applying Transcutaneous Interferential Current
TWI659994B (en) 2013-01-29 2019-05-21 美商普羅托斯數位健康公司 Highly-swellable polymeric films and compositions comprising the same
WO2014151929A1 (en) 2013-03-15 2014-09-25 Proteus Digital Health, Inc. Personal authentication apparatus system and method
JP5941240B2 (en) 2013-03-15 2016-06-29 プロテウス デジタル ヘルス, インコーポレイテッド Metal detector device, system and method
JP6511439B2 (en) 2013-06-04 2019-05-15 プロテウス デジタル ヘルス, インコーポレイテッド Systems, devices, and methods for data collection and outcome assessment
US9210985B2 (en) 2013-06-19 2015-12-15 Gilad Arwatz Electromechanical system for dispensing deodorant / antiperspirant
US9908140B2 (en) 2013-06-19 2018-03-06 Gilad Arwatz Electromechanical system for dispensing a composition
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
AU2014321320B2 (en) 2013-09-20 2019-03-14 Otsuka Pharmaceutical Co., Ltd. Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping
WO2015044722A1 (en) 2013-09-24 2015-04-02 Proteus Digital Health, Inc. Method and apparatus for use with received electromagnetic signal at a frequency not known exactly in advance
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
JP6751351B2 (en) * 2014-05-02 2020-09-02 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. Device to inactivate bacteria
GB201415611D0 (en) * 2014-09-03 2014-10-15 Univ Strathclyde Apparatus for topical application of material
US9839644B2 (en) 2014-09-09 2017-12-12 ARKAY Therapeutics, LLC Formulations and methods for treatment of metabolic syndrome
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
FR3043333B1 (en) * 2015-11-06 2017-12-22 Seb Sa DEVICE FOR APPLYING A PRODUCT TO BE DISTRIBUTED ON THE SKIN OF AN IONTOPHORESIS USER COMPRISING MEANS FOR MEASURING ABSENCE OF PRODUCT AND CORRESPONDING METHOD
FR3043332B1 (en) * 2015-11-06 2019-05-10 Seb S.A. DEVICE FOR APPLYING A PRODUCT TO BE DISTRIBUTED ON THE SKIN OF A USER BY IONTOPHORESIS
EP3389486A1 (en) 2015-12-15 2018-10-24 Koninklijke Philips N.V. Surface treatment device and method
KR20210018961A (en) 2016-07-22 2021-02-18 프로테우스 디지털 헬스, 인코포레이티드 Electromagnetic sensing and detection of ingestible event markers
IL265827B2 (en) 2016-10-26 2023-03-01 Proteus Digital Health Inc Methods for manufacturing capsules with ingestible event markers
JP6445105B2 (en) * 2017-08-23 2018-12-26 マクセルホールディングス株式会社 Beauty system
WO2019043628A2 (en) * 2017-09-01 2019-03-07 Her Technologies, Inc. Skin rejuvenation device and method
CN114081499B (en) * 2021-11-23 2024-01-12 吉林大学 Flexible transparent surface myoelectric electrode with two gradient holes and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4175551A (en) * 1977-11-11 1979-11-27 Electromed Incorporated Electrical massage device
US5797966A (en) * 1996-03-20 1998-08-25 Seb S.A. Painless electric stimulation appliance and corresponding process
WO2001013989A1 (en) * 1999-08-25 2001-03-01 Johnson And Johnson Consumer Companies, Inc. Tissue electroperforation for drug delivery and diagnostic sampling

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4775361A (en) 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US4943290A (en) 1987-06-23 1990-07-24 Concept Inc. Electrolyte purging electrode tip
DE68925030T2 (en) 1988-01-21 1996-07-25 Massachusetts Inst Technology MOLECULE TRANSPORT THROUGH FABRICS WITH THE USE OF ELECTROPORATION.
CA2071321C (en) 1989-05-10 2000-12-12 Dan Sibalis Multi-signal electrical transdermal drug applicator
US5135478A (en) 1989-05-10 1992-08-04 Drug Delivery Systems Inc. Multi-signal electrical transdermal drug applicator
WO1992013265A1 (en) 1991-01-24 1992-08-06 The University Of Maryland Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
EP0694164A1 (en) 1991-05-03 1996-01-31 Joseph R. Lakowicz Method for optically measuring chemical analytes
US5196709A (en) 1991-05-03 1993-03-23 University Of Maryland Systems Fluorometry method and apparatus using a semiconductor laser diode as a light source
US5648269A (en) 1991-05-03 1997-07-15 Joseph R. Lakowicz pH and pCO2 sensing by luminescent lifetimes and energy transfer
US5421817A (en) 1991-05-21 1995-06-06 E.P., Inc. Non-intrusive analgesic neuroaugmentive and iontophoretic delivery apparatus and management system
US5571149A (en) 1991-05-21 1996-11-05 E.P., Inc. Non-intrusive analgesic neuroaugmentive and iontophoretic delivery apparatus and management system
US5203328A (en) 1991-07-17 1993-04-20 Georgia Tech Research Corporation Apparatus and methods for quantitatively measuring molecular changes in the ocular lens
US5281825A (en) 1991-09-05 1994-01-25 The University Of Maryland School Of Medicine Phase fluorometry using a modulated electroluminescent lamp as a light source
US5423803A (en) 1991-10-29 1995-06-13 Thermotrex Corporation Skin surface peeling process using laser
EP0615461B1 (en) 1991-12-03 1996-09-25 Alza Corporation Iontophoretic delivery device and power supply therefor
CA2084734C (en) 1991-12-17 1998-12-01 John L. Haynes Iontophoresis system having features for reducing skin irritation
US5902272A (en) 1992-01-07 1999-05-11 Arthrocare Corporation Planar ablation probe and method for electrosurgical cutting and ablation
US6142992A (en) 1993-05-10 2000-11-07 Arthrocare Corporation Power supply for limiting power in electrosurgery
US6210402B1 (en) 1995-11-22 2001-04-03 Arthrocare Corporation Methods for electrosurgical dermatological treatment
US6024733A (en) 1995-06-07 2000-02-15 Arthrocare Corporation System and method for epidermal tissue ablation
US5697882A (en) 1992-01-07 1997-12-16 Arthrocare Corporation System and method for electrosurgical cutting and ablation
US6159194A (en) 1992-01-07 2000-12-12 Arthrocare Corporation System and method for electrosurgical tissue contraction
US5246867A (en) 1992-01-17 1993-09-21 University Of Maryland At Baltimore Determination and quantification of saccharides by luminescence lifetimes and energy transfer
EP0552108B1 (en) 1992-01-17 1999-11-10 Lakowicz, Joseph R. Energy transfer phase-modulation fluoro-immunoassay
US5165418B1 (en) 1992-03-02 1999-12-14 Nikola I Tankovich Blood sampling device and method using a laser
US5232441A (en) 1992-05-18 1993-08-03 Physion S.R.L. Method of treating schistosomal infestations by iontophoresis
US5720772A (en) 1992-10-20 1998-02-24 Esc Medical Systems Ltd. Method and apparatus for therapeutic electromagnetic treatment
US5409835A (en) 1992-12-30 1995-04-25 The University Of Maryland At Baltimore Long-wavelength fluorescent probe compounds for calcium ions and their use in ratiometrically measuring calcium ion concentrations
US5380272A (en) 1993-01-28 1995-01-10 Scientific Innovations Ltd. Transcutaneous drug delivery applicator
JP2916736B2 (en) 1993-03-04 1999-07-05 宇部興産株式会社 Seed disinfectant
FR2703253B1 (en) 1993-03-30 1995-06-23 Centre Nat Rech Scient APPLICATOR OF ELECTRIC PULSES FOR TREATING BIOLOGICAL TISSUES.
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US6235020B1 (en) 1993-05-10 2001-05-22 Arthrocare Corporation Power supply and methods for fluid delivery in electrosurgery
US6117109A (en) 1995-11-22 2000-09-12 Arthrocare Corporation Systems and methods for electrosurgical incisions on external skin surfaces
US5445609A (en) 1993-05-28 1995-08-29 Alza Corporation Electrotransport agent delivery device having a disposable component and a removable liner
US5885211A (en) 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
US5458140A (en) 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
IL108775A (en) 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
US5660991A (en) 1994-10-28 1997-08-26 Lakowicz; Joseph R. Long lifetime anisotropy (polarization) probes for clinical chemistry, immunoassays, affinity assays and biomedical research
US5697896A (en) 1994-12-08 1997-12-16 Alza Corporation Electrotransport delivery device
US5628310A (en) 1995-05-19 1997-05-13 Joseph R. Lakowicz Method and apparatus to perform trans-cutaneous analyte monitoring
US5983130A (en) 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
US6238391B1 (en) 1995-06-07 2001-05-29 Arthrocare Corporation Systems for tissue resection, ablation and aspiration
US6041253A (en) 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US5983131A (en) 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
EP0858285A4 (en) 1995-08-29 2000-05-17 Spectrx Inc Microporation of human skin for drug delivery and monitoring applications
US5688232A (en) 1995-09-28 1997-11-18 Becton Dickinson And Company Iontophoretic drug delivery device having an improved controller
US6228078B1 (en) 1995-11-22 2001-05-08 Arthrocare Corporation Methods for electrosurgical dermatological treatment
US6090106A (en) 1996-01-09 2000-07-18 Gyrus Medical Limited Electrosurgical instrument
US6045502A (en) 1996-01-17 2000-04-04 Spectrx, Inc. Analyzing system with disposable calibration device
US5860421A (en) 1996-01-17 1999-01-19 Spectrx, Inc. Apparatus and method for calibrating measurement systems
US6002482A (en) 1996-01-17 1999-12-14 Spectrx, Inc. Disposable calibration device
US5792049A (en) 1996-01-17 1998-08-11 Spectrx, Inc. Spectroscopic system with disposable calibration device
US5924981A (en) 1996-01-17 1999-07-20 Spectrx, Inc. Disposable calibration target
DE69722414T2 (en) 1996-07-03 2004-05-19 Altea Therapeutics Corp. MULTIPLE MECHANICAL MICROPERFORATION OF SKIN OR MUCOSA
US5911223A (en) 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US5759767A (en) 1996-10-11 1998-06-02 Joseph R. Lakowicz Two-photon and multi-photon measurement of analytes in animal and human tissues and fluids
US6076012A (en) 1996-12-19 2000-06-13 Ep Technologies, Inc. Structures for supporting porous electrode elements
US5938657A (en) 1997-02-05 1999-08-17 Sahar Technologies, Inc. Apparatus for delivering energy within continuous outline
US6030399A (en) 1997-06-04 2000-02-29 Spectrx, Inc. Fluid jet blood sampling device and methods
US6009344A (en) 1997-07-25 1999-12-28 Becton, Dickinson And Company Iontophoretic drug delivery system
ATE221400T1 (en) 1997-12-11 2002-08-15 Alza Corp DEVICE FOR INCREASE THE TRANSDERMAL FLOW OF ACTIVE INGREDIENTS
DK1037686T3 (en) 1997-12-11 2006-01-02 Alza Corp Apparatus for enhancing transdermal flow of agents
US6055451A (en) 1997-12-12 2000-04-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
US6104952A (en) 1998-01-07 2000-08-15 Tu; Lily Chen Devices for treating canker sores, tissues and methods thereof
US6173202B1 (en) 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US6022316A (en) 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6088606A (en) 1999-03-22 2000-07-11 Spectrx, Inc. Method and apparatus for determining a duration of a medical condition
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4175551A (en) * 1977-11-11 1979-11-27 Electromed Incorporated Electrical massage device
US5797966A (en) * 1996-03-20 1998-08-25 Seb S.A. Painless electric stimulation appliance and corresponding process
WO2001013989A1 (en) * 1999-08-25 2001-03-01 Johnson And Johnson Consumer Companies, Inc. Tissue electroperforation for drug delivery and diagnostic sampling

Also Published As

Publication number Publication date
EP1502622A3 (en) 2005-06-08
US20040230227A1 (en) 2004-11-18
US6708060B1 (en) 2004-03-16
ATE434464T1 (en) 2009-07-15
DE60232747D1 (en) 2009-08-06
CA2445118A1 (en) 2002-10-31
EP1502622B1 (en) 2009-06-24
JP2004528901A (en) 2004-09-24
JP4262985B2 (en) 2009-05-13
US7164942B2 (en) 2007-01-16
AU2002307781B2 (en) 2007-01-25
WO2002085451A2 (en) 2002-10-31
EP1397178A2 (en) 2004-03-17
IL158582A0 (en) 2004-05-12
EP1502622A2 (en) 2005-02-02

Similar Documents

Publication Publication Date Title
WO2002085451A3 (en) Handheld apparatus for transdermal drug delivery and analyte extraction
WO2000053113A9 (en) Apparatus and method for treatment of tissue
IE800248L (en) Iontophoretic treatment apparatus.
ATE419897T1 (en) DEVICE FOR THE CONTROLLED DELIVERY OF AN ACTIVE SUBSTANCE INTO THE SKIN
WO2003089043A3 (en) Handheld transdermal drug delivery and analyte extraction
WO2000048644A3 (en) Systems and methods for shrinking collagen in the dermis
EP1955731A3 (en) Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
MXPA02011842A (en) Electrokinetic delivery device.
EP2357018A3 (en) Device for treatment of human or animal barrier membranes
WO2003026694A8 (en) Method and apparatus for treatment of viral infection
WO2007035710A3 (en) Electrokinetic delivery system and methods therefor
NZ627047A (en) Hand-held device for electrically assisted dermal treatment
WO2005023361A3 (en) Disposable electric bandage
MXPA06000291A (en) Methods of treating pores on the skin with electricity.
PT1843814E (en) Device for the transdermal stimulation of a nerve of the human body
MXPA05012823A (en) Method and apparatus for skin absorption enhancement and transdermal drug delivery of lidocaine and/or other drugs.
EP0378132A3 (en) A device for the administration of medication by iontopheresis for local - regional treatment.
EP2258443A3 (en) Dressing for tissue treatment
AU2002232775A1 (en) Compress garment facilitating the use of medical electrodes
AU2003226305A1 (en) Subcutaneous cardiac stimulator device with small contact surface electrodes
WO2006086063A3 (en) Apparatus and methods for forming lesions in tissue and applying stimulation energy to tissue in which lesions are formed
AU2426792A (en) Transdermal delivery device
EA200501751A1 (en) METHOD, DEVICE AND COMPOSITION FOR THE TREATMENT OF HEATING BULK
WO2004103455A3 (en) Selective nerve fiber stimulation for heart treatment
DE60219336D1 (en) DEVICE FOR IONTOPHORETIC ADMINISTRATION OF MEDICAMENTS THROUGH THE EYELID

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2445118

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 158582

Country of ref document: IL

Ref document number: 2002583024

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2002307781

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2002764094

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2002764094

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2002764094

Country of ref document: EP