WO2002088172A3 - Pentapeptide compounds and uses related thereto - Google Patents

Pentapeptide compounds and uses related thereto Download PDF

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Publication number
WO2002088172A3
WO2002088172A3 PCT/US2002/013435 US0213435W WO02088172A3 WO 2002088172 A3 WO2002088172 A3 WO 2002088172A3 US 0213435 W US0213435 W US 0213435W WO 02088172 A3 WO02088172 A3 WO 02088172A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
pentapeptide
disclosed
uses related
precursors
Prior art date
Application number
PCT/US2002/013435
Other languages
French (fr)
Other versions
WO2002088172B1 (en
WO2002088172A2 (en
Inventor
Svetlana Doronina
Peter D Senter
Brian E Toki
Original Assignee
Seattle Genetics Inc
Svetlana Doronina
Peter D Senter
Brian E Toki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/845,786 external-priority patent/US20030083263A1/en
Application filed by Seattle Genetics Inc, Svetlana Doronina, Peter D Senter, Brian E Toki filed Critical Seattle Genetics Inc
Priority to AU2002308515A priority Critical patent/AU2002308515C1/en
Priority to CA2445875A priority patent/CA2445875C/en
Priority to US10/476,391 priority patent/US7256257B2/en
Priority to EP02766852A priority patent/EP1390393A4/en
Priority to JP2002585470A priority patent/JP4095444B2/en
Publication of WO2002088172A2 publication Critical patent/WO2002088172A2/en
Publication of WO2002088172A3 publication Critical patent/WO2002088172A3/en
Publication of WO2002088172B1 publication Critical patent/WO2002088172B1/en
Priority to US11/451,147 priority patent/US7423116B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Pentapeptide compounds are disclosed. The compounds have biological activity, e.g., cytotoxicity. Prodrugs having targeting groups and pentapeptide moieties, as well as precursors thereof are also disclosed. For example, precursors having a reactive linker that can serve as a reaction site for joining to a targeting agent, e.g., an antibody, as disclosed.
PCT/US2002/013435 2001-04-30 2002-04-30 Pentapeptide compounds and uses related thereto WO2002088172A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2002308515A AU2002308515C1 (en) 2001-04-30 2002-04-30 Pentapeptide compounds and uses related thereto
CA2445875A CA2445875C (en) 2001-04-30 2002-04-30 Pentapeptide compounds and uses related thereto
US10/476,391 US7256257B2 (en) 2001-04-30 2002-04-30 Pentapeptide compounds and uses related thereto
EP02766852A EP1390393A4 (en) 2001-04-30 2002-04-30 Pentapeptide compounds and uses related thereto
JP2002585470A JP4095444B2 (en) 2001-04-30 2002-04-30 Pentapeptide compounds and uses related thereto
US11/451,147 US7423116B2 (en) 2001-04-30 2006-06-12 Pentapeptide compounds and uses related thereto

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/845,786 US20030083263A1 (en) 2001-04-30 2001-04-30 Pentapeptide compounds and uses related thereto
US09/845,786 2001-04-30
US10/001,191 2001-11-01
US10/001,191 US6884869B2 (en) 2001-04-30 2001-11-01 Pentapeptide compounds and uses related thereto

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/001,191 Continuation-In-Part US6884869B2 (en) 2001-04-30 2001-11-01 Pentapeptide compounds and uses related thereto

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10476391 A-371-Of-International 2002-04-30
US11/451,147 Division US7423116B2 (en) 2001-04-30 2006-06-12 Pentapeptide compounds and uses related thereto

Publications (3)

Publication Number Publication Date
WO2002088172A2 WO2002088172A2 (en) 2002-11-07
WO2002088172A3 true WO2002088172A3 (en) 2003-02-27
WO2002088172B1 WO2002088172B1 (en) 2003-06-19

Family

ID=26668695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/013435 WO2002088172A2 (en) 2001-04-30 2002-04-30 Pentapeptide compounds and uses related thereto

Country Status (6)

Country Link
US (2) US6884869B2 (en)
EP (1) EP1390393A4 (en)
JP (1) JP4095444B2 (en)
AU (1) AU2002308515C1 (en)
CA (1) CA2445875C (en)
WO (1) WO2002088172A2 (en)

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US7098308B2 (en) 2006-08-29

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