WO2002088736A3 - Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel - Google Patents

Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel Download PDF

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Publication number
WO2002088736A3
WO2002088736A3 PCT/FR2002/001505 FR0201505W WO02088736A3 WO 2002088736 A3 WO2002088736 A3 WO 2002088736A3 FR 0201505 W FR0201505 W FR 0201505W WO 02088736 A3 WO02088736 A3 WO 02088736A3
Authority
WO
WIPO (PCT)
Prior art keywords
foetus
maternal blood
genetic
prenatal diagnosis
diagnosis method
Prior art date
Application number
PCT/FR2002/001505
Other languages
English (en)
Other versions
WO2002088736A2 (fr
Inventor
Patrizia Paterlini-Brechot
Original Assignee
Metagenex S A R L
Patrizia Paterlini-Brechot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8862866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002088736(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Metagenex S A R L, Patrizia Paterlini-Brechot filed Critical Metagenex S A R L
Priority to AU2002314224A priority Critical patent/AU2002314224B2/en
Priority to EP02740785.7A priority patent/EP1383926B1/fr
Priority to ES02740785.7T priority patent/ES2543709T3/es
Priority to JP2002585985A priority patent/JP4404553B2/ja
Priority to CA2452099A priority patent/CA2452099C/fr
Publication of WO2002088736A2 publication Critical patent/WO2002088736A2/fr
Publication of WO2002088736A3 publication Critical patent/WO2002088736A3/fr
Priority to US10/695,744 priority patent/US7651838B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6879—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for sex determination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

Abstract

La présente invention est relative à une nouvelle méthode de diagnostic prénatal non-invasive mise en oeuvre à partir d'un échantillon de sang maternel. Ladite méthode permet le diagnostic prénatal sur cellules foetales, épithéliales, non apoptotiques isolées du sang maternel après leur enrichissement par filtration, leur analyse morphologique ou immunologique et génétique. Les avantages de cette méthode sont en particulier son innocuité pour la mère ou le foetus et la très grande sensibilité et spécificité du diagnostic. Elle permet la détection précoce d'une anomalie génétique ou chromosomique du foetus, d'une pathologie génétique ou infectieuse (virale, bactérienne ou parasitaire) du foetus, d'un génotype précis, et en particulier du sexe génétique du foetus.
PCT/FR2002/001505 2001-04-30 2002-04-30 Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel WO2002088736A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2002314224A AU2002314224B2 (en) 2001-04-30 2002-04-30 Prenatal diagnosis method on isolated foetal cell of maternal blood
EP02740785.7A EP1383926B1 (fr) 2001-04-30 2002-04-30 Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel
ES02740785.7T ES2543709T3 (es) 2001-04-30 2002-04-30 Procedimiento de diagnóstico prenatal en célula fetal aislada de sangre materna
JP2002585985A JP4404553B2 (ja) 2001-04-30 2002-04-30 単離された母体血液の胎児細胞に対する出生前診断の方法
CA2452099A CA2452099C (fr) 2001-04-30 2002-04-30 Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel
US10/695,744 US7651838B2 (en) 2001-04-30 2003-10-30 Prenatal diagnosis method on isolated foetal cell of maternal blood

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0105824A FR2824144B1 (fr) 2001-04-30 2001-04-30 Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel
FR01/05824 2001-04-30

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/695,744 Continuation US7651838B2 (en) 2001-04-30 2003-10-30 Prenatal diagnosis method on isolated foetal cell of maternal blood

Publications (2)

Publication Number Publication Date
WO2002088736A2 WO2002088736A2 (fr) 2002-11-07
WO2002088736A3 true WO2002088736A3 (fr) 2003-09-25

Family

ID=8862866

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/001505 WO2002088736A2 (fr) 2001-04-30 2002-04-30 Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel

Country Status (8)

Country Link
US (1) US7651838B2 (fr)
EP (1) EP1383926B1 (fr)
JP (1) JP4404553B2 (fr)
AU (1) AU2002314224B2 (fr)
CA (1) CA2452099C (fr)
ES (1) ES2543709T3 (fr)
FR (1) FR2824144B1 (fr)
WO (1) WO2002088736A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107502668A (zh) * 2017-09-23 2017-12-22 上海五色石医学研究股份有限公司 一种人Y染色体标签位点sY1291的检测方法及其应用

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EP1383926B1 (fr) 2015-05-06
CA2452099A1 (fr) 2002-11-07
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US20050049793A1 (en) 2005-03-03
FR2824144A1 (fr) 2002-10-31
JP4404553B2 (ja) 2010-01-27
AU2002314224B2 (en) 2007-08-02
EP1383926A2 (fr) 2004-01-28
FR2824144B1 (fr) 2004-09-17
WO2002088736A2 (fr) 2002-11-07
ES2543709T3 (es) 2015-08-21
US7651838B2 (en) 2010-01-26

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