WO2002092620A3 - Peptides and related molecules that bind to tall-1 - Google Patents

Peptides and related molecules that bind to tall-1 Download PDF

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Publication number
WO2002092620A3
WO2002092620A3 PCT/US2002/015273 US0215273W WO02092620A3 WO 2002092620 A3 WO2002092620 A3 WO 2002092620A3 US 0215273 W US0215273 W US 0215273W WO 02092620 A3 WO02092620 A3 WO 02092620A3
Authority
WO
WIPO (PCT)
Prior art keywords
tall
seq
domain
matter
vehicle
Prior art date
Application number
PCT/US2002/015273
Other languages
French (fr)
Other versions
WO2002092620A2 (en
Inventor
Hosung Min
Hailing Hsu
Fei Xiong
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MXPA03010210A priority Critical patent/MXPA03010210A/en
Priority to IL15871902A priority patent/IL158719A0/en
Application filed by Amgen Inc filed Critical Amgen Inc
Priority to KR1020037014672A priority patent/KR100902687B1/en
Priority to EEP200300552A priority patent/EE05294B1/en
Priority to CA2446189A priority patent/CA2446189C/en
Priority to SI200230645T priority patent/SI1385882T1/en
Priority to AU2002342669A priority patent/AU2002342669C1/en
Priority to SK1489-2003A priority patent/SK288175B6/en
Priority to NZ529267A priority patent/NZ529267A/en
Priority to DK02769739T priority patent/DK1385882T3/en
Priority to HU0700125A priority patent/HU229910B1/en
Priority to EP02769739A priority patent/EP1385882B9/en
Priority to BR0209546-7A priority patent/BR0209546A/en
Priority to DE60222882T priority patent/DE60222882T2/en
Priority to EA200301241A priority patent/EA010435B1/en
Priority to JP2002589503A priority patent/JP4516719B2/en
Publication of WO2002092620A2 publication Critical patent/WO2002092620A2/en
Publication of WO2002092620A3 publication Critical patent/WO2002092620A3/en
Priority to IL158719A priority patent/IL158719A/en
Priority to NO20034980A priority patent/NO331785B1/en
Priority to BG108349A priority patent/BG66270B1/en
Priority to HK04101344A priority patent/HK1059269A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

Abstract

The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4 wherein z2 is an amino acid residue and z4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae a?1a2a3CDa6La8a9a10Ca12a13a14¿ (SEQ.ID.NO:100), b?1b2b3Cb5b6Db8Lb10b11b12b13b14Cb16b17b18¿ (SEQ.ID.NO:104) c?1c2c3Cc5Dc7Lc9c10c11c12c13c14Cc16c17c18¿ (SEQ.ID.NO:105) d?1d2d3Cd5d6d7WDd10Ld13d14d15Cd16d17d18¿ (SEQ.ID.NO:106) e?1e2e3Ce5e6e7De9Le11Ke13Ce15e16e17e18¿ (SEQ.ID.NO:107) f?1f2f3Kf5Df7Lf9f10Qf12f13f14¿ (SEQ.ID NO:109) wherein the substituents are as defined in the specification. The invention further comprises compositions of matter of the formula (X1)a-V1-(X2)b wherein V1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.
PCT/US2002/015273 2001-05-11 2002-05-13 Peptides and related molecules that bind to tall-1 WO2002092620A2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
JP2002589503A JP4516719B2 (en) 2001-05-11 2002-05-13 Peptides binding to TALL-1 and related molecules
DK02769739T DK1385882T3 (en) 2001-05-11 2002-05-13 Peptides and related molecules that bind to TALL-1
KR1020037014672A KR100902687B1 (en) 2001-05-11 2002-05-13 Tall - 1 - binding composition
EEP200300552A EE05294B1 (en) 2001-05-11 2002-05-13 TALL-1 binding agent composition
CA2446189A CA2446189C (en) 2001-05-11 2002-05-13 Peptides and related molecules that bind to tall-1
SI200230645T SI1385882T1 (en) 2001-05-11 2002-05-13 Peptides and related molecules that bind to tall-1
AU2002342669A AU2002342669C1 (en) 2001-05-11 2002-05-13 Peptides and related molecules that bind to TALL-1
SK1489-2003A SK288175B6 (en) 2001-05-11 2002-05-13 Peptides and related molecules that bind to TALL-1
EP02769739A EP1385882B9 (en) 2001-05-11 2002-05-13 Peptides and related molecules that bind to tall-1
MXPA03010210A MXPA03010210A (en) 2001-05-11 2002-05-13 Peptides and related molecules that bind to tall-1.
HU0700125A HU229910B1 (en) 2001-05-11 2002-05-13 Peptides and related molecules that bind to tall-1
NZ529267A NZ529267A (en) 2001-05-11 2002-05-13 Peptides and related molecules that bind to tall-1
BR0209546-7A BR0209546A (en) 2001-05-11 2002-05-13 Composition of matter, DNA, expression vector, host cell, and methods for treating B-cell mediated autoimmune disease, lupus, B-cell mediated cancer, and B-cell lymphoma
DE60222882T DE60222882T2 (en) 2001-05-11 2002-05-13 PEPTIDES AND RELATED MOLECULES BINDING AT TALL-1
EA200301241A EA010435B1 (en) 2001-05-11 2002-05-13 Binding to tall-1 molecules and use thereof
IL15871902A IL158719A0 (en) 2001-05-11 2002-05-13 Peptides and related molecules that bind to tall-1
IL158719A IL158719A (en) 2001-05-11 2003-11-02 Tall-1 binding composition comprising an amino acid sequence, a dna encoding said composition, an expression vector comprising said dna and a host cell comprising said expression vector
NO20034980A NO331785B1 (en) 2001-05-11 2003-11-10 TALL-1 binding compound, DNA encoding the compound, expression vector comprising DNA, host cell comprising the expression vector and use of the compound for the manufacture of drug for the treatment of disease.
BG108349A BG66270B1 (en) 2001-05-11 2003-11-12 Compositions comprising peptides and related molecules that bind to tall-1
HK04101344A HK1059269A1 (en) 2001-05-11 2004-02-25 Peptides and related molecules that bind to tall-1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29019601P 2001-05-11 2001-05-11
US60/290,196 2001-05-11

Publications (2)

Publication Number Publication Date
WO2002092620A2 WO2002092620A2 (en) 2002-11-21
WO2002092620A3 true WO2002092620A3 (en) 2003-08-21

Family

ID=23114926

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/015273 WO2002092620A2 (en) 2001-05-11 2002-05-13 Peptides and related molecules that bind to tall-1

Country Status (30)

Country Link
US (5) US7259137B2 (en)
EP (4) EP1921088B1 (en)
JP (1) JP4516719B2 (en)
KR (1) KR100902687B1 (en)
CN (3) CN100448891C (en)
AT (2) ATE549354T1 (en)
AU (1) AU2002342669C1 (en)
BG (1) BG66270B1 (en)
BR (1) BR0209546A (en)
CA (1) CA2446189C (en)
CY (1) CY1107131T1 (en)
CZ (1) CZ304592B6 (en)
DE (1) DE60222882T2 (en)
DK (1) DK1385882T3 (en)
EA (1) EA010435B1 (en)
EE (1) EE05294B1 (en)
ES (3) ES2527471T3 (en)
HK (3) HK1059269A1 (en)
HU (1) HU229910B1 (en)
IL (2) IL158719A0 (en)
MX (1) MXPA03010210A (en)
NO (1) NO331785B1 (en)
NZ (2) NZ542878A (en)
PL (2) PL393317A1 (en)
PT (1) PT1385882E (en)
RS (1) RS51708B (en)
SI (1) SI1385882T1 (en)
SK (1) SK288175B6 (en)
WO (1) WO2002092620A2 (en)
ZA (1) ZA200308513B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7645861B2 (en) 2004-09-24 2010-01-12 Amgen Inc. Modified Fc molecules
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9382323B2 (en) 2009-04-02 2016-07-05 Roche Glycart Ag Multispecific antibodies comprising full length antibodies and single chain fab fragments

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812327B1 (en) * 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
US8212004B2 (en) * 1999-03-02 2012-07-03 Human Genome Sciences, Inc. Neutrokine-alpha fusion proteins
KR101287395B1 (en) * 2000-06-16 2014-11-04 휴먼 게놈 사이언시즈, 인코포레이티드 Antibodies that immunospecifically bind to BLyS
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
US20030091565A1 (en) * 2000-08-18 2003-05-15 Beltzer James P. Binding polypeptides and methods based thereon
EP2261246A3 (en) 2000-08-18 2011-07-13 Human Genome Sciences, Inc. Binding polypeptides for B-lymphocyte stimulator protein (BLyS)
UA83458C2 (en) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. The isolated polypeptide baff-r (the receptor of the factor of activation of b-cells of the family tnf)
ATE549354T1 (en) * 2001-05-11 2012-03-15 Amgen Inc PEPTIDES AND ASSOCIATED TALL-1 BINDING MOLECULES
US7112410B1 (en) 2001-08-29 2006-09-26 Human Genome Sciences, Inc. Human tumor necrosis factor TR21 and methods based thereon
WO2004060911A2 (en) 2002-12-30 2004-07-22 Amgen Inc. Combination therapy with co-stimulatory factors
AU2004233164B2 (en) 2003-03-28 2009-10-08 Biogen Ma Inc. Truncated BAFF receptors
ES2537738T3 (en) 2003-06-05 2015-06-11 Genentech, Inc. Combination therapy for B cell disorders
US7605120B2 (en) * 2003-10-22 2009-10-20 Amgen Inc. Antagonists of the brandykinin B1 receptor
AU2004315198A1 (en) 2004-01-29 2005-08-18 Genentech, Inc. Variants of the extracellular domain of BCMA and uses thereof
WO2005124342A2 (en) * 2004-06-21 2005-12-29 Galapagos N.V. Methods and means for treatment of osteoarthritis
CN100378122C (en) * 2004-12-03 2008-04-02 中国人民解放军第三军医大学 B lymphocyte stimulus factor inhibiting peptide and its screening and preparing method
CA2610839C (en) 2005-06-14 2019-06-25 Amgen Inc. Self-buffering protein formulations
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
NZ597082A (en) 2005-10-13 2013-11-29 Human Genome Sciences Inc Methods and Compositions for Use in Treatment of Patients with Autoantibody Positive Diseases
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
JP6088723B2 (en) 2005-11-23 2017-03-01 ジェネンテック， インコーポレイテッド Compositions and methods for B cell assays.
WO2007123765A2 (en) 2006-03-31 2007-11-01 Human Genome Sciences Inc. Neutrokine-alpha and neutrokine-alpha splice variant
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
WO2008051383A2 (en) * 2006-10-19 2008-05-02 Amgen Inc. Use of alcohol co-solvents to improve pegylation reaction yields
EP2162540A2 (en) 2007-05-22 2010-03-17 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
JP5570989B2 (en) * 2007-08-31 2014-08-13 アムジエン・インコーポレーテツド Solid protein formulation
AU2008304111B2 (en) 2007-09-27 2014-04-24 Amgen Inc. Pharmaceutical formulations
EP3381445B1 (en) 2007-11-15 2023-10-25 Amgen Inc. Aqueous formulation of antibody stablised by antioxidants for parenteral administration
WO2010075249A2 (en) 2008-12-22 2010-07-01 Genentech, Inc. A method for treating rheumatoid arthritis with b-cell antagonists
EP2396035A4 (en) * 2009-02-12 2012-09-12 Human Genome Sciences Inc Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance
US8734796B2 (en) 2009-03-20 2014-05-27 Amgen Inc. Carrier immunoglobulins
JP5996429B2 (en) 2009-09-03 2016-09-21 ジェネンテック， インコーポレイテッド Method for treatment, diagnosis and monitoring of rheumatoid arthritis
SG10201408401RA (en) 2009-09-16 2015-01-29 Genentech Inc Coiled coil and/or tether containing protein complexes and uses thereof
CA2778105C (en) 2009-10-23 2019-04-02 Amgen Inc. Vial adapter and system
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
MX346731B (en) 2010-04-23 2017-03-30 Genentech Inc * Production of heteromultimeric proteins.
KR102513760B1 (en) 2010-06-07 2023-03-27 암젠 인크 Drug delivery device
CN103154032A (en) 2010-08-13 2013-06-12 弗·哈夫曼-拉罗切有限公司 Antibodies to IL-1beta and IL-18, for treatment of disease
WO2012025530A1 (en) 2010-08-24 2012-03-01 F. Hoffmann-La Roche Ag Bispecific antibodies comprising a disulfide stabilized - fv fragment
WO2012040518A2 (en) 2010-09-22 2012-03-29 Amgen Inc. Carrier immunoglobulins and uses thereof
WO2012085111A1 (en) 2010-12-23 2012-06-28 F. Hoffmann-La Roche Ag Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
AR085138A1 (en) 2011-02-04 2013-09-11 Genentech Inc Fc VARIATIONS AND METHODS FOR PRODUCTION
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
JP6271254B2 (en) 2011-02-28 2018-01-31 ジェネンテック， インコーポレイテッド Methods for predicting biological markers and responses to B cell antagonists
AU2012236573B2 (en) 2011-03-31 2016-06-02 Amgen Inc. Vial adapter and system
CA3021845C (en) 2011-04-20 2022-03-29 Amgen Inc. Autoinjector apparatus
DE102012016127A1 (en) 2011-08-31 2013-02-28 Daniel Elias Error correction encoding apparatus for data stream, supplies one of m' mutually different synchronous words to each block in error correction information
WO2013055958A1 (en) 2011-10-11 2013-04-18 Genentech, Inc. Improved assembly of bispecific antibodies
ES2675035T3 (en) 2011-10-14 2018-07-05 Amgen, Inc Injector and assembly method
EP2809684A1 (en) 2012-01-31 2014-12-10 Genentech, Inc. Anti-ig-e m1' antibodies and methods using same
CA2861124A1 (en) 2012-02-10 2013-08-15 Genentech, Inc. Single-chain antibodies and other heteromultimers
WO2013148117A1 (en) 2012-03-27 2013-10-03 Ngm Biopharmaceuticals, Inc. Compositions and methods of use for treating metabolic disorders
CN104395339A (en) 2012-06-27 2015-03-04 弗·哈夫曼-拉罗切有限公司 Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof
RU2015100656A (en) 2012-06-27 2016-08-20 Ф. Хоффманн-Ля Рош Аг METHOD FOR PRODUCING ANTIBODY FC-FRAGMENT CONNECTING, INCLUDING AT LEAST ONE CONNECTING GROUP, WHICH SPECIALLY RELATED TO THE TARGET, AND THEIR APPLICATION
JP2015535464A (en) 2012-11-21 2015-12-14 アムジエン・インコーポレーテツド Drug delivery device
JP6272907B2 (en) 2013-01-30 2018-01-31 エヌジーエム バイオファーマシューティカルズ インコーポレイテッド Compositions and methods of use in the treatment of metabolic disorders
US9161966B2 (en) 2013-01-30 2015-10-20 Ngm Biopharmaceuticals, Inc. GDF15 mutein polypeptides
JOP20140087B1 (en) 2013-03-13 2021-08-17 Amgen Inc Proteins specific for baff and b7rp1 and uses thereof
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
US10092703B2 (en) 2013-03-15 2018-10-09 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
CA2904661C (en) 2013-03-15 2022-03-15 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
JP6670740B2 (en) 2013-03-22 2020-03-25 アムジエン・インコーポレーテツド Injector and assembly method
US9765166B2 (en) 2013-10-17 2017-09-19 The Nippon Synthetic Chemical Industry Co., Ltd. Crosslinkable polymer
AU2014340174B2 (en) 2013-10-24 2019-09-12 Amgen Inc. Drug delivery system with temperature-sensitive control
KR102458637B1 (en) 2013-10-24 2022-10-24 암겐 인코포레이티드 Injector and method of assembly
WO2015119906A1 (en) 2014-02-05 2015-08-13 Amgen Inc. Drug delivery system with electromagnetic field generator
EP3140392B1 (en) 2014-05-06 2023-07-26 F. Hoffmann-La Roche AG Production of heteromultimeric proteins using mammalian cells
JP6640113B2 (en) 2014-05-07 2020-02-05 アムジエン・インコーポレーテツド Auto-injector with impact reducing element
JP6822843B2 (en) 2014-06-03 2021-01-27 アムジエン・インコーポレーテツド Systems and methods for remotely processing data collected by drug delivery devices
MX370115B (en) 2014-07-30 2019-12-02 Ngm Biopharmaceuticals Inc Compositions and methods of use for treating metabolic disorders.
CA2957960C (en) 2014-10-14 2023-08-22 Amgen, Inc. Drug injection device with visual and audible indicators
MX357994B (en) 2014-10-31 2018-08-01 Ngm Biopharmaceuticals Inc COMPOSITIONS and METHODS OF USE FOR TREATING METABOLIC DISORDERS.
CN107001482B (en) 2014-12-03 2021-06-15 豪夫迈·罗氏有限公司 Multispecific antibodies
WO2016100055A1 (en) 2014-12-19 2016-06-23 Amgen Inc. Drug delivery device with live button or user interface field
JP6716566B2 (en) 2014-12-19 2020-07-01 アムジエン・インコーポレーテツド Drug delivery device with proximity sensor
EP3258988B1 (en) 2015-02-17 2019-08-28 Amgen Inc. Drug delivery device with vacuum assisted securement and/or feedback
ES2905870T3 (en) 2015-02-27 2022-04-12 Amgen Inc Drug delivery device having a needle guard mechanism with an adjustable threshold resistance to movement of the needle guard
HRP20231544T1 (en) 2015-08-13 2024-03-15 Amgen Inc. Charged depth filtration of antigen-binding proteins
WO2017039786A1 (en) 2015-09-02 2017-03-09 Amgen Inc. Syringe assembly adapter for a syringe
WO2017100501A1 (en) 2015-12-09 2017-06-15 Amgen Inc. Auto-injector with signaling cap
US11154661B2 (en) 2016-01-06 2021-10-26 Amgen Inc. Auto-injector with signaling electronics
WO2017160799A1 (en) 2016-03-15 2017-09-21 Amgen Inc. Reducing probability of glass breakage in drug delivery devices
JP7021099B2 (en) 2016-03-31 2022-02-18 エヌジーエム バイオファーマシューティカルス，インコーポレーテッド Bound protein and how to use it
US11541168B2 (en) 2016-04-29 2023-01-03 Amgen Inc. Drug delivery device with messaging label
WO2017192287A1 (en) 2016-05-02 2017-11-09 Amgen Inc. Syringe adapter and guide for filling an on-body injector
AU2017263558B2 (en) 2016-05-13 2022-12-22 Amgen Inc. Vial sleeve assembly
WO2017200989A1 (en) 2016-05-16 2017-11-23 Amgen Inc. Data encryption in medical devices with limited computational capability
US11541176B2 (en) 2016-06-03 2023-01-03 Amgen Inc. Impact testing apparatuses and methods for drug delivery devices
EP3478342A1 (en) 2016-07-01 2019-05-08 Amgen Inc. Drug delivery device having minimized risk of component fracture upon impact events
WO2018034784A1 (en) 2016-08-17 2018-02-22 Amgen Inc. Drug delivery device with placement detection
EP3532127A1 (en) 2016-10-25 2019-09-04 Amgen Inc. On-body injector
MX2019008432A (en) 2017-01-17 2019-11-18 Amgen Inc Injection devices and related methods of use and assembly.
CA3048520A1 (en) 2017-02-17 2018-08-23 Amgen Inc. Drug delivery device with sterile fluid flowpath and related method of assembly
AU2018221351B2 (en) 2017-02-17 2023-02-23 Amgen Inc. Insertion mechanism for drug delivery device
EP3592403A1 (en) 2017-03-06 2020-01-15 Amgen Inc. Drug delivery device with activation prevention feature
JP2020509839A (en) 2017-03-07 2020-04-02 アムジエン・インコーポレーテツド Needle insertion due to overpressure
KR20240005194A (en) 2017-03-09 2024-01-11 암겐 인코포레이티드 Insertion mechanism for drug delivery device
KR102517342B1 (en) 2017-03-28 2023-03-31 암겐 인코포레이티드 Plunger rod and syringe assembly systems and methods
CN111344304B (en) 2017-06-01 2023-09-01 Pb免疫治疗公司 Novel anti-CD 40 antibodies and uses thereof
EP3634539A1 (en) 2017-06-08 2020-04-15 Amgen Inc. Syringe assembly for a drug delivery device and method of assembly
AU2018282077B2 (en) 2017-06-08 2023-11-23 Amgen Inc. Torque driven drug delivery device
MX2019015472A (en) 2017-06-22 2020-02-19 Amgen Inc Device activation impact/shock reduction.
MA49461A (en) 2017-06-23 2020-04-29 Amgen Inc ELECTRONIC DRUG DELIVERY DEVICE INCLUDING A CAP ACTIVATED BY A SWITCH ASSEMBLY
IL270784B2 (en) 2017-07-14 2023-11-01 Amgen Inc Needle insertion-retraction system having dual torsion spring system
IL271173B1 (en) 2017-07-21 2023-12-01 Amgen Inc Gas permeable sealing member for drug container and methods of assembly
WO2019022950A1 (en) 2017-07-25 2019-01-31 Amgen Inc. Drug delivery device with container access system and related method of assembly
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EP3664863A2 (en) 2017-08-09 2020-06-17 Amgen Inc. Hydraulic-pneumatic pressurized chamber drug delivery system
US11077246B2 (en) 2017-08-18 2021-08-03 Amgen Inc. Wearable injector with sterile adhesive patch
US11103636B2 (en) 2017-08-22 2021-08-31 Amgen Inc. Needle insertion mechanism for drug delivery device
EP3691717B1 (en) 2017-10-04 2023-02-08 Amgen Inc. Flow adapter for drug delivery device
WO2019070552A1 (en) 2017-10-06 2019-04-11 Amgen Inc. Drug delivery device with interlock assembly and related method of assembly
EP3694578A1 (en) 2017-10-09 2020-08-19 Amgen Inc. Drug delivery device with drive assembly and related method of assembly
MA50528A (en) 2017-11-03 2020-09-09 Amgen Inc SYSTEMS AND APPROACHES TO STERILIZE A DRUG DELIVERY DEVICE
EP3707075A1 (en) 2017-11-06 2020-09-16 Amgen Inc. Fill-finish assemblies and related methods
JP2021501616A (en) 2017-11-06 2021-01-21 アムジエン・インコーポレーテツド Drug delivery device with placement and flow detection
EP3706826A1 (en) 2017-11-10 2020-09-16 Amgen Inc. Plungers for drug delivery devices
WO2019099322A1 (en) 2017-11-16 2019-05-23 Amgen Inc. Autoinjector with stall and end point detection
MX2020004996A (en) 2017-11-16 2020-08-27 Amgen Inc Door latch mechanism for drug delivery device.
US10835685B2 (en) 2018-05-30 2020-11-17 Amgen Inc. Thermal spring release mechanism for a drug delivery device
US11083840B2 (en) 2018-06-01 2021-08-10 Amgen Inc. Modular fluid path assemblies for drug delivery devices
WO2020023336A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Hybrid drug delivery devices with grip portion
WO2020023444A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Delivery devices for administering drugs
US20210260279A1 (en) 2018-07-24 2021-08-26 Amgen Inc. Hybrid drug delivery devices with optional grip portion and related method of preparation
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JP2022500095A (en) 2018-09-24 2022-01-04 アムジエン・インコーポレーテツド Intervention dosing system and method
AU2019350660A1 (en) 2018-09-28 2021-03-18 Amgen Inc. Muscle wire escapement activation assembly for a drug delivery device
JP2022503983A (en) 2018-10-02 2022-01-12 アムジエン・インコーポレーテツド Injection system for drug delivery with internal force transmission
CA3112214A1 (en) 2018-10-05 2020-04-09 Amgen Inc. Drug delivery device having dose indicator
WO2020081479A1 (en) 2018-10-15 2020-04-23 Amgen Inc. Drug delivery device having damping mechanism
EA202191038A1 (en) 2018-10-15 2021-07-06 Эмджен Инк. METHOD OF PLATFORM ASSEMBLY FOR MEDICINE DELIVERY DEVICE
US11213620B2 (en) 2018-11-01 2022-01-04 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
US20220031953A1 (en) 2018-11-01 2022-02-03 Amgen Inc. Drug delivery devices with partial needle retraction
EP3873563A1 (en) 2018-11-01 2021-09-08 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
MX2021012557A (en) 2019-04-24 2021-11-12 Amgen Inc Syringe sterilization verification assemblies and methods.
US20220273887A1 (en) 2019-08-23 2022-09-01 Amgen Inc. Drug delivery device with configurable needle shield engagement components and related methods
CA3217207A1 (en) 2021-05-21 2022-11-24 Amgen Inc. Method of optimizing a filling recipe for a drug container

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3691016A (en) 1970-04-17 1972-09-12 Monsanto Co Process for the preparation of insoluble enzymes
CA1023287A (en) 1972-12-08 1977-12-27 Boehringer Mannheim G.M.B.H. Process for the preparation of carrier-bound proteins
US3941763A (en) 1975-03-28 1976-03-02 American Home Products Corporation PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
US4195128A (en) 1976-05-03 1980-03-25 Bayer Aktiengesellschaft Polymeric carrier bound ligands
US4330440A (en) 1977-02-08 1982-05-18 Development Finance Corporation Of New Zealand Activated matrix and method of activation
CA1093991A (en) 1977-02-17 1981-01-20 Hideo Hirohara Enzyme immobilization with pullulan gel
US4229537A (en) 1978-02-09 1980-10-21 New York University Preparation of trichloro-s-triazine activated supports for coupling ligands
US4289872A (en) 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4710473A (en) 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
JP2876058B2 (en) 1986-08-18 1999-03-31 エミスフィア・テクノロジーズ・インコーポレイテッド Drug delivery system
US5229490A (en) 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
EP0315456B1 (en) 1987-11-05 1994-06-01 Hybritech Incorporated Polysaccharide-modified immunoglobulins having reduced immunogenic potential or improved pharmacokinetics
US6018026A (en) 1988-01-22 2000-01-25 Zymogenetics, Inc. Biologically active dimerized and multimerized polypeptide fusions
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
NZ241954A (en) 1991-03-15 1994-01-26 Amgen Inc Compositions of g-csf for pulmonary administration.
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5733731A (en) 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
CA2118130A1 (en) 1992-04-14 1993-10-28 Jean M. J. Frechet Dendritic based macromolecules and method of production
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5417972A (en) * 1993-08-02 1995-05-23 The Board Of Trustees Of The Leland Stanford Junior University Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM
US5470952A (en) 1993-10-20 1995-11-28 Regeneron Pharmaceuticals, Inc. CNTF and IL-6 antagonists
US5922545A (en) 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
DE4435919C1 (en) 1994-10-07 1995-12-07 Deutsches Krebsforsch DNA encoding zinc finger protein
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
US6127977A (en) 1996-11-08 2000-10-03 Cohen; Nathan Microstrip patch antenna with fractal structure
ATE279947T1 (en) 1996-03-18 2004-11-15 Univ Texas IMMUNOGLOBULIN-LIKE DOMAIN WITH INCREASED HALF-LIFE TIMES
AU4474497A (en) 1996-10-08 1998-05-05 U-Bisys B.V. Methods and means for selecting peptides and proteins having specific affinity for a target
US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
JP2001503263A (en) 1996-10-25 2001-03-13 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド Neutrokine α
AU5705898A (en) 1996-12-17 1998-07-15 Schering Corporation Mammalian cell surface antigens; related reagents
US5969102A (en) 1997-03-03 1999-10-19 St. Jude Children's Research Hospital Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
CA2232743A1 (en) 1997-04-02 1998-10-02 Smithkline Beecham Corporation A tnf homologue, tl5
IL133315A0 (en) 1997-06-06 2001-04-30 Regeneron Pharma Ntn-2 member of tnf ligand family
WO1998055621A1 (en) 1997-06-06 1998-12-10 Regeneron Pharmaceuticals, Inc. Ntn-2 member of tnf ligand family
WO1999011791A2 (en) 1997-09-05 1999-03-11 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
EA200000311A1 (en) 1997-09-12 2000-10-30 Апотек Р Энд Д Са NEW PROTEIN IMMUNE SYSTEM - KAU
AU2212299A (en) 1998-01-05 1999-07-26 Genentech Inc. Compositions and methods for the treatment of tumor
WO1999062951A1 (en) * 1998-06-04 1999-12-09 Shanghai Second Medical University A human zinc finger protein gene (bmzf3)
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
ATE453712T1 (en) 1999-01-07 2010-01-15 Zymogenetics Inc METHOD FOR THERAPEUTIC USE OF SOLUBLE RECEPTORS BR43X2
US20030095967A1 (en) 1999-01-25 2003-05-22 Mackay Fabienne BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
ES2204528T3 (en) 1999-01-25 2004-05-01 Biogen, Inc. BAFF, ITS INHIBITORS AND THEIR USE IN THE MODULATION OF THE CELL RESPONSE B.
WO2000047740A2 (en) 1999-02-12 2000-08-17 Amgen Inc. Tnf-related proteins
US20030022233A1 (en) 1999-04-30 2003-01-30 Raymond G. Goodwin Methods of use of the taci/taci-l interaction
US6475987B1 (en) 1999-05-06 2002-11-05 National Jewish Medical And Research Center Tall-1 receptor homologues
CA2377731A1 (en) 1999-07-02 2001-01-11 Genentech, Inc. Fusion peptides comprising a peptide ligand domain and a multimerization domain
MXPA02007574A (en) 2000-02-11 2002-12-13 Amgen Inc Receptor from tnf family.
US20030091565A1 (en) 2000-08-18 2003-05-15 Beltzer James P. Binding polypeptides and methods based thereon
EP2261246A3 (en) 2000-08-18 2011-07-13 Human Genome Sciences, Inc. Binding polypeptides for B-lymphocyte stimulator protein (BLyS)
ATE549354T1 (en) * 2001-05-11 2012-03-15 Amgen Inc PEPTIDES AND ASSOCIATED TALL-1 BINDING MOLECULES
AR035119A1 (en) 2001-08-16 2004-04-14 Lilly Co Eli ANTI-HTNFSF13B HUMAN ANTI-BODIES
WO2004060911A2 (en) * 2002-12-30 2004-07-22 Amgen Inc. Combination therapy with co-stimulatory factors
CA2572765C (en) * 2004-07-08 2013-05-21 Amgen Inc. Compound having improved bioefficiency when administered in a multidose regimen
US8008453B2 (en) * 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2008069180A1 (en) 2006-12-05 2008-06-12 Kabushiki Kaisha Kobe Seiko Sho High-strength aluminum alloy plate for printing plate
US9458246B2 (en) * 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
JOP20140087B1 (en) * 2013-03-13 2021-08-17 Amgen Inc Proteins specific for baff and b7rp1 and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KHARE ET AL.: "Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenis mice", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 7, 28 March 2000 (2000-03-28), pages 3370 - 3375, XP002142253 *
SHU H.-B. ET AL.: "B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 16, 1 August 2000 (2000-08-01), pages 9156 - 9161, XP002160851 *

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7645861B2 (en) 2004-09-24 2010-01-12 Amgen Inc. Modified Fc molecules
US7655764B2 (en) 2004-09-24 2010-02-02 Amgen Inc. Modified Fc molecules
US7655765B2 (en) 2004-09-24 2010-02-02 Amgen Inc. Modified Fc molecules
US7662931B2 (en) 2004-09-24 2010-02-16 Amgen Inc. Modified Fc molecules
US7750128B2 (en) 2004-09-24 2010-07-06 Amgen Inc. Modified Fc molecules
US7750127B2 (en) 2004-09-24 2010-07-06 Amgen Inc. Modified Fc molecules
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9114175B2 (en) 2005-08-12 2015-08-25 Amgen Inc. Modified Fc molecules
US9382323B2 (en) 2009-04-02 2016-07-05 Roche Glycart Ag Multispecific antibodies comprising full length antibodies and single chain fab fragments

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