WO2002093127A3 - Methods and reagents for identifying insulin response modulators and therapeutic uses therefor - Google Patents

Methods and reagents for identifying insulin response modulators and therapeutic uses therefor Download PDF

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Publication number
WO2002093127A3
WO2002093127A3 PCT/US2002/015206 US0215206W WO02093127A3 WO 2002093127 A3 WO2002093127 A3 WO 2002093127A3 US 0215206 W US0215206 W US 0215206W WO 02093127 A3 WO02093127 A3 WO 02093127A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
reagents
insulin response
therapeutic uses
uses therefor
Prior art date
Application number
PCT/US2002/015206
Other languages
French (fr)
Other versions
WO2002093127A2 (en
Inventor
Cydney C Brooks
Original Assignee
Adipogenix Inc
Takeda Chemical Industries Ltd
Cydney C Brooks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adipogenix Inc, Takeda Chemical Industries Ltd, Cydney C Brooks filed Critical Adipogenix Inc
Priority to AU2002259209A priority Critical patent/AU2002259209A1/en
Publication of WO2002093127A2 publication Critical patent/WO2002093127A2/en
Publication of WO2002093127A3 publication Critical patent/WO2002093127A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Abstract

Methods of identifying insulin response modulators are provided. In particular, methods that feature identifying modulators of insulin-responsive aminopeptidase (IRAP) and insulin-degrading enzyme (IDE), or activities associated therewith, are provided. Therapeutic methods utilizing compounds identified according to the methods of the invention are also provided.
PCT/US2002/015206 2001-05-11 2002-05-13 Methods and reagents for identifying insulin response modulators and therapeutic uses therefor WO2002093127A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002259209A AU2002259209A1 (en) 2001-05-11 2002-05-13 Methods and reagents for identifying insulin response modulators and therapeutic uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29049401P 2001-05-11 2001-05-11
US60/290,494 2001-05-11

Publications (2)

Publication Number Publication Date
WO2002093127A2 WO2002093127A2 (en) 2002-11-21
WO2002093127A3 true WO2002093127A3 (en) 2004-09-23

Family

ID=23116257

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/015206 WO2002093127A2 (en) 2001-05-11 2002-05-13 Methods and reagents for identifying insulin response modulators and therapeutic uses therefor

Country Status (2)

Country Link
AU (1) AU2002259209A1 (en)
WO (1) WO2002093127A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008332B2 (en) 2006-05-31 2011-08-30 Takeda San Diego, Inc. Substituted indazoles as glucokinase activators
US8034822B2 (en) 2006-03-08 2011-10-11 Takeda San Diego, Inc. Glucokinase activators
US8124617B2 (en) 2005-09-01 2012-02-28 Takeda San Diego, Inc. Imidazopyridine compounds
US8163779B2 (en) 2006-12-20 2012-04-24 Takeda San Diego, Inc. Glucokinase activators
US8173645B2 (en) 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006128026A2 (en) * 2005-05-26 2006-11-30 The United States Of America As Represented By Thesecretary, Dept. Of Health And Human Services National Institutes Of Health Cellular receptor for varicella-zoster virus, methods of inhibiting spread of varicella-zoster and methods of increasing stability and infectivity of the virus
WO2021149040A1 (en) * 2020-01-22 2021-07-29 Ramot At Tel-Aviv University Ltd. Anti-ide antibodies and uses of same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012544A2 (en) * 1998-08-26 2000-03-09 Trustees Of Boston University Novel irap-bp polypeptide and nucleic acid molecules and uses therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012544A2 (en) * 1998-08-26 2000-03-09 Trustees Of Boston University Novel irap-bp polypeptide and nucleic acid molecules and uses therefor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LAUSTEN ET AL: "Mutational analysis of the active site of human insulin-regulated aminopeptidase", EUR. J. BIOCHEM., vol. 268, no. 1, January 2001 (2001-01-01), pages 98 - 104, XP002978918 *
RASMUSSEN ET AL: "Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21", EUR. J. BIOCHEM., vol. 267, no. 8, April 2000 (2000-04-01), pages 2297 - 2306, XP002978919 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8124617B2 (en) 2005-09-01 2012-02-28 Takeda San Diego, Inc. Imidazopyridine compounds
US8034822B2 (en) 2006-03-08 2011-10-11 Takeda San Diego, Inc. Glucokinase activators
US8008332B2 (en) 2006-05-31 2011-08-30 Takeda San Diego, Inc. Substituted indazoles as glucokinase activators
US8394843B2 (en) 2006-05-31 2013-03-12 Takeda California, Inc. Substituted isoindoles as glucokinase activators
US8163779B2 (en) 2006-12-20 2012-04-24 Takeda San Diego, Inc. Glucokinase activators
US8173645B2 (en) 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators

Also Published As

Publication number Publication date
AU2002259209A1 (en) 2002-11-25
WO2002093127A2 (en) 2002-11-21

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