WO2002096484B1 - Apparatus and method for the optical imaging of tissue samples - Google Patents
Apparatus and method for the optical imaging of tissue samplesInfo
- Publication number
- WO2002096484B1 WO2002096484B1 PCT/US2002/017202 US0217202W WO02096484B1 WO 2002096484 B1 WO2002096484 B1 WO 2002096484B1 US 0217202 W US0217202 W US 0217202W WO 02096484 B1 WO02096484 B1 WO 02096484B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fiber arrangement
- optical
- collection
- delivery
- director
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
Abstract
A catheter based optical system (10) for generating data as to the condition of a tissue sample of a mammalian vessel (W). The system includes an elongated catheter shaft (16) having a tissue engaging distal end (18) and a coupled proximal end (20) and an elongated optical delivery fiber arrangement (24) disposed through a lumen of said catheter (16), said optical delivery fiber arrangement (24) having a distal end (28) and a proximal end (32). The distal end of the delivery fiber arrangement (28) has a re-director light emitter (30) thereon for directing light against mammalian tissues (W). An elongated optical collection fiber arrangement (26) is disposed through a lumen of the catheter (16), the optical collection fiber arrangement (26) having distal end (34) and a proximal most end (36). The distal end of the collection fiber arrangement (34) has a re-director light receiver (30) thereon for receiving light reflected from the mammalian tissue (W) by the light emitter (30). The light emitter (42) and the light receiver (40) are longitudinally space (d) apart from one another in the distal end of the catheter (18). The catheter apparatus includes a light source (12) in communication with the delivery fiber (24) and a signal (50) in communication with the receiving fiber (26) for receiving and presenting data collected.
Claims
1. A system for spectroscopic analysis of tissue, the system comprising:
a catheter defining a lumen extending therethrough;
5 an optical delivery fiber arrangement extending through the lumen;
a delivery re-director disposed at a distal end of the delivery fiber arrangement for directing light from the delivery fiber arrangement against the tissue;
10 an optical collection fiber arrangement extending through the lumen
a collection re-director disposed at a distal end of the collection fiber arrangement for receiving light from the tissue and directing the received light into the collection 15 fiber arrangement, the collection re-director being separated from the delivery re-director.
2. The system of claim 1 , further comprising
a light source in communication with the delivery fiber arrangement, and
20 a signal detector in communication with the collection fiber arrangement.
3. The system of claim 1 , wherein the delivery fiber arrangement and the collection fiber arrangement are configured to rotate about a common longitudinal axis within the catheter.
25
32
4 The system of claim 1 , wherein the delivery fiber arrangement and the
collection fiber arrangement have different diameters.
5. The system of claim 2, further comprising a rotary optical coupler
arranged between the light source and the delivery fiber arrangement.
6. The system of claim 2, further comprising a rotary optical coupler
arranged between the collection fiber arrangement and the signal detector.
7. The system of claim 1 wherein the delivery fiber arrangement and the
collection fiber arrangement form a coiled pair
8. The system of claim 1 wherein the delivery fiber arrangement
comprises a plurality of individual delivery fibers
9. The system of claim 1 ^ wherein the collection fiber arrangement comprises a plurality of individual collection fibers.
10. The system of claim 2, further comprising a rotary optical coupler arranged to direct light into the delivery fiber arrangement and to receive light from the collection fiber arrangement.
11. The system of claim 10, wherein the rotary optical coupler comprises a
33 beam splitter.
12. The system of claim 1 t wherein the delivery fiber arrangement and the receiving fiber arrangement are co-axial with respect to one another
13 The system of claim 12, further comprising a containing-cladding separating the delivery fiber arrangement and the collection fiber arrangement
14. The system of claim 13, wherein the containing-cladding longitudinally encloses the delivery fiber arrangement and the collection fiber arrangement,
15. The system of claim 2 further comprising an acousto-optic modulator that selectively provides optical communication to one of the collection fiber arrangement and the delivery fiber arrangement
16. The system of claim 1 , wherein the delivery re-director and the collection rc- director are spaced apan from one another in a longitudinal direction
17. The system of claim 1 , wherein the delivery re-director and the collection re-director are spaced apart from one another in a radial direction
18. A method for spectroscopic analysis of a sample of tissue within a vessel, the method comprising' inserting a catheter into the vessel,
placing an optical delivery fiber arrangement through a lumen of the catheter, the optical delivery fiber arrangement having a distal end in optical communication with a delivery re-director for directing light toward the tissue; arranging an optical collection fiber arrangement through the lumen, the optical collection fiber arrangement having a distal end in optical communication with a collection re- director for receiving light from the tissue, the collection re- director being spaced apart from the delivery re-director
passing light into the delivery fiber arrangement; and
detecting a signal indicative of light received by the collection fiber arrangement.
19. The method of claim 18, further comprising rotating the collection fiber arrangement and the delivery fiber arrangement about a common axis within the catheter.
20 The method of claim 19, wherein passing light into the delivery fiber arrangement and detecting a signal indicative of light received by the collection fiber comprise connecting the collection fiber arrangement and the delivery fiber arrangement to an optical slip ring,
21. The method of claim 20, further comprising twisting the delivery fiber arrangement and the collection fiber arrangement into a coil about one another.
22. The method of claim 20, further comprising placing the collection fiber arrangement and the delivery fiber arrangement co-axial with one another.
23. The method of claim 20, further comprising selecting the collection and delivery re-directors to be angled fiber members arranged at the distal ends of the collection fiber arrangement and the delivery fiber arrangement respectively.
24. The method of claim 20, further comprising selecting the optical slip
35 ring to include a rotating coupler in optical communication with the optical collection fiber arrangement and the optical deliver fiber arrangement
25. The method of claim 23, further comprising selecting the optical delivery fiber and the optical collection fiber to comprise a common fiber.
26. The method of claim 20, further comprising selecting the optical slip ring to include an acousto-optical modulator to selectively provide optical communication to one of the deliver fiber arrangement and the collection fiber arrangement.
27. The method of claim 26, further comprismg causing the acousto- optical modulator to split a source light beam into a pair of beams in a pair of optical fibers and to recombine a split beam into a common light beam for communication to a detector.
28. The method of claim 20, further comprising selecting the optical slip ring to include a rotatable polarizing beamsplitter in attached rotational conformance with the optical delivery fiber arrangement and the optical collection fiber arrangement.
29. The method of claim 28, further comprising selecting the rotatable polarizing beamsplitter to be in optical communication with a stationary polarizing beamsplitter for communication of a light beam to a signal detector.
30. The method of claim 20, further comprising selecting the delivered light beam and the collected light beam to be non co-linear
36
31 A catheter based optical system for generating data indicative of the condition of tissue of a vessel, the system comprising, a catheter defining a lumen;
an optical delivery fiber arrangement extending through a the lumen and configured to rotate about a longitudinal axis of the catheter;
a delivery re-director in optical communication with the optical delivery fiber arrangement, the delivery re-director disposed at a distal end of the optical delivery fiber arrangement for directing light against the tissue;
an optical collection fiber arrangement extending through a the lumen and configured to rotate about a longitudinal axis of the catheter, the optical collection fiber arrangement having a diameter that is different from a diameter of the optical delivery fiber arrangement,
a collection re-director in optical communication with the optical collection fiber arrangement, the collection re- director disposed at a distal end of the optical collection fiber arrangement for receiving light from the tissue, the collection re-director and the delivery re-director being longitudinally spaced apart from one another;
a light source in communication with the delivery fiber arrangement,
a signal detector in communication with the collection fiber arrangement for receiving and presenting the data; and
a rotary optical coupler disposed between the light source and the delivery fiber arrangement.
32. The system of claim 31 , wherein the rotary optical couplei is disposed
37 between the collection fiber arrangement and the signal detector.
33 A method of generating data indicative of a condition of tissue, the method comprising: inserting, into a catheter, an optical delivery fiber having a distal end coupled to a delivery re-director,
inserting, into the catheter, an optical collection fiber having a distal end coupled to a collection re-director;
attaching a rotary optical pickup to proximal ends of each of the fibers to provide optical communication therewith;
attaching a light source to the rotary optical pickup to provide optical communication between the light source and the delivery re-director;
inserting the catheter into a vessel;
energizing the light source to provide light through the delivery fiber to the delivery re-director and onto the tissue;
collecting light from the tissue into the collection re- director;
receiving the collected light through the rotary optical pickup; and
directing the received light into a signal detector for analysis of the tissue
34. The method of claim 33, further compπsing circumferentially scanning the vessel by rotating the delivery fiber and the collection fiber about a common axis.
35. The method of claim 33 , further comprising spacing the collection and
38 delivery re-directors apart by a longitudinal distance.
36. The method of claim 33, further comprising spacing the collection and delivery re-directors apart by a radial distance.
37. The method of claim 35, further comprising adjusting the longitudinal distance between-the collection and delivery re-directors by an adjustment arrangement at the proximal end of the catheter.
38. The method of claim 33, further comprising positioning the delivery fiber and the collection fiber to be co-axial, placing one of said optical fibers within the other of said fibers so as to effect a co-axial arrangement therebetween.
39. The method as recited in of claim 39, further comprising placing a containment layer between said the delivery fiber and the collection fiber optical fibers to prevent optical light exchange therebetween.
39
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002592992A JP4170771B2 (en) | 2001-05-31 | 2002-05-30 | Apparatus and method for optical imaging of tissue samples |
| AU2002305766A AU2002305766B2 (en) | 2001-05-31 | 2002-05-30 | Apparatus and method for the optical imaging of tissue samples |
| EP02734611A EP1411832A4 (en) | 2001-05-31 | 2002-05-30 | Apparatus and method for the optical imaging of tissue samples |
| CA002449111A CA2449111A1 (en) | 2001-05-31 | 2002-05-30 | Apparatus and method for the optical imaging of tissue samples |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/871,578 | 2001-05-31 | ||
| US09/871,578 US6654630B2 (en) | 2001-05-31 | 2001-05-31 | Apparatus and method for the optical imaging of tissue samples |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2002096484A2 WO2002096484A2 (en) | 2002-12-05 |
| WO2002096484A3 WO2002096484A3 (en) | 2003-07-24 |
| WO2002096484B1 true WO2002096484B1 (en) | 2003-09-12 |
Family
ID=25357734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2002/017202 WO2002096484A2 (en) | 2001-05-31 | 2002-05-30 | Apparatus and method for the optical imaging of tissue samples |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6654630B2 (en) |
| EP (1) | EP1411832A4 (en) |
| JP (1) | JP4170771B2 (en) |
| AU (1) | AU2002305766B2 (en) |
| CA (1) | CA2449111A1 (en) |
| WO (1) | WO2002096484A2 (en) |
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-
2002
- 2002-05-30 EP EP02734611A patent/EP1411832A4/en not_active Ceased
- 2002-05-30 JP JP2002592992A patent/JP4170771B2/en not_active Expired - Lifetime
- 2002-05-30 AU AU2002305766A patent/AU2002305766B2/en not_active Ceased
- 2002-05-30 WO PCT/US2002/017202 patent/WO2002096484A2/en active IP Right Grant
- 2002-05-30 CA CA002449111A patent/CA2449111A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20020183622A1 (en) | 2002-12-05 |
| WO2002096484A3 (en) | 2003-07-24 |
| US6654630B2 (en) | 2003-11-25 |
| AU2002305766B2 (en) | 2005-09-15 |
| WO2002096484A2 (en) | 2002-12-05 |
| EP1411832A2 (en) | 2004-04-28 |
| EP1411832A4 (en) | 2009-07-15 |
| JP4170771B2 (en) | 2008-10-22 |
| JP2004538448A (en) | 2004-12-24 |
| CA2449111A1 (en) | 2002-12-05 |
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