WO2002099569A3 - Information processing method for evaluating and using biochemical pathway models using clinical data - Google Patents

Information processing method for evaluating and using biochemical pathway models using clinical data Download PDF

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Publication number
WO2002099569A3
WO2002099569A3 PCT/US2002/017031 US0217031W WO02099569A3 WO 2002099569 A3 WO2002099569 A3 WO 2002099569A3 US 0217031 W US0217031 W US 0217031W WO 02099569 A3 WO02099569 A3 WO 02099569A3
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WO
WIPO (PCT)
Prior art keywords
model
evaluating
clinical data
information processing
processing method
Prior art date
Application number
PCT/US2002/017031
Other languages
French (fr)
Other versions
WO2002099569A2 (en
Inventor
Michael N Liebman
Original Assignee
Michael N Liebman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michael N Liebman filed Critical Michael N Liebman
Priority to AU2002310210A priority Critical patent/AU2002310210A1/en
Priority to US10/478,313 priority patent/US20040167763A1/en
Publication of WO2002099569A2 publication Critical patent/WO2002099569A2/en
Publication of WO2002099569A3 publication Critical patent/WO2002099569A3/en

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks

Abstract

A method of evaluating biochemical pathways models (100) using clinical data, includes representing the biological model (100) within a computing system, in the form of a hierarchy of Petri nets or stochastic activity nets, wherein the nodes of the net represent biological or biochemical components, and the arcs correspond to the flow of biochemical components in the model. A time series of measurements of some of the biochemical components described by the model (100) are recorded and an observed pattern of relationships between inputs and outputs of the respective nodes is compared to an expected pattern of the relationships to determine whether the model (100) describes the behavior of the biochemical components.
PCT/US2002/017031 2001-06-01 2002-05-31 Information processing method for evaluating and using biochemical pathway models using clinical data WO2002099569A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002310210A AU2002310210A1 (en) 2001-06-01 2002-05-31 Information processing method for evaluating and using biochemical pathway models using clinical data
US10/478,313 US20040167763A1 (en) 2002-05-31 2002-05-31 Information processing method for evaluating biochemical pathway models using clinical data

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29463901P 2001-06-01 2001-06-01
US60/294,639 2001-06-01

Publications (2)

Publication Number Publication Date
WO2002099569A2 WO2002099569A2 (en) 2002-12-12
WO2002099569A3 true WO2002099569A3 (en) 2003-05-15

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Application Number Title Priority Date Filing Date
PCT/US2002/017031 WO2002099569A2 (en) 2001-06-01 2002-05-31 Information processing method for evaluating and using biochemical pathway models using clinical data

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AU (1) AU2002310210A1 (en)
WO (1) WO2002099569A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040088116A1 (en) * 2002-11-04 2004-05-06 Gene Network Sciences, Inc. Methods and systems for creating and using comprehensive and data-driven simulations of biological systems for pharmacological and industrial applications
US8103454B2 (en) 2005-08-30 2012-01-24 International Business Machines Corporation Spatially heterogeneous stochastic petri-net modeling
CN106953811B (en) * 2017-03-14 2020-05-26 东华大学 Large-scale network service system behavior reconstruction method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808918A (en) * 1995-04-14 1998-09-15 Medical Science Systems, Inc. Hierarchical biological modelling system and method
US5974201A (en) * 1996-10-01 1999-10-26 Siemens Corporate Research, Inc. Smart image system
US5980096A (en) * 1995-01-17 1999-11-09 Intertech Ventures, Ltd. Computer-based system, methods and graphical interface for information storage, modeling and stimulation of complex systems
US6108635A (en) * 1996-05-22 2000-08-22 Interleukin Genetics, Inc. Integrated disease information system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980096A (en) * 1995-01-17 1999-11-09 Intertech Ventures, Ltd. Computer-based system, methods and graphical interface for information storage, modeling and stimulation of complex systems
US5808918A (en) * 1995-04-14 1998-09-15 Medical Science Systems, Inc. Hierarchical biological modelling system and method
US5808918C1 (en) * 1995-04-14 2002-06-25 Interleukin Genetics Inc Hierarchical biological modelling system and method
US6108635A (en) * 1996-05-22 2000-08-22 Interleukin Genetics, Inc. Integrated disease information system
US5974201A (en) * 1996-10-01 1999-10-26 Siemens Corporate Research, Inc. Smart image system

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WO2002099569A2 (en) 2002-12-12
AU2002310210A1 (en) 2002-12-16

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