WO2002100331A3 - Calcium phosphate delivery vehicles for osteoinductive proteins - Google Patents

Calcium phosphate delivery vehicles for osteoinductive proteins Download PDF

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Publication number
WO2002100331A3
WO2002100331A3 PCT/US2002/017798 US0217798W WO02100331A3 WO 2002100331 A3 WO2002100331 A3 WO 2002100331A3 US 0217798 W US0217798 W US 0217798W WO 02100331 A3 WO02100331 A3 WO 02100331A3
Authority
WO
WIPO (PCT)
Prior art keywords
calcium phosphate
delivery vehicles
osteoinductive proteins
phosphate delivery
methods
Prior art date
Application number
PCT/US2002/017798
Other languages
French (fr)
Other versions
WO2002100331A2 (en
Inventor
Rebecca Hung-Mei Li
Howard Joel Seeherman
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2449713A priority Critical patent/CA2449713C/en
Priority to AU2002314928A priority patent/AU2002314928B2/en
Priority to EP02741855.7A priority patent/EP1404346B1/en
Priority to IL15913602A priority patent/IL159136A0/en
Priority to KR1020107014777A priority patent/KR101105908B1/en
Priority to BRPI0210282A priority patent/BRPI0210282B8/en
Priority to JP2003503158A priority patent/JP4414218B2/en
Priority to KR10-2003-7016020A priority patent/KR20040019300A/en
Application filed by Wyeth Corp filed Critical Wyeth Corp
Priority to MXPA03011236A priority patent/MXPA03011236A/en
Priority to NZ530435A priority patent/NZ530435A/en
Priority to HU0401357A priority patent/HU230046B1/en
Publication of WO2002100331A2 publication Critical patent/WO2002100331A2/en
Publication of WO2002100331A3 publication Critical patent/WO2002100331A3/en
Priority to IL159136A priority patent/IL159136A/en
Priority to NO20035383A priority patent/NO333548B1/en
Priority to HK04105479.5A priority patent/HK1062530A1/en
Priority to IL230994A priority patent/IL230994A0/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/02Peptides of undefined number of amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1875Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/005Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/14Post-treatment to improve physical properties
    • A61L17/145Coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10Polypeptides; Proteins
    • A61L24/108Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02Inorganic materials
    • A61L27/12Phosphorus-containing materials, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

A composition for treating a mammal having a bone defect. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
PCT/US2002/017798 2001-06-08 2002-06-06 Calcium phosphate delivery vehicles for osteoinductive proteins WO2002100331A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
MXPA03011236A MXPA03011236A (en) 2001-06-08 2002-06-06 Calcium phosphate delivery vehicles for osteoinductive proteins.
AU2002314928A AU2002314928B2 (en) 2001-06-08 2002-06-06 Calcium phosphate delivery vehicles for osteoinductive proteins
NZ530435A NZ530435A (en) 2001-06-08 2002-06-06 Calcium phosphate delivery vehicles for osteoinductive proteins
KR1020107014777A KR101105908B1 (en) 2001-06-08 2002-06-06 Calcium phosphate delivery vehicles for osteoinductive proteins
BRPI0210282A BRPI0210282B8 (en) 2001-06-08 2002-06-06 compositions comprising calcium phosphate delivery vehicles for osteoinductive proteins, and their use
JP2003503158A JP4414218B2 (en) 2001-06-08 2002-06-06 Calcium phosphate delivery vehicle for osteoinductive proteins
KR10-2003-7016020A KR20040019300A (en) 2001-06-08 2002-06-06 Calcium phosphate delivery vehicles for osteoinductive proteins
CA2449713A CA2449713C (en) 2001-06-08 2002-06-06 Calcium phosphate delivery vehicles for osteoinductive proteins
EP02741855.7A EP1404346B1 (en) 2001-06-08 2002-06-06 Calcium phosphate delivery vehicles for osteoinductive proteins
IL15913602A IL159136A0 (en) 2001-06-08 2002-06-06 Calcium phosphate delivery vehicles for osteoinductive proteins
HU0401357A HU230046B1 (en) 2001-06-08 2002-06-06 Calcium phosphate delivery vehicles for osteoinductive proteins
IL159136A IL159136A (en) 2001-06-08 2003-11-30 Composition comprising a bmp protein, calcium phosphate and sodium bicarbonate for acceleration of bone growth and use of the composition in the preparation of a medicament
NO20035383A NO333548B1 (en) 2001-06-08 2003-12-03 A composition for treating a mammal with a bone effect and its use.
HK04105479.5A HK1062530A1 (en) 2001-06-08 2004-07-23 Calcium phosphate delivery vehicles for osteoinductive proteins
IL230994A IL230994A0 (en) 2001-06-08 2014-02-16 Composition comprising a bmp protein, calcium phosphate and sodium bicarbonate for accelreation of bone growth and use of the composition in the preparation of a medicament

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29681801P 2001-06-08 2001-06-08
US60/296,818 2001-06-08

Publications (2)

Publication Number Publication Date
WO2002100331A2 WO2002100331A2 (en) 2002-12-19
WO2002100331A3 true WO2002100331A3 (en) 2003-03-20

Family

ID=23143697

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/017798 WO2002100331A2 (en) 2001-06-08 2002-06-06 Calcium phosphate delivery vehicles for osteoinductive proteins

Country Status (19)

Country Link
US (3) US7413753B2 (en)
EP (2) EP1404346B1 (en)
JP (5) JP4414218B2 (en)
KR (3) KR101105908B1 (en)
CN (2) CN101239182B (en)
AR (1) AR034347A1 (en)
AU (1) AU2002314928B2 (en)
BR (1) BRPI0210282B8 (en)
CA (2) CA2449713C (en)
HK (2) HK1062530A1 (en)
HU (1) HU230046B1 (en)
IL (3) IL159136A0 (en)
MX (1) MXPA03011236A (en)
NO (1) NO333548B1 (en)
NZ (1) NZ530435A (en)
PL (1) PL216040B1 (en)
TW (1) TWI267378B (en)
WO (1) WO2002100331A2 (en)
ZA (1) ZA200400066B (en)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7687462B2 (en) 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
DE10032220A1 (en) 2000-07-03 2002-01-24 Sanatis Gmbh Magnesium ammonium phosphate cements, their manufacture and use
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
CA2474919A1 (en) * 2002-02-08 2003-08-14 Wyeth Formulation comprising bioactive agents and method of using same
TW200400062A (en) * 2002-04-03 2004-01-01 Mathys Medizinaltechnik Ag Kneadable, pliable bone replacement material
US7273523B2 (en) 2002-06-07 2007-09-25 Kyphon Inc. Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof
WO2004085998A2 (en) * 2003-03-28 2004-10-07 The Children's Hospital Of Philadelphia Biomimetic hierarchies using functionalized nanoparticles as building blocks
US20040199256A1 (en) * 2003-04-04 2004-10-07 Chao-Jan Wang Support device for supporting between spinal vertebrae
CA2521623C (en) * 2003-04-11 2015-03-17 Etex Corporation Osteoinductive bone material
US7771755B2 (en) 2003-09-12 2010-08-10 Wyeth Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
CA2557436A1 (en) * 2004-03-05 2005-09-29 The Trustees Of Columbia University In The City Of New York Polymer-ceramic-hydrogel composite scaffold for osteochondral repair
US7767221B2 (en) * 2004-03-05 2010-08-03 The Trustees Of Columbia University In The City Of New York Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone
US8216359B2 (en) 2004-04-15 2012-07-10 Etex Corporation Delayed-setting calcium phosphate pastes
CN1988923B (en) 2004-04-27 2012-10-03 凯丰有限责任公司 Bone substitute compositions and method of use
US20060074422A1 (en) * 2004-09-27 2006-04-06 Story Brooks J Suture anchor and void filler combination
US20060089723A1 (en) * 2004-10-25 2006-04-27 Murphy Kieran P Method for bone augmentation
US8852240B2 (en) * 2004-10-25 2014-10-07 Kieran Murphy, Llc Methods and compositions for fostering and preserving bone growth
US7651701B2 (en) 2005-08-29 2010-01-26 Sanatis Gmbh Bone cement composition and method of making the same
US20070248675A1 (en) * 2005-09-08 2007-10-25 Gwangju Institute Of Science And Technology Composite comprising polysaccharide-functionalized nanoparticle and hydrogel matrix, a drug delivery system and a bone defect replacement matrix for sustained release comprising the same, and the preparation method thereof
US8920827B2 (en) * 2005-10-21 2014-12-30 Wake Forest University Health Sciences Keratin bioceramic compositions
US8147860B2 (en) * 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US10300167B2 (en) 2006-03-24 2019-05-28 Cabertech, Inc. Functionalized calcium phosphate artificial bone and joint compositions and methods of use and manufacture
EP2010104B1 (en) 2006-04-25 2018-09-05 Teleflex Medical Incorporated Calcium phosphate polymer composite and method
US7754005B2 (en) 2006-05-02 2010-07-13 Kyphon Sarl Bone cement compositions comprising an indicator agent and related methods thereof
US7507286B2 (en) * 2006-06-08 2009-03-24 Sanatis Gmbh Self-foaming cement for void filling and/or delivery systems
JP2009544411A (en) * 2006-07-26 2009-12-17 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア Bone formation enhancing composition
DE602007011671D1 (en) * 2006-11-30 2011-02-10 Smith & Nephew Inc FIBER REINFORCED COMPOSITE MATERIAL
US20100047309A1 (en) * 2006-12-06 2010-02-25 Lu Helen H Graft collar and scaffold apparatuses for musculoskeletal tissue engineering and related methods
PT3345607T (en) 2006-12-29 2022-11-21 Ossifi Mab Llc Methods of altering bone growth by administration of sost or wise antagonist or agonist
US8753391B2 (en) * 2007-02-12 2014-06-17 The Trustees Of Columbia University In The City Of New York Fully synthetic implantable multi-phased scaffold
US20080241256A1 (en) * 2007-03-30 2008-10-02 Liisa Kuhn Targeted active agent delivery system based on calcium phosphate nanoparticles
AU2007352435B2 (en) * 2007-04-27 2012-01-19 Unigene Laboratories, Inc. Methods and compositions for fostering and preserving bone growth
US20090081276A1 (en) * 2007-08-13 2009-03-26 Eben Alsberg Bioresorbable implant composition
US20090061002A1 (en) 2007-09-05 2009-03-05 Venbrocks Rudolf A Calcium phospate based delivery of growth and differentiation factors to compromised bone
US7968616B2 (en) * 2008-04-22 2011-06-28 Kyphon Sarl Bone cement composition and method
TWI381857B (en) * 2008-12-10 2013-01-11 Univ Taipei Medical Method of preparing amorphous calcium phosphate and the compositions for oral care applications
CN102448983A (en) 2009-05-26 2012-05-09 加州大学董事会 Fibromodulin peptide
US9636109B2 (en) 2009-07-22 2017-05-02 Wisconsin Alumni Research Foundation Biologically active sutures for regenerative medicine
US9937128B2 (en) 2009-08-03 2018-04-10 The University Of North Carolina At Chapel Hill Liposomes comprising a calcium phosphate-containing precipitate
US20110046241A1 (en) * 2009-08-24 2011-02-24 Keizer Timothy S Calcium based carrier particles
US20110046240A1 (en) * 2009-08-24 2011-02-24 Keizer Timothy S Calcium-based carrier particles
US20110046238A1 (en) * 2009-08-24 2011-02-24 Keiser Bruce A Calcium based carrier particles
US20110046239A1 (en) * 2009-08-24 2011-02-24 Keiser Bruce A Calcium based carrier particles
WO2011058443A1 (en) * 2009-11-13 2011-05-19 Barralet Jake E Method and device to induce collagen biomineralisation
US9180137B2 (en) 2010-02-09 2015-11-10 Bone Support Ab Preparation of bone cement compositions
US8388887B2 (en) 2010-04-12 2013-03-05 Biomet Manufacturing Corp. Methods for making textured ceramic implants
TWI579007B (en) 2010-07-02 2017-04-21 艾格諾福斯保健公司 Use of bone regenerative material
AU2011291537B2 (en) 2010-08-19 2016-06-02 The Regents Of The University Of California Compositions comprising perivascular stem cells and Nell-1 protein
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
WO2012093939A1 (en) 2011-01-05 2012-07-12 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Particles comprising calcium phosphate and use thereof
WO2012177759A1 (en) 2011-06-20 2012-12-27 Rdc Holdings, Llc System and method for repairing joints
US8998925B2 (en) 2011-06-20 2015-04-07 Rdc Holdings, Llc Fixation system for orthopedic devices
US9180116B2 (en) 2012-07-19 2015-11-10 Cayman Chemical Company, Inc. Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
WO2014128217A1 (en) 2013-02-20 2014-08-28 Bone Support Ab Improved setting of hardenable bone substitute
CN105120863B (en) 2013-03-14 2021-06-04 奥斯特克有限公司 Alkylamine peganine derivatives for promoting bone growth
WO2014169249A1 (en) 2013-04-12 2014-10-16 The Trustees Of Columbia University In The City Of New York Methods for host cell homing and dental pulp regeneration
US10729810B2 (en) * 2013-07-19 2020-08-04 Cayman Chemical Company, Inc Methods, systems, and compositions for promoting bone growth
JP6145366B2 (en) * 2013-09-10 2017-06-07 HOYA Technosurgical株式会社 Calcium phosphate curable composition
BR112017003428A2 (en) * 2014-08-28 2017-11-28 Bioventus Llc improved osteoinductive substrates and methods for making the same
KR101597203B1 (en) * 2014-09-26 2016-02-24 한국화학연구원 Composite comprising biodegradable polymer and hydroxyapatite and the preparation method thereof
WO2016109555A1 (en) 2014-12-29 2016-07-07 Bioventus, Llc Systems and methods for improved delivery of osteoinductive molecules in bone repair
US10238507B2 (en) 2015-01-12 2019-03-26 Surgentec, Llc Bone graft delivery system and method for using same
US20160374904A1 (en) * 2015-06-23 2016-12-29 South Dakota Board Of Regents Sequential Material Deposition for Remineralization and Desensitization of Teeth
ES2672265B1 (en) 2016-11-07 2019-04-10 Inst Biomecanico De Barcelona S L DEVICE FOR INTERVERTEBRAL FUSION COMPRISING AN INTERVERTEBRAL STABILIZATION SCREW AND A COMPOSITION FOR BONE REMODELING
CN106822991B (en) * 2017-03-13 2019-09-27 深圳市英汉斯科技有限公司 Small-molecular peptides biology bone renovating material and preparation method thereof
WO2018187344A1 (en) * 2017-04-03 2018-10-11 Wisconsin Alumni Research Foundation Mineral coated microparticles for sustained delivery of biologically active molecules
US10687828B2 (en) 2018-04-13 2020-06-23 Surgentec, Llc Bone graft delivery system and method for using same
US11116647B2 (en) 2018-04-13 2021-09-14 Surgentec, Llc Bone graft delivery system and method for using same
CN108815580B (en) * 2018-07-23 2019-11-12 吴容思 A kind of calcium phosphate bone cement and preparation method thereof of controllable degradation
AU2019320773A1 (en) 2018-08-14 2021-03-04 Osteoqc Inc. Fluoro β-carboline compounds
BR112021002614A2 (en) 2018-08-14 2021-05-04 Osteoqc Inc. pyrrole-dipyridine compounds
WO2020118011A1 (en) 2018-12-06 2020-06-11 Alexion Pharmaceuticals, Inc. Anti-alk2 antibodies and uses thereof
CN110064071B (en) * 2019-04-12 2021-09-10 西安理工大学 Preparation method of expandable inorganic bone cement
CN114569732B (en) * 2022-01-24 2023-09-01 国家纳米科学中心 Nanometer medicine and its prepn and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492697A (en) * 1990-03-05 1996-02-20 Board Of Regents, Univ. Of Texas System Biodegradable implant for fracture nonunions
US6077076A (en) * 1997-12-18 2000-06-20 Comfort Biomedical, Inc. Bone augmentation for prosthetic implants and the like

Family Cites Families (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2465357A (en) * 1944-08-14 1949-03-29 Upjohn Co Therapeutic sponge and method of making
CH563767A5 (en) * 1973-01-30 1975-07-15 Pheulpin Jean
US4468464A (en) 1974-11-04 1984-08-28 The Board Of Trustees Of The Leland Stanford Junior University Biologically functional molecular chimeras
DE2657370C2 (en) * 1976-12-17 1982-11-11 Hans Dr.med. Dr.med.dent. 8000 München Scheicher Means for covering and / or filling in bone defects
US4159358A (en) * 1977-05-19 1979-06-26 Board Of Regents, State Of Florida Method of bonding a bioglass to metal
DE2732848A1 (en) * 1977-07-18 1979-02-08 Schering Ag DIURETHANE, HERBICIDAL AGENTS CONTAINING THESE COMPOUNDS AND THE PROCESS FOR THEIR PRODUCTION
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4619989A (en) 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4294753A (en) 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4761471A (en) 1980-08-04 1988-08-02 The Regents Of The University Of California Bone morphogenetic protein composition
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4727028A (en) * 1981-06-22 1988-02-23 Eli Lilly And Company Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transformants thereof
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4472840A (en) 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4474181A (en) 1982-02-18 1984-10-02 Schenck Robert R Method and apparatus for anastomosing small blood vessels
USRE33161E (en) 1982-04-29 1990-02-06 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
USRE33221E (en) 1982-04-29 1990-05-22 American Dental Association Health Foundation Dental restorative cement pastes
IL68218A (en) * 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
US4804744A (en) * 1984-01-04 1989-02-14 International Genetic Engineering, Inc. Osteogenic factors
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4608199A (en) 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
US4662884A (en) * 1984-04-25 1987-05-05 University Of Utah Research Foundation Prostheses and methods for promoting nerve regeneration
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
CA1341617C (en) * 1984-06-08 2011-06-28 Henry George Burger Inhibin isolated from ovarian follicular fluid
US4868161A (en) 1984-06-29 1989-09-19 City Of Hope Method for promoting nerve regeneration
US4627982A (en) 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
US4843063A (en) * 1984-07-16 1989-06-27 Collagen Corporation Polypeptide cartilage-inducing factors found in bone
DE3588058T3 (en) * 1984-07-16 2005-04-07 Celtrix Pharmaceuticals, Inc., Palo Alto Cartilage-inducing polypeptide factors from bone
US5187263A (en) * 1984-10-12 1993-02-16 Zymogenetics, Inc. Expression of biologically active PDGE analogs in eucaryotic cells
US4769328A (en) 1984-10-12 1988-09-06 Zymogenetics Inc. Expression of biologically active PDGF analogs in yeast
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
KR930007429B1 (en) * 1984-12-27 1993-08-10 산도리 가부시기가이샤 Method for purifying interferon
US4886747A (en) 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
US4766067A (en) 1985-05-31 1988-08-23 President And Fellows Of Harvard College Gene amplification
US4681763A (en) * 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US4798885A (en) * 1986-02-07 1989-01-17 Genentech, Inc. Compositions of hormonally active human and porcine inhibin containing an α chain and 62 chain
US5215893A (en) * 1985-10-03 1993-06-01 Genentech, Inc. Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US5089396A (en) * 1985-10-03 1992-02-18 Genentech, Inc. Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US4737578A (en) * 1986-02-10 1988-04-12 The Salk Institute For Biological Studies Human inhibin
US4758233A (en) * 1986-04-22 1988-07-19 N.J. Phillips TPY. Limited Cream applicator
NL8601328A (en) * 1986-05-23 1987-12-16 Langen Research DEVICE FOR INJECTING MEAT WITH A MASS, PARTICULARLY PASTY MASS.
US4839215A (en) * 1986-06-09 1989-06-13 Ceramed Corporation Biocompatible particles and cloth-like article made therefrom
US5187076A (en) 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US4877864A (en) 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US6432919B1 (en) * 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
ZA874681B (en) 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5108922A (en) * 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5366875A (en) 1986-07-01 1994-11-22 Genetics Institute, Inc. Methods for producing BMP-7 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5459047A (en) * 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US5019087A (en) * 1986-10-06 1991-05-28 American Biomaterials Corporation Nerve regeneration conduit
US5124316A (en) * 1986-11-14 1992-06-23 President And Fellows Of Harvard College Method for periodontal regeneration
US5041538A (en) 1987-08-28 1991-08-20 The Salk Institute For Biological Studies Mammalian follistatin
US5202120A (en) * 1987-09-11 1993-04-13 Case Western Reserve University Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes
US5147399A (en) 1988-02-01 1992-09-15 Dellon Arnold L Method of treating nerve defects through use of a bioabsorbable surgical device
IT1215881B (en) 1988-02-16 1990-02-22 Giancarlo Foresti OSTEOTROPIC ACTION SURGICAL AID.
US4968590A (en) 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5354557A (en) 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5053212A (en) 1988-04-20 1991-10-01 Norian Corporation Intimate mixture of calcium and phosphate sources as precursor to hydroxyapatite
US6005162A (en) * 1988-04-20 1999-12-21 Norian Corporation Methods of repairing bone
US5962028A (en) 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
US6002065A (en) * 1988-04-20 1999-12-14 Norian Corporation Kits for preparing calcium phosphate minerals
US5129905A (en) 1988-04-20 1992-07-14 Norian Corporation Methods for in situ prepared calcium phosphate minerals
US5024841A (en) * 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US5071834A (en) 1988-09-16 1991-12-10 Genentech, Inc. Purified activin B composition
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US4955892A (en) 1988-10-24 1990-09-11 Louisiana State University Neural cell adhesion protein nerve prosthesis
US5457038A (en) * 1988-11-10 1995-10-10 Genetics Institute, Inc. Natural killer stimulatory factor
US5011486A (en) * 1988-11-18 1991-04-30 Brown University Research Foundation Composite nerve guidance channels
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US4920962A (en) * 1988-11-23 1990-05-01 Claude Proulx Splint-like element for use in end-to-end nerve suture
US5217867A (en) * 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
US4963146A (en) 1989-04-20 1990-10-16 Colla-Tec Incorporated Multi-layered, semi-permeable conduit for nerve regeneration
US5026381A (en) * 1989-04-20 1991-06-25 Colla-Tec, Incorporated Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5399346A (en) * 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
WO1991000103A1 (en) * 1989-06-29 1991-01-10 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method for protecting bone marrow against chemotherapeutic drugs and radiation therapy using transforming growth factor beta 1
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5422340A (en) * 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
US5236456A (en) * 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5166190A (en) 1990-01-08 1992-11-24 Genentech, Inc. Method for increasing fertility in males
US5187086A (en) * 1990-01-26 1993-02-16 Scripps Clinic And Research Foundation Molecules with antibody combining sites that catalyze hydrolysis reactions through use of a charged hapten
US5256418A (en) 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
EP0452859B1 (en) * 1990-04-18 1997-02-26 Sharp Kabushiki Kaisha Facsimile apparatus comprising cordless telephone set
US5290271A (en) * 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
ATE209251T1 (en) 1990-05-16 2001-12-15 Genetics Inst PROTEINS PRODUCING BONE AND CARTILAGE FORMATION
WO1991017777A2 (en) 1990-05-22 1991-11-28 University Of Florida Injectable bioactive glass compositions and methods for tissue reconstruction
US5168050A (en) 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
US5218090A (en) * 1990-06-12 1993-06-08 Warner-Lambert Company EGF receptor truncates
US5364839A (en) 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
ATE253589T1 (en) * 1990-09-26 2003-11-15 Inst Genetics Llc BMP-5 DERIVATIVES
US5206028A (en) * 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
US5208219A (en) * 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
US5229495A (en) * 1991-06-18 1993-07-20 Ludwig Institute For Cancer Research Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
US5216126A (en) * 1991-06-19 1993-06-01 Genentech, Inc. Receptor polypeptides and their production and uses
WO1993000050A1 (en) 1991-06-21 1993-01-07 Genetics Institute, Inc. Pharmaceutical formulations of osteogenic proteins
US6287816B1 (en) * 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
KR100255415B1 (en) 1991-06-25 2000-05-01 브루스 엠. 에이센 Bone morphogenetic protein-9 compositions
US5356629A (en) 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5306307A (en) * 1991-07-22 1994-04-26 Calcitek, Inc. Spinal disk implant
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5171579A (en) 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
ATE238417T1 (en) * 1991-11-04 2003-05-15 Inst Genetics Llc RECOMBINANT BONE MORPHOGENETIC PROTEIN HETERODIMERS, COMPOSITIONS AND METHODS OF USE
SE469653B (en) * 1992-01-13 1993-08-16 Lucocer Ab POROEST IMPLANT
WO1993016099A2 (en) 1992-02-12 1993-08-19 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Dna sequences encoding novel growth/differentiation factors
DE69331096T2 (en) 1992-02-28 2002-08-14 Cohesion Tech Inc INJECTABLE, CERAMIC COMPOUNDS AND METHOD FOR THE PRODUCTION AND USE THEREOF
AU3920693A (en) * 1992-03-18 1993-10-21 General Hospital Corporation, The Four novel receptors of the TGF-beta receptor family
US5550176A (en) * 1992-04-17 1996-08-27 Ucar Carbon Technology Corporation Room temperature setting carbonaceous cement with increased electrical conductivity and flexural strength
IT1259090B (en) 1992-04-17 1996-03-11 Fidia Spa BIOMATERIALS FOR BONE PROSTHESIS
IT1259100B (en) * 1992-05-20 1996-03-11 Lanfranco Callegaro USE OF HYDROGELS FOR THE LOCKING OF PROSTHETIC SYSTEMS
IL106278A0 (en) 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
AU5125693A (en) 1992-09-03 1994-03-29 Regents Of The University Of California, The Dorsal tissue affecting factor and compositions
CA2153653C (en) 1993-01-12 2010-12-07 Se-Jin Lee Growth differentiation factor-9
WO1994015949A1 (en) 1993-01-12 1994-07-21 Johns Hopkins University School Of Medicine Growth differentiation factor-5
CA2153652A1 (en) 1993-01-12 1994-07-21 Se-Jin Lee Growth differentiation factor-3
US5420243A (en) * 1993-01-26 1995-05-30 Celtrix Pharmaceuticals, Inc. Biologically active TGF-β2 peptides
EP1333035A3 (en) 1993-03-19 2004-07-07 The Johns Hopkins University School Of Medicine Growth differentiation factor-8
GB9308060D0 (en) * 1993-04-19 1993-06-02 Cancer Res Campaign Tech Stem cell inhibitor
US5637480A (en) * 1993-05-12 1997-06-10 Genetics Institute, Inc. DNA molecules encoding bone morphogenetic protein-10
AU677849B2 (en) 1993-05-12 1997-05-08 Genetics Institute, Llc BMP-10 compositions
WO1994026892A1 (en) * 1993-05-12 1994-11-24 Genetics Institute, Inc. Bmp-11 compositions
US5447725A (en) * 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
US5770444A (en) 1993-07-09 1998-06-23 The Johns Hopkins University School Of Medicine Growth differentiation factor-6
EP0717633A4 (en) 1993-07-09 1998-05-20 Univ Johns Hopkins Med Growth differentiation factor-7
DK0716610T3 (en) * 1993-08-26 2006-09-04 Genetics Inst Llc Human bone morphogenetic proteins for use in neural regeneration
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
EP0725796A4 (en) 1993-10-08 1999-12-01 Univ Johns Hopkins Growth differentiation factor-10
US5789543A (en) * 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
CA2175049A1 (en) * 1993-10-28 1995-05-04 Timothy Ringeisen Improved process and device for treating and healing a bone void
US5399677A (en) * 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
US6027919A (en) * 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
JP3717930B2 (en) 1993-12-07 2005-11-16 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー BMP-12, BMP-13 and their tendon-derived compositions
NZ278765A (en) 1993-12-30 1998-05-27 Harvard College Vertebrate proteins involved in spatial arrangements of differentiated tissues called hedgehog proteins, their production and use
JPH07250688A (en) 1994-01-28 1995-10-03 Sagami Chem Res Center New human c-dna coding tgf-beta superfamily protein
JP3424049B2 (en) 1994-03-09 2003-07-07 山之内製薬株式会社 Bone formation implant
EP1574577A3 (en) 1994-07-08 2006-06-14 The Johns Hopkins University School Of Medicine Growth differentiation factor-11
EP0770089B1 (en) 1994-07-13 2000-09-06 The Johns Hopkins University School Of Medicine Growth differentiation factor-12
US5520923A (en) * 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6281332B1 (en) 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
US5676976A (en) * 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6132463A (en) * 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
US6117456A (en) 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US6027742A (en) 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
DK0831884T3 (en) * 1995-06-05 2003-11-03 Inst Genetics Llc Use of bone morphogenetic proteins for healing and repair of connective tissue binding
WO1996039203A1 (en) 1995-06-06 1996-12-12 Gensci Regeneration Laboratories, Inc. Modified osteogenic materials
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
ATE439849T1 (en) * 1996-04-19 2009-09-15 Osiris Therapeutics Inc THE RESTORATION AND STRENGTHENING OF BONE USING MESENCHYMAL STEM CELLS
CA2256400A1 (en) * 1996-05-28 1997-12-04 Brown University Research Foundation Hyaluronan based biodegradable scaffolds for tissue repair
IT1288290B1 (en) 1996-06-21 1998-09-11 Fidia Spa In Amministrazione S SELF-LETICULATED HYALURONIC ACID AND RELATED PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ARTHROPATHIES
US5965403A (en) 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
AU734691B2 (en) 1996-10-16 2001-06-21 Life Science Enterprises, Inc. Bioceramic compositions
WO1998031788A1 (en) 1997-01-21 1998-07-23 Genetics Institute, Inc. Injectable formulations for treatment of osteoporotic bone
US20020098222A1 (en) 1997-03-13 2002-07-25 John F. Wironen Bone paste
US6034062A (en) * 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
US5972368A (en) * 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
IT1296689B1 (en) 1997-11-06 1999-07-14 Fidia Advanced Biopolymers Srl ESTERE DERIVATIVES OF HYALURONIC ACID HAVING VISCOELASTIC PROPERTIES AND THEIR USE IN THE BIOMEDICAL-HEALTH FIELD
US20020076429A1 (en) 1998-01-28 2002-06-20 John F. Wironen Bone paste subjected to irradiative and thermal treatment
IT1302534B1 (en) * 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl INJECTABLE, BIOCOMPATIBLE AND BIODEGRADABLE COMPOSITIONS INCLUDING AT LEAST A DERIVATIVE OF HYALURONIC ACID, CHONDROGENIC CELLS, FOR
AU770196B2 (en) * 1999-02-04 2004-02-12 Warsaw Orthopedic, Inc. Osteogenic paste compositions and uses thereof
US7189392B1 (en) * 1999-10-15 2007-03-13 Genetics Institute, Llc Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
WO2001028603A1 (en) 1999-10-15 2001-04-26 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
KR100485038B1 (en) * 2000-09-29 2005-04-22 혼다 기켄 고교 가부시키가이샤 Bipedal robot
WO2002058755A2 (en) 2001-01-25 2002-08-01 Regeneration Technologies, Inc. Injectable porous bone graft materials
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
NZ536478A (en) 2002-05-17 2008-02-29 Wyeth Corp Injectable or implantable solid, rod- shaped compositions for intraosseous delivery of osteogenic proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492697A (en) * 1990-03-05 1996-02-20 Board Of Regents, Univ. Of Texas System Biodegradable implant for fracture nonunions
US6077076A (en) * 1997-12-18 2000-06-20 Comfort Biomedical, Inc. Bone augmentation for prosthetic implants and the like

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