WO2002100347A3 - Prodrugs of gaba analogs, compositions and uses thereof - Google Patents

Prodrugs of gaba analogs, compositions and uses thereof Download PDF

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Publication number
WO2002100347A3
WO2002100347A3 PCT/US2002/018689 US0218689W WO02100347A3 WO 2002100347 A3 WO2002100347 A3 WO 2002100347A3 US 0218689 W US0218689 W US 0218689W WO 02100347 A3 WO02100347 A3 WO 02100347A3
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WO
WIPO (PCT)
Prior art keywords
prodrugs
gaba analogs
compositions
methods
gaba
Prior art date
Application number
PCT/US2002/018689
Other languages
French (fr)
Other versions
WO2002100347A2 (en
Inventor
Mark A Gallop
Kenneth C Cundy
Cindy X Zhou
Fayang G Qiu
Fenmei Yao
Jia-Ning Xiang
Ian R Ollman
Original Assignee
Xenoport Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27404495&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002100347(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DE60223923T priority Critical patent/DE60223923T3/en
Priority to HU0400167A priority patent/HUP0400167A3/en
Priority to JP2003516067A priority patent/JP4216713B2/en
Priority to KR1020037016230A priority patent/KR100926921B1/en
Priority to CA002449729A priority patent/CA2449729C/en
Priority to IL15930002A priority patent/IL159300A0/en
Priority to CN02814572.0A priority patent/CN1753673B/en
Priority to MXPA03011565A priority patent/MXPA03011565A/en
Priority to AU2002345664A priority patent/AU2002345664C1/en
Priority to NZ530109A priority patent/NZ530109A/en
Priority to EP02744314A priority patent/EP1404324B2/en
Application filed by Xenoport Inc filed Critical Xenoport Inc
Priority to DK02744314.2T priority patent/DK1404324T4/en
Publication of WO2002100347A2 publication Critical patent/WO2002100347A2/en
Publication of WO2002100347A3 publication Critical patent/WO2002100347A3/en
Priority to NO20035474A priority patent/NO333756B1/en
Priority to IL159300A priority patent/IL159300A/en
Priority to ZA2003/09678A priority patent/ZA200309678B/en
Priority to HK06107881.1A priority patent/HK1087628A1/en
Priority to AU2007203364A priority patent/AU2007203364B2/en
Priority to NO20083958A priority patent/NO20083958L/en
Priority to NO20083956A priority patent/NO20083956L/en
Priority to AU2008221505A priority patent/AU2008221505C1/en
Priority to IL197843A priority patent/IL197843A/en
Priority to IL213649A priority patent/IL213649A0/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C07D317/40—Vinylene carbonate; Substituted vinylene carbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using phannaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
PCT/US2002/018689 2001-06-11 2002-06-11 Prodrugs of gaba analogs, compositions and uses thereof WO2002100347A2 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
JP2003516067A JP4216713B2 (en) 2001-06-11 2002-06-11 GABA analog prodrugs, compositions and uses thereof
MXPA03011565A MXPA03011565A (en) 2001-06-11 2002-06-11 Prodrugs of gaba analogs, compositions and uses thereof.
DK02744314.2T DK1404324T4 (en) 2001-06-11 2002-06-11 Preservatives of GABA analogues, compositions and uses thereof
KR1020037016230A KR100926921B1 (en) 2001-06-11 2002-06-11 Prodrugs of BAAA analogs, compositions and uses thereof
NZ530109A NZ530109A (en) 2001-06-14 2002-06-11 Prodrugs of GABA analogs, compositions and uses thereof
IL15930002A IL159300A0 (en) 2001-06-11 2002-06-11 Prodrugs of gaba analogs, compositions and uses thereof
CN02814572.0A CN1753673B (en) 2001-06-11 2002-06-11 Prodrugs of GABA analogs, compositions and uses thereof
CA002449729A CA2449729C (en) 2001-06-11 2002-06-11 Prodrugs of gaba analogs, compositions and uses thereof
AU2002345664A AU2002345664C1 (en) 2001-06-11 2002-06-11 Prodrugs of gaba analogs, compositions and uses thereof
HU0400167A HUP0400167A3 (en) 2001-06-11 2002-06-11 Prodrugs of gaba analogs, compositions and uses thereof
EP02744314A EP1404324B2 (en) 2001-06-11 2002-06-11 Prodrugs of gaba analogs, compositions and uses thereof
DE60223923T DE60223923T3 (en) 2001-06-11 2002-06-11 PROGRUGS OF GABA ANALOGUE, COMPOSITIONS AND ITS USES
NO20035474A NO333756B1 (en) 2001-06-11 2003-12-09 Compounds, their use, and pharmaceutical compositions
IL159300A IL159300A (en) 2001-06-11 2003-12-10 Prodrugs of gabapentin compounds, compositions and their use in the manufacture of a medicament
ZA2003/09678A ZA200309678B (en) 2001-06-11 2003-12-12 Prodrugs of gaba analogs compositions and uses thereof
HK06107881.1A HK1087628A1 (en) 2001-06-11 2006-07-14 Prodrugs of gaba analogs, compositions and uses thereof gaba
AU2007203364A AU2007203364B2 (en) 2001-06-11 2007-07-19 Prodrugs of gaba analogs, compositions and uses thereof
NO20083956A NO20083956L (en) 2001-06-11 2008-09-16 Prodrugs of GABA analogs, compositions and uses thereof
NO20083958A NO20083958L (en) 2001-06-11 2008-09-16 Prodrugs of GABA analogs, compositions and uses thereof
AU2008221505A AU2008221505C1 (en) 2001-06-11 2008-09-17 Prodrugs of gaba analogs, compositions and uses thereof
IL197843A IL197843A (en) 2001-06-11 2009-03-26 Prodrugs of gaba analogs, compositions and their use in the manufacture of a medicament
IL213649A IL213649A0 (en) 2001-06-11 2011-06-19 Prodrugs of gabapentin compounds, compositions and their use in the manufacture of a medicament

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US29752101P 2001-06-11 2001-06-11
US60/297,521 2001-06-11
US29851401P 2001-06-14 2001-06-14
US60/298,514 2001-06-14
US36609002P 2002-03-19 2002-03-19
US60/366,090 2002-03-19

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AT (2) ATE540678T1 (en)
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HK (2) HK1087628A1 (en)
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IL (5) IL159300A0 (en)
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