WO2003002186B1 - Therapeutic methods using electromagnetic radiation - Google Patents

Therapeutic methods using electromagnetic radiation

Info

Publication number
WO2003002186B1
WO2003002186B1 PCT/US2002/020131 US0220131W WO03002186B1 WO 2003002186 B1 WO2003002186 B1 WO 2003002186B1 US 0220131 W US0220131 W US 0220131W WO 03002186 B1 WO03002186 B1 WO 03002186B1
Authority
WO
WIPO (PCT)
Prior art keywords
wavelength
electromagnetic radiation
exposing
monitoring
controlled
Prior art date
Application number
PCT/US2002/020131
Other languages
French (fr)
Other versions
WO2003002186A2 (en
WO2003002186A3 (en
Inventor
Constance Haber
Allan Gardiner
Original Assignee
Photomed Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photomed Technologies Inc filed Critical Photomed Technologies Inc
Priority to PCT/US2002/020131 priority Critical patent/WO2003002186A2/en
Priority to EP02746680A priority patent/EP1414516A2/en
Priority to US10/180,802 priority patent/US7150710B2/en
Publication of WO2003002186A2 publication Critical patent/WO2003002186A2/en
Publication of WO2003002186A3 publication Critical patent/WO2003002186A3/en
Publication of WO2003002186B1 publication Critical patent/WO2003002186B1/en
Priority to US11/486,912 priority patent/US7878965B2/en
Priority to US11/975,665 priority patent/US7918779B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/389—Electromyography [EMG]
    • A61B5/395—Details of stimulation, e.g. nerve stimulation to elicit EMG response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0619—Acupuncture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0229—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using masks, aperture plates, spatial light modulators or spatial filters, e.g. reflective filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0232—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using shutters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531—Measuring skin impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/389—Electromyography [EMG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4519—Muscles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4528—Joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • A61N2005/0663—Coloured light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/12—Generating the spectrum; Monochromators
    • G01J2003/1213—Filters in general, e.g. dichroic, band

Abstract

This invention provides methods for treating a variety of disorders using electromagnetic radiation directed at excitable tissues (19-30), including nerves (21, 22), muscles and blood vessels. By controlling the wavelength, the wavelength bandpass, pulse duration, intensity, pulse frequency, and/or variations of those characteristics over time, and by selecting sites of exposure (19-30) to electromagnetic radiation, improvements in the function of different tissues and organs can be provided. By monitoring physiological variables such as muscle tone and activity, temperature gradients, surface electromyography, blood flow and others, the practitioner can optimize a therapeutic regimen suited for the individual patient

Claims

AMENDED CLAIMS
[received by the International Bureau on 6 May 2003 (06.05.03); original claims 25-67 replaced by amended claims 25-65; remaining claims unchanged (16 pages)]
1. A method for treating pain, comprising the steps of:
(a) exposing a tissue associated with pain to non-coherent electromagnetic radiationhav.^ range; and
(b) momtori-αg a change characteiistjcofsaidtissue associated with said radiation.
2, The method of claim 1, wherein step (a) further comprises using electromagnetic radiation having at least one of a controlled wavelength b-mdwidth • and a controlled wavelength variation over time.
3. The method of claim 1, wherein step (a) -further comprises using electx magnetic radiation having at least one of a selected pulse frequency and a controlled -frequency variation over time-.
4. The method of claim 1, wherein step (a) -fi-ath.er comprises using electromagnetic radiatio-α having at least one of a selected pulse duration and a controlled frequency of variation over time.
5- The method of claim 1, wherein step (a) further comprises using electromagnetic radiation having at least one of a selected intensity and a controlled intensity variation over time..
6. The method of claim 1, further comprising the step of selecting a variable in step (a) based on the monitoring of step b).
7- A method for treating pain, comprising the steps of: 101
(a) exposing a tissue associated with pain to non-coherent electromagnetic radiation having a controlled wavelength in the visible avelength range;
(b) momtoring a change in characteristic of said tissue associated with said radiation; and
(c) selecting a wavelength in step (a) based on the oiήtoi g of step
(b)-
S- A method for treating pain, comprising the steps of: (a) exposing a tissue associated with pain to aon-coheretxt electromagnetic radiation having a controlled variable selected from the group consisting of
(i) wavelength;
(h) bandwidth; (in) pulse duration;
(iv) pulse frequency;
(v) intensity and
(vi) wavelength variation over time;
(b) monitoring a change in characteristic of said tissue associated with said radiation; and
(c) selecting a variable in step (a) based on the monitoring of step (b).
9, A method for treating pain, comprising the steps of:
(a) exposing a -first tissue associated with pain to a beam of electromagnetic radiation --laving a controlled wavelength,
(b) exposing a second tissue associated with pain to a beam of electromagnetic radiation having a controlled wavelength, and
(c) monitoring a change in a characteristic of a tissue associated with said radiation. 102
10. The method of claim 9, wherein at least one of step (a) and step (b) further comprises using electromagnetic radiation having a controlled bandwidth.
11. The method of claim 9, wherein at least one of step (a) and step (b) further comprises using electromagnetic radiation having a controlled pulse frequency.
12. The method of claim 9, wherein at least one of step (a) and step (b) further comprises using electromagnetic radiation having a controlled pulse duration.
13. The method of claim 9, wherein at least one of step (a) and step (b) fαr-her comprises using electromagnetic radiation having a controlled inteiasity.
14. The method of claim 9, -fu-rther comprising the step of selecting a controlled wavelength based on the monitoring of step (c).
15. A method for treating paia, comprising the steps of;
(a) exposing a first tissue associated with pain to a beam of electromagnetic radiation having a controlled variable selected from the group consisting of: (i) wavelength;
(ii) bandwidth;
(iii) pulse duration;
(iv) pulse frequency;
(v) intensity and (vi) wavelength variation over time;
(b) exposing a second tissue associated with pain to a beam of electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength; 103
(ϋ) bandwidth;
(Mi) pulse duration;
(iv) pulse frequency;
(v) intensity; and
(vi) wavelength variation overtime; and
(c) monitoring a change in a characteristic of a said radiation.
1 . The method of claiml 5, fiirther comprising selecting a variable in at least one of step (a) and step (b) based on the monitoring of step (c).
17. A method for treating pain, comprising the steps of:
(a) exposing a first tissue associated with pain to a beam of electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength;
(ii) bandwidth;
(iii) pulse duration;
(iv) pulse frequency; (v) intensity and
(vi) wavelength variation over time;
(b) • exposing a second tissue associated with pain to a beam of electromagnetic radiation having a controlled variable selected from the group consisti-ng of: (i) wavelength;
(ϋ) bandwidth;
(iii) pulse duration;
(iv) pulse frequency;
(v) intensity; and 104
(vi) wavelength variation over time; (c) monitoring a change in a characteristic of a tissue associated with said radiation; and
(d). selecting a variable in at least one of step (a) and step (b) based on the monitoring of step (c).
18- A method for treating a nervous system disorder, comprising the steps of:
(a) exposing aportion of a tissue associated with said nervous system disorder to an effective amount of electromagnetic radiation having a controlled wavelength; and
(b) monitoring a change in a characteristic of said tissue associated with said radiation.
1 . The method of claim 18, wherein step (a) further comprises electromagnetic radiation having a controlled bandwidth.
20. The method of claim 18, wherein step (a) further comprises electromagnetic radiation having a controlled pulse frequency.
21. The ethod of claim 18, wherein step (a) furfher comprises electromagnetic radiation having a controlled pulse duration,
22. Thememodofclai l8,whereiπstep(a)fu-rthercompri radiation having a controlled intensity.
23. The method of claim IS, fr-rther comprising the step of selecting a controlled wavelength based on the monitoring of step (b). 105
24, A method for treating a nervous system disorder comprising the steps of:
(a) exposing a first tissue associated with said disorder to a beam of electromagnetic radiation having a controlled variable selected from the group
' consisting of: (i) wavelength;
(ii) bandwidth; (iii) pulse duration; (iv) pulse frequency; (v) intensity; and (vi) wavelength variation over time;
(b) exposing a second tissue associated with said disorder to a beam of electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength; (ii) bandwidth;
(iii) pulse duration;
(iv) pulse frequency;
(v) intensity; and
(vi) wavelength variation over time; and (c) monitoring a change in a characteristic of a tissue associated with said radiation.
25. A method for treating a nervous system disorder, comprising the steps of: (a) exposing a first tissue associated with said disorder to a beam of electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength; (ii) bandwidth; (iii) pulse duration; 106
(iv) pulse frequency;
(v) intensity; and
(vi) wavelength variation over time;
(b) exposing a second tissue associated with said disorder to a beam of electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength;
(ii) bandwidth;
(iii) pulse duration;
(iv) pulse frequency;
(v) intensity; and
(vi) wavelength variation over time;
(c) monitoring a response of a characteristic of a tissue associated with said radiation; and
(d) selecting a variable in at least one of ste (a) and step b) based on the monitoring of step (c).
26. The method of claim 25, further comprising the step of entraining steps (a) and (b).
27. The method of claim 25, wherein at least one of step (a) and step (b) comprises providing electromagnetic radiation to at least one sensoiy tissue selected from eyes and ears.
28. The method of claim 27, wherein step (a) comprises providing electromagnetic radiation to atieast one sensoiy tissue selected froi-α eyes and ears, and step (b) comprises providing electromagnetic radiation to a peripheral tissue. 107
29. A method for treating a peripheral disorder, comprising the steps of:
(a) exposing a proximal site associated with said disorder to a beam of electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength;
(ii) bandwidth;
(hi) pulse duration;
(iv) pulse frequency;
(v) intensity; and
(vi) wavelength variation over time;
(b) exposing a distal site associated with said disorder to a beam of electromagnetic radiation having a controlled variable selected from the roup consisting of:
(i) wavelength;
(ii) bandwidth;
(iii) pulse duration;
(iv) pulse frequency;
(v) intensity and
(vi) wavelength variation over time;
(c) monitoring a response of a tissue associated with said disorder; and (d). selecting a variable in at least one of step (a) and step' (b) based on the monitoring of step (c).
30. A method for treating myofascial syndrome, comprising the steps of: (a) exposing a proximal portion of a nerve associated with said myofascial syndrome to a beam of electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength;
(ii) bandwidth; 108
(iii) pulse duration; (iv) pulse frequency; (v) intensity; and
(vi) wavelength variation over time; and (b) monitoring a response of a tissue associated with said myofascial syndrome.
31. The method of claim 30, further comprising the step of selecting a variable in step (a) based on the monitoring of step (b).
32. A method for treating symptoms associated with muscle spasm, comprising the steps of:
(a) exposing a proximal portion of a nerve associated with said muscle spasm to a beam of electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength;
(ii) bandwidth;
(iii) pulse duration;
(iv) pulse frequency;
(v) intensity; and
(vi) wavelength variation over time; and
(b) monitoring a response of a tissue associated with said myofascial syndrome.
33. A method for treating headache in a subject, comprising the steps of: (a) exposing a portion of the occipital nerve with a beam of electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength; (ϋ) bandwidth;
(iii) pulse duration;
(iv) pulse frequency;
(v) intensity; and
(vi) wavelength variation over time; and
(b) monitoring a response of a tissue associated with said headache.
34. The method of claim 33, wherein said step of exposing includes exposing said portion of the occipital nerve to a beam of electromagnetic radiation at an angle of about 45° to the cephalad.
35. The method of claim 33- further comprising stimulating said subject with a beam of electromagnetic radiation at a site near the inner canthus of the eye, said radiation having a controlled variable selected from the group consisting of:
(i) wavelength;
(ii) bandwidth;
(iii) pulse duration;
(iv) pulse frequency;
(v) intensity; and
(vi) wavelength variation over time.
36. The method of claim 33, wherein the wavelength of radiation is in the range of about 597 nm to about 622 nm.
37. The method of claim 35, wherein the wavelength of radiation is in the range of about 577 nm to about 597 nm.
38. The method of claim 35, wherein the wavelength of radiation is in the range of about 577 nm to about 622 nm.
39. A method for treating neuronal pain in a subj ct, comprising the steps of-
(a) exposing an affected tissue associated with said nerve to electromagnetic radiation having a wavelength in the range of about 400 to about 700 nm, and a controlled variable selected from the group consisting of:
(i) wavelength;
(ii) bandwidth;
(iii) pulse duration;
(iv) pulse frequency;
(v) intensity; and
(vi) wavelength variation over time; and
(b) monitoring a response of said affected tissue.
40- The method of claim 39, further comprising the step of exposing a contralateral nerve associated with said pain.
41. The method of claim 39, further comprismg the step of exposing said subject to radiation at a site proximal to the site in step (a).
42, A method for treating neuronal pain in a subject, comprising the steps of:
(a) exposing a site near CI to electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength;
(ii) bandwidth;
(iii) pulse duration;
(iv) pulse frequency;
(v) intensity; and
(vi) wavelength variation over time; and
(b) monitoring a response of a tissue associated with said neuronal pain ill
43. A method for treating sympathetic hyperactivity in a subject, comprising the steps of:
(a) exposing a blood vessel associated with said sympathetic hyperactivity to electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength;
(ii) bandwidth;
(iii) pulse duration;
(iv) pulse frequency;
(v) intensity; and
(vi) wavelength variation over time; and
(b) monitoring a response of a tissue associated with said blood vessel.
44. The method of claim 43, wherein said blood vessel is selected from the group consisting of the abdominal aorta, the femoral artery, thebrachial artery and the popliteal artery
45. A method for treating temporomandibular joint syndrome in a subj ect, comprising the steps of:
(a) exposing a tissue associated with said temporomandibular joint syndrome to electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength;
(ii) bandwidth;
(iii) pulse duration;
(iv) pulse frequency,
(v) intensity; and
(vi) wavelength variation over time; and
(b) monitoring a response of a tissue associated with said syndrome. 112
46. The method of claim 45, wherein said wavelength is in the range of about 577 nm to about 622 -nm.
47. The method of claim 45, additionally comprising the step of subsequently exposing said tissue to electromagnetic radiation having a wavelength in the range of about 455 nm to about 492 nm.
48. A method for treating trigeminal neuralgia, comprising the steps of:
(a) exposing a tissue associated with trigeminal neuralgia to electromagnetic radiation having a controlled variable selected from the group consisting of:
(i) wavelength;
(ii) bandwidth;
(iii) pulse duration;
(iv) pulse frequency;
(v) intensity; and
(vi) wavelength variation over time; and
(b) monitoring a response of a tissue associated with trigeminal neuralgia.
49. A method for treating a abnormalities of vascular perfusion, comprising the steps of:
(a) exposing a portion of a tissue associated with said abnormality of vascular perfusion to an effective amount of electromagnetic radiation having a controlled wavelength; and
(b) monitoring a change in a characteristic of said tissue associated with said radiation. 113
50. The method of claim 1 , wherein said pain is associated with a disorder selected from the group consisting of complex regional pain syndrome, sympathetic dystonia, reflex sympathetic dystrophy, post surgical pain, muscle spasm, caipal tunnel syndrome, peripheral neuropathy, tarsal tunnel syndrome, dental pain, gingivitis, and traumatic injury.
51. A method for treating a subject having a neuromuscular abnormality, comprising the steps of:
(a) identifying a site of a neuromuscular abnormality;
(b) selecting at least one site on said subject's body for electromagnetic radiation therapy (E T); and
(c) exposing said at least one site for ERT to a beam comprising an effective amount of electromagnetic radiation having a wavelength in the visible range.
52. The method of claim 51 , wherein said wavelength of electromagnetic radiation comprises a central wavelength and said wherein wavelength changes with time by a pre-determined wavelength variation around said central wavelength.
53. The method of claim 52, wherein said wavelength variation is in the range of about 1 nm to about 100 nm.
54. The method of claim 52, wherein said wavelength variation occurs with a cycle time in the range of about 1 sec to about 100 sec.
55. The method of claim 52, wherein said wavelength variation occurs in a linear fashion. 114
56. The method of claim 52, wherein said wavelength variation occurs in a attern selected from the group consisting of v-waves, sine waves and trapezoidal waves.
57. The method of claim 51, wherein said neuromuscular abnormality is tra ezius spasm.
58. The method of claim 51 , wherein said neuromuscular abnormality is carpal tunnel syndrome.
59. The method of claim 51 , wherein said neuromuscular abnormality is lower extremity neuropathy.
60. The method of claim 51, wherein said neuromuscular abnormality is myofascial syndrome.
61. The method of claim 51 , wherein said site selected in step (b) is an electrodiagnostic point, an acupuncture point, a trigger point, a meridian or is along a nerve distribution to said site of neuromuscular abnormality.
62. The method of claim 51 , wherein said beam of electromagnetic radiation has a cross-sectional shape selected from the group consisting of circular, ellipsoidal, triangular and rectangular.
63. The method of claim 51 , wherein said step (c) includes moving said beam of electromagnetic radiation between locations selected in step (b).
64. The method of claim 51, wherein two sites are selected in step (b) and a first beam of electromagnetic radiation is directed to a first site and 115
wherein a second beam of electromagnetic radiation is directed at a second site.
65. The method of claim 64, wherein said fist beam has at least one property selected from the group consisting of central wavelength, wavelength variation, frequency, change in frequency, intensity, change in intensity or duration of application that is different from the corresponding property of said second beam.
PCT/US2002/020131 2001-06-26 2002-06-26 Therapeutic methods using electromagnetic radiation WO2003002186A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
PCT/US2002/020131 WO2003002186A2 (en) 2001-06-26 2002-06-26 Therapeutic methods using electromagnetic radiation
EP02746680A EP1414516A2 (en) 2001-06-26 2002-06-26 Therapeutic methods using electromagnetic radiation
US10/180,802 US7150710B2 (en) 2001-06-26 2002-06-26 Therapeutic methods using electromagnetic radiation
US11/486,912 US7878965B2 (en) 2001-06-26 2006-07-14 Therapeutic methods using electromagnetic radiation
US11/975,665 US7918779B2 (en) 2001-06-26 2007-10-19 Therapeutic methods using electromagnetic radiation

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30137601P 2001-06-26 2001-06-26
US30131901P 2001-06-26 2001-06-26
US60/301,319 2001-06-26
US60/301,376 2001-06-26
PCT/US2002/020131 WO2003002186A2 (en) 2001-06-26 2002-06-26 Therapeutic methods using electromagnetic radiation

Publications (3)

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WO2003002186A2 WO2003002186A2 (en) 2003-01-09
WO2003002186A3 WO2003002186A3 (en) 2003-09-25
WO2003002186B1 true WO2003002186B1 (en) 2003-11-20

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US (3) US7150710B2 (en)
EP (1) EP1414516A2 (en)
WO (1) WO2003002186A2 (en)

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