WO2003004696A3 - A distributed system for epigenetic based prediction of complex phenotypes - Google Patents

A distributed system for epigenetic based prediction of complex phenotypes Download PDF

Info

Publication number
WO2003004696A3
WO2003004696A3 PCT/EP2002/006587 EP0206587W WO03004696A3 WO 2003004696 A3 WO2003004696 A3 WO 2003004696A3 EP 0206587 W EP0206587 W EP 0206587W WO 03004696 A3 WO03004696 A3 WO 03004696A3
Authority
WO
WIPO (PCT)
Prior art keywords
epigenetic
distributed system
based prediction
phenotypic
complex phenotypes
Prior art date
Application number
PCT/EP2002/006587
Other languages
French (fr)
Other versions
WO2003004696A2 (en
Inventor
Peter Adorjan
Alexander Olek
Christian Piepenbrock
Original Assignee
Epigenomics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag filed Critical Epigenomics Ag
Priority to JP2003510454A priority Critical patent/JP2005516269A/en
Priority to EP02743199A priority patent/EP1502222A2/en
Publication of WO2003004696A2 publication Critical patent/WO2003004696A2/en
Publication of WO2003004696A3 publication Critical patent/WO2003004696A3/en

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

This invention concerns systems for collecting and storing epigenetic and phenotypic information about samples in order to measure and analyse tissue samples and/or cell lines, where the epigenetic parameter is DNA methylation and the phenotypic parameters describe an individual. The method includes parameters such as the diagnosis of diseases and/or drug resistance, wherein the correlation of the epigenetic with the phenotypic parameters is done substantially without human intervention.
PCT/EP2002/006587 2001-07-02 2002-06-14 A distributed system for epigenetic based prediction of complex phenotypes WO2003004696A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2003510454A JP2005516269A (en) 2001-07-02 2002-06-14 A distributed system for predicting complex phenotypes based on epigenetics
EP02743199A EP1502222A2 (en) 2001-07-02 2002-06-14 A distributed system for epigenetic based prediction of complex phenotypes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30249001P 2001-07-02 2001-07-02
US60/302,490 2001-07-02

Publications (2)

Publication Number Publication Date
WO2003004696A2 WO2003004696A2 (en) 2003-01-16
WO2003004696A3 true WO2003004696A3 (en) 2004-11-04

Family

ID=23167936

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/006587 WO2003004696A2 (en) 2001-07-02 2002-06-14 A distributed system for epigenetic based prediction of complex phenotypes

Country Status (4)

Country Link
US (1) US20030036081A1 (en)
EP (1) EP1502222A2 (en)
JP (1) JP2005516269A (en)
WO (1) WO2003004696A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7805388B2 (en) * 1998-05-01 2010-09-28 Health Discovery Corporation Method for feature selection in a support vector machine using feature ranking
US7318051B2 (en) * 2001-05-18 2008-01-08 Health Discovery Corporation Methods for feature selection in a learning machine
US7475048B2 (en) * 1998-05-01 2009-01-06 Health Discovery Corporation Pre-processed feature ranking for a support vector machine
US7970718B2 (en) * 2001-05-18 2011-06-28 Health Discovery Corporation Method for feature selection and for evaluating features identified as significant for classifying data
EP1268855A2 (en) * 2000-03-15 2003-01-02 Epigenomics AG Diagnosis of diseases associated with tumor suppressor genes and oncogenes
EP1370685A2 (en) * 2000-04-06 2003-12-17 Epigenomics AG Diagnosis of diseases associated with dna repair
AU2001289617A1 (en) * 2000-06-30 2002-01-08 Epigenomics Ag Diagnosis of diseases associated with signal transduction
US7624074B2 (en) * 2000-08-07 2009-11-24 Health Discovery Corporation Methods for feature selection in a learning machine
DE10054974A1 (en) * 2000-11-06 2002-06-06 Epigenomics Ag Diagnosis of diseases associated with Cdk4
DE10054972A1 (en) * 2000-11-06 2002-06-06 Epigenomics Ag Diagnosis of diseases associated with humus
DE10128508A1 (en) 2001-06-14 2003-02-06 Epigenomics Ag Methods and nucleic acids for the differentiation of prostate tumors
SG120889A1 (en) * 2001-09-28 2006-04-26 Semiconductor Energy Lab A light emitting device and electronic apparatus using the same
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
JP4367901B2 (en) * 2003-06-20 2009-11-18 キヤノン株式会社 Spotter with spot pattern encryption function and detection device that supports spot pattern encryption
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
WO2008025093A1 (en) * 2006-09-01 2008-03-06 Innovative Dairy Products Pty Ltd Whole genome based genetic evaluation and selection process
US20090049856A1 (en) * 2007-08-20 2009-02-26 Honeywell International Inc. Working fluid of a blend of 1,1,1,3,3-pentafluoropane, 1,1,1,2,3,3-hexafluoropropane, and 1,1,1,2-tetrafluoroethane and method and apparatus for using
US20090094065A1 (en) * 2007-10-04 2009-04-09 Hyde Roderick A Systems and methods for underwriting risks utilizing epigenetic information
US20090094261A1 (en) * 2007-10-04 2009-04-09 Jung Edward K Y Systems and methods for correlating epigenetic information with disability data
US20100027780A1 (en) * 2007-10-04 2010-02-04 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and methods for anonymizing personally identifiable information associated with epigenetic information
US20090099877A1 (en) * 2007-10-11 2009-04-16 Hyde Roderick A Systems and methods for underwriting risks utilizing epigenetic information
US20090094281A1 (en) * 2007-10-04 2009-04-09 Jung Edward K Y Systems and methods for transferring combined epigenetic information and other information
US20090094067A1 (en) * 2007-10-04 2009-04-09 Searete LLC, a limited liability corporation of Systems and methods for company internal optimization utilizing epigenetic data
US20090100095A1 (en) * 2007-10-04 2009-04-16 Jung Edward K Y Systems and methods for reinsurance utilizing epigenetic information
US20090094047A1 (en) * 2007-10-04 2009-04-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems and methods for predicting a risk utilizing epigenetic data
JP5838557B2 (en) 2010-07-05 2016-01-06 ソニー株式会社 Biological information processing method and apparatus, and recording medium
JP6222202B2 (en) * 2010-07-05 2017-11-01 ソニー株式会社 Biological information processing method and apparatus, and recording medium
US10635837B1 (en) 2019-04-30 2020-04-28 HealthBlock, Inc. Dynamic data protection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214556B1 (en) * 1997-11-27 2001-04-10 Epigenomics Ag Method for producing complex DNA methylation fingerprints
DE10054922A1 (en) * 1999-11-06 2001-05-31 Dennis Sunga Fernandez Computerized health service, determines bio-informatic value related to individual genetically-associated risk, and carries out transactions accordingly

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10128508A1 (en) * 2001-06-14 2003-02-06 Epigenomics Ag Methods and nucleic acids for the differentiation of prostate tumors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214556B1 (en) * 1997-11-27 2001-04-10 Epigenomics Ag Method for producing complex DNA methylation fingerprints
DE10054922A1 (en) * 1999-11-06 2001-05-31 Dennis Sunga Fernandez Computerized health service, determines bio-informatic value related to individual genetically-associated risk, and carries out transactions accordingly

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LAIRD P W ET AL: "The role of DNA methylation in cancer genetic and epigenetics.", ANNUAL REVIEW OF GENETICS. 1996, vol. 30, 1996, pages 441 - 464, XP002295974, ISSN: 0066-4197 *
MODEL F ET AL: "FEATURE SELECTION FOR DNA METHYLATION BASED CANCER CLASSIFICATION", BIOINFORMATICS, OXFORD UNIVERSITY PRESS, OXFORD,, GB, vol. 17, no. SUPPL 1, June 2001 (2001-06-01), pages 157 - 164, XP001154594, ISSN: 1367-4803 *
YAN P S ET AL: "CpG island arrays: an application toward deciphering epigenetic signatures of breast cancer", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 6, no. 4, April 2000 (2000-04-01), pages 1432 - 1438, XP002245955, ISSN: 1078-0432 *

Also Published As

Publication number Publication date
EP1502222A2 (en) 2005-02-02
US20030036081A1 (en) 2003-02-20
WO2003004696A2 (en) 2003-01-16
JP2005516269A (en) 2005-06-02

Similar Documents

Publication Publication Date Title
WO2003004696A3 (en) A distributed system for epigenetic based prediction of complex phenotypes
WO2001057274A3 (en) Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
WO2002002807A3 (en) Diagnosis of diseases associated with cell signalling
WO2001077377A3 (en) Diagnosis of diseases associated with dna replication by assessing dna methylation
WO2001068911A8 (en) Diagnosis of diseases associated with the cell cycle
WO2002080079A3 (en) System and method for the detection of genetic interactions in complex trait diseases
HK1026003A1 (en) Method of preparing a standard diagnostic gene transcript pattern.
AU2001247311A1 (en) A system and method for obtaining, processing and evaluating patient information for diagnosing disease and selecting treatment
AU6796600A (en) System, method, and article of manufacture for identifying an individual and managing an individual's health records
AU2001278840A1 (en) Hydrogel biosensor and biosensor-based health alarm system
WO2005033334A3 (en) Method for determining an active ingredient dosage
WO2000070340A3 (en) Materials and methods relating to disease diagnosis
WO2001026029A3 (en) Method and system for providing genotype clinical information over a computer network
WO2002063951A3 (en) Human disease modeling using somatic gene transfer
WO2002036814A3 (en) Diagnosis of diseases associated with cdk4 by determining the methylation state of the cdk4
EP2354228A3 (en) Identification marker responsive to interferon therapy for renal cell cancer
WO2003023056A3 (en) Specific markers for multiple sclerosis
WO2002036604A3 (en) Diagnosis of diseases associated with the human c-mos gene
WO2004046382A3 (en) Product and method
WO2002057499A3 (en) Mdr1 variants and methods for their use
AU2003223033A8 (en) System for point of care diagnosis and/or analysis
WO2002012554A3 (en) Diagnosis of diseases which are associated with cd24
AU2003276727A1 (en) Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
WO2003014879A3 (en) System and method for identifying a genetic risk factor for a disease or pathology
WO2008088236A8 (en) Method for genetically identifying a person according to the analysis of the single nucleotide polymorphism of a human genom by means of a oligonucleotide biological microchip (biochip)

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2002345042

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2003510454

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2002743199

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2002743199

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2002743199

Country of ref document: EP