WO2003005890A3 - Affinity biosensor for monitoring of biological process - Google Patents

Affinity biosensor for monitoring of biological process Download PDF

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Publication number
WO2003005890A3
WO2003005890A3 PCT/US2002/023300 US0223300W WO03005890A3 WO 2003005890 A3 WO2003005890 A3 WO 2003005890A3 US 0223300 W US0223300 W US 0223300W WO 03005890 A3 WO03005890 A3 WO 03005890A3
Authority
WO
WIPO (PCT)
Prior art keywords
probe
marker
binding member
regions
immobilized
Prior art date
Application number
PCT/US2002/023300
Other languages
French (fr)
Other versions
WO2003005890A2 (en
Inventor
Stephen P Beaudoin
Karl S Booksh
Philip A Khairallah
Hassan Loutfi
Alyssa Panitch
Anneta Razatos
Colleen Brophy
Original Assignee
Univ Arizona State
Stephen P Beaudoin
Karl S Booksh
Philip A Khairallah
Hassan Loutfi
Alyssa Panitch
Anneta Razatos
Colleen Brophy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona State, Stephen P Beaudoin, Karl S Booksh, Philip A Khairallah, Hassan Loutfi, Alyssa Panitch, Anneta Razatos, Colleen Brophy filed Critical Univ Arizona State
Priority to JP2003511703A priority Critical patent/JP2005512021A/en
Priority to US10/483,586 priority patent/US20040186359A1/en
Priority to AU2002317557A priority patent/AU2002317557A1/en
Priority to CA002453141A priority patent/CA2453141A1/en
Priority to EP02748225A priority patent/EP1411816A4/en
Publication of WO2003005890A2 publication Critical patent/WO2003005890A2/en
Publication of WO2003005890A3 publication Critical patent/WO2003005890A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
    • A61B5/4312—Breast evaluation or disorder diagnosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography

Abstract

An optical biosensor carries one of more affinity legends or binding members that bind specifically to a marker being monitored. Light directed along optic fibers illuminates a surface plasmon resonance ('SPRN') probe surface on which is immobilized the binding member. A spectrophotometer receives light reflected back along the fiber optic path and provides wavelength information indicative of the absence or presence of surface plasmon resonance indicative of the bound marker in known SPR manner. The probe is used in vitro or in vivo. When used in vivo the fiber optic light path comprises a catheter that directs the probe to an implant site. For in vivo implantation a housing houses the probe at the implant site and is adapted to filter out larger particles that would adversely affect with the spectral analysis. In one embodiment the probe has two regions on its surface. The first region has no immobilized binding member. The second region does have the binding member immobilized on it. Light returned from the first and second regions can be compared. The presence or absence of a marker bound by the binding member on the second surface is apparent in the similarity or dissimilarity of the spectral information returned form the two regions. The probe can monitor blood, spinal fluid, mucous membrane, wound tissue, implanted organs, urine, and other substances for the presence of a marker which may be indicative of a medical condition in an animal or human subject.
PCT/US2002/023300 2001-07-09 2002-07-09 Affinity biosensor for monitoring of biological process WO2003005890A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2003511703A JP2005512021A (en) 2001-07-09 2002-07-09 Affinity biosensor for monitoring biological processes
US10/483,586 US20040186359A1 (en) 2001-07-09 2002-07-09 Afinity biosensor for monitoring biological process
AU2002317557A AU2002317557A1 (en) 2001-07-09 2002-07-09 Afinity biosensor for monitoring of biological process
CA002453141A CA2453141A1 (en) 2001-07-09 2002-07-09 Afinity biosensor for monitoring of biological process
EP02748225A EP1411816A4 (en) 2001-07-09 2002-07-09 Affinity biosensor for monitoring of biological process

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30395601P 2001-07-09 2001-07-09
US60/303,956 2001-07-09

Publications (2)

Publication Number Publication Date
WO2003005890A2 WO2003005890A2 (en) 2003-01-23
WO2003005890A3 true WO2003005890A3 (en) 2003-09-04

Family

ID=23174415

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023300 WO2003005890A2 (en) 2001-07-09 2002-07-09 Affinity biosensor for monitoring of biological process

Country Status (6)

Country Link
US (1) US20040186359A1 (en)
EP (1) EP1411816A4 (en)
JP (1) JP2005512021A (en)
AU (1) AU2002317557A1 (en)
CA (1) CA2453141A1 (en)
WO (1) WO2003005890A2 (en)

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CA2453141A1 (en) 2003-01-23
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